ESTRATÉGIAS EXTENSIONISTAS DO CURSO DE ESPECIALIZAÇÃO EM EDUCAÇÃO AMBIENTAL DA UFSM

http://dx.doi.org/10.5902/223611704024http://dx.doi.org/10.5902/223611704024O curso de especialização em Educação Ambiental da Universidade Federal de Santa Maria completou 15 anos em 2010. São disponibilizados dois formatos distintos, presencial e à distância (EaD), onde são atendidos cinco pólos (cinco cidades do interior do RS) da Universidade Aberta do Brasil (UAB): Agudo, Cacequi, Panambi, São Sepé e Sapiranga. Este trabalho tem como objetivo apresentar algumas ações extensionistas envolvendo gestão informacional e de divulgação científica do curso, de modo a garantir uma maior visibilidade, tanto acadêmica, quanto social do mesmo. São propostas ações a organização bianual de um Congresso Internacional de Educação Ambiental (www.ufsm.br/panambi2011), com o objetivo de gerar discussões multi e interdisciplinares para que a sociedade tome providências na solução dos problemas ambientais, bem como, duas revistas eletrônicas de acesso gratuito e aberto, a Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental – www.ufsm.br/reget) e a Revista Monografias Ambientais (www.ufsm.br/remoa), com o intuito de divulgar as pesquisas realizadas no âmbito do curso, bem como de disponibilizar a outras Instituições de Ensino Superior mais uma possibilidade de mostrar seus trabalhos nos mais diversos níveis acadêmicos, da graduação até resumos de teses de doutorado. Assim, as ações do curso em termos de divulgação científica e gestão informacional têm procurado atender as três temáticas básicas do curso, ou seja, a Educação, Sociedade e Cultura; as Práticas Educativas Ambientais e a Discussão dos Problemas Ambientais

Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds

Animals are frequently used as model systems for determination of safety and efficacy in pharmaceutical research and development. However, significant quantitative and qualitative differences exist between humans and the animal models used in research. This is as a result of genetic variation between human and the laboratory animal. Therefore the development of a system that would allow the assessment of all molecular differences between species after drug exposure would have a significant impact on drug evaluation for toxicity and efficacy. Here we describe a cross-species microarray methodology that identifies and selects orthologous probes after cross-species sequence comparison to develop an orthologous cross-species gene expression analysis tool. The assumptions made by the use of this orthologous gene expression strategy for cross-species extrapolation is that; conserved changes in gene expression equate to conserved pharmacodynamic endpoints. This assumption is supported by the fact that evolution and selection have maintained the structure and function of many biochemical pathways over time, resulting in the conservation of many important processes. We demonstrate this cross-species methodology by investigating species specific differences of the peroxisome proliferatoractivator receptor (PPAR) a response in rat and human

Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells

Dimethyl sulfoxide (DMSO) is used to sustain or favor hepatocyte differentiation in vitro. Thus, DMSO is used in the differentiation protocol of the HepaRG cells that present the closest drug-metabolizing enzyme activities to primary human hepatocytes in culture. The aim of our study is to clarify its influence on liver-specific gene expression. For that purpose, we performed a large-scale analysis (gene expression and histone modification) to determine the global role of DMSO exposure during the differentiation process of the HepaRG cells. The addition of DMSO drives the upregulation of genes mainly regulated by PXR and PPARα whereas genes not affected by this addition are regulated by HNF1α, HNF4α, and PPARα. DMSO-differentiated-HepaRG cells show a differential expression for genes regulated by histone acetylation, while differentiated-HepaRG cells without DMSO show gene signatures associated with histone deacetylases. In addition, we observed an interplay between cytoskeleton organization and EMC remodeling with hepatocyte maturation

Polémiques, traditions et identités : réflexions autour des Discours contre les juifs et les judaïsants de Jean Chrysostome

International audienceIn his History of Antisemitism, Léon Poliakov describes John Chrysostom's Discourses against Judaizing Christians as « invectives of unbelievable violence » showing the « theological antisemitism » of the Fathers of the Church. However, Poliakov seems to ignore the literary traditions which influenced Chrysostom's Discourses. So, while they paid a tribute to the anti-Judaic polemical tradition which had characterized Christian literature since its beginning, the Discourses also depended on the pagan rhetorical tradition, which was conveyed in the teaching received by 4th-century Christian writers. This literary tradition, emphasizing the importance of clarity and reasonable use of passions, was to Chrysostom a powerful way to promote his point of view in the turbulent and violent religious context of Antioch. Thanks to the reconsideration of both of these traditions, we can bring to light what the real meaning of Chrysostom’s discourses is: they were an Antiochean priest’s contribution to the construction of a Christian identity. Therefore, if we study the context of the Discourses' elaboration and place them in the uninterrupted chain of the tradition, we can demonstrate these texts do not attest to « theological antisemitism », as Poliakov said, but are an intensive and vivid reflexion about Christian identity in Late Antiquity.Dans son Histoire de l'antisémitisme, Léon Poliakov qualifie les Discours contre les juifs de Jean Chrysostome (vers 347-407) de « diatribes d'une violence inimaginable » censées illustrer l'« antisémitisme théologique » des Pères de l'Église. Cette analyse prend cependant insuffisamment en compte la tradition, ou plutôt les traditions qui irriguent ces textes du Père antiochien. Ainsi, s'ils sont d'abord imprégnés par la tradition de la polémique antijudaïque, qui marque la littérature chrétienne depuis ses débuts, les textes de Jean Chrysostome se placent aussi dans la tradition de la rhétorique païenne véhiculée dans l'enseignement qu'ont reçu les auteurs chrétiens du IVe siècle. Cette tradition littéraire et son exigence de clarté et d'usage raisonné des sentiments ont été pour notre auteur des outils précieux pour faire valoir son point de vue au sein de la cité d'Antioche, alors marquée par une vie religieuse intense et troublée. Reconsidérer et réévaluer ces deux traditions au sein de l'œuvre de Jean Chrysostome, c'est redonner à ces textes leur signification réelle : la contribution d'un prêtre antiochien à la construction d'une identité chrétienne. Replacer les Discours contre les juifs dans le contexte de leur élaboration et dans la chaîne ininterrompue des traditions dont ils sont tributaires permet donc d'en faire non pas la preuve d'un « antisémitisme théologique », comme le disait Poliakov, mais un témoignage d'une réflexion intense et vivante sur l'identité chrétienne à la fin de l'Antiquité

Produire et répéter les efforts de haute intensité en rugby à XV, relations avec la performance en situation de compétition

This thesis originated in the ambition to contribute to a better understanding of the relationship between performance in rugby union and the ability to produce and repeat high-intensity efforts. Rugby is a complex sport, and this question is of crucial interest to rugby professionals and physical trainers. In this context, our motivation has been to investigate this area in order to provide answers with direct practical implications. Our methodological approach was based on the central question of how the ability to produce and repeat high-intensity effort affects performance in rugby union. We therefore adopted a structured three-axis experimental approach. In the first axis, we examined how the ability to produce high-intensity efforts influences match performance. The second axis aimed to understand how the ability to repeat high-intensity efforts was crucial to the performance of rugby players. The third investigated the development of this ability and the impact of training methods on performance in competition. These axes were supported by four experimental projects which provided key information on the relationship between horizontal force production in sprinting, the ability to repeat sprints, the ability to repeat high-intensity efforts, and match performance. This research offers practical perspectives for the physical preparation of XV rugby players by highlighting the relationships between different performance factors. These direct implications suggest solutions for the development of training programs adapted to the specific requirements of players, depending on their position, in terms of their ability to produce and repeat high-intensity efforts. In this context, the results of this thesis provide practical information that can help to improve performance in rugby union.Cette thèse trouve son origine dans la volonté de contribuer à une meilleure compréhension des liens entre la performance en rugby à XV et la capacité à produire et répéter des efforts de haute intensité. Le rugby étant un sport complexe, cette question revêt un intérêt crucial pour les professionnels du rugby et les préparateurs physiques. Dans ce contexte, notre motivation a été d'approfondir ce domaine afin d'apporter des réponses applicables sur le terrain. Nos choix méthodologiques ont suivi la problématique centrale qui était d’identifier comment la capacité à produire et à répéter des efforts de haute intensité influe sur la performance en rugby à XV. Cette question a été le fil conducteur de nos réflexions et de nos recherches. Nous avons donc adopté une approche expérimentale structurée en trois axes. Dans le premier axe, nous avons examiné comment la capacité à produire des efforts de haute intensité influence la performance en match. Le deuxième axe visait à comprendre comment la capacité à répéter des efforts de haute intensité était cruciale pour la performance des joueurs de rugby. Le troisième axe s'est intéressé au développement de cette capacité et à l'impact des méthodes d'entraînement sur la performance en compétition. Ces axes ont été étayés par quatre projets expérimentaux qui ont fourni des informations clés sur la relation entre la production de force horizontale en sprint, la capacité à répéter des sprints, la capacité à répéter des efforts de haute intensité, et la performance en match. Ces travaux offrent des perspectives pratiques pour la préparation physique des joueurs de rugby à XV en mettant en lumière des relations entre différents facteurs de performance. Ces implications directes suggèrent des pistes pour le développement de programmes d'entraînement adaptés aux besoins spécifiques des joueurs en fonction de leur poste concernant leurs capacités à produire et répéter les efforts de haute intensité. En ce sens, les résultats de cette thèse fournissent des informations pratiques qui peuvent contribuer à améliorer la performance en rugby à XV

The Quod Christus sit Deus attributed to John Chrysostom : edition, traduction and commentary

Nous proposons dans cette étude une nouvelle édition du texte grec du Quod Christus sit Deus, monographie écrite par Jean Chrysostome à la fin des années 380. Cette édition est accompagnée d'une traduction française inédite et précédée d'une introduction qui étudie le texte sous trois aspects majeurs. D'abord, nous avons tenté de confirmer la paternité chrysostomienne de l'ouvrage par des études stylistiques et lexicales précises et de le situer dans son contexte probable de rédaction, celui de la vie à Antioche à la fin du IVe siècle. Nous nous sommes ensuite intéressés au Quod Christus sit Deus en tant que représentant de l'activité polémique des auteurs chrétiens de l'Antiquité et l'avons inscrit dans cette tradition littéraire. Enfin, nous avons pu étudier le texte d'un point de vue philologique. Si l'étude précise des manuscrits a permis de relever de nombreux phénomènes concernant la transmission des textes de Jean Chrysostome, celle des éditions du texte et des auteurs qui empruntent au Quod Christus sit Deus (Nicétas d'Héraclée, Thomas d'Aquin) nous permet d'en mieux appréhender la réception éditoriale et littéraire.I propose in this study a new edition of the Greek text of the Quod Christus sit Deus, a monography written by John Chrysostom around 386. It is published with an unedited French translation and preceeded by an introduction which studies the text through three main aspects. First, I attempted to clearly demonstrate the genuineness of the attribution to John Chrysostom through a lexical and stylistic survey and to put it in its probable context : the life in Antioch at the end of the 4th century. Afterwards, I considered it as a preview of the polemic activities the Christian writers could have in Late Antiquity and inscribe it in this literary tradition of polemics. Lastly, I dealt with the work in a philological point of view. The precise analysis of handwritten witnesses showed us many phaenomena related to the transmission of Chrysostomical works, while studying modern editions and works by authors who were largely inspired by the Quod Christus sit Deus (Niketas of Herakleias, Thomas Aquinas) was a good way to seize its editorial and literary reception

Twenty-One* Pseudo-Chrysostoms and more: authorship verification in the patristic world

International audienceAs the most prolific of the Church Fathers, John Chrysostom (344-407 CE) has a vast textual mass and theological importance that has led to a significant misattribution of texts, resulting in the existence of a second corpus known as the pseudo-Chrysostomian corpus. Like many Greek-language Church Fathers' works, this corpus comprises anonymous texts, which scholars have attempted to reattribute or group together based on factors such as the person's function, biography, ideology, style, etc. One survey conducted by Voicu in 1981 explored potential groupings of such texts and produced a critical list of 21 Pseudo-Chrysostom works identified by scholars, including Montfaucon (1655-1741), one of the first modern editors of Chrysostom's writings. In this paper, we present a novel approach to addressing pseudonymous work in the context of chrysostomian studies. We propose to employ siamese networks within an authorship verification framework, following the methodology commonly used in recent computational linguistic competitions. Our embedding model is trained using commonly used features in the digital humanities landscape, such as the most frequent words, affixes, and POS trigrams, utilizing a signal-to-noise ratio distance and pair mining. The results of our model show high AUCROC scores (0.855). Furthermore, the article concludes with an analysis of the pseudo-Chrysostoms proposed by Voicu. We validate a significant portion of the hypotheses found in Voicu's survey while also providing counter-arguments for two Pseudo-Chrysostoms. This research contributes to shedding light on the attribution of ancient texts and enriches the field of chrysostomian studies

Prévalence et facteurs de risque de complications biliaires après transplantation hépatique entre 2004 et 2009 à Montpellier (série rétrospective de 228 patients)

Résumé non disponibleMONTPELLIER-BU Médecine UPM (341722108) / SudocMONTPELLIER-BU Médecine (341722104) / SudocSudocFranceF