The formation of spiral arms and rings in barred galaxies

In this and in a previous paper (Romero-Gomez et al. 2006) we propose a theory to explain the formation of both spirals and rings in barred galaxies using a common dynamical framework. It is based on the orbital motion driven by the unstable equilibrium points of the rotating bar potential. Thus, spirals, rings and pseudo-rings are related to the invariant manifolds associated to the periodic orbits around these equilibrium points. We examine the parameter space of three barred galaxy models and discuss the formation of the different morphological structures according to the properties of the bar model. We also study the influence of the shape of the rotation curve in the outer parts, by making families of models with rising, flat, or falling rotation curves in the outer parts. The differences between spiral and ringed structures arise from differences in the dynamical parameters of the host galaxies. The results presented here will be discussed and compared with observations in a forthcoming paper.Comment: 16 pages, 13 figures, accepted in A&A. High resolution version available at http://www.oamp.fr/dynamique/pap/merce.htm

How Stigma Impacts the Utilization of Mental Health Services Among Young Adults\u27 Within Three Different Ethnic Minority Communities

Mental health is an important aspect of every individual’s life. However, regardless of its importance, mental health is a topic that does not get much recognition. It is often simply brushed under the rug and ignored. Consequently, individuals who have mental health diagnoses may or may not choose to seek the necessary assistance. This specifically seems to be the case among adolescents and young adults within various ethnic communities, which may be due to the stigma surrounding mental health in their communities. To illustrate, regardless of the high prevalence rate of mental health issues among the minority youth, many of them still do not utilize the appropriate mental health services. With all that being said, this study questions how stigma influences the utilization of mental health services among young adults’ within the Latino/Latinx, African American, and Asian American communities through the descriptive, secondary data analysis of the UCLA Center for Health Policy Research 2021 California Health Interview Survey (CHIS) data. The key hypothesis for this study was that a major factor on whether or not these young adults’ speak out and seek help in regards to their mental health is the stigma that their race and ethnicity face. Descriptive analysis was utilized to identify frequencies of variables, quantitative analysis techniques were used to analyze the additional CHIS data, and a multiple logistic regression was conducted in order to identify any significant relationships between the variables. The findings of this research study indicate that stigma associated with mental health may not be the only factor in determining young adults’ utilization of mental health services

On the origin of rR_1 ring structures in barred galaxies

We propose a new theory for the formation of rR_1 ring structures, i.e. for ring structures with both an inner and an outer ring, the latter having the form of ``8''. We propose that these rings are formed by material from the stable and unstable invariant manifolds associated with the Lyapunov orbits around the equilibrium points of a barred galaxy. We discuss the shape and velocity structure of the rings thus formed and argue that they are in agreement with the observed properties of rR_1 structures.Comment: 8 pages, 9 figures, accepted in Astronomy and Astrophysics. High quality figures are available upon reques

Invariant manifolds as building blocks for the formation of spiral arms and rings in barred galaxies

We propose a theory to explain the formation of spiral arms and of all types of outer rings in barred galaxies, extending and applying the technique used in celestial mechanics to compute transfer orbits. Thus, our theory is based on the chaotic orbital motion driven by the invariant manifolds associated to the periodic orbits around the hyperbolic equilibrium points. In particular, spiral arms and outer rings are related to the presence of heteroclinic or homoclinic orbits. Thus, R1 rings are associated to the presence of heteroclinic orbits, while R1R2 rings are associated to the presence of homoclinic orbits. Spiral arms and R2 rings, however, appear when there exist neither heteroclinic nor homoclinic orbits. We examine the parameter space of three realistic, yet simple, barred galaxy models and discuss the formation of the different morphologies according to the properties of the galaxy model. The different morphologies arise from differences in the dynamical parameters of the galaxy.Comment: 8 pages, 4 figures, in the proceedings of the conference: "Chaos in Astronomy", Athens, September 2007, G. Contopoulos and P.A. Patsis (eds), to be published by Springe

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.

During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits. How such a system works in coordination is not well understood. Cross-regulatory interactions between different signalling pathways and redundancy between them can increase precision and fidelity of guidance systems. Immunoglobulin superfamily proteins of the NCAM and L1 families couple specific substrate recognition and cell adhesion with the activation of receptor tyrosine kinases. Thus it has been shown that L1CAM-mediated cell adhesion promotes the activation of the EGFR (erbB1) from Drosophila to humans. Here we explore the specificity of the molecular interaction between L1CAM and the erbB receptor family. We show that L1CAM binds physically erbB receptors in both heterologous systems and the mammalian developing brain. Different Ig-like domains located in the extracellular part of L1CAM can support this interaction. Interestingly, binding of L1CAM to erbB enhances its response to neuregulins. During development this may synergize with the activation of erbB receptors through L1CAM homophilic interactions, conferring diffusible neuregulins specificity for cells or axons that interact with the substrate through L1CAM

Coherent two pion photoproduction on 12C

We develop the formalism for coherent two pion photoproduction in nuclei and perform actual calculations of cross sections for $\pi^-\pi^+$ and $\pi^0\pi^0$ photoproduction on $^{12}C$. We find that due to the isospin symmetry the cross section for $\pi^0\pi^0$ production is very small and has a maximum when the pions propagate together. However, the kinematical region where the energies and polar angles of the two $\pi^0$ mesons are equal and their relative azimuthal angle $\phi=180^0$ is forbidden. Conversely in the $\pi^-\pi^+$ production the pions prefer to have a relative azimuthal angle 180$^0$ and the production of the pions propagating together is suppressed. The dominant one-body mechanism in both channels is related to the excitation of the $\Delta$ isobar. Hence the reaction can serve as a source of information about $\Delta$'s properties in nucleus. We have found that the reaction is sensitive to effects of the pion and $\Delta$ renormalization in the nuclear medium, similar to those found in the coherent $(\gamma,\pi^0)$ reaction, but magnified because of the presence of the two pions.Comment: 17 pages LATEX and 11 postscript figure

Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice

OBJECTIVE OF THE STUDY: Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia activates the transcription factor NFAT in the arterial wall, inducing the expression of the pro-atherosclerotic protein osteopontin. Here we investigate whether NFAT activation may be a link between diabetes and atherogenesis. METHODOLOGY AND PRINCIPAL FINDINGS: Streptozotocin (STZ)-induced diabetes in apolipoprotein E(-/-) mice resulted in 2.2 fold increased aortic atherosclerosis and enhanced pro-inflammatory burden, as evidenced by elevated blood monocytes, endothelial activation- and inflammatory markers in aorta, and pro-inflammatory cytokines in plasma. In vivo treatment with the NFAT blocker A-285222 for 4 weeks completely inhibited the diabetes-induced aggravation of atherosclerosis, having no effect in non-diabetic mice. STZ-treated mice exhibited hyperglycemia and higher plasma cholesterol and triglycerides, but these were unaffected by A-285222. NFAT-dependent transcriptional activity was examined in aorta, spleen, thymus, brain, heart, liver and kidney, but only augmented in the aorta of diabetic mice. A-285222 completely blocked this diabetes-driven NFAT activation, but had no impact on the other organs or on splenocyte proliferation or cytokine secretion, ruling out systemic immunosuppression as the mechanism behind reduced atherosclerosis. Instead, NFAT inhibition effectively reduced IL-6, osteopontin, monocyte chemotactic protein 1, intercellular adhesion molecule 1, CD68 and tissue factor expression in the arterial wall and lowered plasma IL-6 in diabetic mice. CONCLUSIONS: Targeting NFAT signaling may be a novel and attractive approach for the treatment of diabetic macrovascular complications

Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model

E.K was funded by the British Heart Foundation Grant # FS113028789 and JRW was funded by Arthritis Research-UK Grant #19207