Teacher Knowledge and Classroom Practice: Examining the Connection

This paper extends existing research regarding content knowledge for teaching (CKT) and role it plays in advancing student learning. Two teachers (with high and low measured CKT) are observed on the same day teaching similar content. Many studies have recently been published linking student achievement to teacher’s CKT and many U.S. schools have begun including CKT measures in teacher hiring and retention decisions. Teaching observed for this study illustrates that content can be taught effectively by teachers across the spectrum of CKT levels, but observable and significant differences in teaching leads to important questions for inservice and preservice teacher educators

Cultivation and marketing of farm products in the hinterland of Gombe, NE-Nigeria

The study investigates elements influencing agricultural development in villages of the hinterland of Gombe, Gombe State, Nigeria. It aims to discover changes in socio-economic and socio-cultural interactions that exist among household, region, nation and world market. Of special interests are rural households as well as wholesale markets where dynamic processes in the structure of agricultural enterprises and the individual reasons of innovations are recognisable. The final objective of the study is to analyse the agricultural sector in the investigated villages in time and space, by typifying rural households, there strategies of action in relation to different factors: for example, farmsize, cultivation techniques and marketing of agriculture products. The study is also interested in operational profits and costs of farms, income of households as well as expenditures, etc. Because of the fact that statistical work is still going on, it is only possible to present a small portion of the results. Namely, the change in cultivation and marketing of farm products with special emphasis on cash crops during the last 30 years

Community Foundation for South Sinai

This is a fact sheet of the community Foundation South of Sina

Lysine acetyltransferase 5 in EGFR mutated non-small cell lung cancer

Histone modifications are crucial in activities such as transcriptional activation, gene silencing, and epigenetic cellular memory. In particular, lysine acetylation via lysine (K) acetyltransferases (KATs) has been implicated in cancer development. Interestingly, KAT5, also known as Tip60 (tat-interactive protein-60kDa), has been reported to possess both tumor promoting and tumor suppressing properties depending on the context of malignancy. Herein we report that KAT5 contributes to tumorigenesis in epidermal growth factor receptor (EGFR) mutated lung cancer, and Kat5-knockout mice models demonstrate significantly reduced lung tumor burden. To probe the aberrant modification of KAT5, we demonstrated that KAT5 binds to and is phosphorylated by oncogenic EGFR in co-immunoprecipitation experiments. Next, to investigate whether KAT5 is involved in cell proliferation and survival, H1975 cells harboring L858R-T790M double-activating mutations were transfected with doxycycline inducible short helical RNA (shRNA) targeting KAT5 (shKAT5). Following treatment, shKAT5 cells were observed to have suppressed proliferation rates. Pharmacological inhibition using TH1834, a known KAT5 inhibitor, also suppressed proliferation rates in shKAT5 cells; in contrast BEAS2B cells, an immortalized normal human bronchial cell line, surprisingly exhibited increased viability compared to transformed human lung H1975 cells. This finding supports KAT5’s context-dependent role in in normal and abnormal cell homeostasis. To further investigate KAT5 in lung tumorigenesis in vivo, we generated EGFR-mutant conditional Kat5 knockout mice using a tetracycline-induced Cre/loxP system. Following doxycycline treatment for 10 weeks, isolated mice lungs for EGFRTL/CCSP-rtTA/Cre/Kat5F/F possessed significantly lower tumor volume compared to EGFRTL/CCSP-rtTA/Cre/Kat5wt/F and EGFRTL/CCSP-rtTA/Cre/Kat5wt/wt mice lungs. Hemotoxylin and eosin staining showed no evident hyperproliferation in lungs isolated from EGFRTL/CCSP-rtTA/Cre/Kat5F/F mice whereas lungs isolated from EGFRTL/CCSP-rtTA/Cre/Kat5wt/wt and EGFRTL/CCSP-rtTA/Cre/Kat5wt/F did, signifying that KAT5 has a potential regulatory role in cellular proliferation. RNA-Seq analysis of shKAT5 H1975 cells identified downstream targets involved in tumorigenic pathways. Subsequent quantitative polymerase chain reaction (PCR) of shKAT5 cells served to validate the reported targets. Taken together, these data offer insight into a KAT5 mediated oncogenic pathway that can provide novel therapeutic approaches in treating lung cancer

Making Designing Worth Worth Designing

This position paper on Methods to Account for Values in Human-Centred Computing summarises the Working to Choose framework as an option for addressing several of this CHI 2012 workshop’s topics. It also lists worth-focused design and evaluation approaches that my collaborators and I have developed, applied and assessed

Cycle II.5 aircraft aero-optical turbulent boundary-layer/shear-layer measurements

The aero-optical effects associated with propagating a laser beam through aircraft turbulent boundary layers and shear layers were examined. Observed laser optical performance levels were compared with those inferred from aerodynamic measurements of unsteady densities and correlation lengths within these random flows. Optical instrumentation included a fast shearing interferometer (FSI). A 9 cm diameter collimated helium neon laser beam made a double pass through the aircraft random flow via an airfoil mirror located one meter from the fuselage. Typical aircraft turbulent boundary layer thickness measured 0.3 meters. Averaging many FSI generated modulation transfer functions (MTFs) and Fourier transforming, this average yields the expected far field intensity degradation associated with an aircraft mounted laser system. Aerodynamic instrumentation included fine wire probes to measure unsteady temperature and mass flux. A laser doppler velocimeter measured unsteady velocity within the flows. An analysis of these data yielded point measurements of unsteady density and correlation length