766 research outputs found

    Terahertz Magneto Optical Polarization Modulation Spectroscopy

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    We report the development of new terahertz techniques for rapidly measuring the complex Faraday angle in systems with broken time-reversal symmetry using the cyclotron resonance of a GaAs two-dimensional electron gas in a magnetic field as a system for demonstration of performance. We have made polarization modulation, high sensitivity (< 1 mrad) narrow band rotation measurements with a CW optically pumped molecular gas laser, and by combining the distinct advantages of terahertz (THz) time domain spectroscopy and polarization modulation techniques, we have demonstrated rapid broadband rotation measurements to < 5 mrad precision.Comment: 25 pages including 7 figures, introduces use of rotating polarizer with THz TDS for Complex Faraday Angle determinatio

    Sensitivity of the human circadian system to short wavelength (420 nm) light

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    The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment, melanopsin. Nine action spectrum studies using rodents, monkeys, and human for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 nm to 484 nm, with some disagreement in short wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420 nm light for plasma melatonin suppression. Adult female (N=14) and male (N=12) subjects participated in two studies, each employing a within-subjects design. In a fluence-response study, subjects (N=8) were tested with eight light irradiances at 420 nm ranging over a four log unit photon density range of 1010 to 1014 photons/cm2/sec and one dark exposure control night. In the other study, subjects (N=18) completed an experiment comparing melatonin suppression with equal photon doses (1.21 x 1013 photons/cm2/sec) of 420 nm and 460 nm monochromatic light and a dark exposure control night. The first study demonstrated a clear fluence-response relationship between 420 nm light and melatonin suppression (p\u3c0.001) with a half-saturation constant of 2.74 x 1011 photons/cm2/sec. The second study showed that 460 nm light is significantly stronger than 420 nm light for suppressing melatonin (p\u3c0.04). Together, the results clarify the visible short wavelength sensitivity of the human melatonin suppression action spectrum. This basic physiological finding may be useful for optimizing lighting for therapeutic and other applications

    Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity

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    The uric acid/xanthine H(+) symporter, UapA, is a high-affinity purine transporter from the filamentous fungus Aspergillus nidulans. Here we present the crystal structure of a genetically stabilized version of UapA (UapA-G411VΔ1-11) in complex with xanthine. UapA is formed from two domains, a core domain and a gate domain, similar to the previously solved uracil transporter UraA, which belongs to the same family. The structure shows UapA in an inward-facing conformation with xanthine bound to residues in the core domain. Unlike UraA, which was observed to be a monomer, UapA forms a dimer in the crystals with dimer interactions formed exclusively through the gate domain. Analysis of dominant negative mutants is consistent with dimerization playing a key role in transport. We postulate that UapA uses an elevator transport mechanism likely to be shared with other structurally homologous transporters including anion exchangers and prestin

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    The Fermi GBM Gamma-Ray Burst Spectral Catalog: Four Years Of Data

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    In this catalog we present the updated set of spectral analyses of GRBs detected by the Fermi Gamma-Ray Burst Monitor (GBM) during its first four years of operation. It contains two types of spectra, time-integrated spectral fits and spectral fits at the brightest time bin, from 943 triggered GRBs. Four different spectral models were fitted to the data, resulting in a compendium of more than 7500 spectra. The analysis was performed similarly, but not identically to Goldstein et al. 2012. All 487 GRBs from the first two years have been re-fitted using the same methodology as that of the 456 GRBs in years three and four. We describe, in detail, our procedure and criteria for the analysis, and present the results in the form of parameter distributions both for the observer-frame and rest-frame quantities. The data files containing the complete results are available from the High-Energy Astrophysics Science Archive Research Center (HEASARC).Comment: Accepted for publication in ApJ

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    Multiquasiparticle states in the neutron-rich nucleus 174 Tm

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    Deep inelastic and transfer reactions with an 820-MeV, 136Xe beam and various ytterbium and lutetium targets have been employed to study high-spin structures in the neutron-rich thulium isotopes beyond 171Tm. Results in the doubly odd nucleus, 174Tm, inc

    High-spin structure, K isomers, and state mixing in the neutron-rich isotopes 173 Tm and 175 Tm

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    High-spin states in the odd-proton thulium isotopes 173Tm and 175Tm have been studied using deep-inelastic reactions and γ-ray spectroscopy. In 173Tm, the low-lying structure has been confirmed and numerous new states have been identified, including a t

    Anomalous isomeric decays in 174Lu as a probe of K-mixing and interactions in deformed nuclei

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    A KÏ€=13+, 280 ns four-quasiparticle isomer in the odd-odd nucleus 174Lu has been identified and characterized. The isomer decays to both KÏ€=7+ and KÏ€=0+ rotational bands obtained from the parallel and antiparallel coupling of the proton 7/2+[404] and neutron 7/2+[633] orbitals. K mixing caused by particle-rotation coupling explains the anomalously fast transition rates to the 7+ band but those to the 0+ band are caused by a chance degeneracy between the isomer and a collective state, allowing the mixing matrix element for a large K difference to be deduced
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