In Defense of Truth: Skepticism, Morality, and The Matrix

The Matrix exposes us to the uncomfortable worries of philosophical skepticism in an especially compelling way. However, with a bit more reflection, we can see why we need not share the skeptic’s doubts about the existence of the world. Such doubts are appropriate only in the very special context of the philosophical seminar. When we return to normal life we see immediately that they are groundless. Furthermore, we see also the drastic mistake that Cypher commits in turning his back upon reality and re-entering the matrix. Not only does reason compel us to admit the existence of the external world, it also requires us to face this world, to build for ourselves meaningful lives within it, and to engage, as adults, in the serious business of living

Contribution of informal shallow groundwater irrigation to livelihoods security and poverty reduction in the White Volta Basin (WVB): Current status and future sustainability

Shallow groundwater irrigation (SGI) using hand-dug shallow wells and dugouts is expanding, in the WVB, and is becoming attractive to farmers throughout. SGI is farmer-driven and has developed without any government or donor involvement. The production of vegetables and cash crops during the dry season utilizing SGI has provided farmers with a supplemental source of income and an alternative to seasonal urban migration. Although SGI has been increasing substantially, the extent of this practice is not documented.This project has help assess, the impacts of intensive SGI on sub-basin hydrology, net groundwater recharge farmers' livelihoods and on rural poverty reduction in the Atankuidi catchment a tributary of the WVB with the highest per capita groundwater use

Tanzania: Logistic System Capacity and Site Readiness to expand PMTCT and Initiate ART

In September 2003, JSI/DELIVER conducted an assessment of the logistics system capacity and individual site readiness to provide PMTCT services and to initiate ART at selected public sector health facilities in Tanzania. The purpose of the assessment was to support government expansion of PMTCT from five pilot sites to 28 health facilities in five regions by addressing the logistics system constraints to ensuring a reliable and uninterrupted supply of the broad range of commodities required for PMTCT and ART, and by conducting an evaluation of the overall readiness of each site to provide these services. Several private providers, nongovernmental and faith-based organizations, and employer-based programs were included in the assessment to learn about PMTCT and ART in these sectors and to identify opportunities for public/private sector collaboration in expanding service delivery and ensuring effective commodity distribution. In addition, interviews with pharmaceutical company representatives and visits to retail pharmacies provided an overview of current commercial sector distribution of ARV drugs in Tanzania. The main findings showed an urgent need to build logistics management capacity within the central level MOH to—Coordinate multiple sources of rapidly increasing funding for commodity procurement. Strengthen commodity-forecasting capacity. Align procurement cycles and supplier lead times with the in-country supply pipeline and demand for services. At the facility level, assessment findings showed that individual site readiness is heavily constrained by the availability and quality of human resources; laboratory infrastructure and capacity; and lack of an established inventory control system and standardized pharmacy management procedures

Lake Erie Grape Farm Cost Survey, 2001-2005

E.B. 2006-19This report is a summary of five years of grape costs and returns data collected from Lake Erie Region grape growers for the 2001-2005 seasons. “Concord” and “Niagara” grapes utilized for juice and generic wine accounted for over 90 percent of the survey acreage. About two-thirds of the acreage surveyed was in New York and one-third from Pennsylvania. In recent years, 42 to 49 growers participated, with total vineyard acreage ranging from about 4,400 to 5,200 acres. Average costs per acre over the entire five year period were $1,663, including an imputed value for the operator’s labor. Major cost categories were paid labor ($380 per acre), depreciation ($213), interest ($114), operator labor ($116) and chemicals ($117). Average yield per farm was 6.4 tons per acre with a range of 2.8 to 8.6 tons per acre. Growers suffered through some difficult circumstances (poor weather, declining prices) over the past five years. Juice grape cash market prices tended to drift down over the course of the five years. National Grape members’ returns moved upward through 2004 and then suffered a severe drop in 2005. Some growers had custom harvesting or other farm income not tied to grape prices. Some growers collected income from crop insurance, disaster payments, and/or Trade Adjustment Assistance (TAA) that helped to buoy income in the face of disappointing yields and unharvested grapes in 2003. However, almost half of the farms who were in the survey for all five years had yields of 7 tons or better. These growers are able to compete with other growing regions such as Washington State. Lake Erie Grape Belt farm managers are responding to lower prices in a variety of ways, including becoming more labor efficient, dropping some poor vineyards (especially leased ones), increasing wine grape production, and increasing farm size

Impact experiments into multiple-mesh targets: Concept development of a lightweight collisional bumper

The utility of multiple-mesh targets as potential lightweight shields to protect spacecraft in low-Earth orbit against collisional damage is explored. Earlier studies revealed that single meshes comminute hypervelocity impactors with efficiencies comparable to contiguous targets. Multiple interaction of projectile fragments with any number of meshes should lead to increased comminution, deceleration, and dispersion of the projectile, such that all debris exiting the mesh stack possesses low specific energies (ergs/sq cm) that would readily be tolerated by many flight systems. The study is conceptually exploring the sensitivity of major variables such as impact velocity, the specific areal mass (g/sq cm) of the total mesh stack (SM), and the separation distance (S) between individual meshes. Most experiments employed five or ten meshes with total SM typically less than 0.5 the specific mass of the impactor, and silicate glass impactors rather than metal projectiles. While projectile comminution increases with increasing impact velocity due to progressively higher shock stresses, encounters with multiple-meshes at low velocity (1-2 km/s) already lead to significant disruption of the glass impactors, with the resulting fragments being additionally decelerated and dispersed by subsequent meshes, and, unlike most contiguous single-plate bumpers, leading to respectable performance at low velocity. Total specific bumper mass must be the subject of careful trade-off studies; relatively massive bumpers will generate too much debris being dislodged from the bumper itself, while exceptionally lightweight designs will not cause sufficient comminution, deceleration, or dispersion of the impactor. Separation distance was found to be a crucial design parameter, as it controls the dispersion of the fragment cloud. Substantial mass savings could result if maximum separation distances were employed. The total mass of debris dislodged by multiple-mesh stacks is modestly smaller than that of single, contiguous-membrane shields. The cumulative surface area of all penetration holes in multiple mesh stacks is an order of magnitude smaller than that in analog multiple-foil shields, suggesting good long-term performance of the mesh designs. Due to different experimental conditions, direct and quantitative comparison with other lightweight shields is not possible at present

Bifidobacterium breve with α-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome

peer-reviewedThe aim of this study was to compare the impact of dietary supplementation with a Bifidobacterium breve strain together with linoleic acid & α-linolenic acid, for 7 weeks, on colonic sensitivity and fatty acid metabolism in rats. Maternally separated and non-maternally separated Sprague Dawley rats (n = 15) were orally gavaged with either B. breve DPC6330 (109 microorganisms/day) alone or in combination with 0.5% (w/w) linoleic acid & 0.5% (w/w) α-linolenic acid, daily for 7 weeks and compared with trehalose and bovine serum albumin. Tissue fatty acid composition was assessed by gas-liquid chromatography and visceral hypersensitivity was assessed by colorectal distension. Significant differences in the fatty acid profiles of the non-separated controls and maternally separated controls were observed for α-linolenic acid and arachidonic acid in the liver, oleic acid and eicosenoic acid (c11) in adipose tissue, and for palmitoleic acid and docosahexaenoic acid in serum (p<0.05). Administration of B. breve DPC6330 to MS rats significantly increased palmitoleic acid, arachidonic acid and docosahexaenoic acid in the liver, eicosenoic acid (c11) in adipose tissue and palmitoleic acid in the prefrontal cortex (p<0.05), whereas feeding B. breve DPC6330 to non separated rats significantly increased eicosapentaenoic acid and docosapentaenoic acid in serum (p<0.05) compared with the NS un-supplemented controls. Administration of B. breve DPC6330 in combination with linoleic acid and α-linolenic acid to maternally separated rats significantly increased docosapentaenoic acid in the serum (p<0.01) and α-linolenic acid in adipose tissue (p<0.001), whereas feeding B. breve DPC6330 with fatty acid supplementation to non-separated rats significantly increased liver and serum docosapentaenoic acid (p<0.05), and α-linolenic acid in adipose tissue (p<0.001). B. breve DPC6330 influenced host fatty acid metabolism. Administration of B. breve DPC6330 to maternally separated rats significantly modified the palmitoleic acid, arachidonic acid and docosahexaenoic acid contents in tissues. The effect was not observed in non-separated animals.This work was supported by the Science Foundation of Ireland – funded Centre for Science, Engineering and Technology, the Alimentary Pharmabiotic Centre

A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein.

Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including Huntington's and other neurological maladies. This suggests that the relative length of polyQ stretches is an important modulator of their function. Here, we report the identification of a Populus C-terminus binding protein (CtBP) ANGUSTIFOLIA (PtAN1) which contains a polyQ stretch whose functional relevance had not been established. Analysis of 917 resequenced Populus trichocarpa genotypes revealed three allelic variants at this locus encoding 11-, 13- and 15-glutamine residues. Transient expression assays using Populus leaf mesophyll protoplasts revealed that the 11Q variant exhibited strong nuclear localization whereas the 15Q variant was only found in the cytosol, with the 13Q variant exhibiting localization in both subcellular compartments. We assessed functional implications by evaluating expression changes of putative PtAN1 targets in response to overexpression of the three allelic variants and observed allele-specific differences in expression levels of putative targets. Our results provide evidence that variation in polyQ length modulates PtAN1 function by altering subcellular localization