Platelet reactivity is independent of left atrial wall deformation in patients with atrial fibrillation

It has been documented recently that left atrial (LA) deformation in AF patients (while in AF) is predictive of subsequent stroke risk. Additionally, diminished LA deformation during AF correlates with the presence of LA blood stasis. Given that endothelial function is dependent on laminar blood flow, the present study sought to investigate the effect of diminished LA deformation (during AF) on platelet reactivity and inflammation in AF patients. Patients (n = 17) hospitalised with AF underwent echocardiography (while in AF) for determination of peak positive LA strain (LASp). Whole blood impedance aggregometry was used to measure extent of ADP-induced aggregation and subsequent inhibitory response to the nitric oxide (NO) donor, sodium nitroprusside. Platelet thioredoxin-interacting protein (Txnip) content was determined by immunohistochemistry. LASp tended (p = 0.078) to vary inversely with CHA2DS2VASc scores. However, mediators of inflammation (C-reactive protein, Txnip) did not correlate significantly with LASp nor did extent of ADP-induced platelet aggregation or platelet NO response. These results suggest that the thrombogenic risk associated with LA stasis is independent of secondary effects on platelet aggregability or inflammation.Nathan Procter, Vincent Goh, Gnanadevan Mahadevan, Simon Stewart, and John Horowit

Probing Spin-Charge Relation by Magnetoconductance in One-Dimensional Polymer Nanofibers

Polymer nanofibers are one-dimensional organic hydrocarbon systems containing conducting polymers where the non-linear local excitations such as solitons, polarons and bipolarons formed by the electron-phonon interaction were predicted. Magnetoconductance (MC) can simultaneously probe both the spin and charge of these mobile species and identify the effects of electron-electron interactions on these nonlinear excitations. Here we report our observations of a qualitatively different MC in polyacetylene (PA) and in polyaniline (PANI) and polythiophene (PT) nanofibers. In PA the MC is essentially zero, but it is present in PANI and PT. The universal scaling behavior and the zero (finite) MC in PA (PANI and PT) nanofibers provide evidence of Coulomb interactions between spinless charged solitons (interacting polarons which carry both spin and charge)

Load distribution in weighted complex networks

We study the load distribution in weighted networks by measuring the effective number of optimal paths passing through a given vertex. The optimal path, along which the total cost is minimum, crucially depend on the cost distribution function $p_c(c)$. In the strong disorder limit, where $p_c(c)\sim c^{-1}$, the load distribution follows a power law both in the Erd\H{o}s-R\'enyi (ER) random graphs and in the scale-free (SF) networks, and its characteristics are determined by the structure of the minimum spanning tree. The distribution of loads at vertices with a given vertex degree also follows the SF nature similar to the whole load distribution, implying that the global transport property is not correlated to the local structural information. Finally, we measure the effect of disorder by the correlation coefficient between vertex degree and load, finding that it is larger for ER networks than for SF networks.Comment: 4 pages, 4 figures, final version published in PR

Efficiently identifying pareto solutions when objective values change

Copyright © 2014 ACMThe example code for this paper is available at https://github.com/fieldsend/gecco_2014_changing_objectivesIn many multi-objective problems the objective values assigned to a particular design can change during the course of an optimisation. This may be due to dynamic changes in the problem itself, or updates to estimated objectives in noisy problems. In these situations, designs which are non-dominated at one time step may become dominated later not just because a new and better solution has been found, but because the existing solution's performance has degraded. Likewise, a dominated solution may later be identified as non-dominated because its objectives have comparatively improved. We propose management algorithms based on recording single “guardian dominators" for each solution which allow rapid discovery and updating of the non-dominated subset of solutions evaluated by an optimiser. We examine the computational complexity of our proposed approach, and compare the performance of different ways of selecting the guardian dominators

Dialogue based interfaces for universal access.

Conversation provides an excellent means of communication for almost all people. Consequently, a conversational interface is an excellent mechanism for allowing people to interact with systems. Conversational systems are an active research area, but a wide range of systems can be developed with current technology. More sophisticated interfaces can take considerable effort, but simple interfaces can be developed quite rapidly. This paper gives an introduction to the current state of the art of conversational systems and interfaces. It describes a methodology for developing conversational interfaces and gives an example of an interface for a state benefits web site. The paper discusses how this interface could improve access for a wide range of people, and how further development of this interface would allow a larger range of people to use the system and give them more functionality

Nanofiltration of aerobically-treated palm oil mill effluent: Characterization of the size of colour compounds using synthetic dyes and polyethylene glycols

Membrane-based separation is one of the emerging technologies that have garnered significant interest in recent years for the treatment process of palm oil mill effluent (POME). As documented in the literature, different types of membrane processes such as ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) were used for the POME treatment and the efficiency of separation varied depending on the membrane properties. Unlike the previous works that used membranes to treat POME, the main focus of this current work is to utilize NF membrane to characterize the size of colour compounds in the aerobically-treated POME (AT-POME). Two different markers, i.e., synthetic dyes and polyethylene glycols (PEGs) with molecular weight (MW) in the range of 200-1000 g/mol were used to characterize the colour compounds in the AT-POME. Results showed that dyes are more suitable compared to PEGs for the characterization because dyes possessed negative charge similar as the colour compounds in the AT-POME. By using dyes as the markers, it was found that the size of the colour compounds in the AT-POME was at MW of 300-400 g/mol. Precise determination of the size of colour compounds in the AT-POME is of importance as it could provide useful information on the selection of ideal membrane properties (in particular pore size or molecular weight cut-off) to achieve complete solute separation