EKLEM HASTALIKLARI VE CERRAHISI-JOINT DISEASES AND RELATED SURGERY

Objectives: This study aims to investigate the effect of teicoplanin on fracture healing stereologically and histopatologically. Materials and methods: Twenty male Wistar albino rats were separated into two as the study (teicoplanin) and control groups. After intramedullary fixation of the right tibia of all the rats with 0.5 mm Kirschner wire under general anesthesia, standard closed shaft fractures were created using fracture formation apparatus. Teicoplanin (10 mg/kg) and saline were administered intraperitoneally to the study and control groups, respectively. Control radiographs were taken at the end of the procedure and the rats were sacrificed after 28 days. New bone and connective tissue volumes were calculated on obtained tissue samples using unbiased stereological and histopathological techniques. Results: It was observed that teicoplanin increased the formation of bone, vascularization, and connective tissue. There was a statistically significant difference between the two groups in respect of bone and vascular total volume (p0.05). Conclusion: In addition to its antibacterial effect, teicoplanin may increase new bone formation; thus, it may be used safely in the treatment of bone defects accompanied with infection

Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects

Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K-i values in the range of 447.28 to 1004.65 nM for hCA I, 309.44 to 935.93 nM for hCA II, and 0.28 to 4.01 nM for AChE, respectively. Novel substituted thiophene derivatives can be good candidate drugs for the treatment of some diseases like neurological disorders, epilepsy, glaucoma, gastric and duodenal ulcers, mountain sickness, or osteoporosis as carbonic anhydrase isozymes inhibitors, and for the treatment of Alzheimer's and Parkinson's diseases as acetylcholinesterase inhibitors

Intracranial arterial aneurysm complicating Behcet's disease

WOS: A1996UM20900010PubMed ID: 8738367Behcet's disease, a rare condition in central Europe but more common in Turkey where it was originally described, is characterized clinically by the presence of a diagnostic triad of oral and genital aphthous ulcers, meningitis, and relapsing iridocyclitis. Vascularlesions including arterial and venous occlusions, arterial aneurysms and varices are one of the common complications of Behcet's disease occur most commonly in the abdominal aorta, femoral arteries and pulmonary arteries. There have been only four reports of aneurysms of cerebral arteries in the literature. The authors describe a patient with Behcet's disease who suffered secondary subarachnoid hemorrhage due to a ruptured aneurysm of the anterior communicating artery 3 years after the initial diagnosis. This case report draws further attention to this rare entity in patients with Behcet's disease

Cervical intradural extramedullary hydatid cyst

A case of intradural extramedullary hydatid cyst with spinal cord compression located in the cervical region is presented. The diagnosis was made preoperatively on the basis of MRI findings. Many cases of cranial or spinal extradural hydatid cyst have been reported in the literature, but intradural extramedullar location of the cyst in the cervical region is extremely rare

Coincidence of low social support and high depressive score on quality of life in elderly

Objectives: The aim of this study is to determine the effect of depression and social support on quality of life in elderly

Lipomas of the corpus callosum a report of four cases

Lipomas of the corpus callosum are rare congenital conditions. These lesions are often asymptomatic but may present as epilepsy, hemiplegia, dementia or headache. Computerized tomography and magnetic resonance imaging make the diagnosis of lipomas feasible at any site of the intracranial space, because of very low density attenuation values on computerized tomography and the short T1 and T2 on magnetic resonance. A direct surgical approach is very rarely necessary in these lesions. Four cases with lipoma of the corpus callosum diagnosed by computed tomography are presented and the literature is reviewed. Basic diagnostic considerations and therapeutic options are discussed

An unusual complication of the ventriculo-peritoneal shunt: Migration of the distal end into the scrotum through the inguinal canal

[No abstract available