Effect of an enriched drink on cognitive function in frail elderly persons

Many elderly persons report that they have difficulties learning new things and remembering names, plans, and conversations. Because decreased cognitive function in elderly persons is potentially related to their poor nutritional status, provision of essential nutrients may improve cognitive function. The authors wanted to determine whether consumption of an enriched drink, including moderate doses of all essential micronutrients, improves cognitive function in frail elderly persons. Methods. Frail, white adults (n = 101) who were aged 65 years or older with a body mass index ¿25 kg/m 2 were selected for this randomized, double-blind, placebo-controlled trial. They received either an enriched drink or a placebo product for 6 months. Before and after the intervention, participants' cognitive function was assessed (word learning test [WLT], WLT delayed, category fluency [CF] for animals and professions, and recognition memory test for words [RMTW]) and blood biochemical analyses (vitamin B12, homocysteine) were performed. Results. Sixty-seven residents completed the study period. After 6 months, significant differences were noted in changes of the WLT (0.9 ± 0.3 vs-0.1 ± 0.3; p = .014) and CF professions (1.2 ± 0.7 vs -0.6 ± 0.5; p = .017) in the supplement group (n = 34) compared with the placebo group (n = 33). No significant differences were observed in WLT delayed, RMTW, and CF animals. The plasma vitamin B12 concentration increased (105 ± 50 vs 8 ± 16; p = .003) and the homocysteine concentration decreased (-6.3 ± 5.9 vs -0.3 ± 2.9; p = .000) in the supplement group compared with the placebo group. Conclusions. This study contributes to the evidence that nutritional supplementation may improve neuropsychological performance in frail elderly persons

GABA TURNOVER in MOUSE-BRAIN - AGREEMENT BETWEEN the RATE of GABA ACCUMULATION AFTER AMINOOXYACETIC ACID and the RATE of DISAPPEARANCE AFTER 3-MERCAPTOPROPIONIC ACID

ESCOLA PAULISTA MED,DEPT FARMACOL,BR-01000 São Paulo,BRAZILESCOLA PAULISTA MED,DEPT FARMACOL,BR-01000 São Paulo,BRAZILWeb of Scienc

CIRCULATORY EFFECTS of DECEREBRATION in the UNANESTHETIZED SPONTANEOUSLY HYPERTENSIVE RAT

GOTENBURG UNIV,DEPT PHARMACOL,S-41124 GOTHENBURG,SWEDENWeb of Scienc

INTERACTION of ALPHA-ADRENERGIC and BETA-ADRENERGIC-RECEPTOR BLOCKING-AGENTS in the CONSCIOUS RAT

ESCOLA PAULISTA MED, DEPT FARMACOL, São Paulo 01000, SP, BRAZILESCOLA PAULISTA MED, DEPT FARMACOL, São Paulo 01000, SP, BRAZILWeb of Scienc

ROLE of GABA-ERGIC RECEPTORS for the SYNTHESIS of GABA in DIFFERENT COMPARTMENTS of the RAT CEREBELLUM

ESCOLA PAULISTA MED,DEPT FARMACOL,São Paulo 04023,SP,BRAZILESCOLA PAULISTA MED,DEPT FARMACOL,São Paulo 04023,SP,BRAZILWeb of Scienc

ON the IMPORTANCE of GABA-ERGIC NEURONS for the AOAA INDUCED ACCUMULATION of GABA in the RAT-BRAIN

ESCOLA PAULISTA MED,DEPT FARMACOL,CP 20372,São Paulo 01000,SP,BRAZILESCOLA PAULISTA MED,DEPT FARMACOL,CP 20372,São Paulo 01000,SP,BRAZILWeb of Scienc

EFFECT of AMINOOXYACETIC ACID (AOAA) ON GABA LEVELS in SOME PARTS of the RAT-BRAIN

ESCOLA PAULISTA MED,DEPT FARMACOL,São Paulo 01000,SP,BRAZILESCOLA PAULISTA MED,DEPT FARMACOL,São Paulo 01000,SP,BRAZILWeb of Scienc