351 research outputs found
Nuclear phytochrome a signaling promotes phototropism in Arabidopsis.
Phototropin photoreceptors (phot1 and phot2 in Arabidopsis thaliana) enable responses to directional light cues (e.g., positive phototropism in the hypocotyl). In Arabidopsis, phot1 is essential for phototropism in response to low light, a response that is also modulated by phytochrome A (phyA), representing a classical example of photoreceptor coaction. The molecular mechanisms underlying promotion of phototropism by phyA remain unclear. Most phyA responses require nuclear accumulation of the photoreceptor, but interestingly, it has been proposed that cytosolic phyA promotes phototropism. By comparing the kinetics of phototropism in seedlings with different subcellular localizations of phyA, we show that nuclear phyA accelerates the phototropic response, whereas in the fhy1 fhl mutant, in which phyA remains in the cytosol, phototropic bending is slower than in the wild type. Consistent with this data, we find that transcription factors needed for full phyA responses are needed for normal phototropism. Moreover, we show that phyA is the primary photoreceptor promoting the expression of phototropism regulators in low light (e.g., PHYTOCHROME KINASE SUBSTRATE1 [PKS1] and ROOT PHOTO TROPISM2 [RPT2]). Although phyA remains cytosolic in fhy1 fhl, induction of PKS1 and RPT2 expression still occurs in fhy1 fhl, indicating that a low level of nuclear phyA signaling is still present in fhy1 fhl
Suicides in Psychiatric Patients: Identifying Health Care-Related Factors through Clinical Practice Reviews.
The objective of this study was to identify health care-related factors associated with death by suicide in psychiatric patients and to gain insight into clinician views on how to deal with suicidality. The study material derived from a clinician committee in a psychiatric department reviewing every outpatient and inpatient suicide in a standardized way. Reports' conclusions and corresponding plenary discussion minutes regarding 94 suicides were analyzed using inductive thematic content analysis. Health care-related factors were categorized into 4 themes: patient evaluation, patient management, clinician training, and involvement of relevant non-clinical partners. Clinician views on the themes were expressed through statements (i) promoting or restricting an aspect of care (here called recommendations), which mainly followed existing guidelines and were consensual and (ii) without precise indication (here called comments), which departed from mainstream opinions or addressed topics not covered by existing policy. Involvement of non-clinical partners emerged as a new key issue for suicide prevention in psychiatric departments and should be openly discussed with patients. Clinicians preferred balanced conclusions when they reviewed suicide cases
Laser-driven plasma waves in capillary tubes
The excitation of plasma waves over a length of up to 8 centimeters is, for
the first time, demon- strated using laser guiding of intense laser pulses
through hydrogen filled glass capillary tubes. The plasma waves are diagnosed
by spectral analysis of the transmitted laser radiation. The dependence of the
spectral redshift, measured as a function of filling pressure, capillary tube
length and incident laser energy, is in excellent agreement with simulation
results. The longitudinal accelerating field inferred from the simulations is
in the range 1 -10 GV/m
Spin-to-Orbital Angular Momentum Conversion in Semiconductor Microcavities
We experimentally demonstrate a technique for the generation of optical beams
carrying orbital angular momentum using a planar semiconductor microcavity.
Despite being isotropic systems, the transverse electric - transverse magnetic
(TE-TM) polarization splitting featured by semiconductor microcavities allows
for the conversion of the circular polarization of an incoming laser beam into
the orbital angular momentum of the transmitted light field. The process
implies the formation of topological entities, a pair of optical half-vortices,
in the intracavity field
Hollow microspheres as targets for staged laser-driven proton acceleration
A coated hollow core microsphere is introduced as a novel target in ultra-intense laser-matter interaction experiments. In particular, it facilitates staged laser-driven proton acceleration by combining conventional target normal sheath acceleration (TNSA), power recycling of hot laterally spreading electrons and staging in a very simple and cheap target geometry. During TNSA of protons from one area of the sphere surface, laterally spreading hot electrons form a charge wave. Due to the spherical geometry, this wave refocuses on the opposite side of the sphere, where an opening has been laser micromachined. This leads to a strong transient charge separation field being set up there, which can post-accelerate those TNSA protons passing through the hole at the right time. Experimentally, the feasibility of using such targets is demonstrated. A redistribution is encountered in the experimental proton energy spectra, as predicted by particle-in-cell simulations and attributed to transient fields set up by oscillating currents on the sphere surface
Preventing sexism and sexual harassment in medical schools by using Theater of the Oppressed as an interactive and reflexive tool.
Among the measures taken to combat sexism and sexual harassment, prevention courses for medical students are one possibility. We aimed to describe the process of implementing a training course on the prevention of sexism and sexual harassment for medical students in two Swiss medical schools by using the Theater of the Oppressed as an interactive and reflexive tool within the course. The purpose of this theater was to give the students the opportunity to express themselves and to collectively look for and discuss ways to combat and escape from oppressive situations.
This collaborative, innovative, and interactive implementation showed that different forms of a training course can be implemented with similar objectives in an adaptable and transferable manner. The interactive and reflexive Theater of the Oppressed was an appropriate option to reach the objectives. Courses were based on identifying and acting on concrete problematic situations by focusing on individual, collective, and institutional resources. Students reported a high level of satisfaction
XUV digital in-line holography using high-order harmonics
A step towards a successful implementation of timeresolved digital in-line
holography with extreme ultraviolet radiation is presented. Ultrashort XUV
pulses are produced as high-order harmonics of a femtosecond laser and a
Schwarzschild objective is used to focus harmonic radiation at 38 nm and to
produce a strongly divergent reference beam for holographic recording.
Experimental holograms of thin wires are recorded and the objects
reconstructed. Descriptions of the simulation and reconstruction theory and
algorithms are also given. Spatial resolution of few hundreds of nm is
potentially achievable, and micrometer resolution range is demonstrated.Comment: 8 pages, 8 figure
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