6,891 research outputs found
IMAGE, the First of the NEW MIDEX Missions
The Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) mission will be the first of the new Mediumclass Explorer (MIDEX) missions to fly. Led by Southwest Research Institute with oversight from the Explorers Project Office at NASA GSFC, IMAGE is the first satellite mission dedicated to imaging the Earth\u27s magnetosphere. IMAGE will utilize a combination of ultraviolet and neutral atom imaging instruments plus an RF sounder to map and image the temporal and spatial features of the magnetosphere. The eight science sensors are mounted to a single deckplate. The deckplate is enveloped in an eight-sided spacecraft bus, 225 cm across the flats, developed by Lockheed Martin Missiles and Space Corporation. Constructed of laminated aluminum honeycomb panels, covered extensively by Gallium Arsenide solar cells, the spacecraft structure is designed to withstand the launch loads of a Delta 7326-9.5 ELV. Attitude control is via a single magnetic torque rod and passive nutation damper with aspect information provided by a star camera, sun sensor, and three-axis magnetometer. A single S-band transponder provides telemetry and command functionality. Interfaces between the self-contained payload and the spacecraft are limited to MIL-STD-1553 and power. This paper describes the IMAGE mission as well as the engineering details of the spacecraft
Nanometric depth resolution from multi-focal images in microscopy
We describe a method for tracking the position of small features in three dimensions from images recorded on a standard microscope with an inexpensive attachment between the microscope and the camera. The depth-measurement accuracy of this method is tested experimentally on a wide-field, inverted microscope and is shown to give approximately 8 nm depth resolution, over a specimen depth of approximately 6 µm, when using a 12-bit charge-coupled device (CCD) camera and very bright but unresolved particles. To assess low-flux limitations a theoretical model is used to derive an analytical expression for the minimum variance bound. The approximations used in the analytical treatment are tested using numerical simulations. It is concluded that approximately 14 nm depth resolution is achievable with flux levels available when tracking fluorescent sources in three dimensions in live-cell biology and that the method is suitable for three-dimensional photo-activated localization microscopy resolution. Sub-nanometre resolution could be achieved with photon-counting techniques at high flux levels
Double differentiation in a cross-national comparison of populist political movements and online media uses in the United States and the Netherlands
In a context of highly visible and politically influential populist movements, this study considers the online self-representation of the Tea Party Patriots (TPP) in the United States and the Party for Freedom (PVV) in the Netherlands. A multi-methodological approach was adopted to compare the discursive manifestation of key populism concepts: leadership characteristics, adversary definition and mobilizing information. Analyses reconstruct and account for similarities and differences in discursive framing strategies of 'double differentiation' through which both movements attempt inclusion in and exclusion from the political establishment, and, in doing so, mobilize communities of support. Altogether, this study advances the understanding of what constitutes 'unmediated' content that is presented through user-generated media production, and how self-determined media spaces have facilitated shifts in populist media legitimation and political representation in two politically unique countries
Thermodynamic Behavior of a Model Covalent Material Described by the Environment-Dependent Interatomic Potential
Using molecular dynamics simulations we study the thermodynamic behavior of a
single-component covalent material described by the recently proposed
Environment-Dependent Interatomic Potential (EDIP). The parameterization of
EDIP for silicon exhibits a range of unusual properties typically found in more
complex materials, such as the existence of two structurally distinct
disordered phases, a density decrease upon melting of the low-temperature
amorphous phase, and negative thermal expansion coefficients for both the
crystal (at high temperatures) and the amorphous phase (at all temperatures).
Structural differences between the two disordered phases also lead to a
first-order transition between them, which suggests the existence of a second
critical point, as is believed to exist for amorphous forms of frozen water.
For EDIP-Si, however, the unusual behavior is associated not only with the open
nature of tetrahedral bonding but also with a competition between four-fold
(covalent) and five-fold (metallic) coordination. The unusual behavior of the
model and its unique ability to simulation the liquid/amorphous transition on
molecular-dynamics time scales make it a suitable prototype for fundamental
studies of anomalous thermodynamics in disordeered systems.Comment: 48 pages (double-spaced), 13 figure
Non-preferred habitat increases the activity area of the endangered northern quoll (<i>Dasyurus hallucatus</i>) in a semi-arid landscape
The pros and cons of the inversion method approach to derive 3D dust emission properties in the ISM: the Hi-GAL field centred on (l, b) = (30°, 0°)
Herschel far-infrared continuum data obtained as part of the Hi-GAL survey have been used, together with the GLIMPSE 8 μm and MIPSGAL 24 μm data, to attempt the first 3D-decomposition of dust emission associated with atomic, molecular and ionized gas at 15 arcmin angular resolution. Our initial test case is a 2 × 2 square degrees region centred on (l, b) = (30°, 0°), a direction that encompasses the origin point of the Scutum–Crux Arm at the tip of the Galactic Bar. Coupling the IR maps with velocity maps specific for different gas phases (H i 21cm, ^(12)CO and ^(13)CO, and radio recombination lines), we estimate the properties of dust blended with each of the gas components and at different Galactocentric distances along the line of sight (LOS). A statistical Pearson's coefficients analysis is used to study the correlation between the column densities estimated for each gas component and the intensity of the IR emission. This analysis provides evidence that the 2 × 2 square degree field under consideration is characterized by the presence of a gas component not accounted for by the standard tracers, possibly associated with warm H_2 and cold H I. We demonstrate that the IR radiation in the range 8 < λ < 500 μm is systematically dominated by emission originating within the Scutum–Crux Arm. By applying an inversion method, we recover the dust emissivities associated with atomic, molecular and ionized gas. Using the DustEM model, we fit the spectral energy distributions for each gas phase, and find average dust temperatures of T_(d,H I) = 18.82 ± 0.47 K, T_(d,H_2) = 18.84 ± 1.06 K and T_(d,H II) = 22.56 ± 0.64 K, respectively. We also obtain an indication for polycyclic aromatic hydrocarbons depletion in the diffuse ionized gas. We demonstrate the importance of including the ionized component in 3D-decompositions of the total IR emission. However, the main goal of this work is to discuss the impact of the missing column density associated with the dark gas component on the accurate evaluation of the dust properties, and to shed light on the limitations of the inversion method approach when this is applied to a small section of the Galactic plane and when the working resolution allows sufficient de-blending of the gas components along the LOS
Time-Varying Dark Energy Constraints From the Latest SN Ia, BAO and SGL
Based on the latest SNe Ia data provided by Hicken et al. (2009) with using
MLCS17 light curve fitter, together with the Baryon Acoustic Oscillation(BAO)
and strong gravitational lenses(SGL), we investigate the constraints on the
dark energy equation-of-state parameter in the flat universe, especially
for the time-varying case . The constraints from SNe data
alone are found to be: (a) as the best-fit
results; (b) for
the two parameters in the time-varying case after marginalizing the parameter
; (c) the likelihood of parameter has a high non-Gaussian
distribution; (d) an extra restriction on is necessary to improve
the constraint of the SNe Ia data on the parameters (, ). A joint
analysis of SNe Ia data and BAO is made to break the degeneracy between and
, and leads to the interesting maximum likelihoods and
. When marginalizing the parameter , the fitting results are
found to be . After
adding the splitting angle statistic of SGL data, a consistent constraint is
obtained and the constraints on time-varying
dark energy are further improved to be , which indicates that the phantom type models are
disfavored.Comment: 24 pages, 9 figures, to be published in JCA
High-Redshift Galaxy Outflows and the Formation of Dwarf Galaxies
We examine the effects of galaxy outflows on the formation of dwarf galaxies
in numerical simulations of the high-redshift Universe. Using a Smoothed
Particle Hydrodynamic code, we conduct two detailed simulations of a (5.2
Mpc/h)^3 comoving volume of the Universe. In both simulations we implement
simple, well-motivated models of galaxy identification and star formation,
while our second simulation also includes a simple ``blow-out'' model of galaxy
outflows in which supernova driven winds from newly formed disk galaxies
punch-out and shock the intergalactic medium while leaving the host galaxies
intact. A direct comparison between these simulations suggests that there are
two major mechanisms by which outflows affect dwarf formation. Firstly, the
formation of an outflow slows down the further accretion of gas onto a galaxy,
causing an overall decrease of approximately 50% in the total gas mass accreted
by the objects in our simulations. Additionally, our simulations uncover a
significant population of approximately 10^9 solar mass objects whose formation
is suppressed by the mechanism of ``baryonic stripping,'' in which outflows
from early galaxies strip the gas out of nearby overdense regions that would
have otherwise later formed into dwarf galaxies. This mechanism may be
important in explaining the observed discrepancy between the number of dwarf
galaxies predicted and observed in the local group and provide a natural
explanation for the formation of empty halos which may be required by the
existence of the extremely gas-poor extra-galactic High-Velocity Clouds.Comment: 15 pages, 9 figures, accepted to the Astrophysical Journa
MutLα heterodimers modify the molecular phenotype of Friedreich ataxia
This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA), the most common autosomal recessive ataxia disorder, is caused by a dynamic GAA repeat expansion mutation within intron 1 of FXN gene, resulting in down-regulation of frataxin expression. Studies of cell and mouse models have revealed a role for the mismatch repair (MMR) MutS-heterodimer complexes and the PMS2 component of the MutLα complex in the dynamics of intergenerational and somatic GAA repeat expansions: MSH2, MSH3 and MSH6 promote GAA repeat expansions, while PMS2 inhibits GAA repeat expansions. Methodology/Principal Findings: To determine the potential role of the other component of the MutLα complex, MLH1, in GAA repeat instability in FRDA, we have analyzed intergenerational and somatic GAA repeat expansions from FXN transgenic mice that have been crossed with Mlh1 deficient mice. We find that loss of Mlh1 activity reduces both intergenerational and somatic GAA repeat expansions. However, we also find that loss of either Mlh1 or Pms2 reduces FXN transcription, suggesting different mechanisms of action for Mlh1 and Pms2 on GAA repeat expansion dynamics and regulation of FXN transcription. Conclusions/Significance: Both MutLα components, PMS2 and MLH1, have now been shown to modify the molecular phenotype of FRDA. We propose that upregulation of MLH1 or PMS2 could be potential FRDA therapeutic approaches to increase FXN transcription. © 2014 Ezzatizadeh et al.This article has been made available through the Brunel Open Access Publishing Fund
Measurements of Flavour Dependent Fragmentation Functions in Z^0 -> qq(bar) Events
Fragmentation functions for charged particles in Z -> qq(bar) events have
been measured for bottom (b), charm (c) and light (uds) quarks as well as for
all flavours together. The results are based on data recorded between 1990 and
1995 using the OPAL detector at LEP. Event samples with different flavour
compositions were formed using reconstructed D* mesons and secondary vertices.
The \xi_p = ln(1/x_E) distributions and the position of their maxima \xi_max
are also presented separately for uds, c and b quark events. The fragmentation
function for b quarks is significantly softer than for uds quarks.Comment: 29 pages, LaTeX, 5 eps figures (and colour figs) included, submitted
to Eur. Phys. J.
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