870 micron Imaging of a Transitional Disk in Upper Scorpius: Holdover from the Era of Giant Planet Formation?

We present 880 micron images of the transition disk around the star [PZ99] J160421.7-213028, a solar-mass star in the nearby Upper Scorpius association. With a resolution down to 0.34 arcsec, we resolve the inner hole in this disk, and via model fitting to the visibilities and spectral energy distribution we determine both the structure of the outer region and the presence of sparse dust within the cavity. The disk contains about 0.1 Jupiter masses of mm-emitting grains, with an inner disk edge of about 70 AU. The inner cavity contains a small amount of dust with a depleted surface density in a region extending from about 20-70 AU. Taking into account prior observations indicating little to no stellar accretion, the lack of a binary companion, and the presence of dust near 0.1 AU, we determine that the most likely mechanism for the formation of this inner hole is the presence of one or more giant planets.Comment: 12 pages, 7 figures. To appear in the Astrophysical Journa

A Herschel PACS survey of the dust and gas in Upper Scorpius disks

We present results of far-infrared photometric observations with Herschel PACS of a sample of Upper Scorpius stars, with a detection rate of previously known disk-bearing K and M stars at 70, 100, and 160 micron of 71%, 56%, and 50%, respectively. We fit power-law disk models to the spectral energy distributions of K & M stars with infrared excesses, and have found that while many disks extend in to the sublimation radius, the dust has settled to lower scale heights than in disks of the less evolved Taurus-Auriga population, and have much reduced dust masses. We also conducted Herschel PACS observations for far-infrared line emission and JCMT observations for millimeter CO lines. Among B and A stars, 0 of 5 debris disk hosts exhibit gas line emission, and among K and M stars, only 2 of 14 dusty disk hosts are detected. The OI 63 micron and CII 157 micron lines are detected toward [PZ99] J160421.7-213028 and [PBB2002] J161420.3-190648, which were found in millimeter photometry to host two of the most massive dust disks remaining in the region. Comparison of the OI line emission and 63 micron continuum to that of Taurus sources suggests the emission in the former source is dominated by the disk, while in the other there is a significant contribution from a jet. The low dust masses found by disk modeling and low number of gas line detections suggest that few stars in Upper Scorpius retain sufficient quantities of material for giant planet formation. By the age of Upper Scorpius, giant planet formation is essentially complete.Comment: 48 pages, 14 figures, accepted A&

Chemical mechanical polishing of thin film diamond

The demonstration that Nanocrystalline Diamond (NCD) can retain the superior Young's modulus (1,100 GPa) of single crystal diamond twinned with its ability to be grown at low temperatures (<450 {\deg}C) has driven a revival into the growth and applications of NCD thin films. However, owing to the competitive growth of crystals the resulting film has a roughness that evolves with film thickness, preventing NCD films from reaching their full potential in devices where a smooth film is required. To reduce this roughness, films have been polished using Chemical Mechanical Polishing (CMP). A Logitech Tribo CMP tool equipped with a polyurethane/polyester polishing cloth and an alkaline colloidal silica polishing fluid has been used to polish NCD films. The resulting films have been characterised with Atomic Force Microscopy, Scanning Electron Microscopy and X-ray Photoelectron Spectroscopy. Root mean square roughness values have been reduced from 18.3 nm to 1.7 nm over 25 {\mu}m$^2$, with roughness values as low as 0.42 nm over ~ 0.25 {\mu}m$^2$. A polishing mechanism of wet oxidation of the surface, attachment of silica particles and subsequent shearing away of carbon has also been proposed.Comment: 6 pages, 6 figure

Immunophoretic rapid diagnostic tests as a source of immunoglobulins for estimating malaria sero-prevalence and transmission intensity

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Background Sero-epidemiological methods are being developed as a tool for rapid assessment of malaria transmission intensity. Simple blood collection methods for use in field settings will make this more feasible. This paper describes validation of such a method, by analysing immunoglobulins from blood retained within immunophoretic rapid diagnostic tests (RDTs) for Plasmodium falciparum. RDTs are now widely used for the diagnosis of malaria and estimation of parasite rates, and this method represents a further use for these devices in malaria control. Methods Immunoglobulins eluted from RDTs, designed to detect parasite histidine rich protein-2 (HRP-2), were analysed by indirect ELISA for IgG recognizing the P. falciparum blood stage antigens merozoite surface protein-119 (MSP-119) and apical membrane antigen-1 (AMA-1). Optimal storage conditions for RDTs were evaluated by comparing antibody responses from RDTs stored in dry or humid conditions at 4°C or at ambient temperature (with or without air-conditioning) for 7, 31 or 70 days. Antibody levels estimated using 3,700 RDT samples from attendees at health facilities in North-eastern Tanzania were compared with contemporaneously collected filter paper blood spots (FPBS) and used to estimate seroconversion rates. Results Storage of RDTs at 4°C was optimal for immunoglobulin recovery but short-term storage at ambient temperatures did not substantially affect anti-malarial IgG levels. Results from RDTs were comparable with those from FPBSs, for both antigens. RDT-generated titres tended to be slightly higher than those generated from FPBSs, possibly due to greater recovery of immunoglobulins from RDTs compared to filter paper. Importantly, however, RDT-based seroconversion rates, and hence serological estimates of malaria transmission intensity, agreed closely with those from FPBSs. Conclusion RDTs represent a practical option for collecting blood for sero-epidemiological surveys, with potential cost and logistical advantages over filter paper and other blood collection methods. RDT-based seroepidemiology can be incorporated into routine monitoring of malaria endemicity, providing information to supplement parasite prevalence rates and generating rapid, robust assessment of malaria transmission intensity at minimal extra cost.Published versio

Structural role of the tyrosine residues of cytochrome c

The tertiary structures of horse, tuna, Neurospora crassa, horse [Hse65,Leu67]- and horse [Hse65,Leu74]-cytochromes c were studied with high-resolution 1H n.m.r. spectroscopy. The amino acid sequences of these proteins differ at position 46, which is occupied by phenylalanine in the horse proteins but by tyrosine in the remaining two, and at positions 67, 74 and 97, which are all occupied by tyrosine residues in horse and tuna cytochrome c but in the other proteins are substituted by phenylalanine or leucine, though there is only one such substitution per protein. The various aromatic-amino-acid substitutions do not seriously affect the protein structure

The Masses of Transition Circumstellar Disks: Observational Support for Photoevaporation Models

We report deep Sub-Millimeter Array observations of 26 pre-main-sequence (PMS) stars with evolved inner disks. These observations measure the mass of the outer disk (r ~20-100 AU) across every stage of the dissipation of the inner disk (r < 10 AU) as determined by the IR spectral energy distributions (SEDs). We find that only targets with high mid-IR excesses are detected and have disk masses in the 1-5 M_Jup range, while most of our objects remain undetected to sensitivity levels of M_DISK ~0.2-1.5 M_Jup. To put these results in a more general context, we collected publicly available data to construct the optical to millimeter wavelength SEDs of over 120 additional PMS stars. We find that the near-IR and mid-IR emission remain optically thick in objects whose disk masses span 2 orders of magnitude (~0.5-50 M_Jup). Taken together, these results imply that, in general, inner disks start to dissipate only after the outer disk has been significantly depleted of mass. This provides strong support for photoevaporation being one of the dominant processes driving disk evolution.Comment: Accepted for publication by ApJL, 4 pages and 3 figure

Spring 1966

Massachusetts Turf and Lawn Grass CouncilBetter Turf Through Research and Educatio

Severity of Depression Predicts Remission Rates Using Transcranial Magnetic Stimulation

Background: Multiple factors likely impact response and remission rates in the treatment of depression with repetitive transcranial magnetic stimulation (rTMS). Notably the role of symptom severity in outcomes with rTMS is poorly understood.Objective/Hypothesis: This study investigated the predictors of achieving remission in patients suffering from depression who receive ≥3 rTMS treatments per week. Methods: Available data on 41 patients treated at Walter Reed National Military Medical Center from 2009 to 2014 were included for analysis. Patients received a range of pulse sequences from 3,000 to 5,000 with left sided or bilateral coil placement. Primary outcome measures were total score on the Patient Health Questionnaire (PHQ-9) or the Quick Inventory of Depressive Symptomatology—Self Rated (QIDS-SR). Remission was defined as a total score less than five, and response was defined as a 50% decrease in the total score on both outcome metrics. Outcomes in patients diagnosed as suffering from mild or moderate depression were compared to those suffering from severe depression. Results: Of the 41 patients receiving treatment, 16 reached remission by the end of treatment. Remission rate was associated with the initial severity of depression, with patients with mild or moderate depression reaching remission at a significantly higher rate than those with severe depression. Total number of rTMS sessions or length of treatment were not predictors of remission. Conclusion: Patients with a baseline level of depression characterized as mild or moderate had significantly better outcomes following rTMS compared to patients with severe depression

Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array

An important precondition for the successful development of diagnostic assays of cerebrospinal fluid (CSF) biomarkers of age-related neurodegenerative diseases is an understanding of the dynamic nature of the CSF proteome during the normal aging process. In this study, a novel proteomic technology was used to quantify hundreds of proteins simultaneously in the CSF from 90 cognitively normal adults 21 to 85 years of age. SomaLogic's highly multiplexed proteomic platform can measure more than 800 proteins simultaneously from small volumes of biological fluids using novel slow off-rate modified aptamer (SOMAmer) protein affinity reagents with sensitivity, specificity, and dynamic ranges that meet or exceed those of enzyme-linked immunosorbent assays. In the first application of this technology to CSF, we detected 248 proteins that possessed signals greater than twofold over background. Several novel correlations between detected protein concentrations and age were discovered that indicate that both inflammation and response to injury in the central nervous system may increase with age. Applying this powerful proteomic approach to CSF provides potential new insight into the aging of the human central nervous system that may have utility in discovering new disease-related changes in the CSF proteome