Therapeutic Response After Immunosuppressive Drug Prescription in Non-infectious Uveitis: A Survival Analysis

Immunosuppressive drugs; Response to therapyMedicaments immunosupressors; Resposta al tractamentMedicamentos inmunosupresores; Respuesta al tratamientoIntroduction To identify factors affecting the response rate to immunosuppressive drugs (ISDs) in patients with non-infectious uveitis (NIU). Methods This longitudinal retrospective cohort study included patients from the Hospital Clinico San Carlos Uveitis Clinic diagnosed with NIU from 1992 to 2016. Subjects were followed up from ISD prescription until the achievement of good therapeutic response (GTR), ISD treatment change, or up to 12 months. GTR was defined as the complete resolution of the eye inflammatory manifestations with a corticosteroid dose ≤ 10 or ≤ 5 mg per day of prednisone or equivalent (GTR10 and GTR5, respectively) maintained for at least 28 days. Kaplan–Meier curves were estimated for GTR. Demographic, clinical, and treatment-related factors were analyzed using Cox robust regression. Results A total of 73 patients (100 episodes of ISD prescription) were analyzed. In 44 and 41 episodes, GTR10 and GTR5 were achieved, respectively. A lower hazard for both GTRs was associated with uveitic macular edema at prescription and with a higher “highest oral corticosteroid dose prescribed in the year before ISD prescription”. GTR10 was higher if cyclosporine was prescribed (compared to other ISDs), and if a higher number of ISDs had been previously prescribed. GTR5 hazard was lower for patients with posterior uveitis or if the ISDs were prescribed before 2008, and higher if periocular corticosteroids had been administered before ISD prescription, or if the duration of the posterior segment activity was shorter. Conclusions Factors associated with GTR to ISDs may help to identify patients with NIUs who could benefit from a thorough follow-up.This work was supported by the Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain [ICI19/00020; PI20/01221; RD21/002/0001]. The sponsor or funding organization had no role in the design or conduct of this research. The journal’s Rapid Service Fee was funded by the institution employing the senior author of the manuscript (Fundación Biomédica del Hospital Clínico San Carlos)

Relación entre los niveles de actividad física y la capacidad aeróbica de los estudiantes de primer semestre de la licenciatura en educación física, recreación y deportes de la Corporación Universitaria Minuto de Dios del año 2015

La presente investigación tiene como objetivo analizar el nivel de Actividad Física y la relación entre la Capacidad Aeróbica en los estudiantes de primer semestre de la Licenciatura en Educación Física, Recreación y Deportes, de la Corporación Universitaria Minuto de Dios del año 2015-2

Ciberacoso sexual de niños y adolescentes en redes sociales y su regulación protectora y preventiva en la legislación Peruana – 2021

objetivo: Evaluar la regulación normativa del ciberacoso sexual de las redes sociales en la legislación peruana y su pertinencia protectora y preventiva a la población vulnerable de los niños y adolescentes. Metodología: diseño no experimental, observacional de comportamiento de variables, de tipo básico-teórico. El universo poblacional de estudio fueros los estudiantes de Derecho de la Universidad Nacional José Faustino Sánchez Carrión, y luego se selecciona una muestra representativa la misma que asciende a cincuenta estudiantes de los dos últimos ciclos. Resultados: Se tiene un 62 % en desacuerdo, la regulación normativa del ciberacoso sexual en redes sociales no estaría protegiendo ni previniendo a la población vulnerable de niños y adolescentes. Conclusiones: El ciberacoso sexual es un hecho que se da en el anonimato, es complejo su persecución delictiva, esta conducta acosadora no está prevista típicamente en el Código Penal, es complejo su investigación material y juzgamiento exitoso a los responsables

The A-cation deficient perovskite series La_2-xCoTiO_6-δ (0 ≤ x ≤ 0.20): new components for potential SOFC composite cathodes

The best performances are obtained for low x due to a compromise between sufficiently high amount of defects, but not so high to induce defect clustering.</p

Plan de negocios para la Creación de un Lavadero de Vehículos Portable con Sistema a Vapor para la Ciudad de Villaviencio, meta ( Etapa 1).

86 (4) Hojas.Desarrollar un plan de negocio para la creación de un lavadero de vehículos con un sistema portable de lavado a vapor en Villavicencio, Meta (Etapa I). Realizar un estudio de mercado que permita identificar las características del cliente, precio, calidad, cantidad, competencia, sector, de tal forma que se pueda construir un adecuado plan de marketing para el desarrollo del proyecto (Etapa I). Realizar un análisis del marco legal de acuerdo a la actividad económica del proyecto y al sector en el que se desenvuelve (Etapa I). Realizar un estudio técnico que determine la capacidad de producción, la localización y tamaño óptimo, la ingeniería y la organización humana consecuente con el comportamiento del mercado y las restricciones financieras (Etapa II). Realizar un estudio financiero y ambiental que permita analizar la conveniencia de la propuesta de inversión (Etapa III).Resultado final para optar el título de Especialización en Gerencia de Proyectos, Tesis (Especialista en Gerencia de Proyectos) Universidad de los Llanos. Villavicencio - Meta 2018.EspecializaciónEspecializaciones en Gestion de Proyecto

Observatorio del delito

El "Observatorio del Delito", como su nombre lo expresa es un sistema de vigilancia que utiliza información de tipo geo-referenciada, compartida y analizada interinstitucionalmente como instrumento válido para la definición de estrategias de intervención a nivel local y regional por parte de las administraciones Municipales y Departamentales, en orden a desarrollar una adecuada política criminal.Universidad Libre Seccional Pereira -- Facultad de Derecho, Ciencias Políticas y Sociales -- Derech

Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-gamma/IL-17 release in bladder cancer treatment

The mechanism of action of intravesical Mycobacterium bovis BCG immunotherapy treatment for bladder cancer is not completely known, leading to misinterpretation of BCG-unresponsive patients, who have scarce further therapeutic options. BCG is grown under diverse culture conditions worldwide, which can impact the antitumor effect of BCG strains and could be a key parameter of treatment success. Here, BCG and the nonpathogenic Mycobacterium brumae were grown in four culture media currently used by research laboratories and BCG manufacturers: Sauton-A60, -G15 and -G60 and Middlebrook 7H10, and used as therapies in the orthotopic murine BC model. Our data reveal that each mycobacterium requires specific culture conditions to induce an effective antitumor response. since higher survival rates of tumor-bearing mice were achieved using M. brumae-A60 and BCG-G15 than the rest of the treatments. M. brumae-A60 was the most efficacious among all tested treatments in terms of mouse survival, cytotoxic activity of splenocytes against tumor cells, higher systemic production of IL-17 and IFN-gamma, and bladder infiltration of selected immune cells such as ILCs and CD4(TEM). BCG-G15 triggered an antitumor activity based on a massive infiltration of immune cells, mainly CD3(+) (CD4(+) and CD8(+)) T cells, together with high systemic IFN-gamma release. Finally, a reduced variety of lipids was strikingly observed in the outermost layer of M. brumae-A60 and BCG-G15 compared to the rest of the cultures, suggesting an influence on the antitumor immune response triggered. These findings contribute to understand how mycobacteria create an adequate niche to help the host subvert immunosuppressive tumor actions

Exploring Blue Spaces' Effects on Childhood Leukaemia Incidence: A Population-Based Case-Control Study in Spain

Background: Blue spaces have been a key part of human evolution, providing resources and helping economies develop. To date, no studies have been carried out to explore how they may be linked to paediatric oncological diseases. Objectives: To explore the possible relationship of residential proximity to natural and urban blue spaces on childhood leukaemia. Methods: A population-based case–control study was conducted in four regions of Spain across the period 2000–2018. A total of 936 incident cases and 5616 controls were included, individually matched by sex, year of birth and place of residence. An exposure proxy with four distances (250 m, 500 m, 750 m, and 1 km) to blue spaces was built using the geographical coordinates of the participants’ home residences. Odds ratios (ORs) and 95% confidence intervals (95%CIs) for blue-space exposure were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic and environmental covariates. Results: A decrease in overall childhood leukaemia and ALL-subtype incidence was found as we came nearer to children’s places of residence, showing, for the study as a whole, a reduced incidence at 250 m (odds ratio (OR) = 0.77; 95%CI = 0.60–0.97), 500 m (OR = 0.78; 95%CI = 0.65–0.93), 750 m (OR = 0.80; 95%CI = 0.69–0.93), and 1000 m (OR = 0.84; 95%CI = 0.72–0.97). AML model results showed an increasing incidence at closest to subjects’ homes (OR at 250m = 1.06; 95%CI=0.63–1.71). Conclusions: Our results suggest a possible association between lower childhood leukaemia incidence and blue-space proximity. This study is a first approach to blue spaces’ possible effects on childhood leukaemia incidence; consequently, it is necessary to continue studying these spaces—while taking into account more individualised data and other possible environmental risk factors.This study was funded by Carlos III Institute of Health, Spain (grant numbers PI19CIII/00025, PI16CIII/00009, EPY-505/19-PFIS), and Spain’s Health Research Fund (Fondo de Investigación Sanitaria-FIS grant number 12/01416). The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.S