Translating American Exceptionalism: Comparing Presidential Discourse About the United States at Home and Abroad

This study provides a comparative perspective on the ways U.S. presidents have communicated the idea of American exceptionalism for American and international audiences. I argue that U.S. presidents strategically highlight this culturally potent idea in both domestic and international speeches, but in different ways. To examine these dynamics, I content-analyzed presidential speeches delivered in domestic and foreign contexts since 1933. The study provides comparative perspectives on (a) how themes of American Exceptionalism have been used in domestic versus international speeches and (b) how U.S. presidents seek out diplomatic ways to “translate” American exceptionalism to communicate this potent national idea to foreign audiences

Why Do (We Think) They Hate Us: Anti-Americanism, Patriotic Messages, and Attributions of Blame

This study explores how news coverage about anti-American sentiment interacts with U.S. adults’ sense of national identity and affects their understandings and interpretations of such negative attitudes. We build on scholarship on patriotism and social identity to conduct an experiment in which participants read one of two news stories focused on anti-American impressions. The findings suggest that news content influences both (a) how Americans interpret anti-American sentiment in general and (b) how Americans draw upon their identification with the nation in formulating attributions of blame for such sentiments and in deciding on what foreign policies to support

A Post-American World? Assessing the Cognitive and Attitudinal Impacts of Challenges to American Exceptionalism

A number of voices have emerged in U.S. political discourse questioning the legitimacy of American exceptionalism, suggesting we are in a “post-American world.” Our research examines the effects that political messages that explicitly challenge American exceptionalism can have on U.S. public opinion. Drawing upon social identity theory, we find that explicit challenges to American exceptionalism significantly impact Americans’ views toward their own nation, their willingness to denigrate foreign publics, and their broader foreign policy preferences

Self-similarities in the frequency-amplitude space of a loss-modulated CO2_2 laser

We show the standard two-level continuous-time model of loss-modulated CO$_2$ lasers to display the same regular network of self-similar stability islands known so far to be typically present only in discrete-time models based on mappings. For class B laser models our results suggest that, more than just convenient surrogates, discrete mappings in fact could be isomorphic to continuous flows.Comment: (5 low-res color figs; for ALL figures high-res PDF: http://www.if.ufrgs.br/~jgallas/jg_papers.html

Make no exception, save one: American exceptionalism, the American presidency, and the age of Obama

This paper explores the circumstances under which U.S. presidents have invoked the idea of American exceptionalism in major speeches to the nation and how the invocation of this concept has culminated during the Obama presidency. To explore these dynamics, we conducted a content analysis of all major domestic presidential addresses since the end of World War II. We find that U.S. presidents have become increasingly likely to invoke American exceptionalism, particularly after the end of the Cold War, and that in times of national crises, American exceptionalism becomes most pronounced in U.S. presidential discourse. Moreover, we demonstrate the overwhelming propensity of President Obama, relative to his predecessors, to emphasize American exceptionalism in his public communications. The reason, we argue, has to do with the double-crisis nature of his presidency—two major wars and a recession—in addition to the racial bind that he has been forced to overcome throughout his presidency. We reflect on the implications of these findings for politicians, in particular racial and other minorities, as well as the broader American public

High-Redshift Starbursting Dwarf Galaxies Revealed by GRB Afterglows

We present a study of 15 long-duration gamma-ray burst (GRB) host galaxies at z>2. The GRBs are selected with available early-time afterglow spectra in order to compare interstellar medium (ISM) absorption-line properties with stellar properties of the host galaxies. In addition to five previously studied hosts, we consider new detections for the host galaxies of GRB050820 and GRB060206 and place 2-sigma upper limits to the luminosities of the remaining unidentified hosts. We examine the nature of the host galaxy population and find that (1) the UV luminosity distribution of GRB host galaxies is consistent with expectations from a UV luminosity weighted random galaxy population with a median luminosity of =0.1 L*; (2) there exists a moderate correlation between UV luminosity and SiII 1526 absorption width, which together with the observed large line widths of W(1526)>1.5 Ang for a large fraction of the objects suggests a galactic outflow driven velocity field in the host galaxies; (3) there is tentative evidence for a trend of declining ISM metallicity with decreasing galaxy luminosity in the star-forming galaxy population at z=2-4; (4) the interstellar UV radiation field is found ~ 35-350 times higher in GRB hosts than the Galactic mean value; and (5) additional galaxies are found at < 2" from the GRB host in all fields with known presence of strong MgII absorbers, but no additional faint galaxies are found at < 2" in fields without strong MgII absorbers. Our study confirms that the GRB host galaxies (with known optical afterglows) are representative of unobscured star-forming galaxies at z>2, and demonstrates that high spatial resolution images are necessary for an accurate identification of GRB host galaxies in the presence of strong intervening absorbers.Comment: 24 emulateapj pages, 24 figures, ApJ in press; full-resolution version available at http://lambda.uchicago.edu/public/tmp/ghost.pd

Proteins in tumor-derived plasma extracellular vesicles indicate tumor origin

Cancer-derived extracellular vesicles (EVs) promote tumorigenesis, premetastatic niche formation, and metastasis via their protein cargo. However, the proteins packaged by patient tumors into EVs cannot be determined in vivo because of the presence of EVs derived from other tissues. We therefore developed a cross-species proteomic method to quantify the human tumor-derived proteome of plasma EVs produced by patient-derived xenografts of four cancer types. Proteomic profiling revealed individualized packaging of novel protein cargo, and machine learning accurately classified the type of the underlying tumor

Prenatal exome sequencing in anomalous fetuses: new opportunities and challenges

We investigated the diagnostic and clinical performance of exome sequencing (ES) in fetuses with sonographic abnormalities with normal karyotype, microarray and, in some cases, normal gene specific sequencing

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the apoptotic threshold in a subset of patient-derived glioblastoma (GBM) cells. Mechanistic studies revealed that after attenuated glucose consumption, Bcl-xL blocks cytoplasmic p53 from triggering intrinsic apoptosis. Consequently, targeting of EGFR-driven glucose metabolism in combination with pharmacological stabilization of p53 with the brain-penetrant small molecule idasanutlin resulted in synthetic lethality in orthotopic glioblastoma xenograft models. Notably, neither the degree of EGFR-signaling inhibition nor genetic analysis of EGFR was sufficient to predict sensitivity to this therapeutic combination. However, detection of rapid inhibitory effects on [18F]fluorodeoxyglucose uptake, assessed through noninvasive positron emission tomography, was an effective predictive biomarker of response in vivo. Together, these studies identify a crucial link among oncogene signaling, glucose metabolism, and cytoplasmic p53, which may potentially be exploited for combination therapy in GBM and possibly other malignancies