Semi-analytical approach for the Vaidya metric in double-null coordinates

We reexamine here a problem considered in detail before by Waugh and Lake: the solutions of spherically symmetric Einstein's equations with a radial flow of unpolarized radiation (the Vaidya metric) in double-null coordinates. This problem is known to be not analytically solvable, the only known explicit solutions correspond to the constant mass case (Schwarzschild solution in Kruskal-Szekeres form) and the linear and exponential mass functions originally discovered by Waugh and Lake. We present here a semi-analytical approach that can be used to discuss some qualitative and quantitative aspects of the Vaidya metric in double-null coordinates for generic mass functions. We present also a new analytical solution corresponding to $(1/v)$-mass function.Comment: 5 pages, 6 figure

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

Parkinson's disease is a neurodegenerative disorder characterized by the death of dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the surviving neurons. The dopamine catabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is a highly reactive and toxic molecule that leads to aS oligomerization by covalent modifications to lysine residues. Here we show that DOPAL-induced aS oligomer formation in neurons is associated with damage of synaptic vesicles, and with alterations in the synaptic vesicles pools. To investigate the molecular mechanism that leads to synaptic impairment, we first aimed to characterize the biochemical and biophysical properties of the aS-DOPAL oligomers; heterogeneous ensembles of macromolecules able to permeabilise cholesterol-containing lipid membranes. aS-DOPAL oligomers can induce dopamine leak in an in vitro model of synaptic vesicles and in cellular models. The dopamine released, after conversion to DOPAL in the cytoplasm, could trigger a noxious cycle that further fuels the formation of aS-DOPAL oligomers, inducing neurodegeneration

Sarna sarcóptica dos suínos: estratégia de ação no controle e avaliação econômica.

bitstream/item/58756/1/CUsersPiazzonDocuments172.pd

A desigualdade é a meta: Implicações socioespaciais do Programa Ensino Integral na cidade de São Paulo

This article proposes an analysis of the Integral Teaching Program (PEI), implemented in the São Paulo State (Brazil) public-school system, from a point of view of the dynamics of production of socio-spatial and educational inequalities. In the present case, we have investigated the role of public education policy, under the New Public Management logic, as an inducer and reproducer of inequalities. Our results suggest that PEI is based on an insular logic, which produces school units for students already privileged in their relations with the city. In addition, the implementation of the Program has provoked an outflow of students, with a positive effect on the socioeconomic levels (SEL) of the PEI schools and on their results in large-scale evaluations. This effect was counterbalanced by the negative effect in the school units around the PEI schools, where we observed a decrease in the number of students with higher SEL. In addition, if compared to the surrounding schools and to the public-school system itself, PEI schools have fewer classes and students. They are schools for the minority: the students with highest SEL of the system. In these schools, we also observe the preference for a single-cycle organization, which places PEI in the same line as the controversial proposal of School Reorganization in 2015.Este artículo propone un análisis del Programa Enseñanza Integral (PEI), implantado en la red estatal de São Paulo (Brasil), desde el punto de vista de la dinámica de la producción de las desigualdades socio espacial y educativa. En el caso en tela, investigamos el papel de la política pública de educación, bajo la lógica de la Nueva Gestión Pública, como inductora y reproductora de desigualdades. Los resultados sugieren que el PEI se basa en una lógica insularizante, produciendo unidades escolares destinadas a alumnos ya privilegiados en sus relaciones con la ciudad. Además, la implantación del Programa ha provocado eflujo de matrículas, con efecto positivo en el nivel socioeconómico (NSE) de las escuelas PEI y en sus resultados en las evaluaciones a gran escala. Este efecto es contrabalanceado por el efecto negativo en las unidades escolares en el entorno de las escuelas PEI, en que se observó disminución de la cantidad de estudiantes con NSE más elevado. Además, las escuelas PEI, comparadas a las escuelas del entorno ya la propia red estadual paulista, poseen menos clases y matrículas. Son escuelas para pocos: los estudiantes de mayor NSE de la red estatal. En estas escuelas también se observa la preferencia por una organización en ciclos únicos, lo que coloca al PEI en la misma línea de la polémica propuesta de Reorganización Escolar de 2015.Este artigo propõe uma análise do Programa Ensino Integral (PEI), implantado na rede estadual de São Paulo (Brasil), do ponto de vista da dinâmica da produção das desigualdades socioespacial e educacional. No caso em tela, investigamos o papel da política pública de educação, sob a lógica da Nova Gestão Pública, como indutora e reprodutora de desigualdades. Os resultados sugerem que o PEI se baseia numa lógica insularizante, produzindo unidades escolares destinadas a alunos já privilegiados em suas relações com a cidade. Além disso, a implantação do Programa tem provocado efluxo de matrículas, com efeito positivo no nível socioeconômico (NSE) das escolas PEI e nos seus resultados nas avaliações em larga escala. Tal efeito é contrabalançado pelo efeito negativo nas unidades escolares no entorno das escolas PEI, em que se observou diminuição da quantidade de estudantes com NSE mais elevado. Além disso, as escolas PEI, comparadas às escolas do entorno e à própria rede estadual paulista, possuem menos classes e matrículas. São escolas para poucos: os estudantes de maior NSE da rede estadual. Nessas escolas também se observa a preferência por uma organização em ciclo único, o que coloca o PEI na mesma linha da polêmica proposta de Reorganização Escolar de 2015

INTEGRATING MULTIBAND PHOTOGRAMMETRY, SCANNING, AND GPR FOR BUILT HERITAGE SURVEYS: THE FAÇADES OF CASTELLO DEL VALENTINO

The conservation of built heritage is a complex process that necessitates co-operative efforts. Holistic, integrated documentation constitutes a crucial step towards conservation by contributing to diagnosis and by extension to the effective decision-making about the required preventive and restorative interventions. It involves the recording of interdisciplinary data to produce objective diagnostical conclusions concerning the state of preservation. Although the developments in close-range sensing techniques allow increasingly accurate and rich data recording for heritage building condition surveys, the problem of combining them (to allow integrated processing) often remains unsolved. This is particularly true when surveys include vastly heterogenous documentation data. This work aims to discuss methodologies and implications of such integrations through a monumental heritage survey case—the Castello del Valentino in Turin (Italy). Visible-spectrum and infrared imagery is combined with photogrammetric techniques, terrestrial LiDAR, and microwave measurements conducted on the historical façades’ surfaces, to examine the comprehensiveness of the data fusion results, as well as conclusions that can be drawn regarding previous interventions and the current condition of the monument

Avaliação dos impactos econômicos, sociais e organizacionais do programa de erradicação da doença de Aujeszky no Estado de Santa Catarina.

bitstream/item/58048/1/CUsersPiazzonDocuments472.pdfProjeto/Plano de Ação: 16.00.30004-00

ESTUDO COMPARATIVO DA INFLUÊNCIA DA FOTOPOLIMERIZAÇÃO POR LED E LÂMPADA HALÓGENA NO MANCHAMENTO DA RESINA COMPOSTA SUBMETIDA À ALIMENTOS CORANTES.

O presente estudo teve como propósito, comparar a influência da fotopolimerização por LED e lâmpada halógena no manchamento da resina compostas submetida à alimentos corantes. Foram confeccionados 22 amostras, 10 amostras fotopolimerizadas durante 20 segundos, por Led ( Ultra LED – Dabi Atlante ) fixadas nos dentes 16, e 10 por Luz halógena (Ultralux - Dabi Atlante) fixadas nos dentes 26, em 10 voluntários, orientados a manterem suas dietas normais e relacionar diariamente bebidas corantes, principalmente o café; 2 amostras, uma de cada grupo foram armazenadas em água destilada e posteriormente utilizadas como escala de cor. Após 20 dias as amostras foram removidos para análise visual de alteração de cor sob luz natural e por comparação com o grupo controle. Pode ser observado que ocorreu manchamentos em todas as amostras submetidas à alimentos corantes, demonstrando a limitada estabilidade de cor da resina composta, independente da unidade de luz utilizada

Phosphorus fractions in the vineyard soil of the Serra Gaúcha of Rio Grande do Sul, Brazil.

The study aimed to evaluate the accumulation of P fractions in a vineyard soil profile with successive applications of phosphate fertilizers. In January 2010 an area was selected of native forest and a vineyard at age 33 with a history of phosphate fertilizer application, in Bento Gonçalves, Rio Grande do Sul state. Soil samples were collected from 0-5, 5-10 and 10-20 cm layers, prepared and submitted to chemical fractionation of P. The excessive application of phosphate fertilizers during 33 years in the vineyard soil increased the levels of organic and inorganic P until the 20 cm layer in all P fractions. The highest levels of P in the vineyard soil were found mainly in the labile fractions extracted with anion exchange resin and NaHCO3, which indicates high nutrient availability to plants, but also indicates the potential of transfer of solution from soil to surface run-off or percolated through the soil profile, which represents greater potential for contamination of surface and subsurface waters