550 research outputs found

    Intelligence Requirements for the 1980\u27s: Intelligence and Policy

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    Global Renewable Energy Indicators for Sustainable Development

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    Energy supplies from renewable sources are the essential components of every nation�s energy strategy because of their positive environmental impacts and sustainability. It is economically competitive with fossil fuels. It is one of the pillars of sustainable energy. Climate change, global warming that harms the environment, massive depletion of fossil fuels and hike in rate of oil has driven the governments to support renewable energy legislation and policies. The application and contribution of renewable energy are prominent for sustainable energy development. Renewable energy scenarios such as wind energy, solar energy, bio-energy, geothermal energy, hydro energy and hydrogen energy are presented in this paper. The upward trends of renewable energy installation give motivation and encouragement to enhance the efficiency of renewable energy systems

    Macrophages in Synovial Inflammation

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    Synovial macrophages are one of the resident cell types in synovial tissue and while they remain relatively quiescent in the healthy joint, they become activated in the inflamed joint and, along with infiltrating monocytes/macrophages, regulate secretion of pro-inflammatory cytokines and enzymes involved in driving the inflammatory response and joint destruction. Synovial macrophages are positioned throughout the sub-lining layer and lining layer at the cartilage–pannus junction and mediate articular destruction. Sub-lining macrophages are now also considered as the most reliable biomarker for disease severity and response to therapy in rheumatoid arthritis (RA). There is a growing understanding of the molecular drivers of inflammation and an appreciation that the resolution of inflammation is an active process rather than a passive return to homeostasis, and this has implications for our understanding of the role of macrophages in inflammation. Macrophage phenotype determines the cytokine secretion profile and tissue destruction capabilities of these cells. Whereas inflammatory synovial macrophages have not yet been classified into one phenotype or another it is widely known that TNFα and IL-l, characteristically released by M1 macrophages, are abundant in RA while IL-10 activity, characteristic of M2 macrophages, is somewhat diminished. Here we will briefly review our current understanding of macrophages and macrophage polarization in RA as well as the elements implicated in controlling polarization, such as cytokines and transcription factors like NFκB, IRFs and NR4A, and pro-resolving factors, such as LXA4 and other lipid mediators which may promote a non-inflammatory, pro-resolving phenotype, and may represent a novel therapeutic paradigm

    Polyimides with pendent ethynyl groups

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    Several new polyimides containing pendent ethynyl groups were prepared and characterized. The new polyimides were prepared from the following novel ethynyl containing diamines; 1,1-bis(p aminophenyl)-1-(p ethynylphenyl) 2,2,2-trifluoroethane, and 1,1-bis(p aminophenyl)-1-(p phenylethynylphenyl)-2,2,2 trifluoroethane, and 1,1-bis(p aminophenyl)-1-(p hexynylphenyl)-2,2,2 trifluoroethane by reacting with either 3,3',4,4' benzophenone tetracarboxylic dianhydride or 2,2-bis(3,4 dicarboxyphenyl) hexafluoropropane dianhydride (6FDA). Inherent viscosities for the polymers ranged from 0.26 to 0.94 dL/g. Three copolymers prepared by reacting 10 mole pct. of one of the ethynyl containing diamines and 90 mole pct. of 2,2-bis-(4-(4 aminophenoxy)phenyl) hexafluoropropane with 6FDA were also prepared and characterized. Inherent viscosities for these copolymers ranged from 1.08 to 1.54 dL/g. Original polyimide glass transition temperatures were approx. 265 C while curing at 300 to 350 C for 1 hr in air increased the Tgs by approx. 10 C. Film properties and thermal stability were also measured for these copolyimides

    Investigation of in situ physical properties of surface and subsurface site materials by engineering geophysical techniques Annual report

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    Seismic energy spectrum and attenuation studied in Arizona geological formations for application to lunar surface investigation

    Comparison of cardiovascular responses following self-selected maximal effort in forward, backward and sideways walking

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    Humans learned to walk forward in the course of evolution, while sideways and backward walking are considered to be novel tasks. This study compared the cardiovascular parameters during forward, backward and sideways walking of students in a Nigerian University. Fifty apparently healthy young adult students (25.6±2.0 years) were purposively recruited to participate in the study. Participants had their anthropometric characteristics (weight and height) and cardiovascular parameters (heart rate [HR], systolic blood pressure [SBP], diastolic blood pressure [DBP], mean arterial pressure [MAP], pulse pressure (PP) and rate pressure product (RPP), and rate of perceived exertion [RPE]) determined at baseline. Participants’ HR, SBP, DBP, MAP and RPE responses after a 100 meter walk at the subject’s self-selected maximum speed during the different modes of walking were compared using multiple analysis of variance. Significantly higher DBP, MAP (P<0.05) and RPE (P<0.01) for sideways walking compared to backward walking, higher (P<0.01) HR, SBP and RPE for both sideways walkingand backward walking compared to forward walking, and higher (P<0.01) HR, SBP, DBP, MAP and RPE for sideways walking compared to forward walking were found. We also found higher (P<0.01) HR, SBP and RPE for backward walking compared to the corresponding values during forward walking. Overall, findings of heightened cardiovascular responses suggest higher energy expenditure in sideways walking compared to forward and backward walking. We hypothesize that the differential plane of motion and the more prevalent static muscle workin sideways walking may be responsible for the apparently more strenuous nature of sideways walking compared to the other modes.Keywords: Cardiovascular; Energy expenditure; Ambulation; Walking; Motor patter

    How mindful of their own health are healthcare professionals? perception and practice of personnel in a tertiary hospital in Nigeria

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    Objectives: To assess health professionals’ perception and determinants of their health and practice of preventive self-care Methods: An analytic cross-sectional design was employed, and 232 professionals were selected by stratified sampling from all health professional departments of Delta State University Teaching Hospital. Healthcare professionals who had worked in the hospital for at least six months were included in the sampling frame. Pregnant women and supernumerary professionals were excluded. A self-administered questionnaire was used, and data analysed using SPSS. The main outcome measures were the level of perception of self-health and level of practice of preventive selfcare. Results: More than four-fifths of doctors and 64.8% of nurses had good perception of their health, with significant association between perception and service area (X2 = 11.828, p =0.008). Screening practice was lowest amongst doctors except for HIV/HBV screening. Whereas 63.4% of all participants adjudged their BMI to be normal, only 36.2% actually had normal BMI, the difference being significant (p <0.001). Almost 20% of doctors had not had a BP check in a year or more, and the same proportion of doctors and nurses had never checked their FBS. The proportion of personnel who had never checked their serum lipid profile was high among nurses (76.1%) and doctors (58.3%). Conclusion: Respondents had good perception but poor preventive behaviour, beginning management after disease onset. This may be ominous for the sector. Urgent health promotion action to safeguard productivity is needed. Comprehensive data from a multi-centre study will provide a deeper understanding of the issue

    Remuneration of primary dental care in England: a qualitative framework analysis of perspectives of a new service delivery model incorporating incentives for improved access, quality and health outcomes

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    Objective: This study aimed to describe stakeholder perspectives of a new service delivery model in primary care dentistry incorporating incentives for access, quality and health outcomes. Design: Data were collected through observations, interviews and focus groups. Setting: This was conducted under six UK primary dental care practices, three working under the incentive-driven contract and three working under the traditional activity-based contract. Participants: Observations were made of 30 dental appointments. Eighteen lay people, 15 dental team staff and a member of a commissioning team took part in the interviews and focus groups. Results: Using a qualitative framework analysis informed by Andersen’s model of access, we found oral health assessments influenced patients’ perceptions of need, which led to changes in preventive behaviour. Dentists responded to the contract, with greater emphasis on prevention, use of the disease risk ratings in treatment planning, adherence to the pathways and the utilisation of skill-mix. Participants identified increases in the capacity of practices to deliver more care as a result. These changes were seen to improve evaluated and perceived health and patient satisfaction. These outcomes fed back to shape people’s predispositions to visit the dentist. Conclusion: The incentive-driven contract was perceived to increase access to dental care, determine dentists’ and patients’ perceptions of need, their behaviours, health outcomes and patient satisfaction. Dentists face challenges in refocusing care, perceptions of preventive dentistry, deployment of skill mix and use of the risk assessments and care pathways. Dentists may need support in these areas and to recognise the differences between caring for individual patients and the patient-base of a practice
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