The relationship of the transferor with the transferee in the contract of transfer of debt and liability insurance by looking at the Principles of European Contract Law

The Transfer of debt in the Principles of European Contract Law is a tripartite agreement that may also be concluded between the original debtor and the new debtor. The existence of scattered provisions in Iranian law, especially assuming the formation between the transferor and the transferee, needs to be investigated by the present study with aim to eliminate the shortcomings in the law and with descriptive-analytical method. The results show there is a relationship between the transferor and the transferee in three ways. First, the contract. The transfer of debt, even if it is made between the transferor and the transferee, will lead to the full substitution of new debtor, provided that there is the prior consent of the creditor. In addition, the contract concluded between the transferor and the transferee without the consent of the creditor will lead to the transfer of debt with incomplete substitution of new debtor, like a liability insurance. Second, the existence of debt. Third, the area of responsibility transferred to the transferee. principle is to transfer the debt to the transferee with the same characteristics as the original debtor. However, the liability of debt transferee may increase or decrease, such as a liability insurance

Dissociative Symptoms and Self-Reported Childhood and Current Trauma in Male Incarcerated People with Borderline Personality Disorder - Results from a Small Cross-Sectional Study in Iran

There is evidence that incarcerated people show higher rates of symptoms of psychopathology. In the present study, we assessed male Iranian incarcerated people with borderline personality disorders (BPD) and investigated the occurrence of past and current trauma and their associations with dissociative experiences.; A total of 69 male Iranian incarcerated people (mean age: 33.76 years) diagnosed with PBD completed questionnaires covering sociodemographic information, dissociative experiences, and past and current traumatic events.; Participants reporting the occurrence of childhood trauma also reported the occurrence of adulthood trauma. Dissociation and adulthood trauma were associated in a U-shaped, non-linear fashion: Low and high adulthood trauma were associated with higher dissociation. Younger age, the presence of childhood trauma, and being single or divorced predicted adulthood trauma.; The pattern of results suggests that both childhood and adulthood trauma are highly prevalent among male incarcerated people, while the association between adulthood trauma and dissociation appeared to be more complex. When treating male incarcerated people, a complex interplay between past and current traumas and dissociation should be considered

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019

Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively. Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries

Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026

Background The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic; characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic; and examine expectations for future health spending and put into context the expected need for investment in pandemic preparedness. Methods In this analysis of global health spending between 1990 and 2021, and prediction from 2021 to 2026, we estimated four sources of health spending: development assistance for health (DAH), government spending, out-of-pocket spending, and prepaid private spending across 204 countries and territories. We used the Organisation for Economic Co-operation and Development (OECD)'s Creditor Reporting System (CRS) and the WHO Global Health Expenditure Database (GHED) to estimate spending. We estimated development assistance for general health, COVID-19 response, and pandemic preparedness and response using a keyword search. Health spending estimates were combined with estimates of resources needed for pandemic prevention and preparedness to analyse future health spending patterns, relative to need. Findings In 2019, at the onset of the COVID-19 pandemic, US$9·2 trillion (95$7·3 trillion (95% UI 7·2–7·4) in 2019; 293·7 times the $24·8 billion (95$43·1 billion in development assistance was provided to maintain or improve health. The pandemic led to an unprecedented increase in development assistance targeted towards health; in 2020 and 2021, $1·8 billion in DAH contributions was provided towards pandemic preparedness in LMICs, and$37·8 billion was provided for the health-related COVID-19 response. Although the support for pandemic preparedness is 12·2% of the recommended target by the High-Level Independent Panel (HLIP), the support provided for the health-related COVID-19 response is 252·2% of the recommended target. Additionally, projected spending estimates suggest that between 2022 and 2026, governments in 17 (95% UI 11–21) of the 137 LMICs will observe an increase in national government health spending equivalent to an addition of 1% of GDP, as recommended by the HLIP. Interpretation There was an unprecedented scale-up in DAH in 2020 and 2021. We have a unique opportunity at this time to sustain funding for crucial global health functions, including pandemic preparedness. However, historical patterns of underfunding of pandemic preparedness suggest that deliberate effort must be made to ensure funding is maintained

The effect of compost and combination of compost and biochar application in soil bulk density of planting bed, seedling emergence rate and early growth of saffron ecotypes

Emergence of saffron buds is sensitive to soil compaction and structure. Soil bulk density is introduced as the most important index of soil physical quality. Accordingly, this study was done to evaluate the effect of compost and compost-biochar in planting bed on the emergence and early seedling growth of saffron ecotypes and its relationship to soil bulk density. Experimental treatments consisted of planting beds (without any organic amendment (control), incorporation of 20 t.ha-1 compost and 10 t.ha-1 compost+ 8 t.ha-1 biochar (cellulosic material of hardwood)) and different ecotypes of saffron (Bajestan, Estahban, Ferdows, Gonabad, Natanz, Qaen, Sarayan, Torbate-Heydarieh and Zarand). Data obtained from experiment were subjected to combined analysis of variance among planting beds based on randomized complete block design. The results showed that application of compost and compost+biochar, improved emergence of the main and lateral buds as well as leaf growth parameters compared to the control. Zarand, Torbate-Heydarieh and Estahban ecotypes responded differently to the planting bed types in terms of emergence percent and rate of main bud compared to other ecotypes. Considerable variation was observed among the ecotypes in terms of all studied parameters, which indicated the adaptability of ecotypes to climatic conditions of corm provenance. Generally, the Bajestan, Ferdows and Qaen ecotypes showed superiority in terms of leaf area and dry weight. Compost and compost-biochar significantly (12%) reduced the soil bulk density compared to the control. Linear regression analysis indicated that there was a negative relationship between soil bulk density and the studied parameters, and significant decrease in all parameters was observed with increasing of soil bulk density

Effect of saffron (Crocus sativus L.) corm provenance on its agro-morphological traits and bioactive compounds

A three-year field study was conducted to examine the variation in agronomic performance, apo-carotenoids content, bioactive compounds and antioxidant activity of saffron corms originating from nine different regions of Iran. Significant differences were observed in flower-related traits, corm characteristics, picrocrocin and safranal contents, total phenolic content (TPC), total flavonoid content (TFC) and radical-scavenging activity between saffron corms of different provenance. The largest differences were observed for the flower-related traits and corm properties. Hierarchical classification of the saffron corms of different provenance resulted in three main groups. One of the three groups (provenance: Ferdows, Sarayan, and Bajestan) had high underground and above ground yield potential and also produced significantly higher picrocrocin and TFC in comparison to the other groups. In contrary the group comprising corms from Zarand, Torbat, Natanz, and Estahban were characterized by the lowest agronomic performance, TFC as well as lowest antioxidant activity. The third group, consisting of corms from Gonabad and Qaen, represented medium levels of agronomic-related traits, and the highest TPC and antioxidant ability. These results were further explored and confirmed by principal component analysis (PCA). PCA revealed positive relationships between corm properties on the one hand and flower number and stigma yield on the other hand. No relation between agronomic related traits and quality features was observed. Furthermore, the results indicated a positive relationship between total flavonoid content and antioxidant capacity of saffron. These results can be used for the improvement of the yield and quality as well as in programs for selection of the most suitable corms for particular production locations.</p

The possibility for improvement of flowering, corm properties, bioactive compounds, and antioxidant activity in saffron (Crocus sativus L.) by different nutritional regimes

Saffron as one of the most precious spices and medicinal plants, is highly valued for its bioactive compounds. Quantity and quality in spices and medicinal plants can be improved by the plant nutrition. In this field study the sole and integrated application of various fertilizers types and arbuscular-mycorrhizal fungus (AM), Glomus mosseae with respect to the flower-related traits, corm properties, quality, bioactive compounds and antioxidant activity of saffron at Kerman region, Iran was examined over a three years period. The fertilizer treatments comprised control (non-amended soil); 20 Mg ha −1 compost; 10 Mg ha −1 compost+ 8 Mg ha −1 biochar and chemical fertilizers. In each fertilizer treatment, planting bed was inoculated or non-inoculated with AM. The results showed that during the first flowering period (2015–16), neither AM nor fertilizer types affected flowering. Inoculation with AM particularly in the application of fertilizer treatments through positive effects on different corm properties during the vegetative growing seasons of 2015–16 and 2017–18, improved flower-related traits in the next flowering periods of 2016–17 and 2017–18. Picrocrocin and safranal content as well as total phenolic content and total flavonoid content in tepals were considerably enhanced by organic amendments and chemical fertilizers compared with the control. While the total phenolic content in stigmata was reduced by AM-inoculation, the total flavonoid content and antioxidant activity of stigmata and tepals were not significantly influenced. Principal Component Analysis clearly discriminated the integrated nutritional treatments from the sole ones based on flower-related traits and corm properties which were positively related with integrated treatments. Organic amendments were characterized by a higher total phenolic content and antioxidant activity in stigmata. Chemical fertilizers alone or in AM-inoculation associated with quality attributes and total flavonoid content in tepals. Research findings confirmed that the integrated application of mycorrhizal fungus, organic, and chemical fertilizers significantly influences the overall production of saffron. </p

Identification and characterisation of volatile fingerprints of saffron stigmas and petals using PTR-TOF-MS : Influence of nutritional treatments and corm provenance

This study investigated the effects of different agronomical practices of saffron on the volatile organic compounds (VOCs) of saffron stigmas and petals using proton transfer reaction-time of flight-mass spectrometry. Saffron flower samples treated with different nutritional treatments as well as samples of corms of different provenances were harvested from a three-year-old saffron field. The results revealed that 2(5H)-furanone, safranal, acetic acid, and isobutanal contributed mostly (more than 55% of the identified VOCs) to the volatile profile of the ground saffron stigmas samples. 2(5H)-Furanone, isobutanal, 2,3-butanedione, and acetic acid was likely responsible for the overall aroma of the petals, as it accounted for 67%, 7%, 5%, and 5% of the identified VOCs, respectively. Based on the mass spectral data measured, 2(5H)-furanone and safranal were not the dominant volatile compounds in the intact stigmas samples. In intact form, isobutanal, acetic acid, methanol, and acetone were the most abundant compounds. This finding must be considered in saffron-related analyses. The compounds that were the most abundant in the aroma profile of saffron were the same in both the conventionally and organically grown corms, in spite of some differences in intensities. In general, the organically grown samples presented a higher concentration in safranal, 2(5H)-furanone, phenol, and 1-t-butylcyclopentadiene, whereas acetaldehyde and isobutanal concentrations were higher in the saffron stigmas grown with mineral fertilizers. The organic nutritional treatments applied in this study may be useful for organic saffron producers to select treatments to achieve saffron with high quality. Variation in VOCs in petals and stigmas among corms originating from different regions verifies that the selection of the most suitable corms can be considered as an important factor affecting the quality of saffron.</p

Survey of Anthropometric Indices Addicts due to the History of Addiction and Substance Abuse in Qom Province, 2014

Background: Substance abuse has significant impact on nutritional status. Due to the increased malnutrition during drug use and withdrawal, this study aimed at assessing the anthropometric indices in individuals referring to drug treatment centers in Qom. Methods: In this descriptive-analytical study, 329 addicted individuals referring to addiction centers in Qom were randomly selected. A questionnaire was used with three parts including demographic characteristics, drug abuse history, and anthropometric indices including measurement of height, weight, waist circumference, arm circumference, and skinfold thickness in triceps and calf muscles. Results: The participants consisted of 328 men and only one woman, 29% of whom were in detoxification. The participants' mean age was 39.0 &plusmn; 7.1 years. The first and most-frequently used drug was opium. All anthropometric indices were associated with the consumption of opium substances and drug use was associated significantly with some parameters. With the exception of skinfold thickness in the calf, all the indices were affected by the type of consumed substances. The opium addicts had a higher body mass index compared with other drug users. Conclusions: Due to the importance of nutrition status in drug abusers' health and their lack of self-care, careful monitoring and evaluation of dietary intake, as well as nutrition status can play important roles in the rehabilitation of these individuals and help to prevent from reappearance of these habits