Autoimmune Hemolytic Anemia and Hodgkin's Disease: An Unusual Pediatric Association

Autoimmune hemolytic anemia (AIHA) is a recognized complication of lymphoproliferative disorders. AIHA associated with Hodgkin's disease (HD) is uncommon especially in the pediatric population. The diagnosis of AIHA is usually associated with HD at the time of initial presentation or during the course of disease, but it could precede it by years to months. In adults the association of AIHA and HD is more frequent in advanced stages and in the nodular sclerosis and mixed cellularity type HD. Warm immune hemolytic anemia is mainly controlled with steroids and chemotherapy. We report a case of a pediatric patient with direct antiglobulin positive test at the diagnosis of a late relapse of stage III B mixed cellularity type HD

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Glycans cover the surfaces of all mammalian cells through a process called glycosylation. Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory pathways of the immune system are glycosylated. Growing evidence indicates that the development of the immune system at the origins of T and B cell development is tightly regulated by glycosylation. In this opinion, we hypothesize that the glycome composition of developing T and B cells is developmentally regulated. We discuss how glycans play fundamental roles in lymphocyte development and how glycans early define T and B cell functionality in multiple aspects of adaptive immunity. These advances can provide opportunities for the discovery of novel disease factors and more effective candidate treatments for various conditions.This work was funded by the EU (ERC, GlycanSwitch, Grant Agreement N° 101071386). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Funded by the European Union (GlycanTrigger, Grant Agreement N°: 101093997. Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. M.M.V. and E.L-G. received funding from the Portuguese Foundation for Science and Technology (FCT) of the Portuguese Ministry of Science, Technology and Higher Education (M.M.V.: PD/BD/135452/2017, COVID/BD/152488/2022; E.L-G.: UI/BD/152866/2022)

Twin parenting experience – reshaping the family web

Being a parent of twin siblings is a major challenge for parents and requires a family restructuring to adapt to a new family environment. OBJECTIVE. To understand the experiences of parents of twins and meanings attributed to them. METHODS: a qualitative study was conducted, having the symbolic interactionism as a theoretical referential and the interpretative interactionism as the methodological referential. Twenty-nine parents with children under 4 years participated in this study. A semi-structured interview was conducted for data collection. RESULTS. The twins family responses to parenting challenges are conditioned by the management and articulation of their di*culties, their strengths and personal resources. There is a clear choice in being a family with children that privileges negotiation and involvement of the couple in caring for the family, or, at least, part of the family, meaning the children and playing the parenting role. CONCLUSIONS. The family grows as a complex web, including its elements and interactions. The symbolic construction evidences the way the family adjusts to this environment of twin parenting. The health professionals should be able to anticipate the needs of families going through this process.info:eu-repo/semantics/publishedVersio

Advances on Bacterial and Fungal Biofilms for the Production of Added-Value Compounds

Simple Summary The production of bio-based materials, including organic acids, antibiotics, enzymes, ethanol, and hydrogen, is generally done by the cultivation of suspended cells rather than using immobilized cells. However, several studies suggest the application of productive biofilms as a reliable alternative for biocatalysis, with many advantages over suspended-growth systems. This review gives an overview of the breakthrough in the application of biofilm platforms for the sustainable production of valuable compounds, with particular insight into the latest advances in the production of recombinant proteins. Productive biofilms are shown to improve production rates and product yields, demonstrating great potential for industrial applications. In recent years, abundant research has been performed on biofilms for the production of compounds with biotechnological and industrial relevance. The use of biofilm platforms has been seen as a compelling approach to producing fine and bulk chemicals such as organic acids, alcohols, and solvents. However, the production of recombinant proteins using this system is still scarce. Biofilm reactors are known to have higher biomass density, operational stability, and potential for long-term operation than suspended cell reactors. In addition, there is an increasing demand to harness industrial and agricultural wastes and biorefinery residues to improve process sustainability and reduce production costs. The synthesis of recombinant proteins and other high-value compounds is mainly achieved using suspended cultures of bacteria, yeasts, and fungi. This review discusses the use of biofilm reactors for the production of recombinant proteins and other added-value compounds using bacteria and fungi

An Efficient Local Search for Partial Latin Square Extension Problem

A partial Latin square (PLS) is a partial assignment of n symbols to an nxn grid such that, in each row and in each column, each symbol appears at most once. The partial Latin square extension problem is an NP-hard problem that asks for a largest extension of a given PLS. In this paper we propose an efficient local search for this problem. We focus on the local search such that the neighborhood is defined by (p,q)-swap, i.e., removing exactly p symbols and then assigning symbols to at most q empty cells. For p in {1,2,3}, our neighborhood search algorithm finds an improved solution or concludes that no such solution exists in O(n^{p+1}) time. We also propose a novel swap operation, Trellis-swap, which is a generalization of (1,q)-swap and (2,q)-swap. Our Trellis-neighborhood search algorithm takes O(n^{3.5}) time to do the same thing. Using these neighborhood search algorithms, we design a prototype iterated local search algorithm and show its effectiveness in comparison with state-of-the-art optimization solvers such as IBM ILOG CPLEX and LocalSolver.Comment: 17 pages, 2 figure

Optimal dimensioning model of water distribution systems

This study is aimed at developing a pipe-sizing model for a water distribution system. The optimal solution minimises the system’s total cost, which comprises the hydraulic network capital cost, plus the capitalised cost of pumping energy. The developed model, called Lenhsnet, may also be used for economical design when expanding existing hydraulic networks. The methodology developed includes an iterative dynamic calculation process as well as a hydraulic simulation model. The performance of the method is tested against 4 benchmark examples in the literature. The results obtained show the feasibility of this model, presenting it as a viable alternative for water distribution systems. The method is easily used, once it is performed under EPANET2 software interface

Ancianos residentes en la comunidad: conocer para defender un programa de enfermería de rehabilitación

To analyze the socio-demographic and health conditions of the elderly living in the community and describe the pillars for the design of a rehabilitation nursing program in the community.Objetivo: Analisar as condições sociodemográficas e de saúde dos idosos residentes na comunidade e descrever os pilares para a concepção de um programa de enfermagem de reabilitação na comunidade. Métodos: Estudo descritivo, transversal, com participação de 48 idosos selecionados por amostragem de conveniência. A coleta de dados realizou-se entre setembro de 2018 e julho de 2019, numa unidade de saúde do norte de Portugal, usando um formulário. Resultados: Todos os idosos têm processos patológicos e excesso de peso. Majoritariamente são sedentários, apresentam sentimentos de solidão e comportamentos relacionais inapropriados. Nos últimos seis meses, 25% caíram pelo menos uma vez, tendo sido notórias alterações no equilíbrio, estilos de vida e percepção do estado de saúde. Conclusão: Evidenciou-se a necessidade de os enfermeiros de reabilitação conceberem e implementarem programas de envelhecimento ativo que garantam acompanhamento individual dos idosos valorizando estilos de vida, treino de equilíbrio e promoção da participação social.Objetivo: Analizar las condiciones sociodemográficas y de salud de ancianos residentes en la comunidad y describir los pilares para la concepción de un programa de enfermería de rehabilitación en la comunidad. Métodos: Estudio descriptivo, transversal, con participación de 48 ancianos seleccionados por muestreo de conveniencia. La recogida de datos se realizó entre septiembre de 2018 y julio de 2019, en unidad de salud del norte de Portugal, usando un formulario. Resultados: Todos los ancianos tienen procesos patológicos y sobrepeso. Mayoritariamente son sedentarios, sienten soledad y comportamientos relacionales inapropiados. En los últimos seis meses, 25% cayeron por lo menos una vez, siendo notorias alteraciones en el equilibrio, estilos de vida y percepción en la salud. Conclusión: Se evidenció la necesidad de los enfermeros de rehabilitación concebir e implementar programas de envejecimiento activo que garantizan acompañamiento individual de ancianos valorizando estilos de vida, ejercicios de equilibrio y promoción de la participación social.info:eu-repo/semantics/publishedVersio

Impacto de um programa de reabilitação na gestão urinária do doente acometido por acidente vascular cerebral

Objective: to assess the effect of a Nursing Rehabilitation program on the urinary incontinence management of women after a CVA. Method: quantitative, quasi-experimental, and longitudinal study conducted in a convalescence unit in the Viana do Castelo district, Portugal, between September 2018 and March 2019. The sample included women (n=30) aged between 45 and 90, experiencing urinary incontinence after a CVA, assigned to two groups: experimental group (n=15) and control group (n=15). The functional rehabilitation program was applied to the experimental group for 4 weeks. The program comprises behavioral changes and an exercise plan to strengthen pelvic floor muscles, and the impact of urinary incontinence was assessed before and after the intervention. Results: a statistically significant correlation was found between the level of functional disability and the impact of urinary incontinence (r=-0.499; p=0.005). Hence, the level of functional disability influences the impact of urinary incontinence on quality of life. The functional rehabilitation program implemented in the experimental group obtained positive results and decreased the frequency (t=6.985, p=0.000) and amount (Z=-2.762, p=0.006) of urine loss. Conclusion: the functional rehabilitation program positively impacted and decreased the frequency and amount of urine loss.info:eu-repo/semantics/publishedVersio

A Importância das Famílias nos Cuidados de Enfermagem: Atitudes dos Enfermeiros em Meio hospitalar

Enquadramento: A atitude dos enfermeiros para com as famílias é determinante para a qualidade dos cuidados de enfermagem, facilitando os processos de transição saúde/doença vivenciadas pela família no hospital. Objetivos: O objetivo deste estudo consiste em identificar a atitude dos enfermeiros de diferentes contextos de cuidados hospitalares sobre a importância de incluir a família nos cuidados de Enfermagem. Metodologia: É um estudo de natureza quantitativa, exploratório e descritivo, integrando 160 enfermeiros de diversos contextos de um hospital, através de uma amostra por conveniência. Este estudo recorre à utilização de um questionário, integrando uma avaliação sociodemográfica e a aplicação da escala A importância das famílias nos cuidados de Enfermagem – IFCE-AE. Resultados: Os resultados obtidos da aplicação da escala IFCE-AE revelam scores médios elevados. Contudo, os resultados não evidenciam correlações significativas que justifiquem a influência das variáveis exploradas. Conclusão: Os enfermeiros possuem um grau de concordância elevado sobre a importância das famílias nos cuidados de enfermagem, no que se refere aos diferentes contextos de cuidados.Theoretical framework: Nurses’ attitudes towards families are essential to the quality of nursing care, facilitating the health/ disease transition processes experienced by the family in the hospital. Objectives: The aim of this study is to identify the attitudes of nurses in different hospital settings about the importance of including the family in nursing care. Methodology: A quantitative, exploratory and descriptive study was conducted with a convenience sample of 160 nurses from different units in a hospital. This study used a questionnaire, which included a sociodemographic evaluation and the scale Families’ Importance in Nursing Care - Nurses Attitudes (FINC-NA). Results: The results obtained by applying the FINC-NA scale revealed high mean scores. However, the results showed no significant correlations to justify the influence of the analysed variables. Conclusion: Nurses show a high level of agreement about the importance of families in nursing care within the various contexts of care.info:eu-repo/semantics/publishedVersio

desafios para a saúde

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