Marked increase in breast cancer incidence in young women : A 10-year study from Northern Iran, 2004-2013

Introduction: Breast cancer is the most frequent cancer among women worldwide. Breast cancer incidence in young women is a health issue of concern, especially in middle-income countries such as Iran. The aim of this study is to report the breast cancer incidence variations in Golestan province, Iran, over a 10-year period (2004-2013). Methods: We analyzed data from the Golestan Population-based Cancer Registry (GPCR), which is a high-quality cancer registry collecting data on primary cancers based on standard protocols throughout the Golestan province. Age-standardized incidence rates (ASRs) and age-specific incidence rates per 100,000 person-years were calculated. Time trends in ASRs and age-specific rates were evaluated using Joinpoint regressions. The average annual percentage change (AAPC) with correspondence 95% confidence intervals (95%CIs) were calculated. Results: A total of 2106 new breast cancer cases were diagnosed during the study period. Most cases occurred in women living in urban areas: 1449 cases (68%) versus 657 cases (31%) in rural areas. Statistically significant increasing trends were observed over the 10-year study period amongst women of all ages (AAPC = 4.4; 95%CI: 1.2-7.8) as well as amongst women in the age groups 20-29 years (AAPC = 10.0; 95%CI: 1.7-19.0) and 30-39 years (AAPC = 5.1; 95%CI: 1.4-9.0). Conclusion: The incidence of breast cancer increased between 2004 and 2013 in Golestan province amongst all age groups, and in particular amongst women aged 20-39 years. Breast cancer should be considered a high priority for health policy making in our community.Peer reviewe

Colorectal Cancer: Epidemiology, Risk Factors, and Prevention

Colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancer mortality worldwide. There are disparities in the epidemiology of CRC across different populations, most probably due to differences in exposure to lifestyle and environmental factors related to CRC. Prevention is the most effective method for controlling CRC. Primary prevention includes determining and avoiding modifiable risk factors (e.g., alcohol consumption, smoking, and dietary factors) as well as increasing protective factors (e.g., physical activity, aspirin). Further studies, especially randomized, controlled trials, are needed to clarify the association between CRC incidence and exposure to different risk factors or protective factors. Detection and removal of precancerous colorectal lesions is also an effective strategy for controlling CRC. Multiple factors, both at the individual and community levels (e.g., patient preferences, availability of screening modalities, costs, benefits, and adverse events), should be taken into account in designing and implementing CRC screening programs. Health policymakers should consider the best decision in identifying the starting age and selection of the most effective screening strategies for the target population. This review aims to present updated evidence on the epidemiology, risk factors, and prevention of CRC

Gastrointestinal Complaints and Treatment of Helicobacter pylori in Children: A Narrative Review

Context: The role of Helicobacter pylori infection in children’s problems is considered in recent years. Helicobacter pylori, a gram negative spiral flagellate organism has diverse effects and consequences on children’s health, but in some issues especially in chronic abdominal pain its role continues to debate. The prevalence of H. pylori infection and remedial measures against it in Iranian children is increasing. Evidence Acquisition: Diagnostic tests are divided into two categories: Invasive and noninvasive. Diagnostic methods are available and although invasive methods are more accurate and reliable; non-invasive methods are more acceptable and practical for children. Serological diagnosis assays are not worth much in the pediatric fields. Results: It is important to emphasize that diagnostic methods for H. pylori are revised and in some conditions, such as chronic abdominal pain, contrary to the impression, no treatment is required. Conclusions: Triple therapy is a reasonable method to eradicate H. pylori in the first stage, but different combinations and one week courses in the Iranian studies were successful