Collections Created During Conflict: Preserving the Memory of the First World War

The Great War (1914-1919) forced society to decide whether cultural heritage institutions, as a whole, had value. An examination of the types of materials gathered during the Great War, the identity of the collectors, and the intended purpose the repositories highlights the shift in the methodological practices of libraries, archives, and museums during this period. This study focuses primarily on three Allied museums created during the conflict: The Imperial War Museum in England, the Bibliothèque-Musée de La Guerre in France, and the Liberty Memorial in the United States. These institutions emphasize how types of repositories were used as they instituted contemporary collecting practices to further education, to create community-based collections for increased public understanding, and to create a social memory about the Great War

Through the physician’s lens. A micro-level perspective on the structural adaptation of professional work

To sustain costs while also improving care quality, scholars and policymakers alike have highlighted the need for the reorganization of hospital care delivery, with increased emphasis on implementing new models of financing and restructuring care delivery processes. However, despite a wide range of scholarship, how best to organize hospital care in order to improve care delivery processes remains an open question. The restructuring of secondary care continues to face many challenges, and many proposed solutions prove difficult to translate from theory to practice, indicating a potential mismatch between the two. With this thesis, I attempt to bridge this divide by offering a micro-level view into the challenges, effects, and complexities of organizing secondary care delivery. Three in-depth case studies were conducted in hospital organizations that recently underwent a structural change. Each study focuses centrally on how to organize hospital based medical specialists and brings forward the often-overlooked perspective of clinicians themselves. The empirical results reveal the relational and cultural barriers that are often overlooked, but play a crucial role in determining the outcome of reform efforts. In Chapter 2 and 3 we examine how physicians respond to proposed employment reform. Our findings indicate that while physicians recognize the need to be accountable for costs and care quality, they may view the move to employment as a threat to their core professional values. In Chapter 4 we unveil importance structural, interpersonal, and cultural barriers that undermine integration efforts and disrupt processes of care in the emergency care chain

Treatment of Problem Behavior Multiply Maintained By Access to Tangible Items and Escape from Demands

Functional analysis is a behavioral assessment that identifies sources of operant reinforcement that maintain problem behavior. These assessments may identify single reinforcers (e.g., positive reinforcement in the form of attention) or multiple reinforcers (e.g., positive reinforcement in the form of attention and negative reinforcement in the form of escape from instructions) for the same behavior. In such cases, analysts will design interventions for each identified “function” but the sequencing of these interventions may impact their success at treating problem behavior. The current study evaluated the sequential treatment of problem behavior for a child whose functional analysis identified sensitivity to multiple reinforcers, similar to those described above. We first targeted problem behavior maintained by positive reinforcement in the form of access to tangible items using functional communication training (FCT). We subsequently targeted problem behavior maintained by negative reinforcement in the form of termination of instruction using Differential Reinforcement of Compliance (DRC). The implications for this intervention sequence are discussed

Coyote (Canis latrans) use of marine resources in coastal California: A new behavior relative to their recent ancestors

Coyotes ( Canis latrans) are known to consume marine foods, but the importance and persistence of marine subsidies to coyotes is unknown. Recent access to a marine subsidy, especially if gained following apex predator loss, may facilitate coyote expansion along coastal routes and amplify the effects of mesopredator release. Our goal was to quantify and contextualize past and present marine resource use by coyotes on the central coast of California via stable isotope analysis. We measured δ13C and δ15N values in coyotes, their competitors, and their food resources at two modern sites, seven archaeological sites spanning in age from ~3000 to 750 BP, and from historical (AD 1893–1992) coyote and grizzly bear hair and bone sourced from coastal counties. We found evidence for marine resource use by modern coastal California coyotes at one site, Año Nuevo, which hosts a mainland northern elephant seal ( Mirounga angustirostris) breeding colony. Seals and sea lions account for ~20% of Año Nuevo coyote diet throughout the year and this marine subsidy likely positively impacts coyote population size. Isotopic data suggest that neither historic nor prehistoric coyotes consumed marine-derived foods, even at sites near ancient mainland seal rookeries. Marine resource use by some contemporary California coyotes is a novel behavior relative to their recent ancestors. We hypothesize that human alteration of the environment through extirpation of the California grizzly bear and the more recent protection of marine mammals likely enabled this behavioral shift

Two sides to every coin:Assessing the effects of moving physicians to employment contracts

There is a growing trend of physicians becoming employees of hospital systems and employment is viewed as a mechanism to help achieve health system goals. Yet, the research is mixed on the effects of moving physicians to employment models. While the literature has traditionally placed such forms of employment relationships in opposition to professional autonomy, it has often overlooked the effects on other professional values and there is little empirical work that actually assesses how such a shift affects and is perceived by clinicians themselves. To address these gaps, we conducted a mixed method study at one hospital that recently moved all formerly selfemployed physicians to employment contracts. We interviewed physicians to understand how the shift into employment was perceived to influence their work in three domains: the patient domain, the individual domain and the organizational domain. We then conducted a follow-up survey across both formerly employed and selfemployed physicians to test our initial findings. We find both positive and negative effects in different domains, offering insights into the mixed results found in the current literature

Analyzing Gene Expression from Marine Microbial Communities using Environmental Transcriptomics

Analogous to metagenomics, environmental transcriptomics (metatranscriptomics) retrieves and sequences environmental mRNAs from a microbial assemblage without prior knowledge of what genes the community might be expressing. Thus it provides the most unbiased perspective on community gene expression in situ. Environmental transcriptomics protocols are technically difficult since prokaryotic mRNAs generally lack the poly(A) tails that make isolation of eukaryotic messages relatively straightforward 1 and because of the relatively short half lives of mRNAs 2. In addition, mRNAs are much less abundant than rRNAs in total RNA extracts, thus an rRNA background often overwhelms mRNA signals. However, techniques for overcoming some of these difficulties have recently been developed. A procedure for analyzing environmental transcriptomes by creating clone libraries using random primers to reverse-transcribe and amplify environmental mRNAs was recently described was successful in two different natural environments, but results were biased by selection of the random primers used to initiate cDNA synthesis 3. Advances in linear amplification of mRNA obviate the need for random primers in the amplification step and make it possible to use less starting material decreasing the collection and processing time of samples and thereby minimizing RNA degradation 4. In vitro transcription methods for amplifying mRNA involve polyadenylating the mRNA and incorporating a T7 promoter onto the 3 end of the transcript. Amplified RNA (aRNA) can then be converted to double stranded cDNA using random hexamers and directly sequenced by pyrosequencing 5. A first use of this method at Station ALOHA demonstrated its utility for characterizing microbial community gene expression 6

A scoping review of de-implementation frameworks and models

BACKGROUND: Reduction or elimination of inappropriate, ineffective, or potentially harmful healthcare services and public health programs can help to ensure limited resources are used effectively. Frameworks and models (FM) are valuable tools in conceptualizing and guiding the study of de-implementation. This scoping review sought to identify and characterize FM that can be used to study de-implementation as a phenomenon and identify gaps in the literature to inform future model development and application for research. METHODS: We searched nine databases and eleven journals from a broad array of disciplines (e.g., healthcare, public health, public policy) for de-implementation studies published between 1990 and June 2020. Two raters independently screened titles and abstracts, and then a pair of raters screened all full text records. We extracted information related to setting, discipline, study design, methodology, and FM characteristics from included studies. RESULTS: The final search yielded 1860 records, from which we screened 126 full text records. We extracted data from 27 articles containing 27 unique FM. Most FM (n = 21) were applicable to two or more levels of the Socio-Ecological Framework, and most commonly assessed constructs were at the organization level (n = 18). Most FM (n = 18) depicted a linear relationship between constructs, few depicted a more complex structure, such as a nested or cyclical relationship. Thirteen studies applied FM in empirical investigations of de-implementation, while 14 articles were commentary or review papers that included FM. CONCLUSION: De-implementation is a process studied in a broad array of disciplines, yet implementation science has thus far been limited in the integration of learnings from other fields. This review offers an overview of visual representations of FM that implementation researchers and practitioners can use to inform their work. Additional work is needed to test and refine existing FM and to determine the extent to which FM developed in one setting or for a particular topic can be applied to other contexts. Given the extensive availability of FM in implementation science, we suggest researchers build from existing FM rather than recreating novel FM. REGISTRATION: Not registered

Telomere length associations with cognition depend on Alzheimer's disease biomarkers

Introduction While telomere shortening, a marker of cellular aging, may impact the progression of age‐related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid‐β, tau, and APOE‐ε4. Secondary analyses assessed brain volume and thickness outcomes. Results Longer telomeres at baseline were associated with faster executive function decline. Amyloid‐β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker‐positive individuals. Discussion Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade

Polymer nanoparticles pass the plant interface

As agriculture strives to feed an ever-increasing number of people, it must also adapt to increasing exposure to minute plastic particles. To learn about the accumulation of nanoplastics by plants, we prepared well-defined block copolymer nanoparticles by aqueous dispersion polymerisation. A fluorophore was incorporated via hydrazone formation and uptake into roots and protoplasts of Arabidopsis thaliana was investigated using confocal microscopy. Here we show that uptake is inversely proportional to nanoparticle size. Positively charged particles accumulate around root surfaces and are not taken up by roots or protoplasts, whereas negatively charged nanoparticles accumulate slowly and become prominent over time in the xylem of intact roots. Neutral nanoparticles penetrate rapidly into intact cells at the surfaces of plant roots and into protoplasts, but xylem loading is lower than for negative nanoparticles. These behaviours differ from those of animal cells and our results show that despite the protection of rigid cell walls, plants are accessible to nanoplastics in soil and water