13 research outputs found
ETUDE ANATOMO-CLINIQUE D'UNE SERIE DE 51 ADENOCARCINOMES COLORECTAUX SUPERFICIELS DE TYPE PLAN (COMPARAISON AVEC 47 CANCERS SUPERFICIELS POLYPOIDES)
REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
W1925 Gastroprotection in Patients At Risk of Gastrointestinal NSAID Complications : Results of a General Practitioner Based Survey in France
W1930 Modalities of Low-Dose Aspirin Treatment and Gastroprotective Strategies in General and Specialty Practice in France
W1924 Prevalence and Clinical Impact of Upper Gastrointestinal Symptoms in Patients Treated with Low-Dose Aspirin
W1922 Epidemiological Characteristics of Low-Dose Aspirin Treatment and Gastroprotection in France : Results of a Nation-Wide Postal Survey
Hepatocellular carcinoma: CT texture analysis as a predictor of survival after surgical resection
International audienc
S2081 Impact of Age On Natural History and Response to Treatment of Type 1 Auto-Immune Hepatitis
Investigating preâanalytical requirements for serum and plasma based infrared spectroâdiagnostic
International audienceRadiation therapy (RT) is used to treat approximately 50% of all cancer patients. However, RT causes a wide range of adverse late effects that can affect a patient's quality of life. There are currently no predictive assays in clinical use to identify patients at risk of normal tissue radiation toxicity. This study aimed to investigate the potential of Fourier transform infrared (FTIR) spectroscopy for monitoring radiotherapeutic response. Blood plasma was acquired from 53 prostate cancer patients at five different time points: prior to treatment, after hormone treatment, at the end of radiotherapy, two months post radiotherapy and eight months post radiotherapy. FTIR spectra were recorded from plasma samples at all time points and the data was analysed using MATLAB software. Discrimination was observed between spectra recorded at baseline versus follow up time points, as well as between spectra from patients showing minimal and severe acute and late toxicity using principal component analysis. A partial least squares discriminant analysis model achieved sensitivity and specificity rates ranging from 80% to 99%. This technology may have potential to monitor radiotherapeutic response in prostate cancer patients using non-invasive blood plasma samples and could lead to individualised patient radiotherapy
Morphological and clinical characteristics of 41 cases of flat colorectal cancers (pT1 stage)
Impact of Cytomegalovirus Infection on the Outcome of Patients With Cirrhosis
International audienceGoals: The aims of this study were to evaluate whether cytomegalovirus (CMV) infection is associated with hepatocellular carcinoma (HCC) and liver-related mortality in cirrhotic patients.Background: In cirrhotic patients, the determinants of HCC and liver-related death are imperfectly known. CMV infection, by its prooncogenic and proinflammatory properties, may favor both the development of HCC and deleterious systemic inflammation.Study: In the 1178 patients included between June 2008 and December 2012 in the CIrrhose et Risque de Carcinome HĂ©patocellulaire dans le grand-Est (CIRCE) study, a French multicenter case-control study designed to identify risk factors of HCC among cirrhotic patients, we identified 432 patients with interpretable CMV serological status at baseline. They included 159 cases with HCC and 273 controls. We measured factors associated with HCC at baseline and subsequent HCC in controls, and predictors of overall and liver-related death in the whole study population.Results: During a median follow-up of 31 months, 25 cases of HCC developed in controls, and 209 deaths (163 liver-related) were recorded. There were 247 (57.2%) CMV-seropositive patients. CMV seropositivity was not associated with more frequent HCC at baseline or during follow-up, but among CMV-positive patients with HCC, the proportion of multinodular, infiltrative, or metastatic tumors at diagnosis was higher (73.8% vs. 57.3%; P=0.029), inducing higher mortality (74% vs. 52% at 3 years; P=0.004). By Cox-regression adjusted for age, gender, Model for End-stage Liver Disease (MELD) score, HCC at baseline, and diabetes, CMV seropositivity independently predicted all-cause (hazard ratio=1.45; 95% confidence interval, 1.08-1.94; P=0.013) and liver-related mortality (hazard ratio=1.56; 95% confidence interval, 1.04-2.30; P=0.031).Conclusions: In this preliminary study, CMV-seropositive cirrhotic patients were at higher risk of liver-related death caused by more aggressive HCCs or severe cirrhosis complications. These findings warrant confirmation