114 research outputs found
Moderate versus light pressure massage therapy leads to greater weight gain in preterm infants
Sixty-eight preterm infants (M GA= 30 weeks) were randomly assigned to a moderate or to a light pressure massage therapy group to receive 15 massages three times per day for 5 days. Behavior state, stress behaviors and heart rate were recorded for 15 min before and during the first 15-min therapy session. Weight gain was recorded over the 5-day therapy period. The moderate versus light pressure massage group gained significantly more weight per day. During the behavior observations the moderate versus light pressure massage group showed significantly lower increases from the pre-session to the session recording on: (1) active sleep; (2) fussing; (3) crying; (4) movement; and (5) stress behavior (hiccupping). They also showed a smaller decrease in deep sleep, a greater decrease in heart rate and a greater increase in vagal tone. Thus, the moderate pressure massage therapy group appeared to be more relaxed and less aroused than the light pressure massage group which may have contributed to the greater weight gain of the moderate pressure massage therapy group.We would like to thank the mothers and infants who participated in this study and Julia Beutler, Larissa Feijo, Karla
Gill and Yanexy Vera for their help with participant recruitment and data collection. We would also like to thank John
Allen for his help with EKG analysis software. This research was supported by Senior Research Scientist Awards
(#MH00331 and #AT01585) and an NIHM merit award (MH #46586) and a March of Dimes Grant (#12-FY03-48) to
Tiffany Field, an NCCAM research Grant to Maria Hernandez-Reif (#AT00370) and an NCCAM research supplement
(#AT00370-02S 1) to Miguel A. Diego and funding from Johnson and Johnson Pediatric Institute
Neonatal Handling Affects Durably Bonding and Social Development
The neonatal period in humans and in most mammals is characterized by intense mother-young interactions favoring pair bonding and the adaptation of neonates to their new environment. However, in many post-delivery procedures, human babies commonly experience combined maternal separation and intense handling for about one hour post-birth. Currently, the effects of such disturbances on later attachment and on the development of newborns are still debated: clearly, further investigations are required. As animals present good models for controlled experimentation, we chose domestic horses to investigate this issue. Horses, like humans, are characterized by single births, long lactating periods and selective mother-infant bonds. Routine postnatal procedures for foals, as for human babies, also involve intense handling and maternal separation. In the present study, we monitored the behavior of foals from early stages of development to “adolescence”, in a normal ecological context (social groups with adults and peers). Experimental foals, separated from their mothers and handled for only 1 hour post-birth, were compared to control foals, left undisturbed after birth. Our results revealed short- and long-term effects of this unique neonatal experience on attachment and subsequent social competences. Thus, experimental foals presented patterns of insecure attachment to their mothers (strong dependence on their mothers, little play) and impaired social competences (social withdrawal, aggressiveness) at all ages. We discuss these results in terms of mother-young interactions, timing of interactions and relationships between bonding and subsequent social competences. Our results indicate that this ungulate species could become an interesting animal model. To our knowledge, this is the first clear demonstration that intervention just after birth affects bonding and subsequent social competences (at least until “adolescence”). It opens new research directions for studies on both humans and other animals
Co-regulation of stress in uterus and during early infancy mediates early programming of gender differences in attachment styles: Evolutionary, genetic, and endocrinal perspectives
The concept of coregulation between neurobehavioral subsystems: The logic interplay between excitatory and inhibitory ends
Biofeedback mechanisms between shapeable endogen structures and contingent social complexes: The nature of determination for developmental paths
Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping
The endocannabinoid system (ECS) critically regulates stress responsivity and emotional behavior throughout development. It regulates anxiety-like behaviors in humans and animal models. In addition, it is sensitive to early life stress at the gene expression level in a sex-dependent and region-dependent manner, and these changes are already evident in the adolescent brain. The ECS modulates the neuroendocrine and behavioral effects of stress, and is also capable of being affected by stress exposure itself. Early life stress interferes with the development of corticolimbic circuits, a major location of endocannabinoid receptors, and increases vulnerability to adult psychopathology. Early life stress alters the ontogeny of the ECS, resulting in a sustained deficit in its function, particularly within the hippocampus. Specifically, exposure to early stress results in bidirectional changes in anandamide and 2-AG tissue levels within the amygdala and hippocampus and reduces hippocampal endocannabinoid function at puberty. CB1 receptor densities across all brain regions are downregulated later in life following exposure to early life stress. Manipulations affecting the glucocorticoid and the endocannabinoid systems persistently adjust individual emotional responses and synaptic plasticity. This review aims to show the bidirectional trajectories of endocannabinoid modulation of emotionality in reaction to early life stress
Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico–Striatal Loop That Are Implicated in Major Depression
Depression, the most prevalent psychiatric disorder in the Western world, is characterized by increased negative affect (i.e., depressed mood, cost value increase) and reduced positive affect (i.e., anhedonia, reward value decrease), fatigue, loss of appetite, and reduced psychomotor activity except for cases of agitative depression. Some forms, such as post-partum depression, have a high risk for suicidal attempts. Recent studies in humans and in animal models relate major depression occurrence and reoccurrence to alterations in dopaminergic activity, in addition to other neurotransmitter systems. Imaging studies detected decreased activity in the brain reward circuits in major depression. Therefore, the location of dopamine receptors in these circuits is relevant for understanding major depression. Interestingly, in cortico–striatal–dopaminergic pathways within the reward and cost circuits, the expression of dopamine and its contribution to reward are modulated by endocannabinoid receptors. These receptors are enriched in the striosomal compartment of striatum that selectively projects to dopaminergic neurons of substantia nigra compacta and is vulnerable to stress. This review aims to show the crosstalk between endocannabinoid and dopamine receptors and their vulnerability to stress in the reward circuits, especially in corticostriatal regions. The implications for novel treatments of major depression are discussed
A specific concanavalin A-mediated binding of bovine serum α-mannosidase to cultured human skin fibroblasts
Use of humour in primary care: different perceptions among patients and physicians
Purpose: (1) To explore the frequency with which humorous behaviour and statements occur in family medicine practice in Israel, and (2) to quantitatively assess the correlation between the subjective perceptions of humour in medical encounters between patients and physicians. Method: In a cross sectional study, two populations (doctors and patients) were surveyed with paired structured questionnaires completed immediately after primary care practice visits. Two hundred and fifty consecutive encounters from 15 practices were sampled. The physician questionnaire was self administered, and patient questionnaire was administered by a trained research assistant. Results: A mean of 16.7 questionnaires was completed per physician (range 6–20). The physicians reported having used some humour in only 95 encounters (38%), whereas almost 60% of patients agreed with the statement, "The doctor used some humour during the visit". At the same time, for specific encounters, the agreement between patients' perception and physicians' perceptions on the use of humour, although not completely by chance (p = 0.04), is low (κ = 0.115). Patient characteristics (age, education, gender, family status, mother tongue, self perceived heath status, stress, mood, and expectations) were not related to the degree of agreement between the patients' and physicians' perceptions. Conclusion: Humour was used in a large proportion of encounters, independently of patient characteristics. Patients seem to be more sensitised to humour than physicians, probably because of their high stress level during medical encounters. Cultural differences may also play a part. Physicians should be made aware of this magnifying effect, and the issue should be discussed in medical schools
An Agent Architecture to Design Self-Organizing Collectives: Principles and Application
International audienceDesigning teams which have a task to execute in a very dynamic environment is a complex problem. Determining the relevant organization of these teams by using group or role notions might be very difficult and even impossible for human analysts. Although an organization can be found or approximated, it becomes complicated to design entities, or agents in our case, that take into account, at the conception and design phases, all possible situations an agent could face up to. Emergent and self-organizing approaches to model adaptive multi-agent systems avoid these difficulties. In this paper, we propose a new approach, to design Adaptive Multi-Agent Systems with emergent functionality, which enables us to focus on the design of agents that compose the system. In fact, self-organization of the system is led by the environmental feedback that each agent perceives. Interactions and organization evolve, providing an adequate function to the system, which fits to its environment as well. Such functions have enough properties to be considered as emergent phenomena. First, we briefly present the Adaptive Multi-Agent Systems theory (AMAS) and our view of self-organization. In the second part, a multi-level architecture is proposed to model agents and to consider groups of agents as self-organizing teams. In the third part, we describe a sample robot group behaviour, the setting up of traffic in a constrained environment. Our architecture allows the emergence of a coherent collective behaviour: the dedication of corridors to specific directions. Finally, we show what is emergent by the analysis of results arising from measurements of collective phenomena
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