Who is leaving? - an investigation of the European research landscape

International mobility of researchers has a key role in the creation of excellent research. By developing a novel composite index of international mobility of researchers in the EU space, this paper aims at understanding the differences that are still present to this day between the research environments of the European Union’s member states. Gender differences are highlighted. A distinction between North and South Europe is well apparent in our results. Substantial differences between countries’ research environments are documente

Einstein filosofo-scienziato

La parte iniziale della tesi è incentrata sul “credo epistemologico” einsteiniano. Nella visione di Einstein, esiste uno scarto ineliminabile tra mondo delle idee e mondo sensibile. Al primo appartengono i principi e le proposizioni o leggi che possono essere dedotte logicamente da essi, al secondo i fatti dell'esperienza. Esiste tuttavia una connessione “extralogica” senza la quale il fisico, e lo scienziato in generale, non sarebbe in grado di verificare e validare le sue teorie. Tra le diverse specie di teorie fisiche, Einstein predilige le “teorie dei principi” per la loro perfezione logica e saldezza delle basi. Il principio, nella visione einsteiniana, è una proprietà generale dei fenomeni fisici che è stata verificata sperimentalmente in molti casi e che, tramite arbitraria scelta (“il libero gioco dei concetti”) dello scienziato, viene assunta generale, valida in tutti i casi. Il principio viene dunque elevato a criterio regolatore e si pone al di sopra delle leggi fisiche. Nel presente lavoro si trattano, riprendendo gli articoli fondamentali, i principi che stanno alla base delle teorie della relatività: in particolare si tenta di mettere in luce le conseguenze logiche e filosofiche che questi hanno. Per esempio, il principio di relatività è profondamene legato al “mistero” dell'intelligibilità della natura. La parte conclusiva tratta invece i problemi connessi alla teoria quantistica. La presente teoria, il cui accordo sperimentale è straordinario, sembra suggerire che il carattere statistico della teoria sia una conseguenza necessaria del carattere intrinsecamente probabilistico dei fenomeni microscopici. Per Einstein è fondamentale, come presupposto per la conoscenza, l'idea di una realtà determinata e indipendente dalle osservazioni dello sperimentatore: in questo modo i risultati stocastici andrebbero intesi come epistemici, ovvero come conseguenza dell'incapacità della teoria di fornire una descrizione esaustiva della reale situazione di fatto. La meccanica quantistica andrebbe dunque rifondata sul principio di causalità che, rispetto a quello di casualità, è logicamente più semplice e di conseguenza rappresentazione più fedele della natura.ope

Enhancing creative cognition with a rapid right-parietal neurofeedback procedure

partially_open5noThis study was supported by the CREAM project, funded by the European Commission under Grant Agreement n° 262022. This publication reflects the views of the authors only, and the European Commission cannot be held responsible for any use which may be made of the information contained therein. AA is funded by grants from the Cogito foundation (R117/13; 14-139-R), Fondazione del Monte (339bis/2017), MIUR (RBFR12F0BD) and Ministero della Salute (GR-2010–2319335).The present article describes an innovative neurofeedback training (NFT) procedure aimed at increasing creative cognition through the enhancement of specific brain activities previously associated with divergent thinking. We designed and tested two NFT protocols based on training alpha and beta EEG oscillations selectively measured over the right parietal region. A total of 80 participants were involved, 40 in the alpha NFT protocol and 40 in the beta NFT protocol. The NFT loop was closed on a video stream that would advance only when oscillation power exceeded a normalized threshold. The total duration of the protocol was two hours in a single day, hence its classification as rapid. Changes in ideational fluency and originality, measured with a divergent thinking task, were compared between participants receiving real video feedback and participants receiving sham feedback. We controlled for individual differences in creative achievement level. Results showed that the protocols were effective at enhancing alpha and beta activities in the targeted area. Differences between the two protocols emerged in their effectiveness at promoting divergent thinking. While no significant changes in originality resulted from the rapid alpha NFT, increases in both originality and fluency emerged as a consequence of the rapid beta NFT. These results were particularly evident in participants starting with a low creative achievement level. Possible interpretations and future directions are proposed and discussed.openAgnoli, Sergio*; Zanon, Marco; Mastria, Serena; Avenanti, Alessio; Corazza, Giovanni EmanueleAgnoli, Sergio*; Zanon, Marco; Mastria, Serena; Avenanti, Alessio; Corazza, Giovanni Emanuel

The N=2 Super Yang-Mills Low-Energy Effective Action at Two Loops

We have carried out a two loop computation of the low-energy effective action for the four-dimensional N=2 supersymmetric Yang-Mills system coupled to hypermultiplets, with the chiral superfields of the vector multiplet lying in an abelian subalgebra. We have found a complete cancellation at the level of the integrands of Feynman amplitudes, and therefore the two loop contribution to the action, effective or Wilson, is identically zero.Comment: 8 pages, Latex, 2 .eps figure

Regularised Model Identification Improves Accuracy of Multisensor Systems for Noninvasive Continuous Glucose Monitoring in Diabetes Management

Continuous glucose monitoring (CGM) by suitable portable sensors plays a central role in the treatment of diabetes, a disease currently affecting more than 350 million people worldwide. Noninvasive CGM (NI-CGM), in particular, is appealing for reasons related to patient comfort (no needles are used) but challenging. NI-CGM prototypes exploiting multisensor approaches have been recently proposed to deal with physiological and environmental disturbances. In these prototypes, signals measured noninvasively (e.g., skin impedance, temperature, optical skin properties, etc.) are combined through a static multivariate linear model for estimating glucose levels. In this work, by exploiting a dataset of 45 experimental sessions acquired in diabetic subjects, we show that regularisation-based techniques for the identification of the model, such as the least absolute shrinkage and selection operator (better known as LASSO), Ridge regression, and Elastic-Net regression, improve the accuracy of glucose estimates with respect to techniques, such as partial least squares regression, previously used in the literature. More specifically, the Elastic-Net model (i.e., the model identified using a combination of ${l}_{1}$ and ${l}_{2}$ norms) has the best results, according to the metrics widely accepted in the diabetes community. This model represents an important incremental step toward the development of NI-CGM devices effectively usable by patients

Non abelian N=2 supersymmetric Born Infeld action

We present a N=2 supersymmetric action for the Born Infeld theory in the non abelian case. We quantize the theory in N=1 superspace and compute divergences at one-loop. The result is discussed in the N=4 case.Comment: reference adde

Accuracy Evaluation of an Optical Lattice Clock with Bosonic Atoms

We report the first accuracy evaluation of an optical lattice clock based on the 1S0 - 3P0 transition of an alkaline earth boson, namely 88Sr atoms. This transition has been enabled using a static coupling magnetic field. The clock frequency is determined to be 429 228 066 418 009(32) Hz. The isotopic shift between 87Sr and 88Sr is 62 188 135 Hz with fractional uncertainty 5.10^{-7}. We discuss the conditions necessary to reach a clock accuracy of 10^{-17} or less using this scheme.Comment: 3 pages, 4 figures, uses ol.sty fil

Cardiac resynchronization therapy-defibrillator improves long-term survival compared with cardiac resynchronization therapy-pacemaker in patients with a class IA indication for cardiac resynchronization therapy: Data from the Contak Italian Registry

Aims In candidates for cardiac resynchronization therapy (CRT), the choice between pacemaker (CRT-P) and defibrillator (CRT-D) implantation is still debated. We compared the long-term prognosis of patients who received CRT-D or CRT-P according to class IA recommendations of the European Society of Cardiology (ESC) and who were enrolled in a multicentre prospective registry. Methods and results A total of 620 heart failure patients underwent successful implantation of a CRT device and were enrolled in the Contak Italian Registry. This analysis included 266 patients who received a CRT-D and 108 who received a CRT-P according to class IA ESC indications. Their survival status was verified after a median follow-up of 55 months. During follow-up, 73 CRT-D and 44 CRT-P patients died (rate 6.6 vs. 10.4%/year; log-rank test, P = 0.020). Patients receiving CRT-P were predominantly older, female, had no history of life-threatening ventricular arrhythmias, and more frequently presented non-ischaemic aetiology of heart failure, longer QRS durations, and worse renal function. However, the only independent predictor of death from any cause was the use of CRT-P (hazard ratio, 1.97; 95% confidence interval, 1.21–3.16; P = 0.007). Conclusion The implantation of CRT-D, rather than CRT-P, may be preferable in patients presenting with current class IA ESC indications for CRT. Indeed, CRT-D resulted in greater long-term survival and was independently associated with a better prognosis

F^5 contributions to the nonabelian Born Infeld action from a supersymmetric Yang-Mills five-point function

We consider the N=4 supersymmetric Yang-Mills theory in four dimensions. We compute the one-loop contributions to the effective action with five external vector fields and compare them with corresponding results in open superstring theory. Our calculation determines the structure of the F^5 terms that appear in the nonabelian generalization of the Born Infeld action. The trace operation on the gauge group indices receives contributions from the symmetric as well as the antisymmetric part. We find that in order to study corrections to the symmetrized trace prescription one has to consistently take into account derivative contributions not only with antisymmetrized products \nabla_{[\mu}\nabla_{\nu]} but also with symmetrized ones \nabla_{(\mu}\nabla_{\nu)}.Comment: 25 pages, 7 figures. v4: factor of 2 corrected in formula in the first line after (6.3), and consequently in (6.3)-(6.6); final results in (6.7) and (6.8) agree with hep-th/0210146. Erratum to appear in Nucl.Phys.

Laying the foundations for gene therapy in Italy for patients with haemophilia A: A Delphi consensus study

IntroductionCurrent treatment for haemophilia A involves factor VIII replacement or non-replacement (emicizumab) therapies, neither of which permanently normalise factor VIII levels. Gene therapy using adeno-associated viral (AAV) vectors is an emerging long-term treatment strategy for people with severe haemophilia A (PwSHA) that is likely to be available for clinical use in the near future. AimThis article proposes practical guidelines for the assessment, treatment, and follow-up of potential PwSHA candidates for AAV-based gene therapy. MethodUsing the Delphi method, a working group of Italian stakeholders with expertise in and knowledge of the care of adults with haemophilia A analysed literature for AAV-based gene therapy and drafted a list of statements that were circulated to a panel of Italian peers. During two rounds of voting, panel members voted on their agreement with each statement to reach a consensus. ResultsThe Delphi process yielded 40 statements regarding haemophilia A gene therapy, across five topics: (1) organisational model; (2) multidisciplinary team; (3) patient engagement; (4) laboratory surveillance; and (5) patient follow-up and gene therapy outcomes. The consensus was reached for all 40 statements, with the second round of voting needed for five statements. ConclusionUse of the hub-and-spoke organisational model and multidisciplinary teams are expected to optimise patient selection for gene therapy, as well as the management of dosing and patient follow-up, patient engagement, laboratory surveillance, and patient expectations regarding outcomes. This approach should allow the benefits of AAV-based gene therapy for haemophilia A to be maximised