Symptomatic Mixed Cryoglobulinemia during HIV Primary Infection: A Case Report

We report a patient who developed during HIV primary infection a symptomatic mixed cryoglobulinemia. The patient suffered from arthralgias, vascular purpura of the legs, and proteinuria. Cryoglobulinemia progressively disappeared in several months after HAART

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

Tuft cells represent a fourth type of intestinal secretory cell that constitutes the primary source of endogenous intestinal opioids and are the only epithelial cell that constitutively express cyclooxygenases

Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system

International audienceEpithelial tuft cells (also known as "brush" cells in the airway) were first identified morphologically, almost six decades ago in the trachea and gastro-intestinal tract, but their function remained mysterious until three almost simultaneous reports recently revealed their essential role in the initiation of immune type 2 responses. This is a new and exciting example of cooperation between the epithelial and haematopoietic compartments for the management of enteric parasite infections. Here we review tuft cell functions and markers, and anchors epithelial tuft cells within the current paradigm of type 2 immune responses.Mucosal Immunology advance online publication, 24 August 2016; doi:10.1038/mi.2016.68

Le présent prototypant (contribution à l'étude des appareils formels du français écrit)

GRENOBLE2/3-BU Droit/Lettres (384212101) / SudocSudocFranceF

Who brought the bird remains to the Middle Palaeolithic site of Les Fieux (Southwestern France) ? Direct evidence of a complex taphonomic story

International audienc

DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium.

International audienceIn an editorial of the last issue of Gastroenterology, Montgomery and Shivdasani comment on the known markers of mammalian intestinal epithelial stem cells. We wish to caution that staining for doublecortin and calcium/calmodulin-dependent protein kinase-like-1 (DCAMKL-1), one of the putative stem cell markers mentioned in this editorial, is a highly specific and robust marker of postmitotic, differentiated, tuft cells, a minority cell lineage of the intestinal epithelium, rather than a marker for intestinal epithelial stem cells. This is important since candidate markers of intestinal stem cell are scarce and DCAMKL-1 might be especially attractive to researchers because of the availability of good antibodies, which is not the case for other, functionally validated, markers, such as Lgr5

Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels

International audienc