7 research outputs found
Consumers Perceptions and Motivations in the Choice of Kiwifruits: A Study-Case in Italy, North-East
Agronomic performance of 21 new disease resistant winegrape varieties grown in northeast Italy
The goal of the field trial was to evaluate the agronomic performance of 21 (10 red and 11 white) winegrape varieties obtained from recent breeding programmes for disease resistance developed in Hungary, Germany, and Italy. The tested red varieties were as follows: âCabernet Carbonâ, âCabernet Eidosâ, âCabernet Volosâ, âJuliusâ, âMerlot Khorusâ, âMerlot Kanthusâ, âMonarchâ, âPriorâ, UD. 31.103, âVineraâ. The tested white varieties were as follows: âAromeraâ, âBronnerâ, âFleurtaiâ, âJohanniterâ, âMuscarisâ, âSouvignier Grisâ, âSauvignon Kretosâ, âSauvignon Nepisâ, âSauvignon Rytosâ, âSolarisâ, âSoreliâ. âMerlotâ (red) and âGleraâ (white) were included as control. The experimental vineyard was established in Castelfranco Veneto on the plain, in 2014. Spray treatments were applied against downy and powdery mildew, by using only copper and sulphur. Grape production, grape quality, and phenology were recorded over a six-year-period, while disease resistance (downy mildew, powdery mildew, black rot and anthracnose) was detected only during a few years. The most significant findings were: a) all varieties showed a good level of downy mildew resistance, especially âCabernet Carbonâ, âMonarchâ, âPriorâ, UD 31.103, âMuscarisâ, âSolarisâ, âSouvignier Grisâ, âBronnerâ, âFleurtaiâ, âAromeraâ; b) no powdery mildew attacks were detected in any variety; c) âMonarchâ, âMuscarisâ, âSolarisâ and âSouvignier Grisâ also showed a high level of resistance towards black rot and anthracnose; d) red grape varieties had an earlier bud burst as compared to âMerlotâ, and, concerning ripening, some varieties were earlier than âMerlotâ, other ones were later; e) white varieties had a later bud burst but an earlier ripening time as compared to âGleraâ; f) grape production and quality changed significantly depending on the varieties, being titratable acidity higher than 6.4 g L-1 tartaric acid and pH lower than 3.5; also the year affected in a significant way those parameters as well as the interaction between the genotype and the year. In conclusion, the tested varieties behaved positively in terms of environmental sustainability
PV-SENSING: LO SVILUPPO DI UN NUOVO MODELLO PREVISIONALE PER LA DIFESA DALLA PERONOSPORA DELLA VITE
Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to α<sub>v</sub>ÎČ<sub>3</sub> without Promoting Integrin Allosteric Activation
The isoDGR sequence
is an integrin-binding motif that has been
successfully employed as a tumor-vasculature-homing molecule or for
the targeted delivery of drugs and diagnostic agents to tumors. In
this context, we previously demonstrated that cyclopeptide <b>2</b>, the product of the conjugation of <i>c</i>(CGisoDGRG)
(<b>1</b>) to 4-(<i>N</i>-maleimidomethyl)Âcyclohexane-1-carboxamide,
can be successfully used as a tumor-homing ligand for nanodrug delivery
to neoplastic tissues. Here, combining NMR, computational, and biochemical
methods, we show that the succinimide ring contained in <b>2</b> contributes to stabilizing interactions with α<sub>v</sub>ÎČ<sub>3</sub>, an integrin overexpressed in the tumor vasculature.
Furthermore, we demonstrate that various cyclopeptides containing
the isoDGR sequence embedded in different molecular scaffolds do not
induce α<sub>v</sub>ÎČ<sub>3</sub> allosteric activation
and work as pure integrin antagonists. These results could be profitably
exploited for the rational design of novel isoDGR-based ligands and
tumor-targeting molecules with improved α<sub>v</sub>ÎČ<sub>3</sub>-binding properties and devoid of adverse integrin-activating
effects
Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to α<sub>v</sub>ÎČ<sub>3</sub> without Promoting Integrin Allosteric Activation
The isoDGR sequence
is an integrin-binding motif that has been
successfully employed as a tumor-vasculature-homing molecule or for
the targeted delivery of drugs and diagnostic agents to tumors. In
this context, we previously demonstrated that cyclopeptide <b>2</b>, the product of the conjugation of <i>c</i>(CGisoDGRG)
(<b>1</b>) to 4-(<i>N</i>-maleimidomethyl)Âcyclohexane-1-carboxamide,
can be successfully used as a tumor-homing ligand for nanodrug delivery
to neoplastic tissues. Here, combining NMR, computational, and biochemical
methods, we show that the succinimide ring contained in <b>2</b> contributes to stabilizing interactions with α<sub>v</sub>ÎČ<sub>3</sub>, an integrin overexpressed in the tumor vasculature.
Furthermore, we demonstrate that various cyclopeptides containing
the isoDGR sequence embedded in different molecular scaffolds do not
induce α<sub>v</sub>ÎČ<sub>3</sub> allosteric activation
and work as pure integrin antagonists. These results could be profitably
exploited for the rational design of novel isoDGR-based ligands and
tumor-targeting molecules with improved α<sub>v</sub>ÎČ<sub>3</sub>-binding properties and devoid of adverse integrin-activating
effects