The impact of regional financial development on economic growth in Beijing-Tianjin-Hebei region:a spatial econometric analysis

The Beijing–Tianjin–Hebei (BTH) integration project in China is ambitious which offers great potential with its promotion of sustainable and inclusive development. This study investigates the impact of regional financial development on economic growth in the BTH region, with panel data collected from 2007 to 2016. Two indicators namely, CREDIT (denoted as regional financial development depth) and BRANCH (denoted as regional financial intermediaries accessibility) are used to construct an integrated regional financial development indicator through the spatial econometrics approach. The spatio-temporal distribution characteristics of regional financial development and economic growth are analyzed. Afterward, the global Moran’s I and local Getis–Ord Gi* statistics are applied to detect the presence of spatial autocorrelation. Finally, a spatial Durbin model (SDM) is utilized to examine spatial distribution and spatial association. The research findings of this study suggest that the CREDIT has a positive effect on regional economic growth, while the BRANCH has no impact on regional economic growth. Moreover, it is found that the spatial autocorrelation of CREDIT and BRANCH are statistically significant. The CREDIT of the neighboring areas has a negative spatial spillover effect on economic growth of one area, while the BRANCH in the neighboring areas has a positive effect on the one area. The results and research findings reported in this article highlight the role of regional financial development in improving the economic growth not only for Chinese policy makers but also for other countries’ researchers and practitioners in this field

Core promoter short tandem repeats as evolutionary switch codes for primate speciation

Alteration in gene expression levels underlies many of the phenotypic differences across species. Because of their highly mutable nature, proximity to the +1 transcription start site (TSS), and the emerging evidence of functional impact on gene expression, core promoter short tandem repeats (STRs) may be considered an ideal source of variation across species. In a genome-scale analysis of the entire Homo sapiens protein-coding genes, we have previously identified core promoters with at least one STR of ≥6-repeats, with possible selective advantage in this species. In the current study, we performed reverse analysis of the entire Homo sapiens orthologous genes in mouse in the Ensembl database, in order to identify conserved STRs that have shrunk as an evolutionary advantage to humans. Two protocols were used to minimize ascertainment bias. Firstly, two species sharing a more recent ancestor with Homo sapiens (i.e. Pan troglodytes and Gorilla gorilla gorilla) were also included in the study. Secondly, four non-primate species encompassing the major orders across Mammals, including Scandentia, Laurasiatheria, Afrotheria, and Xenarthra were analyzed as out-groups. We introduce STR evolutionary events specifically identical in primates (i.e. Homo sapiens, Pan troglodytes, and Gorilla gorilla gorilla) vs. non-primate out-groups. The average frequency of the identically shared STR motifs across those primates ranged between 0.00005 and 0.06. The identified genes are involved in important evolutionary and developmental processes, such as normal craniofacial development (TFAP2B), regulation of cell shape (PALMD), learning and long-term memory (RGS14), nervous system development (GFRA2), embryonic limb morphogenesis (PBX2), and forebrain development (APAF1). We provide evidence of core promoter STRs as evolutionary switch codes for primate speciation, and the first instance of identity-by-descent for those motifs at the interspecies level. © 2014 Wiley Periodicals, Inc

Epidemiological characteristics of human brucellosis in Shahin Dezh, Western Azarbaijan, Iran, 2008-2012

Background: Brucellosis is still one of the most challenging issues for health and the economy in many developing countries such as Iran. Objectives: This study investigated the epidemiological features of brucellosis in Shahin Dezh, Western Azarbaijan province, North West of Iran. Patients and Methods: This study had across-sectional design and data was collected from private and public sectors over a five-year period (2008-2012). All cases were studied between years 2008 and 2012 in Shahin Dezh. Results: In total, 492 cases of brucellosis were reported. The prevalence of brucellosis decreased from 152 cases/100000 inhabitants in 2008 to 97 cases/100000 inhabitants at the beginning of 2012. About 52.3 of subjects were male, and most cases of brucellosis were aged 25-30 years. Eighty-one percent of subjects lived in rural areas. There was a statistically significant difference regarding contact with livestock between rural and urban areas (91.7 vs. 68.8) (P value <0.001). Raw milk was the most commonly consumed dairy product; consumed by 37 of cases. Finally, during winter and spring a high prevalence rate of brucellosis was reported. Conclusions: Comprehensive health-related interventions need to empower communities at risk, especially young men and young and adult women in the Shahin Dezh County. Health education is needed to raise awareness of people in the studied area. © 2015, Infectious Diseases and Tropical Medicine Research Center

Sensitive Voltammetric Determination of Acetaminophen at Poly(4-vinyl pyridine)/Graphene Composite Modified Electrode

This study demonstrates the use of a selective and sensitive voltammetric sensor for determination of acetaminophen (AC). This was performed by modifying a glassy carbon electrode with composite film of poly(4-vinylpyridine) and graphene sheet (P4VP/GR-GCE). The redox peak currents of AC increased significantly at P4VP/GR-GCE. The result was achieved by the synergistic effect of combined electron mediator property of P4VP along with remarkable physical properties of GR which improved the kinetics of the catalytic oxidation of AC. The P4VP/GR-GCE exhibited excellent sensitivity, good reproducibilityand long-termstability for measuring AC with detection limits of 3.2 nM in the linear range of 0.04-300 µM. The novel developed sensor was not interfered by physiologically common interference, viz. ascorbic acid (AA) and uric acid (UA). The P4VP/GR-GCE was also successfully applied for detection of AC in tablets and urine samples, so it is reasonable to expect its broad use as AC sensor

Particle and Gas Flow Modeling of Wall-impinging Diesel Spray under Ultra-high Fuel Injection Pressures

Advanced models of spray breakup and droplet collision are implemented in OpenFOAM code for comparing the flat-wall impinging and free fuel sprays under ultra-high pressure direct injection diesel engines. The non-evaporating spray and ambient gas flow characteristics are analyzed by a combination of Eulerian and Lagrangian methods for continuous and dispersed phase, respectively. Various injection pressures and two different impinging distances are used. Reynolds Averaged Navier Stokes (RANS) equations are solved using standard k-ε turbulence model. Computational domain and grid size are determined based on a mesh study. Numerical results are validated by published experimental data for free and wall-impinging sprays. The robustness and accuracy of the proposed scheme are confirmed by comparing the main characteristics of spray and surrounding gas against published experimental data. To accomplish this, spray shape, penetration and gas velocity vectors are compared with experimental data and insightful understanding of the spray characteristics are provided. In comparison with free spray, tip penetration has been limited in impinging sprays. Turbulent flow in impinging sprays leads to more induced air motion. Also, impinging spray leads to more pushed-out gas velocity. The obtained results indicate that the numerical findings are generally in good agreement with experimental data in case of ultra-high injection pressures and micro-hole injectors

Appearance and Disappearance of Quantum Correlations in Measurement-Based Feedback Control of a Mechanical Oscillator

Quantum correlations between imprecision and backaction are a hallmark of continuous linear measurements. Here, we study how measurement-based feedback can be used to improve the visibility of quantum correlations due to the interaction of a laser field with a nanomechanical oscillator. Backaction imparted by the meter laser, due to radiation-pressure quantum fluctuations, gives rise to correlations between its phase and amplitude quadratures. These quantum correlations are observed in the experiment both as squeezing of the meter field fluctuations below the vacuum level in a homodyne measurement and as sideband asymmetry in a heterodyne measurement, demonstrating the common origin of both phenomena. We show that quantum feedback, i.e., feedback that suppresses measurement backaction, can be used to increase the visibility of the sideband asymmetry ratio. In contrast, by operating the feedback loop in the regime of noise squashing, where the in-loop photocurrent variance is reduced below the vacuum level, the visibility of the sideband asymmetry is reduced. This is due to backaction arising from vacuum noise in the homodyne detector. These experiments demonstrate the possibility, as well as the fundamental limits, of measurement-based feedback as a tool to manipulate quantum correlations.Research is funded by an ERC Advanced Grant (QuREM), a Marie Curie Initial Training Network Cavity Quantum Optomechanics, the Swiss National Science Foundation, and through support from the NCCR of Quantum Engineering (QSIT). D. J. W. acknowledges support from the European Commission through a Marie Curie Fellowship (IIF Project No. 331985)