6,261 research outputs found
The influence of defects of the fatigue resistance of butt and girth welds in A106B steel
This three-phase study was directed at developing a fitness for service defect acceptance criteria for welds with defect indications. The study focussed on A106 Gr. B steel pipe. The first phase involved a literature search and critical review to develop the preliminary acceptance criteria to the extent permitted by the data. The second phase developed data for flat plate, wall segment, and vessel specimens containing artificial or natural planar or volumetric defects. The final phase developed acceptance criteria from the test data
Calibration of the LIGO displacement actuators via laser frequency modulation
We present a frequency modulation technique for calibration of the
displacement actuators of the LIGO 4-km-long interferometric gravitational-wave
detectors. With the interferometer locked in a single-arm configuration, we
modulate the frequency of the laser light, creating an effective length
variation that we calibrate by measuring the amplitude of the frequency
modulation. By simultaneously driving the voice coil actuators that control the
length of the arm cavity, we calibrate the voice coil actuation coefficient
with an estimated 1-sigma uncertainty of less than one percent. This technique
enables a force-free, single-step actuator calibration using a displacement
fiducial that is fundamentally different from those employed in other
calibration methods.Comment: 10 pages, 5 figures, submitted to Classical and Quantum Gravit
ΠΠ± ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠ½ΠΈΠΊΠ°, Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΡΠΎ ΡΡΡΡΠ½ΠΎΠΉ
Π Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΈ Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠ°Ρ
ΡΠ΅ΡΠ΅Π½Π° Π·Π°Π΄Π°ΡΠ° ΠΎΠ± ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ½ΡΡ
Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠΉ ΠΎΠ΄Π½ΠΎΠ·Π²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠ½ΠΈΠΊΠ° Π² Π³ΠΈΠ±ΡΠΈΠ΄Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΡΠΎΡΡΠΎΡΡΠ΅ΠΉ ΠΈΠ· Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΠΎ Π·Π°ΠΊΡΠ΅ΠΏΠ»Π΅Π½Π½ΠΎΠΉ ΡΡΡΡΠ½Ρ, Π½Π°Π³ΡΡΠΆΠ΅Π½Π½ΠΎΠΉ ΠΊΠΎΠ»Π΅Π±Π»ΡΡΠ΅ΠΉΡΡ ΡΠΎΡΡΠ΅Π΄ΠΎΡΠΎΡΠ΅Π½Π½ΠΎΠΉ ΠΌΠ°ΡΡΠΎΠΉ.Π£ Π»ΡΠ½ΡΠΉΠ½ΡΠΉ Ρ Π½Π΅Π»ΡΠ½ΡΠΉΠ½ΡΠΉ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠ°Ρ
ΡΠΎΠ·Π²'ΡΠ·Π°Π½ΠΎ Π·Π°Π΄Π°ΡΡ ΠΏΡΠΎ ΡΡΡΠΉΠΊΡΡΡΡ ΡΡΠ°ΡΡΠΎΠ½Π°ΡΠ½ΠΈΡ
ΡΡΡ
ΡΠ² ΠΎΠ΄Π½ΠΎΠ»Π°Π½ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠ½ΠΈΠΊΠ° Π² Π³ΡΠ±ΡΠΈΠ΄Π½ΡΠΉ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΌΠ΅Ρ
Π°Π½ΡΡΠ½ΠΎΡ ΡΠΈΡΡΠ΅ΠΌΠΈ, ΡΠΊΠ° ΡΠΊΠ»Π°Π΄Π°ΡΡΡΡΡ Π· Π³ΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΠΎ ΡΠΎΠ·ΠΌΡΡΠ΅Π½ΠΎΡ ΡΡΡΡΠ½ΠΈ, Π½Π°Π²Π°Π½ΡΠ°ΠΆΠ΅Π½ΠΎΡ ΠΊΠΎΠ»ΠΈΠ²Π½ΠΎΡ Π·ΠΎΡΠ΅ΡΠ΅Π΄ΠΆΠ΅Π½ΠΎΡ ΠΌΠ°ΡΠΎΡ.The problem of stability of the stationary motions of a single-mass pendulum in the hybrid model of one mechanical system is solved in the linear and nonlinear statements. The mechanical system consists of a string which is horizontally disposed and loaded by an oscillating localized mass
Detection and mapping of hydrothermally altered rocks in the vicinity of the comstock lode, Virginia Range, Nevada, using enhanced LANDSAT images
The author has identified the following significant results. LANDSAT images enhanced by the band-ratioing method can be used for reconnaissance alteration mapping in moderately heavily vegetated semiarid terrain as well as in sparsely vegetated to semiarid terrain where the technique was originally developed. Significant vegetation cover in a scene, however, requires the use of MSS ratios 4/5, 4/6, and 6/7 rather than 4/5, 5/6, and 6/7, and requires careful interpretation of the results. Supplemental information suitable to vegetation identification and cover estimates, such as standard LANDSAT false-color composites and low altitude aerial photographs of selected areas is desirable
Invariant sets for discontinuous parabolic area-preserving torus maps
We analyze a class of piecewise linear parabolic maps on the torus, namely
those obtained by considering a linear map with double eigenvalue one and
taking modulo one in each component. We show that within this two parameter
family of maps, the set of noninvertible maps is open and dense. For cases
where the entries in the matrix are rational we show that the maximal invariant
set has positive Lebesgue measure and we give bounds on the measure. For
several examples we find expressions for the measure of the invariant set but
we leave open the question as to whether there are parameters for which this
measure is zero.Comment: 19 pages in Latex (with epsfig,amssymb,graphics) with 5 figures in
eps; revised version: section 2 rewritten, new example and picture adde
Geologic applications of ERTS images on the Colorado Plateau, Arizona
Three areas in central and northern Arizona centered on the (1) Verde Valley, (2) Coconino Plateau, and (3) Shivwits Plateau were studied using ERTS photography. Useful applications results include: (1) upgrading of the existing state geologic map of the Verde Valley region; (2) detection of long NW trending lineaments in the basalt cap SE of Flagstaff which may be favorable locations for drilling for new water supplies; (3) tracing of the Bright Angel and Butte faults to twice their previously known length and correlating the extensions with modern seismic events, showing these faults to be present-day earthquake hazards; (4) discovering and successfully drilling perched sandstone aquifers in the Kaibab Limestone on the Coconino Plateau; and (5) determining the relationship between the Shivwits lavas and the formation of the lower Grand Canyon and showing that the lavas should be an excellent aquifer, as yet untapped
Lasofoxifene versus fulvestrant for ER+/HER2- metastatic breast cancer with an ESR1 mutation: Results from the randomized, phase II ELAINE 1 trial
BACKGROUND: Acquired estrogen receptor alpha (ER/ESR1) mutations commonly cause endocrine resistance in ER+ metastatic breast cancer (mBC). Lasofoxifene, a novel selective ER modulator, stabilizes an antagonist conformation of wild-type and ESR1-mutated ER-ligand binding domains, and has antitumor activity in ESR1-mutated xenografts.
PATIENTS AND METHODS: In this open-label, randomized, phase II, multicenter, ELAINE 1 study (NCT03781063), we randomized women with ESR1-mutated, ER+/human epidermal growth factor receptor 2 negative (HER2-) mBC that had progressed on an aromatase inhibitor (AI) plus a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) to oral lasofoxifene 5 mg daily or IM fulvestrant 500 mg (days 1, 15, and 29, and then every 4 weeks) until disease progression/toxicity. The primary endpoint was progression-free survival (PFS); secondary endpoints were safety/tolerability.
RESULTS: A total of 103 patients received lasofoxifene (n = 52) or fulvestrant (n = 51). The most current efficacy analysis showed that lasofoxifene did not significantly prolong median PFS compared with fulvestrant: 24.2 weeks (βΌ5.6 months) versus 16.2 weeks (βΌ3.7 months; P = 0.138); hazard ratio 0.699 (95% confidence interval 0.434-1.125). However, PFS and other clinical endpoints numerically favored lasofoxifene: clinical benefit rate (36.5% versus 21.6%; P = 0.117), objective response rate [13.2% (including a complete response in one lasofoxifene-treated patient) versus 2.9%; P = 0.124], and 6-month (53.4% versus 37.9%) and 12-month (30.7% versus 14.1%) PFS rates. Most common treatment-emergent adverse events with lasofoxifene were nausea, fatigue, arthralgia, and hot flushes. One death occurred in the fulvestrant arm. Circulating tumor DNA ESR1 mutant allele fraction (MAF) decreased from baseline to week 8 in 82.9% of evaluable lasofoxifene-treated versus 61.5% of fulvestrant-treated patients.
CONCLUSIONS: Lasofoxifene demonstrated encouraging antitumor activity versus fulvestrant and was well tolerated in patients with ESR1-mutated, endocrine-resistant mBC following progression on AI plus CDK4/6i. Consistent with target engagement, lasofoxifene reduced ESR1 MAF, and to a greater extent than fulvestrant. Lasofoxifene may be a promising targeted treatment for patients with ESR1-mutated mBC and warrants further investigation
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