26,099 research outputs found
PEA‐15 (Phosphoprotein Enriched in Astrocytes 15) Is a Protective Mediator in the Vasculature and Is Regulated During Neointimal Hyperplasia
This work was supported by a grant from the Medical Research Council, UK (MR/K012789/1). Additional information can be downloaded from the publisher's websitePeer reviewedPublisher PD
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Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.
Extracts from BSC-40 cells infected with vaccinia recombinants expressing either the yeast KEX2 prohormone endoprotease or a human structural homologue (fur gene product) contained an elevated level of a membrane-associated endoproteolytic activity that could cleave at pairs of basic amino acids (-LysArg- and -ArgArg-). The fur-directed activity (furin) shared many properties with Kex2p including activity at pH 7.3 and a requirement for calcium. By using antifurin antibodies, immunoblot analysis detected two furin translation products (90 and 96 kD), while immunofluorescence indicated localization to the Golgi apparatus. Coexpression of either Kex2p or furin with the mouse beta-nerve growth factor precursor (pro-beta-NGF) resulted in greatly enhanced conversion of the precursor to mature nerve growth factor. Thus, the sequence homology shared by furin and the yeast KEX2 prohormone processing enzyme is reflected by significant functional homology both in vitro and in vivo
Rim curvature anomaly in thin conical sheets revisited
This paper revisits one of the puzzling behaviors in a developable cone
(d-cone), the shape obtained by pushing a thin sheet into a circular container
of radius by a distance [E. Cerda, S. Chaieb, F. Melo, and L.
Mahadevan, {\sl Nature} {\bf 401}, 46 (1999)]. The mean curvature was reported
to vanish at the rim where the d-cone is supported [T. Liang and T. A. Witten,
{\sl Phys. Rev. E} {\bf 73}, 046604 (2006)]. We investigate the ratio of the
two principal curvatures versus sheet thickness over a wider dynamic range
than was used previously, holding and fixed. Instead of tending
towards 1 as suggested by previous work, the ratio scales as .
Thus the mean curvature does not vanish for very thin sheets as previously
claimed. Moreover, we find that the normalized rim profile of radial curvature
in a d-cone is identical to that in a "c-cone" which is made by pushing a
regular cone into a circular container. In both c-cones and d-cones, the ratio
of the principal curvatures at the rim scales as ,
where is the pushing force and is the Young's modulus. Scaling
arguments and analytical solutions confirm the numerical results.Comment: 25 pages, 12 figures. Added references. Corrected typos. Results
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Turbulence and Fossil Turbulence in Oceans and Lakes
Turbulence is defined as an eddy-like state of fluid motion where the
inertial-vortex forces of the eddies are larger than any of the other forces
that tend to damp the eddies out. Energy cascades of irrotational flows from
large scales to small are non-turbulent, even if they supply energy to
turbulence. Turbulent flows are rotational and cascade from small scales to
large, with feedback. Viscous forces limit the smallest turbulent eddy size to
the Kolmogorov scale. In stratified fluids, buoyancy forces limit large
vertical overturns to the Ozmidov scale and convert the largest turbulent
eddies into a unique class of saturated, non-propagating, internal waves,
termed fossil-vorticity-turbulence. These waves have the same energy but
different properties and spectral forms than the original turbulence patch. The
Gibson (1980, 1986) theory of fossil turbulence applies universal similarity
theories of turbulence and turbulent mixing to the vertical evolution of an
isolated patch of turbulence in a stratified fluid as its growth is constrained
and fossilized by buoyancy forces. These theories apply to the dynamics of
atmospheric, astrophysical and cosmological turbulence.Comment: 31 pages, 11 figures, 2 tables, see http://www-acs.ucsd.edu/~ir118
Accepted for publication by the Chinese Journal of Oceanology and Limnolog
Early catastrophic acetabular failure in Furlong total hip replacements
The use of uncemented hip arthroplasty prostheses with ceramic articulations are popular, especially in the young, because of a perceived reduction in wear. We highlight a complication of ceramic on polyethylene articulating couples not previously described in the Furlong replacement. Despite widespread metalosis and particulate debris, osteolysis was not initially seen. The contamination compromised subsequent revision
Lunar resources: Oxygen from rocks and soil
The first set of hydrogen reduction experiments to use actual lunar material was recently completed. The sample, 70035, is a coarse-grained vesicular basalt containing 18.46 wt. percent FeO and 12.97 wt. percent TiO2. The mineralogy includes pyroxene, ilmenite, plagioclase, and minor olivine. The sample was crushed to a grain size of less than 500 microns. The crushed basalt was reduced with hydrogen in seven tests at temperatures of 900-1050 C and pressures of 1-10 atm for 30-60 minutes. A capacitance probe, measuring the dew point of the gas stream, was used to follow reaction progress. Experiments were also conducted using a terrestrial basalt similar to some lunar mare samples. Minnesota Lunar Simulant (MLS-1) contains 13.29 wt. percent FeO, 2.96 wt. percent Fe2O3, and 6.56 wt. percent TiO2. The major minerals include plagioclase, pyroxene, olivine, ilmenite, and magnetite. The rock was ground and seived, and experiments were run on the less than 74- and 500-1168-micron fractions. Experiments were also conducted on less than 74-micron powders of olivine, pyroxene, synthetic ilmenite, and TiO2. The terrestrial rock and mineral samples were reduced with flowing hydrogen at 1100 C in a microbalance furnace, with reaction progress monitored by weight loss. Experiments were run at atmospheric pressure for durations of 3-4 hr. Solid samples from both sets of experiments were analyzed by Mossbauer spectroscopy, petrographic microscopy, scanning electron microscopy, tunneling electron microscopy, and x-ray diffraction. Apollo 17 soil 78221 was examined for evidence of natural reduction in the lunar environment. This sample was chosen based on its high maturity level (I sub s/FeO = 93.0). The FeO content is 11.68 wt. percent and the TiO2 content is 3.84 wt. percent. A polished thin section of the 90-150 micron size fraction was analyzed by petrographic microscopy and scanning electron microscopy
Mechanical and microstructural investigations of tungsten and doped tungsten materials produced via powder injection molding
The physical properties of tungsten such as the high melting point of 3420°C, the high strength and thermal conductivity, the low thermal expansion and low erosion rate make this material attractive as a plasma facing material. However, the manufacturing of such tungsten parts by mechanical machining such as milling and turning is extremely costly and time intensive because this material is very hard and brittle. Powder Injection Molding (PIM) as special process allows the mass production of components, the joining of different materials without brazing and the creation of composite and prototype materials, and is an ideal tool for scientific investigations. This contribution describes the characterization and analyses of prototype materials produced via PIM. The investigation of the pure tungsten and oxide or carbide doped tungsten materials comprises the microstructure examination, element allocation, texture analyses, and mechanical testing via four-point bend (4-PB). Furthermore, the different materials were characterized by high heat flux (HHF) tests applying transient thermal loads at different base temperatures to address thermal shock and thermal fatigue performance. Additionally, HHF investigations provide information about the thermo-mechanical behavior to extreme steady state thermal loading and measurements of the thermal conductivity as well as oxidation tests were done. Post mortem analyses are performed quantifying and qualifying the occurring damage with respect to reference tungsten grades by metallographic and microscopical means
Peacock Bundles: Bundle Coloring for Graphs with Globality-Locality Trade-off
Bundling of graph edges (node-to-node connections) is a common technique to
enhance visibility of overall trends in the edge structure of a large graph
layout, and a large variety of bundling algorithms have been proposed. However,
with strong bundling, it becomes hard to identify origins and destinations of
individual edges. We propose a solution: we optimize edge coloring to
differentiate bundled edges. We quantify strength of bundling in a flexible
pairwise fashion between edges, and among bundled edges, we quantify how
dissimilar their colors should be by dissimilarity of their origins and
destinations. We solve the resulting nonlinear optimization, which is also
interpretable as a novel dimensionality reduction task. In large graphs the
necessary compromise is whether to differentiate colors sharply between locally
occurring strongly bundled edges ("local bundles"), or also between the weakly
bundled edges occurring globally over the graph ("global bundles"); we allow a
user-set global-local tradeoff. We call the technique "peacock bundles".
Experiments show the coloring clearly enhances comprehensibility of graph
layouts with edge bundling.Comment: Appears in the Proceedings of the 24th International Symposium on
Graph Drawing and Network Visualization (GD 2016
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