HydroPol2D -- Distributed Hydrodynamic and Water Quality Model: Challenges and Opportunities in Poorly-Gauged Catchments

Floods are one of the deadliest natural hazards and are fueled by excessive urbanization. Urban development decreases infiltration by reducing pervious areas and increases the accumulation of pollutants during dry weather. During wet weather events, there is an increase in the levels of pollution concentrations and stormwater runoff that eventually reach creeks and rivers. Polluted stormwater runoff may be sources of water supply. Modeling the quantity and quality dynamics of stormwater runoff requires a coupled hydrodynamic module capable of estimating the transport and fate of pollutants. In this paper, we evaluate the applicability of a distributed hydrodynamic model coupled with a water quality model (HydroPol2D). First, the model is compared to GSSHA and WCA2D in the V-Tilted catchment, and the limitation of the critical velocity of WCA2D is investigated. We also applied the model in a laboratory wooden board catchment, focusing on the validation of the numerical approach to simulate water quality dynamics. Then, we apply HydroPol2D in the Tijuco Preto catchment, in Sao Carlos - Brazil, and compare the modeling results with the full momentum solver of the Hydrologic Engineering Center - River System Analysis (HEC-RAS). The model implementation, the governing equations, and the estimation of input data are discussed, indicating the challenges and opportunities of the application of distributed models in poorly-gauged catchments. For a 1-yr return period of rainfall and antecedent dry days and assuming an uncertainty of $40\%$ in the water quality parameters, the results indicate that the maximum concentration of total suspended solids (TSS), the maximum load and the mass of the pollutant washed in $30\%$ of the volume are, $456~\pm~260~\mathrm{mg.L^{-1}.km^{-2}}$, $\mathrm{2.56 \pm 0.4~kg.s^{-1}.km^{-2}}$, and $\mathrm{89\%~\pm~10\%}$, respectively.Comment: Preprint submitted to Journal of Hydrolog

Overactive bladder-18 years - Part II

Traditionally, the treatment of overactive bladder syndrome has been based on the use of oral medications with the purpose of reestablishing the detrusor stability. The recent better understanding of the urothelial physiology fostered conceptual changes, and the oral anticholinergics - pillars of the overactive bladder pharmacotherapy - started to be not only recognized for their properties of inhibiting the detrusor contractile activity, but also their action on the bladder afference, and therefore, on the reduction of the symptoms that constitute the syndrome. Beta-adrenergic agonists, which were recently added to the list of drugs for the treatment of overactive bladder, still wait for a definitive positioning - as either a second-line therapy or an adjuvant to oral anticholinergics. Conservative treatment failure, whether due to unsatisfactory results or the presence of adverse side effects, define it as refractory overactive bladder. In this context, the intravesical injection of botulinum toxin type A emerged as an effective option for the existing gap between the primary measures and more complex procedures such as bladder augmentation. Sacral neuromodulation, described three decades ago, had its indication reinforced in this overactive bladder era. Likewise, the electric stimulation of the tibial nerve is now a minimally invasive alternative to treat those with refractory overactive bladder. The results of the systematic literature review on the oral pharmacological treatment and the treatment of refractory overactive bladder gave rise to this second part of the review article Overactive Bladder - 18 years, prepared during the 1st Latin-American Consultation on Overactive Bladder.Univ Fed Sao Paulo, EPM, Sao Paulo, SP, BrazilUniv Sao Paulo, Dept Urol, BR-05508 Sao Paulo, SP, BrazilFac Med ABC, Dept Urol, Sao Paulo, SP, BrazilUniv Los Andes, Dept Urol, Bogota, ColombiaEscuela Med Mil, Dept Urol, Mexico City, DF, MexicoHosp Clin Jose San Martin, Catedra Urol, Buenos Aires, DF, ArgentinaMae de Deus Ctr Hosp, Dept Urol, Porto Alegre, RS, BrazilUniv Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, BrazilAC Camargo Hosp, Dept Urol, Sao Paulo, SP, BrazilHosp Clinico Fuerza Area Chile, Santiago, ChileInst Mexicano Seguro Social, Mexico City, DF, MexicoHosp Souza Aguiar, Dept Urol, Rio De Janeiro, RJ, BrazilComplejo Med Policial Churruca Visca, Serv Urol, Buenos Aires, DF, ArgentinaCtr Policlin Valencia Vina, Valencia, VenezuelaHosp Pablo Tobon Uribe, Medellin, ColombiaClin Indisa, Serv Urol, Providencia, ChileCtr Reabilitacao & Readaptacao Dr Henriqe Santill, Goiania, Go, BrazilHosp Univ Caracas, Serv Urol, Caracas, VenezuelaUniv Fed Ceara, Div Urol, Fortaleza, Ceara, BrazilUniv Fed Sao Paulo, EPM, Sao Paulo, SP, BrazilWeb of Scienc

Overactive bladder-18 years - Part I

Overactive bladder syndrome is one of the lower urinary tract dysfunctions with the highest number of scientific publications over the past two decades. This shows the growing interest in better understanding this syndrome, which gathers symptoms of urinary urgency and increased daytime and nighttime voiding frequency, with or without urinary incontinence and results in a negative impact on the quality of life of approximately one out of six individuals - including both genders and almost all age groups. The possibility of establishing the diagnosis just from clinical data made patients' access to specialized care easier. Physiotherapy resources have been incorporated into the urological daily practice. A number of more selective antimuscarinic drugs with consequent lower adverse event rates were released. Recently, a new class of oral drugs, beta-adrenergic agonists has become part of the armamentarium for Overactive Bladder. Botulinum toxin injections in the bladder and sacral neuromodulation are routine modalities of treatment for refractory cases. During the 1st Latin-American Consultation on Overactive Bladder, a comprehensive review of the literature related to the evolution of the concept, epidemiology, diagnosis, and management was conducted. This text corresponds to the first part of the review Overactive Bladder 18-years.Univ Fed Sao Paulo, EPM, Rua Dr Oscar Monteiro Barros 617-141, BR-05641010 Sao Paulo, SP, BrazilUniv Sao Paulo, Dept Urol, BR-05508 Sao Paulo, SP, BrazilFac Med ABC, Dept Urol, Sao Paulo, SP, BrazilUniv Los Andes, Dept Urol, Bogota, ColombiaEscuela Med, Dept Urol, Mexico City, DF, MexicoHosp Clin Jose San Martin, Catedra Urol, Buenos Aires, DF, ArgentinaMae de Deus Ctr Hosp, Dept Urol, Porto Alegre, RS, BrazilUniv Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, BrazilAC Camargo Hosp, Dept Urol, Sao Paulo, BrazilHosp Clin Fuerza Area Chile, Santiago, ChileInst Mexicano Seguro Social, Mexico City, DF, MexicoHosp Souza Aguiar, Dept Urol, Rio De Janeiro, RJ, BrazilComplejo Med Policial Churruca Visca, Serv Urol, Buenos Aires, DF, ArgentinaCtr Policlin Valencia Vina, Valencia, VenezuelaHosp Pablo Tobon Uribe, Medellin, ColombiaClin Indisa, Serv Urol, Providencia, ChileCtr Reabilitacao & Readaptacao Dr Henriqe Santill, Goiania, Go, BrazilHosp Univ Caracas, Serv Urol, Caracas, VenezuelaUniv Fed Ceara, Div Urol, Fortaleza, Ceara, BrazilUniv Fed Sao Paulo, EPM, Rua Dr Oscar Monteiro Barros 617-141, BR-05641010 Sao Paulo, SP, BrazilWeb of Scienc

ANÁLISE DA INTERNAÇÃO POR NEOPLASIA MALIGNA DO ENCÉFALO DO BRASIL NO PERÍODO DE 2011 A AGOSTO DE 2022

INTRODUÇÃO: A neoplasia maligna do encéfalo é uma forma de tumor cerebral caracterizado pela proliferação de células anormais no interior da região. Essa patologia está inserida dentro do grupo das neoplasias malignas do Sistema Nervoso Central (SNC), as quais representam entre 1,4 a 1,8% de todos os tumores malignos presentes no mundo. OBJETIVOS: Analisar a quantidade e as variáveis dos índices de internação por neoplasia maligna do encéfalo no Brasil. MÉTODO: Trata-se de um estudo quantitativo e retrospectivo com coleta de dados do Departamento de Informática do Sistema Único de Saúde - DATASUS. A pesquisa foi realizada mediante informações de estatísticas vitais no grupo de Morbidade Hospitalar do SUS (SIH/ SUS). Foram analisados os dados disponíveis pelo CID 10 de ambos os sexos, faixas etárias e região com maior incidência. RESULTADOS: Foram constatados no período analisado 161.269 casos de internação por neoplasia maligna do encéfalo. No tocante ao sexo, 52,28% dos casos são do sexo masculino e 47,72% do sexo feminino. Das faixas etárias, as internações são mais prevalentes entre 50 a 59 anos de idade com 19,22% dos casos totais de internação por neoplasia maligna do encéfalo, sendo 43,63% da região sudeste os maiores casos de notificações. CONCLUSÕES: Depreende-se, portanto, que o número de internações por neoplasia maligna do encéfalo é maior em pessoas do sexo masculino, sobretudo na faixa etária dos 50 a 59 anos, com destaque marcante para a região sudeste do país. PALAVRAS-CHAVE: Neoplasia. Cérebro. Internaçã

A GRANDE VARIAÇÃO NOS TIPOS DE SINTOMAS E AS DOENÇAS SECUNDÁRIAS CAUSADAS PELA COVID-19

Em dezembro de 2019 surgiu o primeiro caso de COVID-19 na China e rapidamente atingiu todos os continentes. A grande quantidade de questões e dúvidas a serem respondidas trouxe um desafio para pesquisadores de todo o mundo. A presente revisão narrativa da literatura teve como objetivo identificar os principais sintomas da COVID-19 e as doenças causadas secundariamente. A COVID-19, doença causada pelo SARS-CoV-2, tem apresentado uma grande variabilidade de sinais e sintomas, tropismos a diferentes órgãos e sistemas, tem gerado doenças crônicas secundárias a importantes sistemas como o respiratório, cardiovascular, nervoso, renal, hepático e até mesmo ocular. Além dos fatores supracitados, a saúde mental da população e dos profissionais de saúde tem sido afetada pelo excesso de informações desencontradas pela imprensa e pelas mídias sociais. Já o público formado por crianças e adolescentes tem tido como principal agente agressor da saúde mental o isolamento social. Apesar de mais de um ano passado do início da pandemia, muito pouco ainda se sabe sobre o comportamento deste vírus em diferentes populações, sexos, faixas etárias e quais problemas secundários esta doença pode deixar a seus infectados

Looking at Data Science through the Lens of Scheduling and Load Balancing

The growth in data generated by private and public organizations leads to several opportunities to obtain valuable knowledge. In this scenario, data science becomes pertinent to define a structured methodology to extract valuable knowledge from raw data. It encompasses a heterogeneous group of techniques that challenge the implementation of a single platform capable of incorporating all the available resources. Thus, it is necessary to formulate a data science workflow based on different tools to extract knowledge from massive datasets. In this context, high-performance computing (HPC) provides the infrastructure required to optimize the processing time of data science workflows, which become a collection of tasks that must be efficiently scheduled to provide results in acceptable time intervals. While few studies explore the use of HPC for data science tasks, in the best of our knowledge, none conducts an in-depth analysis of scheduling and load balancing on such workflows. In this context, this chapter proposes an analysis of scheduling and load balancing from the perspective of data science scenarios. It presents concepts, environments, and tools to summarize the theoretical background required to define, assign, and execute data science workflows. Furthermore, we are also presenting new trends concerning the intersection of data science, scheduling, and load balance