Which publics? When? Exploring the policy potential of involving different publics in dialogue around science and technology.

How should we understand ‘the public’ in public dialogue given the dominant assumption within policy-making that the people brought together in these events must constitute a representative sample of the wider population? To improve the prospects for public dialogue and clarify what it can contribute to policy-making, this report explores ‘who or what is the public’ to make better sense of why and when public dialogue is carried out

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Field and experimental studies of bovine pneumonic pasteurellosis

The condition known as shipping fever was a severe source of financial loss to the beef industry in North America, where it was regarded as being a disease in which stress or viral infection preceded a severe pneumonic pasteurellosis. In Britain, a similar disease, transit fever, was recorded but no extensive research had been conducted into the condition. In these studies 29 incidents of acute respiratory disease, described as transit fever, were investigated in single-suckled calves, 24 of these were in recently housed single suckled calves and five in single suckled calves at foot with their dams. All the incidents occurred within 24 days of housing, irrespective of whether they were homebred or purchased and all but one of the incidents occurred between October 1 and December 31. In 20 of the incidents in weaned calves the disease was confirmed on clinical, microbiological and pathological grounds as a pneumonic pasteurellosis. Pasteurella haemolytica Al was recovered from slaughtered clinical cases of the disease in 18 of these incidents. The four other incidents which presented clinically as transit fever could not be confirmed as pneumonic pasteurellosis on either microbiological or pathological grounds. The five incidents in singlesuckled calves at foot were all confirmed as pneumonic pasteurellosis, three associated with P. haemolytica Al and two with P. haemolytica T10. Diagnosis of pneumonic pasteurellosis was based on the clinical findings of dullness, inappetence, pyrexia and pneumonia, usually with minimal coughing, isolation of Pasteurella spp. from a number of sites in the upper and lower respiratory tracts, and a distinctive pathology including consolidation, fibrinous pneumonia which could be diffuse or focal (nodules), fibrinous pleurisy and gross dilatation of the interlobular septa. Examination of the affected cattle at post-mortem did not demonstrate the regular presence of viral or other microbiological agents at any stage of the disease process. The examination of nasopharyngeal swabs and paired serology from groups of cattle in-contact with the cases of confirmed pneumonic pasteurellosis indicated that although there was sometimes seroconversion to viruses known to cause respiratory disease (PI3 and RS viruses) this was not a consistent feature, and similar numbers of seroconversions were seen in monitor groups of similar calves in which no respiratory disease occurred. Similarly, the presence of P. haemolytica Al in the nasopharynx and seroconversion to that organism within a group of suckled calves were at similar levels in groups of calves in which pneumonic pasteurellosis had been confirmed and those in which no respiratory disease had occurred. The development of an experimental model was attempted using stationary phase cultures of an isolate of P. haemolytica Al, from an incident of confirmed bovine pneumonic pasteurellosis,together with P13 virus infection or hormonal and physical stress. Pneumonic pasteurellosis was not produced. However, the use of a log phase culture of P. haemolytica Al in the absence of other infectious or stressor agents was successful. Calves were inoculated intranasally and intratracheally and the clinical signs seen were indistinguishable from those seen in field cases of confirmed pneumonic pasteurellosis. At post-mortem the infecting strain of P. haemolytica Al was recovered in large numbers throughout the upper and lower respiratory tract and the pathology was indistinguishable from that seen in the field cases of confirmed pneumonic pasteurellosis. As a result of these investigations it has been shown that transit fever as it occurs in Scotland is almost exclusively a primary pneumonic pasteurellosis

Immersion freezing of supercooled water drops containing glassy volcanic ash particles

AbstractThe freezing temperatures of hundreds of water drops with radii 20–50μm containing known average concentrations of suspended, mostly micron- to submicron-sized, volcanic ash particles composed of SiO2-rich glass were recorded using optical microscopy. As expected, the ash suppresses supercooling, and in contrast to earlier studies of much larger ash particles, the median freezing temperature clearly scales with the available ash surface area per drop. The heterogeneous nucleation rate coefficient per unit mass of ash (jm) increases exponentially with decreasing temperature (T) (increasing supercooling) with a possible change in the slope of a plot of logjm against T at T=245±1K. Although uncertainties in the ash surface area limit quantitative comparisons, we conclude that volcanic glass is a less effective ice-nucleating agent than feldspar crystals and more similar to other minerals previously studied

Approximate reasoning for real-time probabilistic processes

We develop a pseudo-metric analogue of bisimulation for generalized semi-Markov processes. The kernel of this pseudo-metric corresponds to bisimulation; thus we have extended bisimulation for continuous-time probabilistic processes to a much broader class of distributions than exponential distributions. This pseudo-metric gives a useful handle on approximate reasoning in the presence of numerical information -- such as probabilities and time -- in the model. We give a fixed point characterization of the pseudo-metric. This makes available coinductive reasoning principles for reasoning about distances. We demonstrate that our approach is insensitive to potentially ad hoc articulations of distance by showing that it is intrinsic to an underlying uniformity. We provide a logical characterization of this uniformity using a real-valued modal logic. We show that several quantitative properties of interest are continuous with respect to the pseudo-metric. Thus, if two processes are metrically close, then observable quantitative properties of interest are indeed close.Comment: Preliminary version appeared in QEST 0

Securing tropical forest carbon: the contribution of protected areas to REDD

Forest loss and degradation in the tropics contribute 6-17% of all greenhouse gas emissions. Protected areas cover 217.2 million ha (19.6%) of the world's humid tropical forests and contain c. 70.3 petagrams of carbon (Pg C) in biomass and soil to 1 m depth. Between 2000 and 2005, we estimate that 1.75 million ha of forest were lost from protected areas in humid tropical forests, causing the emission of 0.25-0.33 Pg C. Protected areas lost about half as much carbon as the same area of unprotected forest. We estimate that the reduction of these carbon emissions from ongoing deforestation in protected sites in humid tropical forests could be valued at USD 6,200-7,400 million depending on the land use after clearance. This is >1.5 times the estimated spending on protected area management in these regions. Improving management of protected areas to retain forest cover better may be an important, although certainly not sufficient, component of an overall strategy for reducing emissions from deforestation and forest degradation (REDD

Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians

<p>Abstract</p> <p>Background</p> <p>There is increasing global acceptance that viscous soluble fibers lower serum LDL cholesterol (LDL-C), but most evidence for this comes from studies in Caucasians. To see if oat β-glucan lowers LDL-C in Caucasians and non-Caucasians we conducted a post-hoc analysis of the results of a randomized, controlled, double-blind, multi-center clinical trial whose primary aim was to determine if molecular-weight (MW) influenced the LDL-C-lowering effect of oat β-glucan.</p> <p>Results</p> <p>Caucasian and non-Caucasian subjects with LDL-C-C ≥ 3.0 and ≤ 5.0 mmol/L (n = 786 screened, n = 400 ineligible, n = 19 refused, n = 367 randomized, n = 345 completed, n = 1 excluded for missing ethnicity) were randomly assigned to consume cereal containing wheat-fiber (Control, n = 74:13 Caucasian:non-Caucasian) or 3 g high-MW (3H, 2,250,000 g/mol, n = 67:19), 4 g medium-MW (4 M, 850,000 g/mol, n = 50:17), 3 g medium-MW (3M, 530,000 g/mol, n = 54:9) or 4 g low-MW (4 L, 210,000 g/mol, n = 51:12) oat β-glucan daily for 4 weeks. LDL-C after 4 weeks was influenced by baseline LDL-C (p < 0.001) and treatment (p = 0.003), but not ethnicity (p = 0.74). In all subjects, compared to control, 3 H, 4 M and 3 M reduced LDL-C significantly by 4.8 to 6.5%, but 4 L had no effect. Compared to control, the bioactive oat β-glucan treatments (3H, 4M and 3M) reduced LDL-C by a combined mean (95% CI) of 0.18 (0.06, 0.31) mmol/L (4.8%, n = 171, p = 0.004) in Caucasians, a value not significantly different from the 0.37 (0.09, 0.65) mmol/L (10.3%, n = 45, p = 0.008) reduction in non-Caucasians.</p> <p>Conclusion</p> <p>We conclude that oat β-glucan reduces LDL-C in both Caucasians and non-Caucasians; there was insufficient power to determine if the magnitude of LDL-C-lowering differed by ethnicity.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00981981">NCT00981981</a></p

Mapping vulnerability of tropical forest to conversion, and resulting potential CO2 emissions: A rapid assessment for the Eliasch Review

This report is a rapid assessment analysis undertaken to inform the UK's Eliasch Review on the role of international finance mechanisms to preserve global forests in tackling climate change. The results should be used with an understanding of the caveats specified at the end of the report

Stepping Stones and Creating Futures intervention : shortened interrupted time series evaluation of a behavioural and structural health promotion and violence prevention intervention for young people in informal settlements in Durban, South Africa

BACKGROUND : Gender-based violence and HIV are highly prevalent in the harsh environment of informal settlements and reducing violence here is very challenging. The group intervention Stepping Stones has been shown to reduce men’s perpetration of violence in more rural areas, but violence experienced by women in the study was not affected. Economic empowerment interventions with gender training can protect older women from violence, but microloan interventions have proved challenging with young women. We investigated whether combining a broad economic empowerment intervention and Stepping Stones could impact on violence among young men and women. The intervention, Creating Futures, was developed as a new generation of economic empowerment intervention, which enabled livelihood strengthening though helping participants find work or set up a business, and did not give cash or make loans. METHODS : We piloted Stepping Stones with Creating Futures in two informal settlements of Durban with 232 out of school youth, mostly aged 18–30 and evaluated with a shortened interrupted time series of two baseline surveys and at 28 and 58 weeks post-baseline. 94/110 men and 111/122 women completed the last assessment, 85.5% and 90.2% respectively of those enrolled. To determine trend, we built random effects regression models with each individual as the cluster for each variable, and measured the slope of the line across the time points. RESULTS : Men’s mean earnings in the past month increased by 247% from R411 (~$40) to R1015 (~$102, and women’s by 278% R 174 (~$17) to R 484 (about$48) (trend test, p < 0.0001). There was a significant reduction in women’s experience of the combined measure of physical and/or sexual IPV in the prior three months from 30.3% to 18.9% (p = 0.037). This was not seen for men. However both men and women scored significantly better on gender attitudes and men significantly reduced their controlling practices in their relationship. The prevalence of moderate or severe depression symptomatology among men and suicidal thoughts decreased significantly (p < 0.0001 and p = 0.01). CONCLUSIONS : These findings are very positive for an exploratory study and indicate that the Creating Futures/ Stepping Stones intervention has potential for impact in these difficult areas with young men and women. Further evaluation is needed.http://www.biomedcentral.com/bmcpublichealthhb201

A genome-wide association study identifies protein quantitative trait loci (pQTLs)

There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and elsewhere in the genome - trans effects. The role of genetic variation in determining protein levels has not been systematically assessed. Using a genome-wide association approach we show that common genetic variation influences levels of clinically relevant proteins in human serum and plasma. We evaluated the role of 496,032 polymorphisms on levels of 42 proteins measured in 1200 fasting individuals from the population based InCHIANTI study. Proteins included insulin, several interleukins, adipokines, chemokines, and liver function markers that are implicated in many common diseases including metabolic, inflammatory, and infectious conditions. We identified eight Cis effects, including variants in or near the IL6R (p = 1.8×10 -57), CCL4L1 (p = 3.9×10-21), IL18 (p = 6.8×10-13), LPA (p = 4.4×10-10), GGT1 (p = 1.5×10-7), SHBG (p = 3.1×10-7), CRP (p = 6.4×10-6) and IL1RN (p = 7.3×10-6) genes, all associated with their respective protein products with effect sizes ranging from 0.19 to 0.69 standard deviations per allele. Mechanisms implicated include altered rates of cleavage of bound to unbound soluble receptor (IL6R), altered secretion rates of different sized proteins (LPA), variation in gene copy number (CCL4L1) and altered transcription (GGT1). We identified one novel trans effect that was an association between ABO blood group and tumour necrosis factor alpha (TNF-alpha) levels (p = 6.8×10-40), but this finding was not present when TNF-alpha was measured using a different assay , or in a second study, suggesting an assay-specific association. Our results show that protein levels share some of the features of the genetics of gene expression. These include the presence of strong genetic effects in cis locations. The identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving our understanding of disease pathways. © 2008 Melzer et al