Human Rights in the Management Literature: Leading Publications and Research Agenda

This is the final version of the article. Available from Universidade Federal do Rio de Janeiro via the DOI in this record.This paper identifies and examines leading publications on human rights within the management literature. For that, we used features of a bibliometric analysis – specifically exploring product and impact indicators – in order to identify the leading publications on human rights that were examined aiming to portray how the issue has been addressed within this field. Moreover, by identifying the key articles and concepts adopted by the leading publications, this paper offers an interpretation of the academic context that enabled the emergence of a human rights approach within the management field. Thus, a contribution of this paper is to highlight how the debate on human rights in management has been strengthened, identifying articles and journals that can be a source of reference for future research. Our study has identified a shift in the discussion regarding human rights. During the last decade the topic, which was initially focused on the role of states in guaranteeing human rights, has started to examine the relationship between organizations and society. Such transformation has placed human rights as both, a responsibility and a duty of corporations. It is suggested that the literature on ethics and corporate social responsibility (CSR) was the entrance for a human rights approach within management literature. However, the discipline has already engaged in elaborating different interpretation of human rights. Our research shows the potential of human rights in consolidate a research agenda on corporate impact in our societies

Checking Whether an Automaton Is Monotonic Is NP-complete

An automaton is monotonic if its states can be arranged in a linear order that is preserved by the action of every letter. We prove that the problem of deciding whether a given automaton is monotonic is NP-complete. The same result is obtained for oriented automata, whose states can be arranged in a cyclic order. Moreover, both problems remain hard under the restriction to binary input alphabets.Comment: 13 pages, 4 figures. CIAA 2015. The final publication is available at http://link.springer.com/chapter/10.1007/978-3-319-22360-5_2

Restriction semigroups and λ -Zappa-Szép products

The aim of this paper is to study λ-semidirect and λ-Zappa-Szép products of restriction semigroups. The former concept was introduced for inverse semigroups by Billhardt, and has been extended to some classes of left restriction semigroups. The latter was introduced, again in the inverse case, by Gilbert and Wazzan. We unify these concepts by considering what we name the scaffold of a Zappa-Szép product S⋈ T where S and T are restriction. Under certain conditions this scaffold becomes a category. If one action is trivial, or if S is a semilattice and T a monoid, the scaffold may be ordered so that it becomes an inductive category. A standard technique, developed by Lawson and based on the Ehresmann-Schein-Nambooripad result for inverse semigroups, allows us to define a product on our category. We thus obtain restriction semigroups that are λ-semidirect products and λ-Zappa-Szép products, extending the work of Billhardt and of Gilbert and Wazzan. Finally, we explicate the internal structure of λ-semidirect products

Social and economic value of Portuguese community pharmacies in health care

Background: Community pharmacies are major contributors to health care systems across the world. Several studies have been conducted to evaluate community pharmacies services in health care. The purpose of this study was to estimate the social and economic benefits of current and potential future community pharmacies services provided by pharmacists in health care in Portugal. Methods: The social and economic value of community pharmacies services was estimated through a decision-model. Model inputs included effectiveness data, quality of life (QoL) and health resource consumption, obtained though literature review and adapted to Portuguese reality by an expert panel. The estimated economic value was the result of non-remunerated pharmaceutical services plus health resource consumption potentially avoided. Social and economic value of community pharmacies services derives from the comparison of two scenarios: "with service" versus "without service". Results: It is estimated that current community pharmacies services in Portugal provide a gain in QoL of 8.3% and an economic value of 879.6 million euros (Msic), including 342.1 Msic in non-remunerated pharmaceutical services and 448. 1 Msic in avoided expense with health resource consumption. Potential future community pharmacies services may provide an additional increase of 6.9% in QoL and be associated with an economic value of 144.8 Msic: 120.3 Msic in non-remunerated services and 24.5 Msic in potential savings with health resource consumption. Conclusions: Community pharmacies services provide considerable benefit in QoL and economic value. An increase range of services including a greater integration in primary and secondary care, among other transversal services, may add further social and economic value to the society

Using Sat solvers for synchronization issues in partial deterministic automata

We approach the task of computing a carefully synchronizing word of minimum length for a given partial deterministic automaton, encoding the problem as an instance of SAT and invoking a SAT solver. Our experimental results demonstrate that this approach gives satisfactory results for automata with up to 100 states even if very modest computational resources are used.Comment: 15 pages, 3 figure

Single and two-particle energy gaps across the disorder-driven superconductor-insulator transition

The competition between superconductivity and localization raises profound questions in condensed matter physics. In spite of decades of research, the mechanism of the superconductor-insulator transition (SIT) and the nature of the insulator are not understood. We use quantum Monte Carlo simulations that treat, on an equal footing, inhomogeneous amplitude variations and phase fluctuations, a major advance over previous theories. We gain new microscopic insights and make testable predictions for local spectroscopic probes. The energy gap in the density of states survives across the transition, but coherence peaks exist only in the superconductor. A characteristic pseudogap persists above the critical disorder and critical temperature, in contrast to conventional theories. Surprisingly, the insulator has a two-particle gap scale that vanishes at the SIT, despite a robust single-particle gap.Comment: 7 pages, 5 figures (plus supplement with 4 pages, 5 figures

Ranks of ideals in inverse semigroups of difunctional binary relations

The set Dn of all difunctional relations on an n element set is an inverse semigroup under a variation of the usual composition operation. We solve an open problem of Kudryavtseva and Maltcev (Publ Math Debrecen 78(2):253–282, 2011), which asks: What is the rank (smallest size of a generating set) of Dn? Specifically, we show that the rank of Dn is B(n)+n, where B(n) is the nth Bell number. We also give the rank of an arbitrary ideal of Dn. Although Dn bears many similarities with families such as the full transformation semigroups and symmetric inverse semigroups (all contain the symmetric group and have a chain of J-classes), we note that the fast growth of rank(Dn) as a function of n is a property not shared with these other families

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy

Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without collapsing their membrane potential (ΔΨm). PMI is an inhibitor of the protein-protein interaction (PPI) between the transcription factor Nrf2 and its negative regulator, Keap1 and is able to up-regulate the expression of autophagy-associated proteins, including p62/SQSTM1. Here we show that PMI promotes mitochondrial respiration, leading to a superoxide-dependent activation of mitophagy. Structurally distinct Keap1-Nrf2 PPI inhibitors promote mitochondrial turnover, while covalent Keap1 modifiers, including sulforaphane (SFN) and dimethyl fumarate (DMF), are unable to induce a similar response. Additionally, we demonstrate that SFN reverses the effects of PMI in co-treated cells by reducing the accumulation of p62 in mitochondria and subsequently limiting their autophagic degradation. This study highlights the unique features of Keap1-Nrf2 PPI inhibitors as inducers of mitophagy and their potential as pharmacological agents for the treatment of pathological conditions characterized by impaired mitochondrial quality control