725 research outputs found
Démarche diagnostique en mycologie
Troisième partie : Maladies fongiques</p
Autres mycoses profondes
Mucormycoses tropicalesTroisième partie: Maladies fongiques</p
Introduction à la mycologie en zones tropicales
Troisième partie : Maladies fongiques</p
Age-dependent skewing of X chromosome inactivation appears delayed in centenarians\u2019 offspring. Is there a role for allelic imbalance in Healthy Aging and Longevity?
Recently, it has been proposed that age-related X chromosome inactivation (XCI) skewing can clinically result in late-onset X-linked disorders. This observation leads to hypothesize that age-related skewed XCI might also influence lifespan in women. To investigate this issue, we employed a new experimental model of longevity and healthy aging including 55 female centenarians, 40 of their offspring, 33 age-matched offspring of both non-long-lived parents and 41 young women. Peripheral blood DNA from 169 females was screened for heterozygosity at the HUMARA locus. We confirmed that skewing of XCI is an age-dependent phenomenon. However, skewed XCI was significantly less severe and frequent in centenarians' offspring [degree of skewing (DS) = 0.16 \ub1 0.02] compared to age-matched offspring of both non-long-lived parents (DS = 0.24 \ub1 0.02) (P < 0.05). A second goal was to assess whether changes in XCI pattern could be a consequence of loss of methylation on X chromosome. Using a methylation array evaluating 1085 CpG sites across X chromosome and eleven CpG sites located at HUMARA locus, no differences in methylation levels and profiles emerged between all groups analysed, thus suggesting that age-associated epigenetic changes could not influence HUMARA results. In conclusion, the results presented herein highlight for the first time an interesting link between skewing of XCI and healthy aging and longevity. We speculate that the allelic imbalance produced by XCI skewing may compromise the cooperative and compensatory organization occurring between the two cell populations that make up the female mosaic
OBDD-Based Representation of Interval Graphs
A graph can be described by the characteristic function of the
edge set which maps a pair of binary encoded nodes to 1 iff the nodes
are adjacent. Using \emph{Ordered Binary Decision Diagrams} (OBDDs) to store
can lead to a (hopefully) compact representation. Given the OBDD as an
input, symbolic/implicit OBDD-based graph algorithms can solve optimization
problems by mainly using functional operations, e.g. quantification or binary
synthesis. While the OBDD representation size can not be small in general, it
can be provable small for special graph classes and then also lead to fast
algorithms. In this paper, we show that the OBDD size of unit interval graphs
is and the OBDD size of interval graphs is $O(\
| V \ | \log \ | V \ |)\Omega(\ | V \ | \log
\ | V \ |)O(\log \ | V \ |)O(\log^2 \ | V \ |)$ operations and
evaluate the algorithms empirically.Comment: 29 pages, accepted for 39th International Workshop on Graph-Theoretic
Concepts 201
No association between frailty index and epigenetic clocks in Italian semi-supercentenarians
Centenarians experience successful ageing, although they still present high heterogeneity in their health status. The frailty index is a biomarker of biological age, able to capture such heterogeneity, even at extreme old age. At the same time, other biomarkers (e.g., epigenetic clocks) may be informative the biological age of the individual and potentially describe the ageing status in centenarians. In this article, we explore the relationship between epigenetic clocks and frailty index in a cohort of Italian centenarians. No association was reported, suggesting that these two approaches may describe different aspects of the same ageing process
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