Analysis and evaluation of the pilot attentional model

Pendant les opérations de vol, les pilotes sont exposés à une variété de conditions émotionnelles, mentales et physiques qui peuvent affecter leurs performances et leur attention. Par conséquent, il est crucial de surveiller leur charge de travail et leurs niveaux d'attention pour maintenir la sécurité et l'efficacité de l'aviation, notamment dans les situations d'urgence. La charge de travail fait référence aux exigences cognitives et physiques imposées aux pilotes lors d'un vol. Des niveaux élevés de charge de travail peuvent entraîner une fatigue mentale, une attention réduite et une surcharge cognitive, ce qui peut entraver leur capacité à effectuer leurs tâches de manière efficace et efficiente. L'attention est un processus cognitif complexe qui limite la capacité de se concentrer et de comprendre tout en même temps. Dans les tâches de traitement de l'information visuelle, la vision humaine est la principale source du mécanisme d'attention visuelle. Le mode de distribution de l'attention d'un pilote a un impact significatif sur la quantité d'informations qu'il acquiert, car la vision est le canal le plus critique pour l'acquisition d'informations. Une mauvaise allocation des ressources attentionnelles peut amener les pilotes à négliger ou à oublier des paramètres spécifiques, ce qui entraîne des risques graves pour la sécurité des aéronefs. Ainsi, cette étude vise à étudier les niveaux d'attention des pilotes lors d'une procédure de décollage simulée, en mettant l'accent particulièrement sur les périodes critiques telles que les pannes de moteur. Pour ce faire, l'étude examine s'il existe une corrélation entre la dilatation de la pupille, mesurée à l'aide de la technologie de suivi oculaire, et les niveaux d'engagement, mesurés à l'aide de l'EEG. Les résultats indiquent que les changements de taille de la pupille sont effectivement corrélés aux changements d'activité de l'EEG, suggérant que la dilatation de la pupille peut être utilisée comme un indicateur fiable de l'engagement et de l'attention. Sur la base de ces résultats, la dilatation de la pupille et l'EEG peuvent être utilisés en combinaison pour examiner de manière globale le comportement des pilotes, car les deux mesures sont des indicateurs valides de l'engagement et de la charge cognitive. De plus, l'utilisation de ces mesures peut aider à identifier les périodes critiques où les niveaux d'attention des pilotes nécessitent une surveillance étroite pour garantir la sécurité et l'efficacité de l'aviation. Cette étude met en évidence l'importance de surveiller la charge de travail et les niveaux d'attention des pilotes et recommande d'utiliser les mesures de dilatation de la pupille et d'EEG pour évaluer la charge cognitive et l'engagement d'un pilote pendant les opérations de vol, améliorant ainsi la sécurité et l'efficacité de l'aviation.During flight operations, pilots are exposed to a variety of emotional, mental, and physical conditions that can affect their performance and attention. Therefore, it is crucial to monitor their workload and attention levels to maintain aviation safety and efficiency, particularly in emergency situations. Workload refers to the cognitive and physical demands placed on pilots during a flight. High levels of workload can lead to mental fatigue, reduced attention, and cognitive overload, which can hinder their ability to perform their tasks effectively and efficiently. Attention is a complex cognitive process that limits the ability to focus and comprehend everything simultaneously. In visual information processing tasks, human vision is the primary source of the visual attention mechanism. A pilot's attention distribution mode significantly impacts the amount of information they acquire, as vision is the most critical channel for information acquisition. Improper allocation of attention resources can cause pilots to overlook or forget specific parameters, resulting in severe risks to aircraft safety. Thus, this study aims to investigate pilots' attention levels during a simulated takeoff procedure, with a specific focus on critical periods such as engine failures. To achieve this, the study examines whether there is a correlation between pupil dilation, measured using eye-tracking technology, and engagement levels, measured using EEG. The results indicate that changes in pupil size are indeed correlated with changes in EEG activity, suggesting that pupil dilation can be used as a reliable indicator of engagement and attention. Based on these findings, pupil dilation and EEG can be used in combination to comprehensively examine pilot behavior since both measures are valid indicators of engagement and cognitive workload. Furthermore, using these measures can help identify critical periods where pilots' attention levels require close monitoring to ensure aviation safety and efficiency. This study emphasizes the significance of monitoring pilots' workload and attention levels and recommends using pupil dilation and EEG measures to assess a pilot's cognitive workload and engagement during flight operations, ultimately enhancing aviation safety and efficiency

The relationship between attachment styles and autistic traits: considering the mediating role of empathy

Introduction: This purpose of this study is to investigate the relationship between autistic traits and attachment styles, and also the mediating role of empathy. Materials and Methods: 254 students of Tehran’s universities were chosen by using cluster-sampling method. After that, the demographic questionnaire, Close Relationship-Revised Questionnaire (ECR-R), Autism Spectrum Quotient–Short (AQ-S), and The Empathy Quotient-Short (EQ-S) forms were distributed amongst them in order to be filled. Results: Pearson product-moment correlation coefficient indicated that there is a significant relationship between the components of autistic traits with empathy, and avoidance and anxiety attachment. Also, there was a significant relationship between empathy and avoidance and anxiety attachment. Chi-square, SRMR, and other indexes indicate that empathy mediates the relationship between the autistic traits with the anxiety and avoidance attachment styles. Conclusion: According to the results, it can be concluded in the way that individuals with high autistic traits have lower empathy. Individuals, who report more anxiety and avoidance attachment, are less likely to have empathy in their relationships. As a final point, the high autistic traits are correlated with anxiety and avoidance attachment through their association with low empathy. &nbsp

Evaluation of mouse embryos produced in vitro after electromagnetic waves exposure; Morphometric study.

INTRODUCTION Today, the use of electromagnetic waves in medical diagnostic devices, such as magnetic resonance imaging (MRI), has increased, and many of its biological effects have been reported. The aim of the present study was to assess the biological effects of 1.5 Tesla (T) magnetic resonance imaging (MRI) on fertility and reproductive parameters. METHODS Eighty adult male and female NMRI mice (NMRI: Naval Medical Research Institute) of age 6-8 weeks were studied and randomly divided into two study and control groups. After confirmation of pregnancy, the mice in the study group were exposed to the MRI (1.5 T) machine's waves over the next three weeks, once a week for 36 minutes. One day and thirty-five days after the last radiation, the mice were killed in order to do the in vitro fertilization (IVF) by neck beads' displacement and the impact on the evolution of embryos, and its quality was studied. Data were analyzed using SPSS version 20 and the significance level of less than 0.05 was considered. RESULTS Embryo morphometry showed that the total diameter and the cytoplasm diameter of the study group embryos suffered significant reduction compared to the control group, 1 day after the last irradiation (p < 0.05), but the diameter of the perivitelline space of this group's embryos had a significant increase (p < 0.05). The qualitative results during 35 days after irradiation showed that morphologically parameters of the embryos in the study group had no significant differences from the control group. CONCLUSION Exposure to MRI irradiation can transiently disturb the development of mouse embryos and fertility, but these effects are reversible 35 days after the last irradiation

Investigation of Local Scouring around Hydrodynamic and Circular Pile Groups under the Influence of River Material Harvesting Pits

Mining activities can endanger the stability of hydraulic structures. Numerical modeling of local scouring around hydrodynamic and circular bridge pile groups, due to the action of clear water conditions via non-cohesive sediment, was performed using a computational fluid dynamics (CFD) model, a large eddy simulation (LES) turbulence model, and a van Rijn sedimentary model with FLOW-3D software. The pile groups were positioned upstream and downstream of a sand mining pit. The results showed that the scour depth around the downstream pile group was greater than that of the upstream one. Using hydrodynamic piers reduced the scour depth upstream of all piers and the material harvesting pit. The maximum reduction in scour depth was observed in front of the fifth pier, with a 29% reduction in scour depth. Additionally, for all models, as the material harvesting pit was moved downstream, the downstream turbulence was enhanced and stronger flow reversal and horseshoe vortices were detected in from of the downstream pile group. The flow patterns around the pile group showed that the presence of hydrodynamic piers in the upstream pile group leads to a decrease in the maximum flow velocity, whereas, when such piers were positioned in the downstream pile group, the velocity increases

Feasibility Study for Reuse of Zarand Thermal Power Plant Wastewater Passed through Reverse Osmosis Process

Increased urbanization and industrialization have disturbed the balance between water demand and water supply. Thermal power plants are among the largest water consumers and wastewater producers, while wastewater reuse can deal with the both concerns. Effluents of thermal power plants contain various pollutants, so remediation is needed before any other usage. Assessment the efficacy of Reverse Osmosis (RO) system in treatment of Zarand power plant wastewater for reuse was the aim of present work. Physical and chemical parameters including pH, temperature, turbidity, BOD, COD, chromium, sulphate, chloride, nitrate, and phosphate ions were determined in samples collected from three locations of power station: feed water, influent to RO, and effluent. Sampling was done in the first six months of 2012. Data was characterized using descriptive statistics and Excel software. The average performance of RO in the removal percent of turbidity, BOD, COD, chromium, sulphate, chloride, nitrate, and phosphate was 57.5, 14.5, 27.4, 28, 46, 26, 73, and 99% respectively. In spite of less satisfying values of efficiency, mean values of pH, turbidity, BOD, COD, chromium, chloride, nitrate, and phosphate measured in effluent passing through RO were 7.5, 0.14 NTU, 1.8, 2.83, 0.018, 320, 1.6, and 0.001 mg/l respectively, all in compliance with discharging or irrigation standards, while 704 mg/l of sulphate ions detected in effluent, were much higher than acceptable limits

Atorvastatin’s Therapeutic Potential in Atherosclerosis: Inhibiting TGF-β-Induced Proteoglycan Glycosaminoglycan Chain Elongation through ROS-ERK1/2-Smad2L Signaling Pathway Modulation in Vascular Smooth Muscle Cells

Objective: According to the response-to-retention hypothesis, the inception of atherosclerosis is attributed to thedeposition and retention of lipoprotein in the arterial intima, facilitated by altered proteoglycans with hyperelongatedglycosaminoglycan (GAG) chains. Recent studies have elucidated a signaling pathway whereby transforming growthfactor-β (TGF-β) promotes the expression of genes linked to proteoglycan GAG chain elongation (CHSY1 and CHST11)via reactive oxygen species (ROS) and the downstream phosphorylation of ERK1/2 and Smad2L. Atorvastatin is knownto exhibit pleiotropic effects, including antioxidant and anti-inflammatory. The purpose of the present research wasto ascertain the influence of atorvastatin on TGF-β-stimulated expression of CHST11 and CHSY1 and associatedsignaling pathways using an in vitro model.Materials and Methods: In this experimental study, vascular smooth muscle cells (VSMCs) were pre-incubatedwith atorvastatin (0.1-10 μM) prior to being stimulated with TGF-β (2 ng/ml). The experiment aimed to evaluate thephosphorylation levels of Smad2C, Smad2L, ERK1/2, the NOX p47phox subunit, ROS production, and the mRNAexpression of CHST11 and CHSY1.Results: Our research results indicated that atorvastatin inhibited TGF-β-stimulated CHSY1 and CHST11 mRNAexpression. Further experiments showed that atorvastatin diminished TGF-β-stimulated ROS production and weakenedTGF-β-stimulated phosphorylation of p47phox, ERK1/2, and Smad2L; however, we observed no effect on the TGF-β-Smad2C pathway.Conclusion: These data suggest that atorvastatin demonstrates anti-atherogenic properties through the modulationof the ROS-ERK1/2-Smad2L signaling pathway. This provides valuable insight into the potential mechanisms by whichatorvastatin exerts its pleiotropic effects against atherosclerosis

Brain diffusion MRI biomarkers after oncology treatments

In addition to providing a measurement of the tumor’s size and dimensions, magnetic resonance imaging (MRI) provides excellent noninvasive radiographic detection of tumor location. The MRI technique is an important modality that has been shown to be useful in the prognosis, diagnosis, treatment planning, and evaluation of response and recurrence in solid cancers. Diffusion-weighted imaging (DWI) is an imaging technique that quantifies water mobility. This imaging approach is good for identifying sub-voxel microstructure of tissues, correlates with tumor cellularity, and has been proven to be valuable in the early assessment of cytotoxic treatment for a variety of malignancies. Diffusion tensor imaging (DTI) is an MRI method that assesses the preferred amount of water transport inside tissues. This enables precise measurements of water diffusion, which changes according to the direction of white matter fibers, their density, and myelination.  This measurement corresponds to some related variables: fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), and others. DTI biomarkers can detect subtle changes in white matter microstructure and integrity following radiation therapy (RT) or chemoradiotherapy, which may have implications for cognitive function and quality of life. In our study, these indices were evaluated after brain chemoradiotherapy

Hepatic cysteine sulphinic acid decarboxylase depletion and defective taurine metabolism in a rat partial nephrectomy model of chronic kidney disease

© 2021, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Background: Taurine depletion occurs in patients with end-stage chronic kidney disease (CKD). In contrast, in the absence of CKD, plasma taurine is reported to increase following dietary L-glutamine supplementation. This study tested the hypothesis that taurine biosynthesis decreases in a rat CKD model, but is rectified by L-glutamine supplementation. Methods: CKD was induced by partial nephrectomy in male Sprague-Dawley rats, followed 2 weeks later by 2 weeks of 12% w/w L-glutamine supplemented diet (designated NxT) or control diet (NxC). Sham-operated control rats (S) received control diet. Results: Taurine concentration in plasma, liver and skeletal muscle was not depleted, but steady-state urinary taurine excretion (a measure of whole-body taurine biosynthesis) was strongly suppressed (28.3 ± 8.7 in NxC rats versus 78.5 ± 7.6 μmol/24 h in S, P < 0.05), accompanied by reduced taurine clearance (NxC 0.14 ± 0.05 versus 0.70 ± 0.11 ml/min/Kg body weight in S, P < 0.05). Hepatic expression of mRNAs encoding key enzymes of taurine biosynthesis (cysteine sulphinic acid decarboxylase (CSAD) and cysteine dioxygenase (CDO)) showed no statistically significant response to CKD (mean relative expression of CSAD and CDO in NxC versus S was 0.91 ± 0.18 and 0.87 ± 0.14 respectively). Expression of CDO protein was also unaffected. However, CSAD protein decreased strongly in NxC livers (45.0 ± 16.8% of that in S livers, P < 0.005). L-glutamine supplementation failed to rectify taurine biosynthesis or CSAD protein expression, but worsened CKD (proteinuria in NxT 12.5 ± 1.2 versus 6.7 ± 1.5 mg/24 h in NxC, P < 0.05). Conclusion: In CKD, hepatic CSAD is depleted and taurine biosynthesis impaired. This is important in view of taurine’s reported protective effect against cardio-vascular disease - the leading cause of death in human CKD.Peer reviewe

NMDA RECEPTORS ARE INVOLVED IN THE ANTIDEPRESSANT-LIKE EFFECTS OF CAPSAICIN FOLLOWING AMPHETAMINE WITHDRAWAL IN MALE MICE

Abstract—Amphetamine withdrawal (AW) is accompanied by diminished pleasure and depression which plays a key role in drug relapse and addictive behaviors. There is no effi- cient treatment for AW-induced depression and underpinning mechanisms were not well determined. Considering both transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and N-Methyl-D-aspartate (NMDA) receptors contribute to pathophysiology of mood and addictive disorders, in this study, we investigated the role of TRPV1 and NMDA receptors in mediating depressive-like behaviors following AW in male mice. Results revealed that administration of capsaicin, TRPV1 agonist, (100 lg/mouse, i.c.v.) and MK-801, NMDA receptor antagonist (0.005 mg/kg, i.p.) reversed AW-induced depressive-like behaviors in forced swimming test (FST) and splash test with no effect on animals’ locomotion. Co-administration of sub-effective doses of MK-801 (0.001 mg/kg, i.p.) and capsaicin (10 lg/mouse, i.c.v) exerted antidepressant-like effects in behavioral tests. Capsazepine, TRPV1 antagonist, (100 lg/mouse, i.c.v) and NMDA, NMDA receptor agonist (7.5 mg/kg, i.p.) abolished the effects of capsaicin and MK801, respectively. None of aforementioned treatments had any effect on behavior of control animals. Collectively, our findings showed that activation of TRPV1 and blockade of NMDA receptors produced antidepressant-like effects in male mice following AW, and these receptors are involved in AW-induced depressive-like behaviors. Further, we found that rapid antidepressant-like effects of capsaicin in FST and splash test are partly mediated by NMDA receptors. � 2016 Published by Elsevier Ltd on behalf of IBRO