2,359 research outputs found
Production of trans-Neptunian binaries through chaos-assisted capture
The recent discovery of binary objects in the Kuiper-belt opens an invaluable
window into past and present conditions in the trans-Neptunian part of the
Solar System. For example, knowledge of how these objects formed can be used to
impose constraints on planetary formation theories. We have recently proposed a
binary-object formation model based on the notion of chaos-assisted capture.
Here we present a more detailed analysis with calculations performed in the
spatial (three-dimensional) three- and four-body Hill approximations. It is
assumed that the potential binary partners are initially following heliocentric
Keplerian orbits and that their relative motion becomes perturbed as these
objects undergo close encounters. First, the mass, velocity, and orbital
element distribu- tions which favour binary formation are identified in the
circular and elliptical Hill limits. We then consider intruder scattering in
the circular Hill four-body problem and find that the chaos-assisted capture
mechanism is consistent with observed, apparently randomly distributed, binary
mutual orbit inclinations. It also predicts asymmetric distributions of
retrograde versus prograde orbits. The time-delay induced by chaos on particle
transport through the Hill sphere is analogous to the formation of a resonance
in a chemical reaction. Implications for binary formation rates are considered
and the 'fine-tuning' problem recently identified by Noll et al. (2007) is also
addressed.Comment: submitted to MNRA
Atomic Cluster Au<sub>10</sub><sup>+</sup> Is a Strong Broadband Midinfrared Chromophore
We report an intense broadband midinfrared absorption band in the Au10+ cluster in a region in which only molecular vibrations would normally be expected. Observed in the infrared multiple photon dissociation spectra of Au10Ar+, Au10(N2O)+, and Au10(OCS)+, the smooth feature stretches 700–3400 cm-1 (λ=14–2.9 μm). Calculations confirm unusually low-energy allowed electronic excitations consistent with the observed spectra. In Au10(OCS)+, IR absorption throughout the band drives OCS decomposition resulting in CO loss, providing an alternative method of bond activation or breaking
Football (Soccer) as a probable cause of long-term neurological impairment and neurodegeneration: a narrative review of the debate
Football (soccer) is the most widely played sport across the globe. Due to some recent high-profile cases and epidemiological studies suggesting football can lead to neurodegeneration, scientific and public interest has been piqued. This has resulted in research into whether an association between football participation and neurodegeneration or neurological impairment is present. It has been theorised that a combination of repeated sub-concussive and concussive injuries, due to ball-heading and head collisions, may lead to neurodegeneration. However, evidence remains conflicting. Due to the popularity of the sport, and the serious conditions it has been linked to, it is important to determine whether repeated head impacts during football participation can play a causative role in neurodegenerative disease. To answer this question, a review of the current literature was carried out. Epidemiological evidence showed a higher incidence of amyotrophic lateral sclerosis amongst amateur and professional footballers and that footballers in positions that involve less contact and heading, e.g., goalkeepers lead significantly longer lives. Additionally, imaging studies reach a similar conclusion, reporting changes in brain structure, blood flow, and inflammatory markers in footballers when compared to controls. However, studies looking at an association between heading frequency and cognition show a lack of consensus on whether a higher heading exposure results in reduced cognition. Similarly, in neuropathological studies, signs of chronic traumatic encephalopathy (CTE) have been found in some former players, with contrasting studies suggesting low levels of CTE-type pathology are found in the general population, regardless of exposure to head trauma. The majority of studies suggest a link between football and neurodegenerative disease. However, the high prevalence of retrospective cohort and cross-sectional studies, often plagued by recall bias, undermine the conclusions drawn. Therefore, until larger prospective cohort studies are conducted, concrete conclusions cannot be made. However, caution can be exercised to limit head impacts
ShortRead: a bioconductor package for input, quality assessment and exploration of high-throughput sequence data
Summary: ShortRead is a package for input, quality assessment, manipulation and output of high-throughput sequencing data. ShortRead is provided in the R and Bioconductor environments, allowing ready access to additional facilities for advanced statistical analysis, data transformation, visualization and integration with diverse genomic resources
Faster disease progression in Parkinson's disease with type 2 diabetes is not associated with increased α-synuclein, tau, amyloid-β or vascular pathology
AIMS: Growing evidence suggests a shared pathogenesis between Parkinson's disease and diabetes although the underlying mechanisms remain unknown. The aim of this study is to evaluate the effect of type 2 diabetes on Parkinson's disease progression and to correlate neuropathological findings to elucidate pathogenic mechanisms. METHODS: In this cohort study, medical records were retrospectively reviewed of cases with pathologically-confirmed Parkinson's disease with and without pre-existing type 2 diabetes. Time to disability milestones (recurrent falls, wheelchair dependence, dementia, and care home placement) and survival were compared to assess disease progression and their risk estimated using Cox hazard regression models. Correlation with pathological data was performed, including quantification of α-synuclein in key brain regions and staging of vascular, Lewy and Alzheimer's pathologies. RESULTS: Patients with PD and diabetes (male 76%; age at death 78.6 ± 6.2 years) developed earlier falls (P < 0.001), wheelchair dependence (P = 0.004), dementia (P < 0.001), care home admission (P < 0.001) and had reduced survival (P < 0.001). Predating diabetes was independently associated with a two to three-fold increase in the risk of disability and death. Neuropathological assessment did not show any differences in global or regional vascular pathology, α-synuclein load in key brain areas, staging of Lewy pathology or Alzheimer's disease pathology. CONCLUSIONS: Pre-existing type 2 diabetes contributes to faster disease progression and reduced survival in Parkinson's disease which is not driven by increased vascular, Lewy or Alzheimer's pathologies. Additional non-specific neurodegeneration related to chronic brain insulin resistance may be involved
Dissociation energies of AgRG (RG = Ar, Kr, Xe) and AgO molecules from velocity map imaging studies
The near ultraviolet photodissociation dynamics of silver atom rare gas
dimers have been studied by velocity map imaging. AgRG (RG = Ar, Kr, Xe)
species generated by laser ablation are excited in the region of the C <- X
continuum leading to direct, near threshold dissociation generating Ag* (2P3/2)
+ RG (1S0) products. Images recorded at excitation wavelengths throughout the C
<- X continuum, coupled with known atomic energy levels, permit determination
of the ground X (2SIGMA+) state dissociation energies of 85.9 +/- 23.4 cm-1
(AgAr), 149.3 +/- 22.4 cm-1 (AgKr) and 256.3 +/- 16.0 cm-1 (AgXe). Three
additional photolysis processes, each yielding Ag atom photoproducts, are
observed in the same spectral region. Two of these are markedly enhanced in
intensity upon seeding the molecular beam with nitrous oxide, and are assigned
to photodissociation of AgO at the two photon level. These features yield an
improved ground state dissociation energy for AgO of 15965 +/- 81 cm-1, which
is in good agreement with high level calculations. The third process results in
Ag atom fragments whose kinetic energy shows anomalously weak photon energy
dependence and is assigned tentatively to dissociative ionization of the silver
dimer Ag2
R/Bioconductor software for Illumina's Infinium whole-genome genotyping BeadChips
Summary: Illumina produces a number of microarray-based technologies for human genotyping. An Infinium BeadChip is a two-color platform that types between 105 and 106 single nucleotide polymorphisms (SNPs) per sample. Despite being widely used, there is a shortage of open source software to process the raw intensities from this platform into genotype calls. To this end, we have developed the R/Bioconductor package crlmm for analyzing BeadChip data. After careful preprocessing, our software applies the CRLMM algorithm to produce genotype calls, confidence scores and other quality metrics at both the SNP and sample levels. We provide access to the raw summary-level intensity data, allowing users to develop their own methods for genotype calling or copy number analysis if they wish
Properties of continuous Fourier extension of the discrete cosine transform and its multidimensional generalization
A versatile method is described for the practical computation of the discrete
Fourier transforms (DFT) of a continuous function given by its values
at the points of a uniform grid generated by conjugacy classes
of elements of finite adjoint order in the fundamental region of
compact semisimple Lie groups. The present implementation of the method is for
the groups SU(2), when is reduced to a one-dimensional segment, and for
in multidimensional cases. This simplest case
turns out to result in a transform known as discrete cosine transform (DCT),
which is often considered to be simply a specific type of the standard DFT.
Here we show that the DCT is very different from the standard DFT when the
properties of the continuous extensions of these two discrete transforms from
the discrete grid points to all points are
considered. (A) Unlike the continuous extension of the DFT, the continuous
extension of (the inverse) DCT, called CEDCT, closely approximates
between the grid points . (B) For increasing , the derivative of CEDCT
converges to the derivative of . And (C), for CEDCT the principle of
locality is valid. Finally, we use the continuous extension of 2-dimensional
DCT to illustrate its potential for interpolation, as well as for the data
compression of 2D images.Comment: submitted to JMP on April 3, 2003; still waiting for the referee's
Repor
Quality Assessment and Data Analysis for microRNA Expression Arrays
MicroRNAs are small (∼22 nt) RNAs that regulate gene expression and play important roles in both normal and disease physiology. The use of microarrays for global characterization of microRNA expression is becoming increasingly popular and has the potential to be a widely used and valuable research tool. However, microarray profiling of microRNA expression raises a number of data analytic challenges that must be addressed in order to obtain reliable results. We introduce here a universal reference microRNA reagent set as well as a series of nonhuman spiked-in synthetic microRNA controls, and demonstrate their use for quality control and between-array normalization of microRNA expression data. We also introduce diagnostic plots designed to assess and compare various normalization methods. We anticipate that the reagents and analytic approach presented here will be useful for improving the reliability of microRNA microarray experiments
- …