Affrontare il cyberbullismo in classe. Comprendere e riconoscere gli effetti collaterali dei social network

Il cyberbullismo rappresenta un fenomeno complesso che si manifesta con modalità articolate. Le difficoltà più evidenti sono: la possibilità, da parte dell'aggressore di rimanere anonimo; la numerosità degli spettatori; l'assenza di supervisione da parte degli adulti; il distacco tra gesto e significato attribuito. Tale fenomeno implica la necessità di promuovere un'educazione digitale e affettivo-relazionale attraverso attività educative capaci di prevenire i numerosi e complessi pericoli della rete. Fondamentale, ancora, risulta educare al rispetto della reciprocità, delle norme sociali, dell'intenzionalità del Noi, così da favorire un sano sviluppo psicosociale della persona inserita - o intrappolata - in una rete di relazioni da connettere ad una linea di pensiero protetta. [Testo dell'editore].The cyberbullying represents a complex phenomenon that manifests him with articulate formality. Most evident difficulties are: the possibility, from the aggressor to remain name-less; the numerousness of the viewers; the absence of supervision from the adults; the sepa-ration between gesture and attributed meaning. Such phenomenon implicates the necessity to promote a digital education and affective-relational through educational activity able to prevent the numerous ones and complexes dangers of the net. Fundamental, it still results to educate to the respect of the reciprocity, of the social norms, of the intentionality of the Us, so that to favor a healthy development psyco-social of the inserted person - or trapped - in a net of relationships to be connected to a line of thought protected. [Publisher's text]

LONG PENTRAXIN-3 INHIBITS FGF-DEPENDENT ANGIOGENESIS AND GROWTH OF STEROID HORMONE-REGULATED TUMORS

Abstract Fibroblast growth factor-8b (FGF8b) exerts nonredundant autocrine/paracrine functions in steroid hormone–regulated tumors. Previous observations had shown that the soluble pattern recognition receptor long pentraxin-3 (PTX3) is a natural selective antagonist for a restricted number of FGF family members, inhibiting FGF2 but not FGF1 and FGF4 activity. Here, we assessed the capacity of PTX3 to antagonize FGF8b and to inhibit the vascularization and growth of steroid hormone–regulated tumors. Surface plasmon resonance analysis shows that PTX3 binds FGF8b with high affinity (Kd = 30–90 nmol/L). As a consequence, PTX3 prevents the binding of FGF8b to its receptors, inhibits FGF8b-driven ERK1/2 activation, cell proliferation, and chemotaxis in endothelial cells, and suppresses FGF8b-induced neovascularization in vivo. Also, PTX3 inhibits dihydrotestosterone (DHT)- and FGF8b-driven proliferation of androgen-regulated Shionogi 115 (S115) mouse breast tumor cells. Furthermore, DHT-treated, PTX3 overexpressing hPTX3_S115 cell transfectants show a reduced proliferation rate in vitro and a limited angiogenic activity in the chick embryo chorioallantoic membrane and murine s.c. Matrigel plug assays. Accordingly, hPTX3_S115 cells show a dramatic decrease of their tumorigenic activity when grafted in immunodeficient male mice. These results identify PTX3 as a novel FGF8b antagonist endowed with antiangiogenic and antineoplastic activity with possible implications for the therapy of hormonal tumors. Mol Cancer Ther; 10(9); 1600–10. ©2011 AACR.</jats:p

Long Pentraxin-3 inhibits FGF-dependent angiogenesis andgrowth of steroid hormone-regulated tumors

Steroid hormone-regulated tumors, including breast and prostate cancers, represent a class of epithelial lesions whose growth is finely tuned by steroid hormones. However, as these tumors progress, they may become independent from steroid hormones for growth, limiting the effectiveness of hormonal ablation therapies. Fibroblast growth factors (FGFs) are potent angiogenic factors that exert non-redundant autocrine/paracrine functions in various tumors types. Experimental and clinical evidences indicate that the FGF/FGF receptor (FGFR) axis can drive the progression of steroid hormone-dependent cancers to a hormone-independent state, thus representing a possible alternative target for the treatment of hormonal cancers. Previous observations had shown that the soluble pattern recognition receptor long pentraxin-3 (PTX3) is a natural selective antagonist for a restricted number of FGF family members, inhibiting FGF2 but not FGF1 and FGF4 activity. Here, we extended these findings and assessed the capacity of PTX3 to antagonize also FGF8b and to inhibit the vascularization and growth of steroid hormone-regulated breast and prostate cancers. Surface plasmon resonance analysis demonstrates that PTX3 binds FGF8b with high affinity. As a consequence, PTX3 prevents the binding of FGF8b to its receptors, inhibits FGF8b-driven ERK1/2 activation, cell proliferation and chemotaxis in endothelial cells, and suppresses FGF8b-induced neovascularization in vivo. Also, PTX3 inhibits testosterone and FGF8b-driven proliferation in androgen-regulated Shionogi 115 (S115) mouse breast and LNCaP human prostate tumor cells and the FGF8b/FGF2-driven proliferation of TRAMP-C2 murine prostate cancer cells. Furthermore, when transfected into S115 or TRAMP-C2 cells, PTX3 impairs FGF/testosterone induced cell proliferation and angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Accordingly, hPTX3_S115 and hPTX3_TRAMP-C2 cells show a dramatic decrease of their tumorigenic capacity in vivo. These results identify PTX3 as a novel FGF2/FGF8b antagonist endowed with antiangiogenic and antineoplastic activity with possible implications for the therapy of breast and prostate steroid hormone-regulated tumors

Histology for nephrology, from pre-implantation to post-transplant kidney biopsy. Lesson learned from ReBIrth (Renal BIopsy for Kidney Transplantation Therapy)

: A meeting entitled Renal BIopsy for Kidney Transplantation Therapy (ReBIrth) took place on May 31st, 2022 in Bologna, Italy. The meeting drew together nephrologists, surgeons, and pathologists and recognized as experts in the field of kidney transplantation in Italy. In this paper, we present our experience working with kidney transplants in the current era of immunosuppression therapy. The primary aim is to report the histopathological characteristics of failed kidney allografts after a consensus of experts reviewed the cases on a wholeslide imaging digital platform. Regardless of the cases discussed, digital pathology was reliable in identifying all the morphological and immunohistochemical features required to improve the correct use of immunosuppressive therapy to prevent graft failure and optimize patient management