Acute Psychophysiological Responses to Cyclic Variation of Intermittent Hypoxic Exposure in Adults with Obesity

Hobbins, Liam, Olivier Girard, Nadia Gaoua, and Steve Hunter. Acute psychophysiological responses to cyclic variation of intermittent hypoxic exposure in adults with obesity. High Alt Med Biol 00:000-000, 2019. Background: We compared acute psychophysiological responses with a single intermittent hypoxic exposure (IHE)/normoxic exposure trial with varying cycle lengths in adults with obesity. Materials and Methods: Eight obese adults (body mass index = 33.0 ± 2.2 kg/m2) completed three 60-minute IHE trials (passive seating), separated by 7 days. Trials comprised 30-minute hypoxia/30-minute normoxia (inspired oxygen fraction = 12.0%/20.9%) over Short (15 × 2/2 minutes), Medium (10 × 3/3 minutes), and Long (5 × 6/6 minutes) hypoxic/normoxic cycles and a control trial (60-minute normoxia). Results: Arterial oxygen saturation was lower during hypoxic periods of Long versus Medium and Short trials (90.1% vs. 93.0% and 94.2%; p = 0.02 and p = 0.05), with no differences between Short and Medium. Prefrontal cortex oxygenation was lower (-5.1%) during all IHE interventions versus control (p < 0.02), independent of cycle length. Perceived breathlessness was unaffected during IHE but increased 15 minutes after exposure versus baseline (+34%; p = 0.04). Breathlessness was lowest after Short versus control from 15 to 60 minutes (-7%; p = 0.01). Conclusions: When implementing IHE, greater desaturation is observed during longer compared with shorter hypoxic/normoxic cycles in adults with obesity. However, IHE tends to be better tolerated perceptually with shorter rather than longer cycles. Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/ham.2019.000

Psycho-physiological responses to perceptually-regulated interval runs in hypoxia and normoxia

We investigated whether perceptually-regulated high-intensity intervals in hypoxia are associated with slower running velocities versus normoxia, when physiological responses and exercise-related sensations remain the same. Nineteen trained runners (33.4 ± 9.1 years) completed a high-intensity interval running protocol (4 × 4-min intervals at a clamped perceived rating exertion of 16 on the 6-20 Borg scale, 3-min passive recoveries) in either hypoxic (HYP; FiO2 15.0%) or normoxic (NOR; FiO2 20.9%) conditions. Participants adjusted to a progressively slower running velocity from interval 1-4 (-7.0%), and more so in HYP vs. NOR for intervals 2, 3 and 4 (-4.6%, -6.4% and - 7.9%, respectively; p < .01). Heart rate increased from interval 1-4 (+4.8%; p < .01), independent of condition. Arterial oxygen saturation was lower in HYP vs. NOR (86.0% vs. 94.8%; p < .01). Oxyhemoglobin (-23.7%) and total hemoglobin (-77.0%) decreased, whilst deoxyhemoglobin increased (+44.9%) from interval 1-4 (p < .01), independent of condition. Perceived recovery (-41.6%) and motivation (-21.8%) were progressively lower from interval 1-4, and more so in HYP vs. NOR for intervals 2, 3 and 4 (recovery: -8.8%, -24.2% and - 29.3%; motivation: -5.3%, -20.3% and - 22.4%, respectively; p < .01). Perceived breathlessness (+18.6%), limb discomfort (+44.0%) and pleasure (-32.2%) changed from interval 1-4, with significant differences (+21.8%, +11.3% and - 31.3%, respectively) between HYP and NOR (p < .01). Slower interval running velocities in hypoxia achieve similar heart rate and muscle oxygenation responses to those observed in normoxia when perceptually-regulated, yet at the expense of less favourable exercise-related sensations

Arboriculture Biologique : 11 années d'expérimentation en vergers de pêchers et pommiers

Un programme de recherche a été conduit en arboriculture biologique pendant 11 ans (1994-2004) à l'unité expérimentale INRA (Institut National de la Recherche Agronomique) de Gotheron dans le Sud-Est de la France, en partenariat avec Agribiodrôme (F-26150 Die), asssociation de développement de l'Agriculture Biologique (AB) en Drôme, et le GRAB (Groupe de Recherche en Agriculture Biologique, F-84911 Avignon). Les objectifs étaient : (i) acquérir des références en arboriculture biologique ; (ii) identifier et analyser les verrous techniques de la production de pêches et pommes biologiques, afin d'optimiser la conduite des vergers AB et/ou de proposer de nouvelles expérimentations ; (iii) évaluer à long terme l'impact du mode de production pour le sol et la communauté d'arthropodes du verger. Le suivi longitudinal réalisé dans les 3 vergers expérimentaux de pêchers et pommiers a permis de souligner certaines contraintes en culture pérenne AB, notamment pour la conduite du sol (entretien de la fertilité, enracinement limité par le travail du sol sur le rang pour limiter les adventices) et la protection du verger. Probablement en rapport avec une fertilisation modérée et une conduite de la protection favorable à des régulations naturelles, certains ravageurs ne se sont pas développés : acariens phytophages, pucerons du pêcher,... D'autres bio-agresseurs ont pu être contrôlés par l'utilisation de méthodes biotechnique ou microbiologique : confusion sexuelle (tordeuse orientale), virus de la granulose (carpocapse),... En revanche, la maîtrise de certains bio-agresseurs a nécessité l'utilisation d'importantes quantités de matières actives présentant des effets non intentionnels (cuivre contre la cloque du pêcher, soufre contre la tavelure du pommier) et/ou a été insuffisante (puceron cendré du pommier, maladies de conservation du pêcher). Le suivi de la teneur en nitrates de la solution du sol à différentes profondeurs a permis d'établir que le risque de lessivage, et donc de pollution par les nitrates, était nul pour notre stratégie de fertilisation et notre situation. Enfin, l'étude de la communauté des arthropodes dans le verger de pommiers AB (2001-2003) a mis en évidence une biomasse plus élevée et un cortège d'auxiliaires de structure différente (prédominance de prédateurs polyphages) par rapport à d'autres vergers conduits en conventionnel. En raison d'une efficacité limitée et/ou d'effets non intentionnels de la lutte directe contre les bio-agresseurs en verger, il est donc important de concevoir et de gérer le verger AB afin de limiter le recours aux intrants phytosanitaires : variétés, distances de plantation, architecture de l'arbre, aménagement de l'environnement du verger, prophylaxie,..

A New Linear Logic for Deadlock-Free Session-Typed Processes

The π -calculus, viewed as a core concurrent programming language, has been used as the target of much research on type systems for concurrency. In this paper we propose a new type system for deadlock-free session-typed π -calculus processes, by integrating two separate lines of work. The first is the propositions-as-types approach by Caires and Pfenning, which provides a linear logic foundation for session types and guarantees deadlock-freedom by forbidding cyclic process connections. The second is Kobayashi’s approach in which types are annotated with priorities so that the type system can check whether or not processes contain genuine cyclic dependencies between communication operations. We combine these two techniques for the first time, and define a new and more expressive variant of classical linear logic with a proof assignment that gives a session type system with Kobayashi-style priorities. This can be seen in three ways: (i) as a new linear logic in which cyclic structures can be derived and a CYCLE -elimination theorem generalises CUT -elimination; (ii) as a logically-based session type system, which is more expressive than Caires and Pfenning’s; (iii) as a logical foundation for Kobayashi’s system, bringing it into the sphere of the propositions-as-types paradigm

Polarization state of the optical near-field

The polarization state of the optical electromagnetic field lying several nanometers above complex dielectric structures reveals the intricate light-matter interaction that occurs in this near-field zone. This information can only be extracted from an analysis of the polarization state of the detected light in the near-field. These polarization states can be calculated by different numerical methods well-suited to near--field optics. In this paper, we apply two different techniques (Localized Green Function Method and Differential Theory of Gratings) to separate each polarisation component associated with both electric and magnetic optical near-fields produced by nanometer sized objects. The analysis is carried out in two stages: in the first stage, we use a simple dipolar model to achieve insight into the physical origin of the near-field polarization state. In the second stage, we calculate accurate numerical field maps, simulating experimental near-field light detection, to supplement the data produced by analytical models. We conclude this study by demonstrating the role played by the near-field polarization in the formation of the local density of states.Comment: 9 pages, 11 figures, accepted for publication in Phys. Rev.

Coherent magnetic plasmon modes in a contacting gold nano-sphere chain on a gold Slab

A coupled magnetic resonator waveguide, composed of a contacting gold nanosphere chain on a gold slab, is proposed and investigated. A broadband coherent magnetic plasmon mode can be excited in this one dimensional nanostructure. By employing the Lagrangian formalism and the Fourier transform method, the dispersion properties of the wave vector and group velocity of the magnetic plasmon mode are investigated. Small group velocity can be obtained from this system which can be applied as subwavelength slow wave waveguides.Comment: 11pages, 5 figures, This work is published at Optics Express 19, 23782 (2011

Running mechanics adjustments to perceptually-regulated interval runs in hypoxia and normoxia

Objectives We determined whether perceptually-regulated, high-intensity intermittent runs in hypoxia and normoxia induce similar running mechanics adjustments within and between intervals. Design Within-participants repeated measures. Methods Nineteen trained runners completed a high-intensity intermittent running protocol (4×4-min intervals at a perceived rating exertion of 16 on the 6–20 Borg scale, 3-min passive recoveries) in either hypoxic (FiO2 =0.15) or normoxic (FiO2 =0.21) conditions. Running mechanics were collected over 10 consecutive steps, at constant velocity (∼15.0±2.0km.h−1), at the beginning and the end of each 4-min interval. Repeated measure ANOVA were used to assess within intervals (onset vs. end of each interval), between intervals (interval 1, 2, 3 vs. 4) and FiO2 (0.15 vs. 0.21) main effects and any potential interaction. Results Participants progressively reduced running velocity from interval 1–4, and more so in hypoxia compared to normoxia for intervals 2, 3 and 4 (P 0.298) and FiO2 (across all intervals P >0.082) main effects or any significant between intervals×within intervals×FiO2 interactions (all P >0.098) for any running mechanics variables. Irrespective of interval number or FiO2, peak loading rate (+10.6±7.7%; P <0.001) and duration of push-off phase (+2.0±3.1%; P =0.001) increased from the onset to the end of 4-min intervals, whereas peak push-off force decreased (−4.0±4.0%; P <0.001). Conclusions When carrying out perceptually-regulated interval treadmill runs, runners adjust to progressively slower velocities in hypoxia compared to normoxia. However, only subtle constant-velocity modifications of their mechanical behaviour occurred within each set, independently of FiO2 or interval number