The repeatability of self-reported exposure after miscarriage

BACKGROUND: The Avon Longitudinal Study of Pregnancy and Childhood is a prospective study of women who were resident in Avon and who were expected to deliver a baby between April 1991 and December 1992. METHODS: The study provided an opportunity to test the repeatability of responses from 220 women who experienced a miscarriage and who reported exposure to occupational substances and common household products and appliances in two questionnaires. The first questionnaire was completed in the early part of the pregnancy and the second after the miscarriage. Women were asked to score their frequency of exposure on a five-point scale from 'daily' to 'never'. Their responses were analysed to assess the degree of agreement between replies to identical questions in the two questionnaires using the kappa statistic. A new frequency variable was created which compared the replies for the two questionnaires; this was analysed for all exposures by cross-tabulation with possible explanatory variables (age of mother, social class, history of miscarriage and the time lag between questionnaires). RESULTS: In general there was good agreement in the reported exposures to 48 substances and products. The results showed a small and consistent pattern of reporting exposures less frequently in the second questionnaire, i.e. after miscarriage. This was not explained by the analysis of possible confounding variables. Given the literature, the authors had expected to find a shift in the opposite direction. CONCLUSION: The study reinforces the need to be cautious when using the results from single surveys of retrospective self-reported exposure

Every learner counts: Learning mathematics across the curriculum

In the 21st century, mathematical confidence and functionality are considered to be of crucial importance to individuals and to national economies, which is reflected in national policies, as well as in the status of international performance comparisons such as the Programme for International Student Assessment (PISA) (Organisation for Economic Cooperation and Development (OECD), 2009) and Trends in International Mathematics and Science Study (TIMSS) (International Association for the Evaluation of Educational Achievement (IAEEA), n.d.), which compare educational systems and outcomes for participating countries. However, as a subject specialist in another subject, you might well think you simply can’t afford the teaching time to deliberately embed mathematics in your lesson. In this chapter we try to show how, by being aware of how your subject harnesses mathematical thinking, even if only in low-key ways, you can support learners in making confident and informed use of that – but we also encourage you to keep talking to the teachers of mathematics in your school, so that they become more aware of what your learners are meeting and when. That way, learners can begin to make meaningful connections across the curriculum, and enhance their grasp of, and interest in, your own subject

Holidaying with the family pet: No dogs allowed!

This paper assesses the extent to which dog owners located in Brisbane, Australia, wish to holiday with their pets, and whether there is a gap between this desire and reality. The paper also examines the extent to which this demand is being catered for by the tourism accommodation sector. The need for this study reflects the increasingly significant role dogs are playing in the lives of humans, and the scale of the dog-owning population. The results suggest that, although there is a strong desire among dog owners to take holidays with their pets, the actualisation of this desire is comparatively low. A significant obstacle to the realisation of this desire appears to be a dearth of pet-friendly accommodation. This has implications for the ability of the tourism industry to benefit from this potentially lucrative market, that is, the dog-owning population

A 3D <i>in vitro</i> model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury.

Aim: This study aimed to develop a 3D culture model to test the extent to which transplanted stem cells modulate astrocyte reactivity, where exacerbated glial cell activation could be detrimental to CNS repair success. Materials & methods: The reactivity of rat astrocytes to bone marrow mesenchymal stem cells, neural crest stem cells (NCSCs) and differentiated adipose-derived stem cells was assessed after 5 days. Schwann cells were used as a positive control. Results: NCSCs and differentiated Schwann cell-like adipose-derived stem cells did not increase astrocyte reactivity. Highly reactive responses to bone marrow mesenchymal stem cells and Schwann cells were equivalent. Conclusion: This approach can screen therapeutic cells prior to in vivo testing, allowing cells likely to trigger a substantial astrocyte response to be identified at an early stage. NCSCs and differentiated Schwann cell-like adipose-derived stem cells may be useful in treating CNS damage without increasing astrogliosis

Systematic Variation of Ligand and Cation Parameters Enables Site-Selective C-C and C-N Cross-Coupling of Multiply Chlorinated Arenes through Substrate-Ligand Electrostatic Interactions.

Use of attractive noncovalent interactions between ligand and substrate is an emerging strategy for controlling positional selectivity. A key question relates to whether fine control on molecules with multiple, closely spaced reactive positions is achievable using typically less directional electrostatic interactions. Herein, we apply a 10-piece "toolkit" comprising of two closely related sulfonated phosphine ligands and five bases, each possessing varying cation size, to the challenge of site-selective cross-coupling of multiply chlorinated arenes. The fine tuning provided by these ligand/base combinations is effective for Suzuki-Miyaura coupling and Buchwald-Hartwig coupling on a range of isomeric dichlorinated and trichlorinated arenes, substrates that would produce intractable mixtures when typical ligands are used. This study develops a practical solution for site-selective cross-coupling to generate complex, highly substituted arenes

Cohort profile: the avon longitudinal study of parents and children: ALSPAC mothers cohort

The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13 761 women (contributing 13 867 pregnancies) were recruited. These women have been followed over the last 19–22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17–18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on &gt;10 000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile

Two-phase gravity currents in porous media

We develop a model describing the buoyancy-driven propagation of two-phase gravity currents, motivated by problems in groundwater hydrology and geological storage of carbon dioxide (CO2). In these settings, fluid invades a porous medium saturated with an immiscible second fluid of different density and viscosity. The action of capillary forces in the porous medium results in spatial variations of the saturation of the two fluids. Here, we consider the propagation of fluid in a semi-infinite porous medium across a horizontal, impermeable boundary. In such systems, once the aspect ratio is large, fluid flow is mainly horizontal and the local saturation is determined by the vertical balance between capillary and gravitational forces. Gradients in the hydrostatic pressure along the current drive fluid flow in proportion to the saturation-dependent relative permeabilities, thus determining the shape and dynamics of two-phase currents. The resulting two-phase gravity current model is attractive because the formalism captures the essential macroscopic physics of multiphase flow in porous media. Residual trapping of CO2 by capillary forces is one of the key mechanisms that can permanently immobilize CO2 in the societally important example of geological CO2 sequestration. The magnitude of residual trapping is set by the areal extent and saturation distribution within the current, both of which are predicted by the two-phase gravity current model. Hence the magnitude of residual trapping during the post-injection buoyant rise of CO2 can be estimated quantitatively. We show that residual trapping increases in the presence of a capillary fringe, despite the decrease in average saturation

UK Large-scale Wind Power Programme from 1970 to 1990: the Carmarthen Bay experiments and the Musgrove Vertical-Axis Turbines

This article describes the development of the Musgrove Vertical Axis Wind Turbine (VAWT) concept, the UK ‘Carmarthen Bay’ wind turbine test programme, and UK government’s wind power programme to 1990. One of the most significant developments in the story of British wind power occurred during the 1970s, 1980s, and 1990s, with the development of the Musgrove vertical axis wind turbine and its inclusion within the UK Government’s wind turbine test programme. Evolving from a supervisor’s idea for an undergraduate project at Reading University, the Musgrove VAWT was once seen as an able competitor to the horizontal axis wind systems that were also being encouraged at the time by both the UK government and the Central Electricity Generating Board, the then nationalised electricity utility for England and Wales. During the 1980s and 1990s the most developed Musgrove VAWT system, along with three other commercial turbine designs was tested at Carmarthen Bay, South Wales as part of a national wind power test programme. From these developmental tests, operational data was collected and lessons learnt, which were incorporated into subsequent wind power operations.http://dx.doi.org/10.1260/03095240677860621

Living apart, losing sympathy? How neighbourhood context affects attitudes to redistribution and to welfare recipients

Rising levels of income inequality have been directly linked to rising levels of spatial segregation. In this paper, we explore whether rising segregation may in turn erode support for the redistributive policies of the welfare state, further increasing levels of inequality – a form of positive feedback. The role of the neighbourhood has been neglected in attitudes research but, building on both political geography and ‘neighbourhood effects’ literatures, we theorise that neighbourhood context may shape attitudes through the transmission of attitudes directly and through the accumulation of relevant knowledge. We test this through multilevel modelling of data from England on individual attitudes to redistribution in general and to welfare benefit recipients in particular. We show that the individual factors shaping these attitudes are quite different and that the influence of neighbourhood context also varies as a result. The findings support the idea that neighbourhood context shapes attitudes, with the knowledge accumulation mechanism likely to be the more important. Rising spatial segregation would appear to erode support for redistribution but to increase support for welfare recipients – at least in a context where the dominant media discourse presents such a stigmatising image of those on welfare benefits