Une page de Giovanni Macchia

Cet article de Giovanni Macchia revient sur l’un des thèmes fondamentaux de sa recherche, c’est-à-dire Baudelaire critique littéraire. Le monologue, tout comme le dialogue fictif, est un dispositif souvent employé par Macchia à l’intérieur de ses ouvrages de critique littéraire. Dans sa lecture croisée de la critique de Madame Bovary par Baudelaire et d’un passage du roman, Macchia analyse justement le monologue d’Emma greffé par Baudelaire dans son compte rendu de et « inexistant » chez Flaubert. Dans son article, Macchia fusionne son discours avec ceux de Baudelaire et de Flaubert, en les traduisant et en réécrivant leurs textes de manière assez libre.In this essay on Baudelaire’s literary criticism, Giovanni Macchia returns to one of the main topics of his research. Macchia often uses monolog and fictional dialog as a device in his critic works. In his cross reading of Baudelaire’s critical article on Madame Bovary and a passage of Flaubert’s novel, he analyses the monolog that Baudelaire inserted in his review but that does not exist in the novel. In this essay, Macchia merges his own discourse with Flaubert’s and Baudelaire’s words, by translating and re-writing their texts quite freely

Expansion of the Universe and Spacetime Ontology

The debate on the ontological status of spacetime in General Relativity has historically seen two principal philosophical contenders: substantivalism, roughly the view that holds that spacetime exists apart from the material contents of the universe, and relationism, the doctrine that spacetime does not exist, i.e., it is a mere abstract web of spatiotemporal relations among bodies. This dispute, however, has rarely been fought on a cosmological battlefield. In this paper an attempt in this direction is made. The question at issue is the following: is there any feature of our universe that requires or is best explained in terms of a substantival space? I claim that there is indeed: the expansion of the universe, perhaps the most important phenomenon in cosmology, can play such a role

Optimal Task Mapping for NEMO Model

The climate numerical models require a considerable amount of computing power. The modern parallel architectures provide the needed computing power to perform scientific simulations at acceptable resolutions. However, the efficiency of the exploitation of the parallel architectures by the climate models is often poor. Several factors influence the parallel efficiency such as the parallel overhead due to the communications among concurrent tasks, the memory contention among tasks on the same computing node, the load balancing and the tasks synchronization. The work here described aims at addressing two of the factors influencing the efficiency: the communications and the memory contention. The used approach is based on the optimal mapping of the tasks on the SMP nodes of a parallel cluster. The best mapping can heavily influence the time spent for communications between tasks belonging to the same node either to different nodes. Moreover, if we consider that each parallel task will allocate different amount of memory, the optimal tasks mapping can balance the total amount of main memory allocated on the same node and hence reduce the overall memory contention. The climate model taken into consideration is PELAGOS025 made by coupling the NEMO oceanic model with the BFM biogeochemical model. It has been used in a global configuration with a horizontal resolution of 0.25◦. Three different mapping strategies have been implemented, analyzed and compared with the standard allocation performed by the local scheduler. The parallel architecture used for the evaluation is an IBM iDataPlex with Intel SandyBridge processors located at the CMCC’s Supercomputing Center

Performance and results of the high-resolution biogeochemical model PELAGOS025 v1.0 within NEMO v3.4

Abstract. The present work aims at evaluating the scalability performance of a high-resolution global ocean biogeochemistry model (PELAGOS025) on massive parallel architectures and the benefits in terms of the time-to-solution reduction. PELAGOS025 is an on-line coupling between the Nucleus for the European Modelling of the Ocean (NEMO) physical ocean model and the Biogeochemical Flux Model (BFM) biogeochemical model. Both the models use a parallel domain decomposition along the horizontal dimension. The parallelisation is based on the message passing paradigm. The performance analysis has been done on two parallel architectures, an IBM BlueGene/Q at ALCF (Argonne Leadership Computing Facilities) and an IBM iDataPlex with Sandy Bridge processors at the CMCC (Euro Mediterranean Center on Climate Change). The outcome of the analysis demonstrated that the lack of scalability is due to several factors such as the I/O operations, the memory contention, the load unbalancing due to the memory structure of the BFM component and, for the BlueGene/Q, the absence of a hybrid parallelisation approach

Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

PURPOSE: This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage. SUBJECTS/METHODS: Forty-three obese patients (44% males; BMI: 36.7-58.8 kg/m2) were consecutively included. PREvención con DIeta MEDiterránea (PREDIMED) and the 7-day food records were used to assess the adherence to MD and dietary pattern, respectively. Visceral adiposity index (VAI) was calculated. Sirt4 levels were detected by ELISA method. RESULTS: The majority of the obese participants (62.8%) had an average adherence to MD. Compared with average adherers, low adherers had higher BMI, energy intake, and percentage of energy from lipids, mainly saturated fat and polyunsaturated fatty acids (PUFA), and lower Sirt4 levels. After adjusting for BMI, Sirt4 levels remained negatively correlated with VAI. After adjusting for total energy intake, Sirt4 levels remained negatively associated with PREDIMED and consumption of n-3 PUFA, vitamins C and E. The threshold value of PREDIMED predicting the lowest decrease in Sirt4 levels was found at a score of 6. CONCLUSIONS: Less reduced Sirt4 levels in obese patients adhering to MD suggest a further aspect of the antioxidant advantage of MD

Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire

Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association between diet and psoriasis. The 7-day food records is considered the "gold standard" of self-administered food frequency questionnaires. In this study, we evaluated the differences in the dietary intake, anthropometric measurements and cardio-metabolic risk profile in a group of psoriatic patients compared with an age and Body Mass Index (BMI)-matched control group. In addition, in the group of psoriatic patients we investigated the association between the dietary intake and clinical severity of psoriasis

Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease

The plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNA gene involved in human disease, mainly in cancer onset/ progression. Although widely analysed, its biological roles need to be further clarified. Notably, functional studies on PVT1 are complicated by the occurrence of multiple transcript variants, linear and circular, which generate technical issues in the experimental procedures used to evaluate its impact on human disease. Among the many PVT1 transcripts, the linear PVT1 (lncPVT1) and the circular hsa_circ_0001821 (circPVT1) are frequently reported to perform similar pathologic and pro-tumorigenic functions when overexpressed. The stimulation of cell proliferation, invasion and drug resistance, cell metabolism regulation, and apoptosis inhibition is controlled through multiple targets, including MYC, p21, STAT3, vimentin, cadherins, the PI3K/AKT, HK2, BCL2, and CASP3. However, some of this evidence may originate from an incorrect evaluation of these transcripts as two separate molecules, as they share the lncPVT1 exon-2 sequence. We here summarise lncPVT1/circPVT1 functions by mainly focusing on shared pathways, pointing out the potential bias that may exist when the biological role of each transcript is analysed. These considerations may improve the knowledge about lncPVT1/circPVT1 and their specific targets, which deserve further studies due to their diagnostic, prognostic, and therapeutic potential

Vespa crabro immunotherapy versus Vespula-venom immunotherapy in Vespa crabro allergy: a comparison study in field re-stings

Background: In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. However, antigen 5 immunoblotting studies showed that a genuine sensitization to VC venom may exist. In such cases, a specific VC venom would be preferable for VIT treatment. Since in the last few years, VC venom extracts became available for diagnosis and desensitization, we assessed the efficacy and safety of VIT with a VC-VIT, compared to VE extract. Methods: Patients stung by VC, and carefully diagnosed for specific sensitization and indication to VIT underwent a 5-year course of immunotherapy with either VE or VC extracts. The severity of reactions at the first sting (pre-VIT) and after field re-stings (during VIT) were compared. Results: Eighty-three patients, treated with VE extract and 130 patients treated with VC extract completed the 5-year course of VIT. Only a fraction of those patients (43,8%) were field-re-stung by VC: 64 patients on VC VIT and 69 on VE VIT. In the VC VIT group, reactions at re-sting were: 50 negative, 12 large local reactions, 4 systemic reactions (Muller grade I). In this group the VC VIT efficacy was 93,8%. In the VE VIT treated group the reactions at VC re-sting were: 51 negative, 10 large local reactions and 9 systemic reactions (5 Muller I, 3 Mueller III, 1 Muller IV). In this group the overall efficacy of VIT was 87,0%. The difference in efficacy between the two groups was not statistically significant, as previously reported in literature. Nonetheless, field sting systemic reactions Muller III and IV were recorded only in those patients receiving VE VIT. Conclusion: This observation suggests that in patients with ascertained VC-induced allergic reactions a specific VC VIT, where available, would be more adequate, at least concerning the safety profile

Guidelines for the use and interpretation of diagnostic methods in adult food allergy

Food allergy has an increasing prevalence in the general population and in Italy concerns 8 % of people with allergies. The spectrum of its clinical manifestations ranges from mild symptoms up to potentially fatal anaphylactic shock. A number of patients can be diagnosed easily by the use of first- and second-level procedures (history, skin tests and allergen specific IgE). Patients with complex presentation, such as multiple sensitizations and pollen-food syndromes, frequently require a third-level approach including molecular diagnostics, which enables the design of a component-resolved sensitization profile for each patient. The use of such techniques involves specialists' and experts' skills on the issue to appropriately meet the diagnostic and therapeutic needs of patients. Particularly, educational programs for allergists on the use and interpretation of molecular diagnostics are needed