2,236 research outputs found

    Magic Writings in Modern China.

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    Space Suit Attachment Quick Release System

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    NASA plans to make it back to the Moon by 2024 with their Artemis Program, and stay there for a longer period of time to conduct research which will support the future of space exploration. While on the lunar surface, astronauts need to maximize their efficiency by carrying tools on their Exploration Extravehicular Mobility Unit (xEMU), and to accommodate this need, the Extravehicular Activity (EVA) Tools Team is pursuing a utility belt concept. The objective of this project is to develop a system capable of interfacing between the utility belt and any given tool, while also accommodating numerous restrictions and obstacles present on the lunar surface. The design proposed in the Final Design Review Report is a two-piece system made of the tool probe and belt receptacle. The tool probe is made of a wire frame flexure which locks the system in place when docked. The receptacle half is a simple two rung sleeve. This document outlines the final design concept, including the preliminary design process, initial background research, preliminary design concept, design requirements, project timeline, design justification, final design manufacturing procedure, and design verification

    Coaxial Jets with Disparate Viscosity: Mixing and Laminarization Characteristics

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    Mixing of fluids in a coaxial jet is studied under four distinct viscosity ratios, m = 1, 10, 20 and 40, using highly resolved large-eddy simulations (LES), particle image velocimetry and planar laser-induced fluorescence. The accuracy of predictions is tested against data obtained by the simultaneous experimental measurements of velocity and concentration fields. For the highest and lowest viscosity ratios, standard RANS models with unclosed terms pertaining to viscosity variations are employed. We show that the standard Reynolds-averaged Navier-Stokes (RANS) approach with no explicit modelling for variable-viscosity terms is not applicable whereas dynamic LES models provide high-quality agreement with the measurements. To identify the underlying mixing physics and sources of discrepancy in RANS predictions, two distinct mixing modes are defined based on the viscosity ratio. Then, for each mode, the evolution of mixing structures, momentum budget analysis with emphasis on variable-viscosity terms, analysis of the turbulent activity and decay of turbulence are investigated using highly resolved LES data. The mixing dynamics is found to be quite distinct in each mixing mode. Variable viscosity manifests multiple effects that are working against each other. Viscosity gradients induce additional instabilities while increasing overall viscosity decreases the effective Reynolds number leading to laminarization of the turbulent jet, explaining the lack of dispersion and turbulent diffusion. Momentum budget analysis reveals that variable-viscosity terms are significant to be neglected. The scaling of the energy spectrum cascade suggests that in the TLL mode the unsteady laminar shedding is responsible for the eddies observed

    SIV Infection Induces Accumulation of Plasmacytoid Dendritic Cells in the Gut Mucosa

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    Multiple studies suggest that plasmacytoid dendritic cells (pDCs) are depleted and dysfunctional during human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but little is known about pDCs in the gut—the primary site of virus replication. Here, we show that during SIV infection, pDCs were reduced 3-fold in the circulation and significantly upregulated the gut-homing marker α4β7, but were increased 4-fold in rectal biopsies of infected compared to naive macaques. These data revise the understanding of pDC immunobiology during SIV infection, indicating that pDCs are not necessarily depleted, but instead may traffic to and accumulate in the gut mucosa

    Search for supersolidity in 4He in low-frequency sound experiments

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    We present results of the search for supersolid 4He using low-frequency, low-level mechanical excitation of a solid sample grown and cooled at fixed volume. We have observed low frequency non-linear resonances that constitute anomalous features. These features, which appear below about 0.8 K, are absent in 3He. The frequency, the amplitude at which the nonlinearity sets in, and the upper temperature limit of existence of these resonances depend markedly on the sample history.Comment: Submitted to the Quantum Fluids and Solids Conf. Aug. 2006 Kyot

    SIV Infection Induces Accumulation of Plasmacytoid Dendritic Cells in the Gut Mucosa

    Get PDF
    Multiple studies suggest that plasmacytoid dendritic cells (pDCs) are depleted and dysfunctional during human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but little is known about pDCs in the gut—the primary site of virus replication. Here, we show that during SIV infection, pDCs were reduced 3-fold in the circulation and significantly upregulated the gut-homing marker α4β7, but were increased 4-fold in rectal biopsies of infected compared to naive macaques. These data revise the understanding of pDC immunobiology during SIV infection, indicating that pDCs are not necessarily depleted, but instead may traffic to and accumulate in the gut mucosa
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