Relación entre hábitos de vida y calificaciones escolares en adolescentes

Diversos estudios han mostrado que el rendimiento académico de los adolescentes está estrechamente vinculado al consumo de alcohol y tabaco y a las horas que pasan viendo televisión. El objetivo del presente estudio es determinar la relación del tiempo viendo televisión, el tabaquismo y el consumo de alcohol con las calificaciones escolares de adolescentes de Mallorca, España. Métodos: Se registraron datos sobre la práctica de deportes, el consumo de alcohol y tabaco, el tiempo que pasan ante el televisor y el número de asignaturas suspendidas en el último curso entre 7.361 escolares de 13 a 15 años de edad. El nivel socioeconómico de la familia se determinó a partir de los datos proporcionados por los padres de los adolescentes. Mediante un análisis multivariante se identificaron las variables asociadas al hecho de presentar un mayor riesgo de suspender. Resultados: Las variables significativamente asociadas a problemas académicos fueron: tabaco (odds ratio [OR] = 2,64: intervalo de confianza [IC] del 95%: 2,17-3,20); alcohol (OR = 1,58; IC del 95%: 1,34-1,87); ver más de 2 h de televisión por día (OR = 1,42; IC del 95%: 1,19-1,69); proceder del nivel socioeconómico más bajo (OR = 5,72; IC del 95%: 3,74-8,73) y tener más edad (OR = 1,23; IC del 95%: 1,16-1,31). Las variables que se revelaron como positivamente asociadas a un buen rendimiento académico fueron: practicar deportes a nivel competitivo (OR = 0,648; IC del 95%: 0,594-0,787); practicar deportes más de 2 veces por semana (OR = 0,820; IC del 95%: 0,712-0,945), y ser mujer (OR = 0,422; IC del 95%: 0,373-0,477). Conclusiones: Entre los adolescentes españoles, fumar, beber alcohol, tener más años, ser varón, ver televisión más de 2 h al día y proceder de un nivel socioeconómico más bajo están estrechamente asociados al fracaso escolar. Practicar deporte más de 2 veces por semana está asociado a un mejor rendimiento académico

Minimum detectable and minimal clinically important changes for pain in patients with nonspecific neck pain

<p>Abstract</p> <p>Background</p> <p>The minimal detectable change (MDC) and the minimal clinically important changes (MCIC) have been explored for nonspecific low back pain patients and are similar across different cultural settings. No data on MDC and MCIC for pain severity are available for neck pain patients. The objectives of this study were to estimate MDC and MCIC for pain severity in subacute and chronic neck pain (NP) patients, to assess if MDC and MCIC values are influenced by baseline values and to explore if they are different in the subset of patients reporting referred pain, and in subacute versus chronic patients.</p> <p>Methods</p> <p>Subacute and chronic patients treated in routine clinical practice of the Spanish National Health Service for neck pain, with or without pain referred to the arm, and a pain severity ≥ 3 points on a pain intensity number rating scale (PI-NRS), were included in this study. Patients' own "global perceived effect" over a 3 month period was used as the external criterion. The minimal detectable change (MDC) was estimated by means of the standard error of measurement in patients who self-assess as unchanged. MCIC were estimated by the mean value of change score in patients who self-assess as improved (mean change score, MCS), and by the optimal cutoff point in receiver operating characteristics curves (ROC). The effect on MDC and MCIC of initial scores, duration of pain, and existence of referred pain were assessed.</p> <p>Results</p> <p>658 patients were included, 487 of them with referred pain. MDC was 4.0 PI-NRS points for neck pain in the entire sample, 4.2 for neck pain in patients who also had referred pain, and 6.2 for referred pain. MCS was 4.1 and ROC was 1.5 for referred and for neck pain, both in the entire sample and in patients who also complained of referred pain. ROC was lower (0.5 PI-NRS points) for subacute than for chronic patients (1.5 points). MCS was higher for patients with more intense baseline pain, ranging from 2.4 to 4.9 PI-NRS for neck pain and from 2.4 to 5.3 for referred pain.</p> <p>Conclusion</p> <p>In general, improvements ≤ 1.5 PI-NRS points could be seen as irrelevant. Above that value, the cutoff point for clinical relevance depends on the methods used to estimate MCIC and on the patient's baseline severity of pain. MDC and MCIC values in neck pain patients are similar to those for low back pain and other painful conditions.</p

Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

IntroductionMacrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophage polarization and function and, conversely, phenotypic polarization may drive metabolic reprogramming.MethodsHere we use biochemical analysis, correlative cryogenic fluorescence microscopy and cryo-focused ion-beam scanning electron microscopy.ResultsWe demonstrate that growth hormone (GH) reprograms inflammatory GM-CSF-primed monocyte-derived macrophages (GM-MØ) by functioning as a metabolic modulator. We found that exogenous treatment of GM-MØ with recombinant human GH reduced glycolysis and lactate production to levels similar to those found in anti-inflammatory M-MØ. Moreover, GH treatment of GM-MØ augmented mitochondrial volume and altered mitochondrial dynamics, including the remodeling of the inner membrane to increase the density of cristae.ConclusionsOur data demonstrate that GH likely serves a modulatory role in the metabolism of inflammatory macrophages and suggest that metabolic reprogramming of macrophages should be considered as a new target to intervene in inflammatory diseases

Psychometric characteristics of the Spanish version of instruments to measure neck pain disability

[EN] Background. The NDI, COM and NPQ are evaluation instruments for disability due to NP. There was no Spanish version of NDI or COM for which psychometric characteristics were known. The objectives of this study were to translate and culturally adapt the Spanish version of the Neck Disability Index Questionnaire (NDI), and the Core Outcome Measure (COM), to validate its use in Spanish speaking patients with non-specific neck pain (NP), and to compare their psychometric characteristics with those of the Spanish version of the Northwick Pain Questionnaire (NPQ). Methods. Translation/re-translation of the English versions of the NDI and the COM was done blindly and independently by a multidisciplinary team. The study was done in 9 primary care Centers and 12 specialty services from 9 regions in Spain, with 221 acute, subacute and chronic patients who visited their physician for NP: 54 in the pilot phase and 167 in the validation phase. Neck pain (VAS), referred pain (VAS), disability (NDI, COM and NPQ), catastrophizing (CSQ) and quality of life (SF-12) were measured on their first visit and 14 days later. Patients' self-assessment was used as the external criterion for pain and disability. In the pilot phase, patients' understanding of each item in the NDI and COM was assessed, and on day 1 test-retest reliability was estimated by giving a second NDI and COM in which the name of the questionnaires and the order of the items had been changed. Results. Comprehensibility of NDI and COM were good. Minutes needed to fill out the questionnaires [median, (P25, P75)]: NDI. 4 (2.2, 10.0), COM: 2.1 (1.0, 4.9). Reliability: [ICC, (95%CI)]: NDI: 0.88 (0.80, 0.93). COM: 0.85 (0.75,0.91). Sensitivity to change: Effect size for patients having worsened, not changed and improved between days 1 and 15, according to the external criterion for disability: NDI: -0.24, 0.15, 0.66; NPQ: -0.14, 0.06, 0.67; COM: 0.05, 0.19, 0.92. Validity: Results of NDI, NPQ and COM were consistent with the external criterion for disability, whereas only those from NDI were consistent with the one for pain. Correlations with VAS, CSQ and SF-12 were similar for NDI and NPQ (absolute values between 0.36 and 0.50 on day 1, between 0.38 and 0.70 on day 15), and slightly lower for COM (between 0.36 and 0.48 on day 1, and between 0.33 and 0.61 on day 15). Correlation between NDI and NPQ: r = 0.84 on day 1, r = 0.91 on day 15. Correlation between COM and NPQ: r = 0.63 on day 1, r = 0.71 on day 15. Conclusion. Although most psychometric characteristics of NDI, NPQ and COM are similar, those from the latter one are worse and its use may lead to patients' evolution seeming more positive than it actually is. NDI seems to be the best instrument for measuring NP-related disability, since its results are the most consistent with patient's assessment of their own clinical status and evolution. It takes two more minutes to answer the NDI than to answer the COM, but it can be reliably filled out by the patient without assistanceS

Psychometric characteristics of the Spanish version of instruments to measure neck pain disability

Background: The NDI, COM and NPQ are evaluation instruments for disability due to NP. There was no Spanish version of NDI or COM for which psychometric characteristics were known. The objectives of this study were to translate and culturally adapt the Spanish version of the Neck Disability Index Questionnaire (NDI), and the Core Outcome Measure (COM), to validate its use in Spanish speaking patients with non-specific neck pain (NP), and to compare their psychometric characteristics with those of the Spanish version of the Northwick Pain Questionnaire (NPQ). Methods: Translation/re-translation of the English versions of the NDI and the COM was done blindly and independently by a multidisciplinary team. The study was done in 9 primary care Centers and 12 specialty services from 9 regions in Spain, with 221 acute, subacute and chronic patients who visited their physician for NP: 54 in the pilot phase and 167 in the validation phase. Neck pain (VAS), referred pain (VAS), disability (NDI, COM and NPQ), catastrophizing (CSQ) and quality of life (SF-12) were measured on their first visit and 14 days later. Patients' self-assessment was used as the external criterion for pain and disability. In the pilot phase, patients' understanding of each item in the NDI and COM was assessed, and on day 1 test-retest reliability was estimated by giving a second NDI and COM in which the name of the questionnaires and the order of the items had been changed. Results: Comprehensibility of NDI and COM were good. Minutes needed to fill out the questionnaires [median, (P25, P75)]: NDI. 4 (2.2, 10.0), COM: 2.1 (1.0, 4.9). Reliability: [ICC, (95%CI)]: NDI: 0.88 (0.80, 0.93). COM: 0.85 (0.75,0.91). Sensitivity to change: Effect size for patients having worsened, not changed and improved between days 1 and 15, according to the external criterion for disability: NDI: -0.24, 0.15, 0.66; NPQ: -0.14, 0.06, 0.67; COM: 0.05, 0.19, 0.92. Validity: Results of NDI, NPQ and COM were consistent with the external criterion for disability, whereas only those from NDI were consistent with the one for pain. Correlations with VAS, CSQ and SF-12 were similar for NDI and NPQ (absolute values between 0.36 and 0.50 on day 1, between 0.38 and 0.70 on day 15), and slightly lower for COM (between 0.36 and 0.48 on day 1, and between 0.33 and 0.61 on day 15). Correlation between NDI and NPQ: r = 0.84 on day 1, r = 0.91 on day 15. Correlation between COM and NPQ: r = 0.63 on day 1, r = 0.71 on day 15. Conclusion: Although most psychometric characteristics of NDI, NPQ and COM are similar, those from the latter one are worse and its use may lead to patients' evolution seeming more positive than it actually is. NDI seems to be the best instrument for measuring NP-related disability, since its results are the most consistent with patient's assessment of their own clinical status and evolution. It takes two more minutes to answer the NDI than to answer the COM, but it can be reliably filled out by the patient without assistance

Famílies botàniques de plantes medicinals

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica

La influencia de los padres sobre el consumo de alcohol y tabaco y otros hábitos de los adolescentes de Palma de Mallorca en 2003

Fundamento. El consumo de alcohol y tabaco es frecuente entre los adolescentes. El objetivo de este estudio fue determinar la influencia de los hábitos de los padres en los de sus hijos. Métodos. Se estudió a los adolescentes de 13 a 15 años de la isla de Mallorca y a sus padres. Mediante métodos previamente validados se recabó su nivel socioeconómico, sus hábitos (ingesta de alcohol, tabaquismo, práctica de deportes y consumo de televisión), y el rendimiento académico de los adolescentes. Resultados. Participaron 4.019 adolescentes y 7.359 padres. Un bajo nivel socioeconómico se asoció con un mayor riesgo de que los adolescentes fumaran (OR=3,86, IC 95%: 2,30-6,48; p=0,000), bebieran alcohol (OR=1,88; 95% IC: 1,40- 2,54; p=0,000), suspendieran alguna asignatura (OR=6,37, IC 95%: 4,23-9,61; p=0,000), vieran > 2 horas diarias de televisión (OR=1,97;95%IC: 1,69-2,29; p=0,000), y no practicaran deporte (OR=0,55, IC 95%: 0,38-0,80; p=0,001). Además, en el riesgo de que fumaran influyó que la madre bebiera (OR 1,76 IC95% 1,24-1,51; p=0,002), en el de que suspendieran los hijos (no las hijas) que los padres fumaran (OR 1,89 IC95% 1,33- 2,68; p=0,000), y los correspondientes hábitos en los padres aumentaron la probabilidad de que los adolescentes bebieran alcohol (OR 1,91 IC95% 1,43-2,51; p=0,000), vieran más de 2 horas diarias la televisión (OR 1,97 IC95% 1,68-2,29; p=0,000) e hicieran deporte (OR 6,67 IC95% 2,57-14,96; p=0,000). Conclusiones. Un bajo nivel socioeconómico se asocia a un mayor riesgo de que los adolescentes españoles fumen, beban alcohol, suspendan, vean más televisión y no practiquen deporte. Además, el que la madre beba se asocia a un mayor riesgo de que sus hijos fumen y beban, y el que ambos padres beban se asocia a un mayor riesgo de que sus hijos lo hagan. La práctica de deportes y el tiempo que pasan ante el televisor los padres influyen en los hábitos correspondientes por parte de sus hijos, pero no influyen en que el adolescente beba o fume

Towards the creation of a teaching learning community in the area of ​​Statistics and Operational Research

El objetivo del presente proyecto ha sido crear un espacio de reflexión y evaluación de estrategias didácticas aplicadas en asignaturas de Estadística e Investigación Operativa facilitando la creación de una comunidad docente de aprendizaje en el área,Depto. de Estadística e Investigación OperativaFac. de Ciencias MatemáticasFALSEsubmitte