THE PROFESSOR – TALENTS SCULPTOR

This work was born from the need to bring to the fore the urgent need to have at the department, for this purely vocational art, honest, talented, mature, creative, humorous teachers with a minimum of 5-10 years of career behind them, from which to share their experiences with the students. The obligation to have such teachers comes against the background of a superficiality that has been insinuated in almost all artistic fields. Today’s neo-modernists (the euphemistic form of neo-Marxists) are able to completely erase the history of an art in order to claim that they are the new founders and to show us the versatility and incoherence of the past. To erase the Greek theater, to forget the commedia dell’arte, to omit Shakespeare, to elude the amazing Russians, to forget the controversial creators of the absurd, to revoke Caragiale or to cancel the comic, and to say that a collection of definitions and information, strictly related to statistics, in a text cannot be called a play, that’s it the atricide

The global context of economic crises and cohesion funds in the EU

The currently finalized financial crisis, which began in the US then spread to Europe, has become global at some point. Even the emerging markets and the less developed countries that have managed their economy well, have resisted unfavorable lending practices, kept high levels of foreign exchange reserves, bought no toxic mortgages, and did not allow banks to engage in excessive risk through financial derivatives so they get involved and suffer as a consequence. Any global solution – short-term measures to stabilize the current situation and long-term measures to make another less likely reappearance – must pay due attention to the effects on these countries. Without doing so, global economic stability cannot be restored, and economic growth as well as global poverty reduction will be threatened

Hábitos de estudio y aprendizaje significativo en estudiantes de secundaria, Trujillo – 2022

El presente trabajo de investigación tuvo como principal objetivo determinar la relación entre hábitos de estudio y aprendizaje significativo, se siguió un enfoque cuantitativo, con un alcance descriptivo – correlacional, con un diseño no experimental. Se utilizó como técnica la encuesta y se aplicó una adaptación del instrumento Inventario de Hábitos de Estudios CASM-85, que consta de tres dimensiones: acercamiento a la clase, comprensión de la clase y desarrollo de evidencias; a su vez se usó un cuestionario Aprendizaje Significativo estandarizado, que consta de 3 dimensiones: experiencias previas, nuevos conocimientos y relación entre nuevos y antiguos conocimientos. Para el análisis de datos se utilizó el software SPSS v26, cuya muestra compuesta de 50 alumnos fue probabilística aleatoria simple; como resultados se obtuvo que existe una correlación positiva considerable de p=0.001 <0.05 y rho=0,585, entre las variables; además entre las dimensiones de acercamiento a la clase y experiencias nuevas se obtuvo una correlación de rho=0.580 lo que indica una relación positiva considerable, para las dimensiones de comprensión de la clase y nuevos conocimientos de rho=0.352 lo que indica una relación positiva media; caso similar para las dimensiones desarrollo de la evidencia y relación entre antiguos y nuevos conocimientos es de rho= 0.40

Geomorphosites and geotourism in Bucharest city center (Romania)

The present paper aims at inventorying the geomophosites in Bucharest as well as introducing geotouristic itineraries that take into account the long-time developed high value cultural heritage of the area. The process included several stages: studying Bucharest’s relief and cultural- historical elements with tourist value from existing bibliography, cartographic methods (aerial photos and different editions of topographic maps), as well as the information gathered from field investigations; identifying and inventorying geomorphosites, assessing the population’s opinion about geoheritage (geomorphosites) and its capitalization in tourism activities, 100 questionnaires were applied; creating geotouristic itineraries and later promoting them. The most valuable and representative geomorphosites identified are: on Colentina Valley (the Plumbuita, Ostrov, Dobroeşti and Pantelimon hills) (aren’t located in the study area), on Dâmboviței Valley (Cotroceni, Șerban Vodă, Mitropoliei, Spirii, Filaret and Arsenal hills, Țăcăliei, Procopoaiei, University terraces, Dâmbovița Meadow). The authors suggest two geotouristic itineraries that emphasize the relationship between the scientific, cultural, and historic elements as well as the human-nature report within the urban area

Phase I/II Study of Refametinib (BAY 86-9766) in Combination with Gemcitabine in Advanced Pancreatic cancer

Background Activating KRAS mutations are reported in up to 90% of pancreatic cancers. Refametinib potently inhibits MEK1/2, part of the MAPK signaling pathway. This phase I/II study evaluated the safety and efficacy of refametinib plus gemcitabine in patients with advanced pancreatic cancer. Methods Phase I comprised dose escalation, followed by phase II expansion. Refametinib and gemcitabine plasma levels were analyzed for pharmacokinetics. KRAS mutational status was determined from circulating tumor DNA. Results Ninety patients overall received treatment. The maximum tolerated dose was refametinib 50 mg twice daily plus standard gemcitabine (1000 mg/m2 weekly). The combination was well tolerated, with no pharmacokinetic interaction. Treatment-emergent toxicities included thrombocytopenia, fatigue, anemia, and edema. The objective response rate was 23% and the disease control rate was 73%. Overall response rate, disease control rate, progression-free survival, and overall survival were higher in patients without detectable KRAS mutations (48% vs. 28%, 81% vs. 69%, 8.8 vs. 5.3 months, and 18.2 vs. 6.6 months, respectively). Conclusion Refametinib plus gemcitabine was well tolerated, with a promising objective response rate, and had an acceptable safety profile and no pharmacokinetic interaction. There was a trend towards improved outcomes in patients without detectable KRAS mutations that deserves future investigation

Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL.

Dynamic contrast-enhanced (DCE) MRI provides both morphological and functional information regarding breast tumor response to neoadjuvant chemotherapy (NAC). The purpose of this retrospective study is to test if prediction models combining multiple MRI features outperform models with single features. Four features were quantitatively calculated in each MRI exam: functional tumor volume, longest diameter, sphericity, and contralateral background parenchymal enhancement. Logistic regression analysis was used to study the relationship between MRI variables and pathologic complete response (pCR). Predictive performance was estimated using the area under the receiver operating characteristic curve (AUC). The full cohort was stratified by hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status (positive or negative). A total of 384 patients (median age: 49 y/o) were included. Results showed analysis with combined features achieved higher AUCs than analysis with any feature alone. AUCs estimated for the combined versus highest AUCs among single features were 0.81 (95% confidence interval [CI]: 0.76, 0.86) versus 0.79 (95% CI: 0.73, 0.85) in the full cohort, 0.83 (95% CI: 0.77, 0.92) versus 0.73 (95% CI: 0.61, 0.84) in HR-positive/HER2-negative, 0.88 (95% CI: 0.79, 0.97) versus 0.78 (95% CI: 0.63, 0.89) in HR-positive/HER2-positive, 0.83 (95% CI not available) versus 0.75 (95% CI: 0.46, 0.81) in HR-negative/HER2-positive, and 0.82 (95% CI: 0.74, 0.91) versus 0.75 (95% CI: 0.64, 0.83) in triple negatives. Multi-feature MRI analysis improved pCR prediction over analysis of any individual feature that we examined. Additionally, the improvements in prediction were more notable when analysis was conducted according to cancer subtype