Intelligent Diagnosis of Phlebothrombosis

Este artículo presenta la aplicación de una técnica de Inteligencia Artificial al campo de la Medicina. Se trata de una red bayesiana especialmente creada para efectuar el diagnóstico de trombosis venosa profunda o flebotrombosis profunda. La red desarrollada toma en consideración síntomas, antecedentes clínicos, y resultados de determinadas prácticas médicas y de laboratorio para efectuar la detección de la afección en un paciente. Para realizar el testeo de la red se contó con los datos pertenecientes a sesenta casos reales suministrados por una institución de salud y sus correspondientes diagnósticos efectuados por dos médicos especializados. Sobre los resultados se aplicaron las métricas Precision y Recall obteniéndose valores satisfactorios.This article presents a bayesian network to diagnose deep vein thrombosis or deep phlebothrombosis. To detect this condition in a patient, the network considers symptoms, medical history and medical practice, and laboratory results. The network test was carried out with 59 real cases and in collaboration with two specialist doctors. The results of the applied metrics were satisfactory

Realidad aumentada en diálogos de estudiantes colaborativos

Los beneficios que los entornos de Aprendizaje Colaborativo Soportado por Computadora aportan a los procesos de enseñanza y de aprendizaje están ampliamente investigados. Sin embargo, la inclusión tecnologías actuales en estos entornos, como es la realidad aumentada, abrió nuevos caminos de investigación. Docentes y estudiantes de la Universidad Nacional de Santiago del Estero disponen desde hace varios años de la aplicación COLLAB. Esta aplicación fue especialmente creada para dar soporte a las actividades de diálogo en pequeños grupos de estudiantes colaborativos. La presente línea de investigación se enfoca en el estudio de la realidad aumentada aplicada en contextos colaborativos de educación. En particular, se quiere incorporar nuevas funcionalidades a la aplicación COLLAB para posibilitar la gestión de recursos aumentados por parte de docentes y estudiantes. Para esto, se desarrollará especialmente un módulo que luego será acoplado a COLLAB. La experimentación con grupos de estudiantes reales, que usarán la aplicación durante sesiones colaborativas especialmente diseñadas, permitirá recopilar los datos necesarios para efectuar la validación correspondiente.Red de Universidades con Carreras en Informátic

Deficiencia del factor XIII: reporte de un caso

La deficiencia del factor XIII de la cuagulación se describió por primera vez en 1960 y han sido publicados alrededor de 200 casos. Se caracteriza por la aparición de sangrados tardíos después de un traumatismo, se confirma con la cuantifi cación del factor XIII. Se informa de un paciente de 2 años de edad con deficiencia del factor XIII. Primer caso en nuestro hospital. Abstract: Congenital Factor XIII defi ciency was fi rst described in 1960 and about 200 cases have been published about it. It is characterized by the appearance of delayed bleeding after suffering a trauma. It is diagnosed by demonstrating an increase in the solubility of a clot in urea and is confi rmed by quantifi cation of factor XIII. We report a 2-year-old patient with factor XIII defi ciency. This is the fi rst case seen in our hospita

Incidencia de helicoverpa gelotopoeon Dyar. sobre el cultivo de garbanzo (Cicer arietinum L.) en el NE de Córdoba

Trabajo Final Integrador (Área de Consolidación Métodos Cuantitativos para la Investigación Agropecuaria) -- UNC- Facultad de Ciencias Agropecuarias, 2017Helicoverpa gelotopoeon es un Lepidoptero (Noctuidae) ampliamente polífago que muestra preferencia por plantas de la familia leguminosas en general. En el cultivo de garbanzo esta especie no se consideraba importante respecto a pérdidas económicas que producía. No obstante, en las últimas campañas se ha registrado un aumento en la población de la plaga sobre el cultivo de garbanzo que ha despertado interés en el estudio de la misma. En este trabajo se planteó como objetivo evaluar la incidencia de H. gelotopoeon sobre el rendimiento de las líneas Chañarito y Norteño en condiciones de campo. Se trabajó en parcelas experimentales sembradas en la localidad de Chalacea, Dpto. Río I Córdoba. Se realizaron muestreos de orugas revisando manualmente 15 plantas al azar de cada cultivar, en cada fecha de muestreo y con frecuencia quincenal, desde fines del período vegetativo hasta cosecha, durante los años 2012, 2013 y 2014. Bajo estas condiciones, el cv. Norteño registró mayor rendimiento que el cv. Chañarito para los tres años. El porcentaje de vainas dañadas fue mayor en Chañarito. Se registró una importante variabilidad en el rendimiento del cultivo entre los años del estudio, destacándose el año 2012 con los menores rendimientos debido a un aumento en la incidencia de la plaga fundamentada en las condiciones de escasas precipitaciones y altas temperaturas

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 4: System models and data analysis

In this volume, volume 4 (of five volumes), the discussion is focussed on the system models and related data references and has the following subsections: space shuttle main engine, integrated solid rocket booster, orbiter auxiliary power units/hydraulics, and electrical power system

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation, volume 1

This document is the Executive Summary of a technical report on a probabilistic risk assessment (PRA) of the Space Shuttle vehicle performed under the sponsorship of the Office of Space Flight of the US National Aeronautics and Space Administration. It briefly summarizes the methodology and results of the Shuttle PRA. The primary objective of this project was to support management and engineering decision-making with respect to the Shuttle program by producing (1) a quantitative probabilistic risk model of the Space Shuttle during flight, (2) a quantitative assessment of in-flight safety risk, (3) an identification and prioritization of the design and operations that principally contribute to in-flight safety risk, and (4) a mechanism for risk-based evaluation proposed modifications to the Shuttle System. Secondary objectives were to provide a vehicle for introducing and transferring PRA technology to the NASA community, and to demonstrate the value of PRA by applying it beneficially to a real program of great international importance

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 5: Auxiliary shuttle risk analyses

Volume 5 is Appendix C, Auxiliary Shuttle Risk Analyses, and contains the following reports: Probabilistic Risk Assessment of Space Shuttle Phase 1 - Space Shuttle Catastrophic Failure Frequency Final Report; Risk Analysis Applied to the Space Shuttle Main Engine - Demonstration Project for the Main Combustion Chamber Risk Assessment; An Investigation of the Risk Implications of Space Shuttle Solid Rocket Booster Chamber Pressure Excursions; Safety of the Thermal Protection System of the Space Shuttle Orbiter - Quantitative Analysis and Organizational Factors; Space Shuttle Main Propulsion Pressurization System Probabilistic Risk Assessment, Final Report; and Space Shuttle Probabilistic Risk Assessment Proof-of-Concept Study - Auxiliary Power Unit and Hydraulic Power Unit Analysis Report

Probabilistic risk assessment of the Space Shuttle. Phase 3: A study of the potential of losing the vehicle during nominal operation. Volume 2: Integrated loss of vehicle model

The application of the probabilistic risk assessment methodology to a Space Shuttle environment, particularly to the potential of losing the Shuttle during nominal operation is addressed. The different related concerns are identified and combined to determine overall program risks. A fault tree model is used to allocate system probabilities to the subsystem level. The loss of the vehicle due to failure to contain energetic gas and debris, to maintain proper propulsion and configuration is analyzed, along with the loss due to Orbiter, external tank failure, and landing failure or error

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson’s disease in vivo

Abstract: Abnormal alpha-synuclein (αSyn) and iron accumulation in the brain play an important role in Parkinson's disease (PD). Herein, we aim to visualize αSyn inclusions and iron deposition in the brains of M83 (A53T) mouse models of PD in vivo. The fluorescent pyrimidoindole derivative THK-565 probe was characterized by means of recombinant fibrils and brains from 10- to 11-month-old M83 mice. Concurrent wide-field fluorescence and volumetric multispectral optoacoustic tomography (vMSOT) imaging were subsequently performed in vivo. Structural and susceptibility weighted imaging (SWI) magnetic resonance imaging (MRI) at 9.4 T as well as scanning transmission x-ray microscopy (STXM) were performed to characterize the iron deposits in the perfused brains. Immunofluorescence and Prussian blue staining were further performed on brain slices to validate the detection of αSyn inclusions and iron deposition. THK-565 showed increased fluorescence upon binding to recombinant αSyn fibrils and αSyn inclusions in post-mortem brain slices from patients with PD and M83 mice. Administration of THK-565 in M83 mice showed higher cerebral retention at 20 and 40 min post-intravenous injection by wide-field fluorescence compared to nontransgenic littermate mice, in congruence with the vMSOT findings. SWI/phase images and Prussian blue indicated the accumulation of iron deposits in the brains of M83 mice, presumably in the Fe3+ form, as evinced by the STXM results. In conclusion, we demonstrated in vivo mapping of αSyn by means of noninvasive epifluorescence and vMSOT imaging and validated the results by targeting the THK-565 label and SWI/STXM identification of iron deposits in M83 mouse brains ex vivo

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

BACKGROUND Abnormal alpha-synuclein and iron accumulation in the brain play an important role in Parkinson's disease (PD). Herein, we aim at visualizing alpha-synuclein inclusions and iron deposition in the brains of M83 (A53T) mouse models of PD in vivo . METHODS Fluorescently labelled pyrimidoindole-derivative THK-565 was characterized by using recombinant fibrils and brains from 10-11 months old M83 mice, which subsequently underwent in vivo concurrent wide-field fluorescence and volumetric multispectral optoacoustic tomography (vMSOT) imaging. The in vivo results were verified against structural and susceptibility weighted imaging (SWI) magnetic resonance imaging (MRI) at 9.4 Tesla and scanning transmission X-ray microscopy (STXM) of perfused brains. Brain slice immunofluorescence and Prussian blue staining were further performed to validate the detection of alpha-synuclein inclusions and iron deposition in the brain, respectively. RESULTS THK-565 showed increased fluorescence upon binding to recombinant alpha-synuclein fibrils and alpha-synuclein inclusions in post-mortem brain slices from patients with Parkinson's disease and M83 mice. i.v. administration of THK-565 in M83 mice showed higher cerebral retention at 20 and 40 minutes post-injection by wide-field fluorescence compared to non-transgenic littermate mice, in congruence with the vMSOT findings. SWI/phase images and Prussian blue indicated the accumulation of iron deposits in the brains of M83 mice, presumably in the Fe $^{3+}$ form, as evinced by the STXM results. CONCLUSION We demonstrated in vivo mapping of alpha-synuclein by means of non-invasive epifluorescence and vMSOT imaging assisted with a targeted THK-565 label and SWI/STXM identification of iron deposits in M83 mouse brains ex vivo