The angular power spectrum of radio emission at 2.3 GHz

We have analysed the Rhodes/HartRAO survey at 2326 MHz and derived the global angular power spectrum of Galactic continuum emission. In order to measure the angular power spectrum of the diffuse component, point sources were removed from the map by median filtering. A least-square fit to the angular power spectrum of the entire survey with a power law spectrum C_l proportional to l^{-alpha}, gives alpha = 2.43 +/- 0.01 for l = 2-100. The angular power spectrum of radio emission appears to steepen at high Galactic latitudes and for observed regions with |b| > 20 deg, the fitted spectral index is alpha = 2.92 +/- 0.07. We have extrapolated this result to 30 GHz (the lowest frequency channel of Planck) and estimate that no significant contribution to the sky temperature fluctuation is likely to come from synchrotron at degree-angular scalesComment: 10 pages, 10 figures, accepted for publication by Astronomy & Astrophysic

Analysis of CMB foregrounds using a database for Planck

Within the scope of the Planck IDIS (Integrated Data Information System) project we have started to develop the data model for time-ordered data and full-sky maps. The data model is part of the Data Management Component (DMC), a software system designed according to a three-tier architecture which allows complete separation between data storage and processing. The DMC is already being used for simulation activities and the modeling of some foreground components. We have ingested several Galactic surveys into the database and used the science data-access interface to process the data. The data structure for full-sky maps utilises the HEALPix tessellation of the sphere. We have been able to obtain consistent measures of the angular power spectrum of the Galactic radio continuum emission between 408 MHz and 2417 MHz.Comment: 7 pages, 6 figures. To appear in the Proceedings of the MPA/ESO/MPE Joint Astronomy Conference "Mining The Sky

The role of nuclear receptors in the differentiation of oligodendrocyteprecursor cells derived from fetal and adult neural stem cells.

Oligodendrocyte precursor cells (OPCs) differentiation from multipotent neural stem cells (NSCs) into mature oligodendrocytes is driven by thyroid hormone and mediated by thyroid hormone receptors (TRs). We show that several nuclear receptors display strong changes in expression levels between fetal and adult NSCs, with an overexpression of TR\u3b2 and a lower expression of RXR\u3b3 in adult. Such changes may determine the reduced capacity of adult OPCs to differentiate as supported by reduced yield of maturation and compromised mRNA expression of key genes. RXR\u3b3 may be the determinant of these differences, on the evidence of reduced number of mature oligodendrocytes and increased number of proliferating OPCs in RXR\u3b3-/- cultures. Such data also points to RXR\u3b3 as an important regulator of the cell cycle exit, as proved by the dysregulation of T3-induced cell cycle exit-related genes. Our data highlight the biological differences between fetal and adult OPCs and demonstrate the essential role of RXR\u3b3 in the T3-mediated OPCs maturation process

Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system

Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a definitive role for these cells remains elusive. Here we combined targeted viral manipulations and gene array profiling of EWcp neurons with mass behavioral phenotyping in C57BL/6 J mice to directly define the links between EWcp-specific urocortin-1 expression and voluntary binge alcohol intake, demonstrating a specific importance for EWcp urocortin-1 activity in escalation of alcohol intake

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

Commensal bacteria impact host health and immunity through various mechanisms, including the production of immunomodulatory molecules. Bacteroides fragilis produces a capsular polysaccharide (PSA), which induces regulatory T cells and mucosal tolerance. However, unlike pathogens, which employ secretion systems, the mechanisms by which commensal bacteria deliver molecules to the host remain unknown. We reveal that Bacteroides fragilis releases PSA in outer membrane vesicles (OMVs) that induce immunomodulatory effects and prevent experimental colitis. Dendritic cells (DCs) sense OMV-associated PSA through TLR2, resulting in enhanced regulatory T cells and anti-inflammatory cytokine production. OMV-induced signaling in DCs requires growth arrest and DNA-damage-inducible protein (Gadd45α). DCs treated with PSA-containing OMVs prevent experimental colitis, whereas Gadd45α^(−/−) DCs are unable to promote regulatory T cell responses or suppress proinflammatory cytokine production and host pathology. These findings demonstrate that OMV-mediated delivery of a commensal molecule prevents disease, uncovering a mechanism of interkingdom communication between the microbiota and mammals

Can the concentration of citric acid affects its cytotoxicity and antimicrobial activity?

Background: There has been no unanimity concerning the ideal concentration of citric acid for safe use in clinical practice. This study evaluated the cytotoxicity and the antibacterial activity in infected dentinal tubules of 10% and 1% citric acid (CA) solutions. Methods: The cytotoxicity of CA solutions in DMEM (diluted 1/10, 1/100) was assessed in L-929 fibroblasts. A broth macrodilution method (MIC and MBC) was used to assess CA antibacterial concentration. The antimicrobial activity of CA solutions was also evaluated after their final rinse inside root canals in previously Enterococcus faecalis-contaminated dentinal tubules. Ten infected dentine samples were rinsed for 5 min with 5% NaOCl and subsequently with 1% citric acid for 3 min. Another 10 were rinsed with 5% NaOCl and 10% citric acid for 3 min; the remaining four specimens were utilized as positive controls. Two uncontaminated specimens were used as negative controls. After LIVE/DEAD BacLight staining, the samples were assessed using CLSM to analyze the percentage of residual live and dead cells. Results: Both undiluted and diluted CA solutions showed severe toxicity; no changes from normal morphology were displayed when diluted 1/100. The MIC and MBC of CA were 6.25 mg/mL and 12.50 mg/mL, respectively. CA solutions demonstrated significantly low levels of bacterial counts than the positive control group, reporting a value of 9.3% for the 10% solution versus the 1% solution (35.2%). Conclusions: Despite its valuable antimicrobial properties, the cytotoxic effects of citric acid should be considered during endodontic treatment

Small Island Developing States under threat by rising seas even in a 1.5 °C warming world

Small Island Developing States (SIDS) have long been recognized as some of the planet’s most vulnerable areas to climate change, notably to rising sea levels and coastal extremes. They have been crucial in raising ambitions to keep global warming below 1.5 °C and in advancing the difficult debate on loss and damage. Still, quantitative estimates of loss and damage for SIDS under different mitigation targets are lacking. Here we carry out an assessment of future flood risk from slow-onset sea-level rise and episodic sea-level extremes along the coastlines of SIDS worldwide. We show that by the end of this century, without adaptation, climate change would amplify present direct economic damages from coastal flooding by more than 14 times under high-emissions scenarios. Keeping global warming below 1.5 °C could avoid almost half of unmitigated damage, depending on the region. Achieving this climate target, however, would still not prevent several SIDS from suffering economic losses that correspond to considerable shares of their GDP, probably leading to forced migration from low-lying coastal zones. Our results underline that investments in adaptation and sustainable development in SIDS are urgently needed, as well as dedicated support to assisting developing countries in responding to loss and damage due to climate change

Close binary companions of the HAeBe stars LkHa 198, Elias 1, HK Ori and V380 Ori

We present diffraction-limited bispectrum speckle interferometry observations of four well-known Herbig Ae/Be (HAeBe) stars, LkHa 198, Elias 1, HK Ori and V380 Ori. For two of these, LkHa 198 and Elias 1, we present the first unambiguous detection of close companions. The plane of the orbit of the new LkHa 198 companion appears to be significantly inclined to the plane of the circumprimary disk, as inferred from the orientation of the outflow. We show that the Elias 1 companion may be a convective star, and suggest that it could therefore be the true origin of the X-ray emission from this object. In the cases of HK Ori and V380 Ori, we present new measurements of the relative positions of already-known companions, indicating orbital motion. For HK Ori, photometric measurements of the brightness of the individual components in four bands allowed us to decompose the system spectral energy distribution (SED) into the two separate component SEDs. The primary exhibits a strong infrared excess which suggests the presence of circumstellar material, whereas the companion can be modelled as a naked photosphere. The infrared excess of HK Ori A was found to contribute around two thirds of the total emission from this component, suggesting that accretion power contributes significantly to the flux. Submillimetre constraints mean that the circumstellar disk cannot be particularly massive, whilst the near-infrared data indicates a high accretion rate. Either the disk lifetime is very short, or the disk must be seen in an outburst phase.Comment: 14 pages, 10 figures, 22 separate figure file

Scientific optimization of a ground-based CMB polarization experiment

We investigate the science goals achievable with the upcoming generation of ground-based Cosmic Microwave Background polarization experiments and calculate the optimal sky coverage for such an experiment including the effects of foregrounds. We find that with current technology an E-mode measurement will be sample-limited, while a B-mode measurement will be detector-noise-limited. We conclude that a 300 sq deg survey is an optimal compromise for a two-year experiment to measure both E and B-modes, and that ground-based polarization experiments can make an important contribution to B-mode surveys. Focusing on one particular experiment, QUaD, a proposed bolometric polarimeter operating from the South Pole, we find that a ground-based experiment can make a high significance measurement of the acoustic peaks in the E-mode spectrum, and will be able to detect the gravitational lensing signal in the B-mode spectrum. Such an experiment could also directly detect the gravitational wave component of the B-mode spectrum if the amplitude of the signal is close to current upper limits. We also investigate how a ground-based experiment can improve constraints on the cosmological parameters. We estimate that by combining two years of QUaD data with the four-year WMAP data, an optimized ground-based polarization experiment can improve constraints on cosmological parameters by a factor of two. If the foreground contamination can be reduced, the measurement of the tensor-to-scalar ratio can be improved by up to a factor of six over that obtainable from WMAP alone.Comment: 17 pages, 11 figures replaced with version accepted by MNRA

Flavor Violating Higgs Decays

We study a class of nonstandard interactions of the newly discovered 125 GeV Higgs-like resonance that are especially interesting probes of new physics: flavor violating Higgs couplings to leptons and quarks. These interaction can arise in many frameworks of new physics at the electroweak scale such as two Higgs doublet models, extra dimensions, or models of compositeness. We rederive constraints on flavor violating Higgs couplings using data on rare decays, electric and magnetic dipole moments, and meson oscillations. We confirm that flavor violating Higgs boson decays to leptons can be sizeable with, e.g., h -> tau mu and h -> tau e branching ratios of order 10% perfectly allowed by low energy constraints. We estimate the current LHC limits on h -> tau mu and h -> tau e decays by recasting existing searches for the SM Higgs in the tau-tau channel and find that these bounds are already stronger than those from rare tau decays. We also show that these limits can be improved significantly with dedicated searches and we outline a possible search strategy. Flavor violating Higgs decays therefore present an opportunity for discovery of new physics which in some cases may be easier to access experimentally than flavor conserving deviations from the Standard Model Higgs framework.Comment: 39 pages, 12 figures, 3 tables; v2: Improved referencing, updated mu -> 3e bounds to include large loop contributions, corrected single top constraints; conclusions unchanged; matches version to be published in JHEP; v3: included 2-loop contributions in mu -> e conversion, improved discussion of tau -> 3 mu and of EDM constraints on FV top-Higgs couplings; conclusions unchange