Advances of nanotechnology in agro-environmental studies

With the increase in the world population and the demand for food, new agricultural practices have been developed to improve food production through the use of more effective pesticides and fertilisers. These technologies can lead to an uncontrolled release of undesired substances into the environment, with the potential to contaminate soil and groundwater. Today, nanotechnology represents a promising approach to improve agricultural production and remediate polluted sites. This paper reviews the recent applications of nanotechnologies in agro-environmental studies with particular attention to the fate of nanomaterials once introduced in water and soil, to the advantages of their use and their possible toxicology. Findings show that the use of nanomaterials can improve the quality of the environment and help detect and remediate polluted sites. Only a small number of nanomaterials demonstrated potential toxic effects. These are discussed in detail

Deliverable 2.3-Research needs in terms of statistical methodologies and new data

The MAKSWELL project was set up to help strengthening the use of evidence and information on well-being and sustainability for policy-making in the EU, as also the political attention to well-being and sustainability indicators has been increasing in recent years. Traditionally sample surveys are the data source used for measurement frameworks for well-being and sustainability. Over the last decades more and more new, alternative data sources become available. Examples are administrative data like tax registers, or other large data sets - so called big data - that are generated as a by-product of processes not directly related to statistical production purposes. In Deliverables 2.1, 2.2 as well as 3.1, 4.1 and 4.3 it is discussed in detail how these new data sources can be used in the production of official statistics and measurement frameworks for well-being and sustainability indicators. This Deliverable extends on the experiences obtained in these preceding deliverables by pointing out the needs for new data sources and methods in this context

Religious Barriers to the Diffusion of Same-sex Civil Unions in Italy

AbstractThe legal recognition of civil unions between same-sex partners, in May 2016, could be defined as a revolution for the system of legal norms regarding the "heterosexual family-centric-system" in Italy. Using official data on the 17,341 people resulting in a same-sex civil union collected by the Italian National Institute of Statistics in the years 2016–2018, this paper analysed the relationship between religious secularization and the diffusion of same-sex civil unions at the regional level in Italy. In particular, an indicator of the incidence of civilly united individuals over total population has been regressed on the rate of heterosexual marriages celebrated according to the civil rite. According to abundant literature, the latter variable could be interpreted as a proxy of secularization. The results indicate that less secularized regions are also those where less civil unions have been celebrated. The results are confirmed also when an instrumental variable approach is implemented. Studying this topic in Italy is particularly interesting since the country has been defined as the least secularized among economically developed nations

Xeno-Hybrid composite scaffold manufactured with CAD/CAM technology for horizontal bone-augmentation in edentulous atrophic maxilla: a short communication

Abstract: The present short communication described a new procedure for the reconstruction of the horizontal severely resorbed edentulous maxilla with custom-made deproteinized bovine bone block, fabricated using three-dimensional imaging of the patient and computer-aided design/computer-aided manufacturing (CAD/CAM) technology. The protocol consisted of three phases. In the diagnosis and treatment planning, cone-beam computed tomographic scans of the patient were saved in DICOM (digital imaging and communication in medicine) format, anatomic and prosthetic data were imported into a dedicated diagnostic and medical imaging software, the prosthetic-driven position of the implants, and the graft blocks perfectly adapted to the residual bone structure were virtually planned. In the manufacturing of customized graft blocks, the CAD-CAM technology and the bovine-derived xenohybrid composite bone (SmartBone® on Demand - IBI SA - Industrie Biomediche Insubri SA Switzerland) were used to fabricate the grafts in the exact shape of the 3D planning virtual model. In the surgical and prosthetic procedure, the maxillary ridge augmentation with custom-made blocks and implant-supported full-arch screw-retained rehabilitation were performed. The described protocol offered some advantages when compared to conventional augmentation techniques. The use of deproteinized bovine bone did not require additional surgery for bone harvesting, avoided the risk of donor site morbidity, and provided unlimited biomaterial availability. The customization of the graft blocks reduced the surgical invasiveness, shorting operating times because the manual shaping of the blocks and its adaptation at recipient sites are not necessary and less dependent on the clinician’s skill and experience

Meaning coconstruction in group counseling: The development of innovative moments

This study discusses a model of group counseling, the narrative mediation path (NMP), which is a unique narrative, multimodal approach that combines four narrative modes (metaphoric, iconographic, writing, and bodily ) and the narrative group. The purpose of the NMP is to foster reflexive processes with underachieving university students and to improve their academic performance. The study analyzes a single case of group counseling for seven underachieving economics students at an Italian university and the process of meaning construction among NMP narrative modes and the follow-up session. It applies the innovative moments coding system, a reliable method for studying change by tracking narrative innovations in sessions. More specifically, we focus on how innovative moments (IMs: action, reflection, protest, and reconceptualization) evolve during the four different narrative modes and the follow-up session. The findings suggest that the NMP fosters narrative innovations, mainly of a reflexive nature (reflection and reconceptualization). Moreover, during counseling and the follow-up session, the pattern of change is primarily characterized by reconceptualization IMs, the most complex form of narrative innovationEuropean Commission (Grant Agreement 2011-4040 Project 517750-LLP-1-2011-1-IT-ERASMUS-ESIN

Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015–2019

Invasive infections by group B streptococci (iGBS) are the leading cause of sepsis and meningitis in the first three months of life worldwide. The clinical and microbiological characteristics of neonatal and infant iGBS in Italy during the years 2015–2019 were investigated. Voluntary-based surveillance reported 191 cases (67 early-onset (EOD) and 124 late-onset disease (LOD)) and 89 bacterial isolates were received. The main clinical manifestations were sepsis (59.2%) followed by meningitis (21.5%), bacteremia (12.0%) and septic shock (6.3%). Hospitalized preterm babies accounted for one third of iGBS and constituted the most fragile population in terms of mortality (8.2%) and brain damage (16.4%). GBS serotype III was predominant in EOD (56%) and caused almost all LOD (95%). The rate of resistance to clindamycin reached 28.8%. Most of clindamycin-resistant GBS strains (76%) were serotype III-ST17 and possessed the genetic markers of the emerging multidrug resistant (MDR) CC-17 sub-clone. Our data revealed that iGBS is changing since it is increasingly reported as a healthcare-associated infection (22.6%), mainly caused by MDR-CC17. Continuous monitoring of the clinical and microbiological characteristics of iGBS remains of primary importance and it represents, at present, the most effective tool to support prevention strategies and the research on the developing GBS vaccine

Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015–2019

Invasive infections by group B streptococci (iGBS) are the leading cause of sepsis and meningitis in the first three months of life worldwide. The clinical and microbiological characteristics of neonatal and infant iGBS in Italy during the years 2015–2019 were investigated. Voluntary-based surveillance reported 191 cases (67 early-onset (EOD) and 124 late-onset disease (LOD)) and 89 bacterial isolates were received. The main clinical manifestations were sepsis (59.2%) followed by meningitis (21.5%), bacteremia (12.0%) and septic shock (6.3%). Hospitalized preterm babies accounted for one third of iGBS and constituted the most fragile population in terms of mortality (8.2%) and brain damage (16.4%). GBS serotype III was predominant in EOD (56%) and caused almost all LOD (95%). The rate of resistance to clindamycin reached 28.8%. Most of clindamycin-resistant GBS strains (76%) were serotype III-ST17 and possessed the genetic markers of the emerging multidrug resistant (MDR) CC-17 sub-clone. Our data revealed that iGBS is changing since it is increasingly reported as a healthcare-associated infection (22.6%), mainly caused by MDR-CC17. Continuous monitoring of the clinical and microbiological characteristics of iGBS remains of primary importance and it represents, at present, the most effective tool to support prevention strategies and the research on the developing GBS vaccine

Measuring Prosocial Behaviors: Psychometric Properties and Cross-National Validation of the Prosociality Scale in Five Countries

This research investigated the psychometric properties of the Prosociality Scale and its cross-cultural validation and generalizability across five different western and non-western countries (China, Chile, Italy, Spain, and the United States). The scale was designed to measure individual differences in a global tendency to behave in prosocial ways during late adolescence and adulthood. Study 1 was designed to identify the best factorial structure of the Prosociality Scale and Study 2 tested the model’s equivalence across five countries (N = 1,630 young adults coming from China, Chile, Italy, Spain and the United States; general Mage = 21.34; SD = 3.34). Findings supported a bifactor model in which prosocial responding was characterized by a general latent factor (i.e., prosociality) and two other specific factors (prosocial actions and prosocial feelings). New evidence of construct validity of the Prosociality Scale was provided

Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1. Although the essential role of EWSR1-FLI1 protein in the regulation of oncogenesis, survival, and tumor progression processes has been described in-depth, little is known about the regulation of chimeric fusion-gene expression. Here, we demonstrate that the active nuclear HDAC6 in EWS modulates the acetylation status of specificity protein 1 (SP1), consequently regulating the SP1/P300 activator complex binding to EWSR1 and EWSR1-FLI1 promoters. Selective inhibition of HDAC6 impairs binding of the activator complex SP1/P300, thereby inducing EWSR1-FLI1 downregulation and significantly reducing its oncogenic functions. In addition, sensitivity of EWS cell lines to HDAC6 inhibition is higher than other tumor or non-tumor cell lines. High expression of HDAC6 in primary EWS tumor samples from patients correlates with a poor prognosis in two independent series accounting 279 patients. Notably, a combination treatment of a selective HDAC6 and doxorubicin (a DNA damage agent used as a standard therapy of EWS patients) dramatically inhibits tumor growth in two EWS murine xenograft models. These results could lead to suitable and promising therapeutic alternatives for patients with EWS.Research in the E.D.A. lab is supported by Asociación Española Contra el Cáncer (AECC), the Ministry of Science of Spain-FEDER (CIBERONC, PI1700464, PI2000003, RD06/0020/0059)S. D.G.D. and L.H.P. are supported by CIBERONC (CB16/12/00361). D.G.D., M.J.R. and L.H.P. are PhD researchers funded by the Consejería de Salud, Junta de Andalucía (PI-0197-2016, ECAI F2-0012-2018 and PI-0013-2018, respectively).Peer reviewe

I Celti e il Veneto. Storie di culture a confronto

Il volume intende offrire una visione di sintesi sulla tematica del contatto tra mondo celtico e mondo veneto tra la fine del VI e il I secolo a.C., tematica spesso travisata o male interpretata. Sulla base di una raccota sistematica di dati si offre un panorama diviso per epoche, sottolineando per ogni periodo le specificità e le complesse dinamiche che portarono all'integrazione di piccoli nulcei o singoli individui testimoniati spesso non solo dai materiali archeologici, ma dai reperti epigrafici. Uno specifico contribto sul materiale numismatico, dovuto a Federico Biondani, compelta il quadro