Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes

Transformações na cientificidade e o ajuste inferencial na Ciência Política: argumento e evidências na produção de alto fator de impacto

O artigo analisa as transformações nos padrões de cientificidade da Ciência Política ao longo das duas últimas décadas. A análise oferece evidências que corroboram a hipótese de que a produção de alto fator de impacto na Ciência Política vem passando por um processo de ajuste às regras de inferência. Este ajuste termina por configurar uma condição característica que conceituamos como o Pluralismo Inferencial, no qual coexistem múltiplas lógicas de causação para a produção de inferências válidas. A partir de uma metodologia original e de dados de contagem, a análise empírica busca testar a ocorrência deste ajuste numa população composta por 2.321 artigos publicados em cinco periódicos no período 2005-2015

Author correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia liability

Several occurrences of the word 'schizophrenia' have been re-worded as 'liability to schizophrenia' or 'schizophrenia risk', including in the title, which should have been "GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability", as well as in Supplementary Figures 1-10 and Supplementary Tables 7-10, to more accurately reflect the findings of the work