Planificación de la producción para la mejora de la productividad de la línea de enrollados de canela en la empresa Cinnabon, Bellavista,” Lima 2017-2018”

En la investigación “Planificación de la producción para la mejora de la productividad de la línea de enrollado de canela de la empresa Cinnabon, Bellavista 2018”, el objetivo general fue determinar cómo la Planificación de la producción mejora la productividad de la línea de enrollados de canela de la empresa Cinnabon, Bellavista, 2018.La metodología de investigación es de enfoque cuantitativo, de tipo aplicada y diseño cuasi experimental. La población fueron los datos numéricos de las variables bajo estudio, planificación de producción y productividad de la empresa Cinnabon. La muestra determinada fueron los datos numéricos de los meses, desde agosto a octubre del año 2017 (pre) y de enero a marzo del año 2018 (post) referidos a la planificación de la producción y productividad. La técnica empleada fue la observación y el instrumento fue la ficha de observación. La validación de los instrumentos se realizó a través del juicio de expertos. Para realizar el análisis de los datos se utilizó el programa estadístico SPSS Versión 25 con el cual se buscó representar los datos cuantitativos, a través de la estadística descriptiva y la estadística inferencial, para la interpretación de los resultados. Se concluyó que la Planificación de la producción mejora la Productividad de la línea de enrollados de canela en la empresa Cinnabon en 45%, con respecto a la eficiencia lo que antes se tenía un índice de 0,284, actualmente hubo un aumento a 0,5095 por lo que se puede deducir que la eficiencia ha mejorado en un 51%. La eficacia antes era de un 07910 y luego paso a un índice de 0,8907, por lo que se puede deducir que hubo un incremento de 89%. Los resultados estadísticos de la comparación de medias que se realizaron con la prueba t student para muestras relacionadas en el pretest y postest, evaluadas en un promedio de tiempo de 12 meses ratificaron la aceptación de la hipótesis general, demostrando así que la productividad mejora en 45% en el 2018.Por lo tanto, se aprueba la hipótesis general: la Planificación de la producción mejora la productividad de la línea de enrollados de canela de la empresa Cinnabon, Bellavista, 2018

Quantitative methods for assessing local and bodywide contributions to Wolbachia titer in maternal germline cells of Drosophila

Background Little is known about how bacterial endosymbionts colonize host tissues. Because many insect endosymbionts are maternally transmitted, egg colonization is critical for endosymbiont success. Wolbachia bacteria, carried by approximately half of all insect species, provide an excellent model for characterizing endosymbiont infection dynamics. To date, technical limitations have precluded stepwise analysis of germline colonization by Wolbachia. It is not clear to what extent titer-altering effects are primarily mediated by growth rates of Wolbachia within cell lineages or migration of Wolbachia between cells. Results The objective of this work is to inform mechanisms of germline colonization through use of optimized methodology. The approaches are framed in terms of nutritional impacts on Wolbachia. Yeast-rich diets in particular have been shown to suppress Wolbachia titer in the Drosophila melanogaster germline. To determine the extent of Wolbachia sensitivity to diet, we optimized 3-dimensional, multi-stage quantification of Wolbachia titer in maternal germline cells. Technical and statistical validation confirmed the identity of Wolbachia in vivo, the reproducibility of Wolbachia quantification and the statistical power to detect these effects. The data from adult feeding experiments demonstrated that germline Wolbachia titer is distinctly sensitive to yeast-rich host diets in late oogenesis. To investigate the physiological basis for these nutritional impacts, we optimized methodology for absolute Wolbachia quantification by real-time qPCR. We found that yeast-rich diets exerted no significant effect on bodywide Wolbachia titer, although ovarian titers were significantly reduced. This suggests that host diets affects Wolbachia distribution between the soma and late stage germline cells. Notably, relative qPCR methods distorted apparent wsp abundance, due to altered host DNA copy number in yeast-rich conditions. This highlights the importance of absolute quantification data for testing mechanistic hypotheses. Conclusions We demonstrate that absolute quantification of Wolbachia, using well-controlled cytological and qPCR-based methods, creates new opportunities to determine how bacterial abundance within the germline relates to bacterial distribution within the body. This methodology can be applied to further test germline infection dynamics in response to chemical treatments, genetic conditions, new host/endosymbiont combinations, or potentially adapted to analyze other cell and tissue types

Amigas Latinas Motivando el ALMA (ALMA): Development and Pilot Implementation of a Stress Reduction Promotora Intervention

Use of mental health care services for psychological distress is limited among Latino immigrants. In geographic areas where migration has been rapid, mental health systems possess limited capacity to provide bilingual and bicultural assistance. The development of a bilingual and bicultural workforce is a necessary yet long-term solution. More immediate strategies, however, are needed to meet the needs of immigrant Latinos. This paper describes the development of a stress-reduction focused, lay health advisor training that targets individual behavior change among Latina immigrants. The theoretical foundation, curriculum components, and pilot implementation of the training are discussed. As natural leaders, Latina promotoras disseminated learned strategies and resources within their communities. The lay health advisor model is a salient method for disseminating information regarding mental health and stress reduction among Latinas

Su salud a la mano (your health at hand): patient perceptions about a bilingual patient portal in the Los Angeles safety net.

ObjectivesDriven by beneficial patient-centered outcomes associated with patient portal use and the Affordable Care Act, portal implementation has expanded into safety nets-health systems that offer access to care to a large share of uninsured, Medicaid, and other vulnerable populations. However, little attention has been paid to the factors that affect portal accessibility by the vulnerable patients served by these health systems-including those who are limited English proficient (LEP).Materials and methodsThe Los Angeles County Department of Health Services (LAC DHS), the second-largest safety net system in the nation, launched its first patient portal, and one of the few bilingual English-Spanish interfaces in existence, in March of 2015. To explore portal awareness and perceptions, we conducted focus groups with LAC DHS patients, in English and Spanish (LEP). The Technology Acceptance Model was used to guide thematic analysis of focus group data.ResultsOf the 46 participants, 37 were patients and 9 were caretakers; 23 were English-speaking and 23 Spanish-speaking LEP. All patients had diabetes or hypertension. Over half had an annual household income <$10 000, yet 78% of English-speaking and 65% of Spanish-speaking LEP participants reported at-home Internet access. Participants' discussion centered around 3 major thematic narratives: (1) participants' awareness or attitudes about the LAC DHS portal; (2) role of culture, language, or community with regard to portal accessibility and utility; and (3) perceived needs for successful portal implementation.ConclusionsSafety net participants identified concrete benefits to the portal and emphasized the need for portal engagement that offered accessible education, support, and resources in clinical and community settings. The portal offers an additional opportunity to engage the patient and family with trusted and validated health information, and should be further developed in this capacity. This study provides a better understanding of preferred improvements of patient portal engagement that guide broader health technology efforts to address electronic health disparities

Construction, purification, and characterization of a chimeric TH1 antagonist

BACKGROUND: TH1 immune response antagonism is a desirable approach to mitigate some autoimmune and inflammatory reactions during the course of several diseases where IL-2 and IFN-γ are two central players. Therefore, the neutralization of both cytokines could provide beneficial effects in patients suffering from autoimmune or inflammatory illnesses. RESULTS: A chimeric antagonist that can antagonize the action of TH1 immunity mediators, IFN-γ and IL-2, was designed, engineered, expressed in E. coli, purified and evaluated for its in vitro biological activities. The TH1 antagonist molecule consists of the extracellular region for the human IFNγ receptor chain 1 fused by a four-aminoacid linker peptide to human 60 N-terminal aminoacid residues of IL-2. The corresponding gene fragments were isolated by RT-PCR and cloned in the pTPV-1 vector. E. coli (W3110 strain) was transformed with this vector. The chimeric protein was expressed at high level as inclusion bodies. The protein was partially purified by pelleting and washing. It was then solubilized with strong denaturant and finally refolded by gel filtration. In vitro biological activity of chimera was demonstrated by inhibition of IFN-γ-dependent HLA-DR expression in Colo 205 cells, inhibition of IFN-γ antiproliferative effect on HEp-2 cells, and by a bidirectional effect in assays for IL-2 T-cell dependent proliferation: agonism in the absence versus inhibition in the presence of IL-2. CONCLUSION: TH1 antagonist is a chimeric protein that inhibits the in vitro biological activities of human IFN-γ, and is a partial agonist/antagonist of human IL-2. With these attributes, the chimera has the potential to offer a new opportunity for the treatment of autoimmune and inflammatory diseases

Lamellar Ichthyosis: a case study in a neonatal unit

Introducción: en el recién nacido pueden ser evidentes numerosos trastornos hereditarios, que causan afectaciones en la pigmentación, textura, elasticidad e integridad estructural del tegumento. La ictiosis laminar o eritrodermiaictiosiforme congénita es una genodermatosis autosómica recesiva poco frecuente, caracterizada por un cuadro eritrodérmico, queratodermia palmo-plantar, onicosis y otros trastornos.Presentación del caso: recién nacido con ictiosis lamelar, hospitalizado en la unidad de cuidados intensivos neonatal del hospital Ginecobstétrico Fe del Valle Ramos, en el municipio de Manzanillo. El tratamiento se centró en mantener la entereza de la piel mediante humectación y lubricación continua con emolientes, control de la temperatura, nutrición y prevención de infecciones secundarias.Conclusiones: se afirma que la atención multidisciplinaria y la implementación del plan de cuidados, fue esencial para el éxito del tratamiento. Hubo mejora de la piel y mucosas, prevención de infecciones. Se favorecieron las condiciones de supervivencia y autonomía de los padres para los cuidados en domicilio.Introduction: in the newborn, numerous hereditary disorders may be evident, which can cause various aberrations of pigmentation, texture, elasticity and structural integrity of the integument. Among these pathologies are ichthyosis, from the Greek ichthys which means fish. Laminar Ichthyosis or Congenital Ichthyosiform Erythroderma (CIE) is a rare autosomal recessive genodermatosis (1/300 000 births worldwide), characterized by an erythrodermic condition, palmoplantar keratoderma (PPK), onicosis, and other disorders.Case report: a newborn with Lamellar Ichthyosis hospitalized in the neonatal intensive care unit at Fe del Valle Ramos Gynecological Obstetric Hospital, in Manzanillo municipality, Granma province. Medical care was based on maintaining the integrity of the skin through moisturizing and continuous lubrication with emollients, temperature control, nutrition and prevention of secondary infections.Conclusions: through the case study, it is stated that the medical appointments with other specialties for the multidisciplinary care and the implementation of the care plan were essential regarding the multidisciplinary success of the treatment. There was improvement of the skin and mucosa, prevention of infections, concluding with favorable conditions of survival and autonomy of the parents for home care

Ictiosis lamelar en una unidad neonatal

Introduction: in the newborn, numerous hereditary disorders may be evident, which can cause various aberrations of pigmentation, texture, elasticity and structural integrity of the integument. Among these pathologies are ichthyosis, from the Greek ichthys which means fish. Laminar Ichthyosis or Congenital Ichthyosiform Erythroderma (CIE) is a rare autosomal recessive genodermatosis (1/300 000 births worldwide), characterized by an erythrodermic condition, palmoplantar keratoderma (PPK), onicosis, and other disorders.Case report: a newborn with Lamellar Ichthyosis hospitalized in the neonatal intensive care unit at Fe del Valle Ramos Gynecological Obstetric Hospital, in Manzanillo municipality, Granma province. Medical care was based on maintaining the integrity of the skin through moisturizing and continuous lubrication with emollients, temperature control, nutrition and prevention of secondary infections.Conclusions: through the case study, it is stated that the medical appointments with other specialties for the multidisciplinary care and the implementation of the care plan were essential regarding the multidisciplinary success of the treatment. There was improvement of the skin and mucosa, prevention of infections, concluding with favorable conditions of survival and autonomy of the parents for home care.Introducción: en el recién nacido pueden ser evidentes numerosos trastornos hereditarios, que causan afectaciones en la pigmentación, textura, elasticidad e integridad estructural del tegumento. La ictiosis laminar o eritrodermiaictiosiforme congénita es una genodermatosis autosómica recesiva poco frecuente, caracterizada por un cuadro eritrodérmico, queratodermia palmo-plantar, onicosis y otros trastornos.Presentación del caso: recién nacido con ictiosis lamelar, hospitalizado en la unidad de cuidados intensivos neonatal del hospital Ginecobstétrico Fe del Valle Ramos, en el municipio de Manzanillo. El tratamiento se centró en mantener la entereza de la piel mediante humectación y lubricación continua con emolientes, control de la temperatura, nutrición y prevención de infecciones secundarias.Conclusiones: se afirma que la atención multidisciplinaria y la implementación del plan de cuidados, fue esencial para el éxito del tratamiento. Hubo mejora de la piel y mucosas, prevención de infecciones. Se favorecieron las condiciones de supervivencia y autonomía de los padres para los cuidados en domicilio

Ceniza de cáscara de coco como susituto del cemento: efecto de la temperatura de calcinación

 The disposal of coconut shell is a waste problem in countries where coconut production is in abundance. When coconut shell is calcinated produces ashes, which are a potential binder material to concrete preparation. In this work, coconut shell was calcinated at 400, 500 and 600 °C for 3 h. The ashes produced were employed as cement substitute. The characteristics of ashes were evaluated by surface area and XRD. The effect of replacing ashes as cement substitute was evaluated by workability and mechanical strength test. Experimental results demonstrated that 600 °C is the most suitable burning temperature for CSA calcination with amorphous SiO2 and low surface area. Results showed that, in contrast to control concrete, that burning temperature decrease concrete workability of concrete. Further, the increasing of burning temperature of coconut shell improves the mechanical strength. The compressive strength of mixture incorporating the ashes of coconut shell burned at 600 °C was higher than the others. Additionally, this temperature was found convincing considering cost to prepare the ashes.La disposición de la cáscara de coco es un problema de eliminación de desechos en países donde la producción de coco es abundante. Cuando la cáscara de coco se calcina produce cenizas, las cuales son un material aglutinante potencial para preparar hormigón. En este trabajo se calcinó cáscara de coco a 400°C, 500°C y 600 °C durante 3 h. Las cenizas producidas se emplearon como sustituto del cemento. Las características de las cenizas se evaluaron por área superficial y DRX. El efecto de la sustitución de las cenizas como sustituto del cemento se evaluó mediante ensayos de trabajabilidad y resistencia mecánica. Los resultados experimentales demostraron que 600 °C es la temperatura de combustión más adecuada para la calcinación de la cascara, con presencia de SiO2 amorfo y baja superficial alta. Los resultados mostraron que, en contraste con el hormigón de referencia, la temperatura de combustión disminuye la trabajabilidad del concreto. Además, el aumento de la temperatura de calcinación de la cáscara de coco mejora la resistencia mecánica. La resistencia a compresión de la mezcla que incorporó cenizas de cáscara de coco calcinadas a 600 °C fue superior a las demás. Se encontró adicionalmente que esta temperatura era convincente considerando el costo de preparar las cenizas. &nbsp

Neuroprotective effect of a pharmaceutical extract of cannabis with high content on CBD against rotenone in primary cerebellar granule cell cultures and the relevance of formulations

Preclinical research supports the benefits of pharmaceutical cannabis-based extracts for treating different medical conditions (e.g., epilepsy); however, their neuroprotective potential has not been widely investigated. Using primary cultures of cerebellar granule cells, we evaluated the neuroprotective activity of Epifractan (EPI), a cannabis-based medicinal extract containing a high level of cannabidiol (CBD), components like terpenoids and flavonoids, and trace levels of Δ9-tetrahydrocannabinol and the acid form of CBD. We determined the ability of EPI to counteract the rotenone-induced neurotoxicity by analyzing cell viability and morphology of neurons and astrocytes by immunocytochemical assays. The effect of EPI was compared with XALEX, a plant-derived and highly purified CBD formulation (XAL), and pure CBD crystals (CBD). The results revealed that EPI induced a significant reduction in the rotenone induced neurotoxicity in a wide range of concentrations without causing neurotoxicity per se. EPI showed a similar effect to XAL suggesting that no additive or synergistic interactions between individual substances present in EPI occurred. In contrast, CBD did show a different profile to EPI and XAL since a neurotoxic effect per se was observed at the higher concentrations assayed. Medium-chain triglyceride (MCT) oil used in EPI formulation could explain this difference. Our data support a neuroprotective effect of EPI which may provide neuroprotection in different neurodegenerative processes. The results highlight the role of CBD as the active component of EPI but also support the need for an appropriate formulation to dilute pharmaceutical cannabis-based products, which could be critical to avoid neurotoxicity at very high doses.Agencia Nacional de Investigación e Innovació