La rebeldia de la letra. Escritura, viaje y teoria en la novela espanola y argentina del siglo XX

This dissertation uses an interdisciplinary approach to analyze and problematize the intersections of writing, theory and travel in a body of contemporary literature from Argentina and Spain. In the first chapter, I examined the paths of three travelers, Jose Ortega y Gasset, Victoria Ocampo and Witold Gombrowicz, who despite their dissimilar experiences, produce a form of writing closely linked to movement and becoming. Through the medieval topos of homo viator, which conceives the human as pilgrim and life as a voyage of deciphering, I examine the practice of writing as a constant movement requiring the writer to embark on a journey through what Martin Heidegger called, the holzwege. In so doing, the writer must exit the polis, and from the position of the outsider, the writer will be able to write and do the work of theory. In subsequent chapters, I analyze writing spaces in the novels of Enrique Vila-Matas and Hector Libertella and how those places are, in fact, traveling spaces that question any concept of fixed or permanent belonging. By proposing a practice of writing that is self-reflexive and preoccupied with the possibilities of writing, I look at the responses of Libertella and Vila-Matas to the twentieth century nihilistic malaise that leads to silence. Ultimately, my goal is to construct a theory of writing that portrays the practice of writing as mobile, fluid, and desobedient to national formations and literary traditions

The Remote Learning Experience at Portland State University in Spring 2020

It is an endeavor to understand what we have and will learn about the impact of remote instruction on faculty, students and relevant academic support teams. Simply put: We want to learn from an experiment foisted upon us by a health crisis. We have engaged in an incredibly innovative response. And now, we ask what have we learned? How might we improve? And, most importantly, are there implications from this experiment for the future of instruction at PSU and throughout higher education? The project was organized around two stages in the Spring 2020 term. Stage One: Out of the Gate: Reflections and Lessons Learned (First half of the term) Stage Two: Reaching the Finish Line: Lessons Learned and Recommendations for moving forward (Second half of the term). The project began the week of April 20 and continued through June 12. The original plan called for the following participants: (a) ten undergraduate students to put together a group of 8-10 other students to discuss the questions posed in the study; (b) Three graduate students who would assemble 5-7 fellow graduate students; (c) Three tenured or tenure-track faculty, two non-tenure-track faculty and three adjunct faculty, each of whom would form a chat group of 5-7 other faculty to discuss the questions posed in the study. In addition, Judith Ramaley put together a chat group of a dozen student support unit leaders to explore how each unit adjusted as the university moved quickly to remote learning and remote work and then, in a second round, what lessons each had learned throughout the spring term about ways to support students and assist faculty members who were also seeking to help their students

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Cúrcuma

La cúrcuma se ha utilizado desde tiempo ancestrales con diversas aplicaciones biológicas, que motivaron la investigación científica sobre sus posibles aplicaciones terapéuticas. Aunque se han realizado un sin número de estudios con extractos y polvo de rizoma de C. longa, que incluyen ensayos in vitro, preclínicos y clínicos, todavía no se han desarrollado fármacos, sólo se encuentran formando parte de suplementos dietarios aprobados en numerosos países, incluso la curcumina como sustancia pura o mezcla de curcuminoides. Dado que la curcumina se puede obtener en forma pura, sería preferible desarrollar nuevos medicamentos a partir de este compuesto en virtud de la amplia gama de efectos biológicos que ha demostrado. Sin embargo, el potencial terapéutico de curcumina está limitado debido a su escasa biodisponibilidad oral e insuficiente solubilidad en disolventes acuosos que conducen a una pobre absorción, un metabolismo rápido y una rápida eliminación sistémica. Para superar este obstáculo, se han desarrollado numerosas estrategias, desde el diseño de análogos semisintéticos, el uso de adyuvantes, preparación de nanoportadores, nanopartículas, micelas y liposomas, hasta procesos de microencapsulación, que han mejorado su bioactividad y biodisponibi- lidad, así como una mayor absorción celular en comparación con la curcumina. Curcumina es un compuesto natural antioxidante que, por sus efectos antivirales, antiinflamatorios e inmunomoduladores se postula como un posible fármaco para el tratamiento de COVID-19. Sin embargo, es necesario llevar a cabo extensos estudios sobre sus efectos farmacológicos, mecanismos de acción, farmacodinamia, farmacocinética, toxicidad, y principalmente ensayos clínicos.Fil: Gomez, Tomás Isaac. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Marioni, Juliana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Mugas, María Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentin

Propuesta de modelo de negocio para localización, acceso y actualización de historial médico de adultos mayores en situaciones de riesgo en Perú

Dada la creciente inseguridad y el precario sistema de salud en el Perú, los adultos mayores por su condición de vulnerabilidad están expuestos a situaciones de alto riesgo, debido a que en la práctica resulta difícil ser localizables rápidamente y no disponen en el momento de datos médicos básicos que pueden resultar vitales en estas situaciones de emergencia. La propuesta de solución consiste en ofrecer un dispositivo electrónico de alta tecnología, ligero, portátil y de fácil uso, capaz de enviar señales de auxilio, posicionamiento GPS y con acceso a la información médica del adulto mayor en emergencia, entre otras funcionalidades configurables y escalables en el tiempo con la seguridad y confiabilidad que requiere el usuario. El objetivo de la solución es que los adultos mayores y sus familiares puedan elevar su capacidad de respuesta frente a estas circunstancias. Ello permitirá incrementar la autonomía de los adultos mayores, mientras que a su vez se sentirán empoderados en gestionar mejor su seguridad y salud. Asimismo, brindará a sus familiares la tranquilidad de saber dónde se encuentran y con la confianza de poder responder de mejor manera ante cualquier emergencia. La meta es que la gran mayoría de los adultos mayores en el Perú puedan beneficiarse de la propuesta de solución.Given the growing insecurity and the precarious health system in Peru, elderly adults due to their vulnerable condition, are exposed to high-risk situations, because in practice, it is difficult to be located quickly, and they do not have primary medical data that can be vital in these emergencies available in the moment. The proposed solution consists of offering a high-tech, lightweight, portable and easy-to-use electronic device, capable of sending distress signals, GPS positioning, and access to medical information of the person in an emergency, among other configurable and scalable functionalities over time with the security and reliability required by the user. The objective of the solution is elderly, and their families will be able to increase their capacity to respond to these circumstances. This solution will increase the autonomy of older adults while at the same time will feel empowered to manage their safety and health better. Likewise, it will give their family members peace of mind of knowing where they are and with the confidence of being able to respond better to any emergency. The goal is that most elderly people in Peru can benefit from the proposed solution

Equinácea

En el arduo contexto pandemia de COVID-19, caracterizado con más de 6.000.000 de muertos en todo el mundo hasta la actualidad, la búsqueda de nuevos agentes terapeúticos resulta sumamente importante para tratar dicha infección. Con el inicio de la pandemia, los preparados a base de "equinácea" cobraron un gran auge en todo el mundo. Esto se debe a su actual y establecida popularidad como fortalecedores del sistema inmunológico, cumpliendo un rol importante en el tratamiento y prevención de infecciones del tracto respiratorio superior; por lo que, estos son sugeridos como una potencial alternativa preventiva y terapéutica para el manejo de la infección por COVID-19. En esta revisión, se desarrollan los avances científicos en cuanto a la bioactividad y seguridad de Echinacea que atañan al potencial uso de esta droga vegetal como agentes terapéuticos y/o preventivos de COVID-19.Fil: Gomez, Tomás Isaac. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Mugas, María Laura. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; ArgentinaFil: Marioni, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Konigheim, Brenda Salome. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Núñez Montoya, Susana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentin

Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay

Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances

Rapid Epidemic Expansion of Chikungunya Virus East/Central/South African Lineage, Paraguay

The spread of Chikungunya virus is a major public health concern in the Americas. There were >120,000 cases and 51 deaths in 2023, of which 46 occurred in Paraguay. Using a suite of genomic, phylodynamic, and epidemiologic techniques, we characterized the ongoing large chikungunya epidemic in Paraguay