Programas internacionais de capacitação em pesquisa para enfermeiros no estudo do fenómeno das drogas na América Latina: desafios e perspectivas

The First International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in the Americas is a result of a partnership between the Inter-American Drug Abuse Control Commission (CICAD) of the Organization of American States (OAS) and the Faculty of Nursing in the University of Alberta, with financial support from the Government of Canada. The program was divided into two parts. The first part of the program was held at the University of Alberta in Edmonton, Alberta, Canada. It involved capacity-building in research methodologies at the Faculty of Nursing, which lead to the preparation of four multi-centric research proposals for drug demand reduction in the home countries of the eleven participants in the program. The second part of the program was related to the implementation of multi-centric research proposals in seven countries in Latin America and in Canada. This program presented expertise in research methodology to members of Latin American Schools of Nursing and introduced Latin American expertise to members of a Canadian Faculty of Nursing. The International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in the Americas has fostered the kind of inter-cultural respect and mutual appreciation necessary to confront the global health problem of the abuse of both licit and illicit drugs.El Primer Programa Internacional de Capacitación en Investigación para Enfermeros en el Estudio del Fenómeno de las Drogas en las Américas resultó de una colaboración entre la Comisión Interamericana para el Control del Abuso de Drogas (CICAD) de la Organización de los Estados Americanos (OEA) y la Facultad de Enfermería en la Universidad de Alberta, con apoyo financiero del Gobierno de Canadá. El programa fue dividido en dos partes. La primera parte del programa se organizó en la Universidad de Alberta en Edmonton, Alberta, Canadá. Abarcó la capacitación en metodologías de investigación en la Facultad de Enfermería, que llevó a la preparación de cuatro propuestas de investigación multicéntrica con vistas a la reducción de la demanda de drogas en los países de origen de los once participantes en el programa. La segunda parte del programa estaba relacionada a la implementación de propuestas de investigación multicéntrica en siete países de América Latina y en Canadá. Este programa presentó conocimientos especializados en metodologías de investigación a miembros de Escuelas de Enfermería latinoamericanas e introdujo los conocimientos especializados latinoamericanos a miembros de una Facultad de Enfermería canadiense. El Programa Internacional de Capacitación en Investigación para Enfermeros en el Estudio del Fenómeno de las Drogas en las Américas estimuló el tipo de respecto intercultural y apreciación mutua necesario para confrontar el problema de salud global del abuso de drogas lícitas e ilícitas.O Primeiro Programa Internacional de Capacitação para Enfermeiros no Estudo do Fenômeno das Drogas nas Américas é resultado de uma parceria entre a Comissão Interamericana para o Controle do Abuso das Drogas (CICAD) da Organização dos Estados Americanos (OEA) e a Faculdade de Enfermagem da Universidade de Alberta, com apoio financeiro do Governo do Canadá. O programa foi dividido em duas partes. A primeira parte do programa foi realizada na Universidade de Alberta em Edmonton, Alberta, Canadá. Compreendeu a capacitação em metodologias de pesquisa na Faculdade de Enfermagem, que levou à preparação de quatro propostas de pesquisas multicêntricas para a redução da demanda de drogas nos países de origem dos onze participantes no programa. A segunda parte do programa estava relacionada à implementação de propostas de pesquisa multicêntricas em sete países da América Latina e no Canadá. Este programa apresentou expertise em metodologias de pesquisa a membros de Escolas de Enfermagem latino-americanas e introduziu expertise latino-americana a membros de uma Faculdade de Enfermagem canadense. O Primeiro Programa Internacional de Capacitação para Enfermeiros no Estudo do Fenômeno das Drogas nas Américas estimulou o tipo de respeito intercultural e apreço mútuo necessário para confrontar o problema de saúde global do abuso das drogas lícitas e ilícitas

Gerenciamento do enfermeiro na prática clínica: problemas e desafios em busca de competência

With the purpose to enable reflections concerning nurses' managerial performance in hospitalization units, three studies conducted in three different decades, in the same university hospital, were analyzed. From this analysis, it was observed that nurses' managerial practice has been mainly characterized by the accentuated compliance to pre-established norms, thus showing a reiterative praxis. Understanding the fragility of this managerial situation in terms of involvement with and commitment to clients and service givers, an alternative managerial conduct, which is based on the creative praxis, is presented to nurses.Com o propósito de possibilitar reflexão sobre o desempenho gerencial do enfermeiro na unidade de internação, os autores analisaram três estudos efetuados em décadas distintas no mesmo hospital escola. Desta análise, constataram que o exercício gerencial do enfermeiro tem-se caracterizado, sobretudo, pela vinculação acentuada a normas preestabelecidas, configurando uma práxis reiterativa. Compreendendo a fragilidade desta situação gerencial em termos de envolvimento e compromisso com os clientes e prestadores de serviços, os autores apresentam uma alternativa de conduta gerencial para o enfermeiro fundamentada na práxis criadora.With the purpose to enable reflections concerning nurses' managerial performance in hospitalization units, three studies conducted in three different decades, in the same university hospital, were analyzed. From this analysis, it was observed that nurses' managerial practice has been mainly characterized by the accentuated compliance to pre-established norms, thus showing a reiterative praxis. Understanding the fragility of this managerial situation in terms of involvement with and commitment to clients and service givers, an alternative managerial conduct, which is based on the creative praxis, is presented to nurses

Hearing Aid Patients in Private Practice and Public Health (Veterans Affairs) Clinics: Are They Different?

Objective: In hearing aid research, it is commonplace to combine data across subjects whose hearing aids were provided in different service delivery models. There is reason to question whether these types of patients are always similar enough to justify this practice. To explore this matter, this investigation evaluated similarities and differences in self-report data obtained from hearing aid patients derived from public health (Veterans Affairs, VA) and private practice (PP) settings. Design: The study was a multisite, cross-sectional survey in which 230 hearing aid patients from VA and PP audiology clinic settings provided self-report data on a collection of questionnaires both before and after the hearing aid fitting. Subjects were all older adults with mild to moderately severe hearing loss. About half of them had previous experience wearing hearing aids. All subjects were fitted with wide-dynamic-range-compression instruments and received similar treatment protocols. Results: Numerous statistically significant differences were observed between the VA and PP subject groups. Before the fitting, VA patients reported higher expectations from the hearing aids and more severe unaided problems compared with PP patients with similar audiograms. Three wks after the fitting, VA patients reported more satisfaction with their hearing aids. On some measures VA patients reported more benefit, but different measures of benefit did not give completely consistent results. Both groups reported using the hearing aids an average of approximately 8 hrs per day. VA patients reported age-normal physical and mental health, but PP patients tended to report better than typical health for their age group. Conclusions: These data indicate that hearing aid patients seen in the VA public health hearing services are systematically different in self-report domains from those seen in private practice services. It is therefore risky to casually combine data from these two types of subjects or to generalize research results from one group to the other. Further, compared with PP patients, VA patients consistently reported more favorable hearing aid fitting outcomes. Additional study is indicated to explore the determinants of this result and its generalizability to other public health service delivery systems such as those in other countries. Moreover, efforts should be made to assess the potential for transferring positive elements from the VA system to the PP service delivery system, if possible. (Ear & Hearing 2005;26;513-528) It is arguable that audiology in the United States had its origins in the programs designed to provide rehabilitation for veterans who had sustained hearing damage as a result of military service in World War II. One of the major components of those programs was provision of amplification and counseling about its use. Since that time, the Department of Veterans Affairs (VA) has been a major supporter of research oriented toward the acquisition of scientific and clinical knowledge about provision of hearing aids for adults. A large volume of literature has accumulated describing the results of experiments that have featured hearing-impaired veterans as subjects. These patients receive services in a public health system in which public funds are used to provide services to improve or protect the health of veterans. At least two other entities have supported and produced research exploring hearing aids and fitting methods: hearing aid manufacturers and academic institutions such as universities and the National Institutes of Health. Many of the subjects serving in these studies were recruited from sources that would not be classified as public health services, such as free-standing dispensing practices or university-based dispensing clinics. In this article, patients seen in free-standing dispensing practices are classified as receiving services in a private practice (PP) system. University-based clinics might differ from freestanding dispensaries along several dimensions. a Some university-based clinics operate in a way that is similar to a private practice, whereas others do not follow this model. The VA public health service delivery setting is different in several key respects from most PP service delivery settings. The VA clinic is usually lo

Adrenal Cushing Syndrome Diagnosed during Pregnancy: Successful Medical Management with Metyrapone

Adrenal Cushing syndrome during pregnancy is rare, and there is limited information on the effect and safety of metyrapone treatment both for mother and fetus. We present a 24-year-old woman diagnosed with adrenal Cushing syndrome at the end of the second trimester. We elected treatment with metyrapone titrated to 250 mg 3 times daily, resulting in good clinical response and maternal serum and saliva cortisol levels in the upper half of the normal pregnancy range. A healthy male infant was born at 35 weeks\u27 gestation, with no clinical signs of adrenal insufficiency, this despite a low cortisol of 5 nmol/L on the first day of life. We measured metyrapone in maternal and umbilical cord blood samples, demonstrating fetal venous metyrapone levels similar to maternal venous concentration, and a fetal arterial cord concentration at about 60% of the fetal venous cord concentration. This case demonstrates that salivary cortisol levels may be used to monitor the effect of metyrapone on adrenal Cushing syndrome during pregnancy. We show, for the first time in humans, that metyrapone does cross the placenta and may suppress fetal cortisol production without necessarily causing clinical signs of adrenal insufficiency

Adrenal Cushing Syndrome Diagnosed during Pregnancy: Successful Medical Management with Metyrapone

Adrenal Cushing syndrome during pregnancy is rare, and there is limited information on the effect and safety of metyrapone treatment both for mother and fetus. We present a 24-year-old woman diagnosed with adrenal Cushing syndrome at the end of the second trimester. We elected treatment with metyrapone titrated to 250 mg 3 times daily, resulting in good clinical response and maternal serum and saliva cortisol levels in the upper half of the normal pregnancy range. A healthy male infant was born at 35 weeks\u27 gestation, with no clinical signs of adrenal insufficiency, this despite a low cortisol of 5 nmol/L on the first day of life. We measured metyrapone in maternal and umbilical cord blood samples, demonstrating fetal venous metyrapone levels similar to maternal venous concentration, and a fetal arterial cord concentration at about 60% of the fetal venous cord concentration. This case demonstrates that salivary cortisol levels may be used to monitor the effect of metyrapone on adrenal Cushing syndrome during pregnancy. We show, for the first time in humans, that metyrapone does cross the placenta and may suppress fetal cortisol production without necessarily causing clinical signs of adrenal insufficiency

Liderança internacional em enfermagem relacionada ao fenômeno das drogas: um estudo de caso da experiência de colaboração entre a Comissão Interamericana para o Controle do Abuso das Drogas (CICAD) e a Universidade de Alberta - Faculdade de Enfermagem

In this article, the authors discuss the value of international health in advancing the nursing profession through the development of strong leadership in the area of drug demand reduction. Paradigms for nursing leadership are briefly reviewed and linked to the development of the "International Nursing Leadership Institutes" organized by the Inter-American Commission for the Control of Drug Abuse (CICAD). The "International Nursing Leadership Institutes" have facilitated the implementation of Phase III of the CICAD Schools of Nursing Project: a) planning and implementing the first "International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in Latin America", b) development of Regional and National Strategic Plans for Nursing Professionals in the Area of Demand Reduction in Latin America, and c) preparation of a document that provides guidelines on how to include drug content into undergraduate and graduate nursing curricula. The article also brings reflections directly from several of the participants in the first International Research Capacity-Building Program for Nurses to Study the Drug Phenomenon in the Americas, offered in collaboration with the Faculty of Nursing at the University of Alberta in Edmonton, Canada. These reflections demonstrate the multiplicity of ways in which this capacity-building program has made it easier for these members of Latin American Schools of Nursing to show leadership in the area of drug demand reduction.En este artículo, los autores debaten el valor de la salud internacional para el avance de la profesión de enfermería a través del desarrollo de un sólido liderazgo en el área de reducción de la demanda de drogas. Los paradigmas de liderazgo de enfermería son brevemente revisados y tiene apoyado el desarrollo de la serie de "Institutos Internacionales de Liderazgo de Enfermería", organizados por la Comisión Interamericana para el Control del Abuso de Drogas (CICAD). Los "Institutos Internacionales de Liderazgo de Enfermería" han servido como facilitadores de la implementación de la Fase III del Proyecto de la CICAD de las Escuelas de Enfermería: a) planeamiento e implementación del primer "Programa Internacional de Capacitación de Enfermeras(os) para Estudiar el Fenómeno de las Drogas en América Latina", b) desarrollo de los Planes Estratégicos Regionales y Nacionales para la Profesión de Enfermería en el Área de la Reducción de la Demanda de Drogas y c) preparación de un documento directriz de como incluir el contenido de drogas en los currículos de pregrado y postgrado de enfermería. El articulo presenta también las consideraciones de los diversos participantes del primer Programa Internacional de Capacitación para Enfermeras(os), realizado en colaboración con la Facultad de Enfermería de la Universidad de Alberta, Edmonton, Canadá. Estas consideraciones demuestran la multiplicidad de maneras que el programa de capacitación ha presentado a los miembros de las Escuelas de Enfermería de América Latina para avanzar el liderazgo en el área de Reducción de la demanda de drogas.Neste artigo, os autores discutem o valor da saúde internacional para o avanço da profissão de enfermagem através do desenvolvimento de uma sólida Liderança na área de redução da demanda de drogas. Os paradigmas de Liderança em enfermagem são brevemente revisados e têm apoiado o desenvolvimento de uma série de "Institutos Internacionais de Liderança em Enfermagem", organizados pela Comissão Interamericana para o Controle do Abuso de Drogas (CICAD). Os "Institutos Internacionais de Liderança em Enfermagem" têm servido como facilitadores da implementação da Fase III do Projeto da CICAD das Escolas de Enfermagem: a) planejamento e implementação do primeiro "Programa Internacional de Capacitação de Enfermeiros no Estudo do Fenômeno das Drogas na América Latina", b) desenvolvimento de Planos Estratégicos Regionais e Nacionais para a Profissão de Enfermagem na Área da Redução da Demanda de Drogas e c) preparação de um documento de diretrizes de como incluir o conteúdo de drogas nos currículos de graduação e pós-graduação em enfermagem. O artigo apresenta também as considerações dos diversos participantes do primeiro Programa Internacional de Capacitação para Enfermeiras(os), realizado com a colaboração da Faculdade de Enfermagem da Universidade de Alberta, Edmonton, Canadá. Estas considerações demonstram a multiplicidade de maneiras que o programa de capacitação trouxe para os membros das Escolas de Enfermagem da América Latina para avançar a Liderança na área de redução da demanda de drogas

Implementation and engagement of the SMART Work & Life sitting reduction intervention: an exploratory analysis on intervention effectiveness

Background: To enhance the impact of interventions, it is important to understand how intervention engagement relates to study outcomes. We report on the level of implementation and engagement with the SMART Work & Life (SWAL) programme (delivered with (SWAL plus desk) and without a height-adjustable desk (SWAL)) and explore the effects of different levels of this on change in daily sitting time in comparison to the control group. Methods: The extent of intervention delivery by workplace champions and the extent of engagement by champions and participants (staff) with each intervention activity was assessed by training attendance logs, workplace champion withdrawal dates, intervention activities logs and questionnaires. These data were used to assess whether a cluster met defined criteria for low, medium, or high implementation and engagement or none of these. Mixed effects linear regression analyses tested whether change in sitting time varied by: (i) the number of intervention activities implemented and engaged with, and (ii) the percentage of implementation and engagement with all intervention strategies. Results: Workplace champions were recruited for all clusters, with 51/52 (98%) attending training. Overall, 12/27 (44.4%) SWAL and 9/25 (36.0%) SWAL plus desk clusters implemented all main intervention strategies. Across remaining clusters, the level of intervention implementation varied. Those in the SWAL (n = 8 (29.6%) clusters, 80 (32.1%) participants) and SWAL plus desk (n = 5 (20.0%) clusters, 41 (17.1%) participants) intervention groups who implemented and engaged with the most intervention strategies and had the highest percentage of cluster implementation and engagement with all intervention strategies sat for 30.9 (95% CI -53.9 to -7.9, p = 0.01) and 75.6 (95% CI -103.6 to -47.7, p < 0.001) fewer minutes/day respectively compared to the control group at 12 month follow up. These differences were larger than the complete case analysis. The differences in sitting time observed for the medium and low levels were similar to the complete case analysis. Conclusions: Most intervention strategies were delivered to some extent across the clusters although there was large variation. Superior effects for sitting reduction were seen for those intervention groups who implemented and engaged with the most intervention components and had the highest level of cluster implementation and engagement. Trial Registration: ISRCTN11618007. Registered on 24 January 2018. https://www.isrctn.com/ISRCTNISRCTN11618007

A three arm cluster randomised controlled trial to test the effectiveness and cost-effectiveness of the SMART work & life intervention for reducing daily sitting time in office workers : study protocol

Background:Office-based workers typically spend 70-85% of working hours, and a large proportion of leisure time, sitting. High levels of sitting have been linked to poor health. There is a need for fully powered randomised controlled trials (RCTs) with long-term follow-up to test the effectiveness of interventions to reduce sitting. This paper describes the methodology of a three-arm cluster RCT designed to determine the effectiveness and cost-effectiveness of the SMART Work &amp; Life intervention, delivered with and without a height-adjustable desk, for reducing daily sitting. Methods/Design:A three-arm cluster RCT of 33 clusters (660 council workers) will be conducted in three areas in England (Leicester; Manchester; Liverpool). Office groups (clusters) will be randomised to the SMART Work &amp; Life intervention delivered with (group 1) or without (group 2) a height-adjustable desk or a control group (group 3). SMART Work &amp; Life includes organisational (e.g., management buy-in, provision/support for standing meetings), environmental (e.g., relocating waste bins, printers), and group/individual (education, action planning, goal setting, addressing barriers, coaching, self-monitoring, social support) level behaviour change strategies, with strategies driven by workplace champions. Baseline, 3, 12 and 24 month measures will be taken. Objectively measured daily sitting time (activPAL3). objectively measured sitting, standing, stepping, prolonged sitting and moderate-to-vigorous physical activity time and number of steps at work and daily; objectively measured sleep (wrist accelerometry). Adiposity, blood pressure, fasting glucose, glycated haemoglobin, cholesterol (total, HDL, LDL) and triglycerides will be assessed from capillary blood samples. Questionnaires will examine dietary intake, fatigue, musculoskeletal issues, job performance and satisfaction, work engagement, occupational and general fatigue, stress, presenteeism, anxiety and depression and sickness absence (organisational records). Quality of life and resources used (e.g. GP visits, outpatient attendances) will also be assessed. We will conduct a full process evaluation and cost-effectiveness analysis. Discussion:The results of this RCT will 1) help to understand how effective an important simple, yet relatively expensive environmental change is for reducing sitting, 2) provide evidence on changing behaviour across all waking hours, and 3) provide evidence for policy guidelines around population and workplace health and well-being. Trial registration: ISRCTN11618007 . Registered on 21 January 2018

Participant and workplace champion experiences of an intervention designed to reduce sitting time in desk-based workers: SMART work & life

Background: A cluster randomised controlled trial demonstrated the effectiveness of the SMART Work & Life (SWAL) behaviour change intervention, with and without a height-adjustable desk, for reducing sitting time in desk-based workers. Staff within organisations volunteered to be trained to facilitate delivery of the SWAL intervention and act as workplace champions. This paper presents the experiences of these champions on the training and intervention delivery, and from participants on their intervention participation. Methods: Quantitative and qualitative feedback from workplace champions on their training session was collected. Participants provided quantitative feedback via questionnaires at 3 and 12 month follow-up on the intervention strategies (education, group catch ups, sitting less challenges, self-monitoring and prompts, and the height-adjustable desk [SWAL plus desk group only]). Interviews and focus groups were also conducted at 12 month follow-up with workplace champions and participants respectively to gather more detailed feedback. Transcripts were uploaded to NVivo and the constant comparative approach informed the analysis of the interviews and focus groups. Results: Workplace champions rated the training highly with mean scores ranging from 5.3/6 to 5.7/6 for the eight parts. Most participants felt the education increased their awareness of the health consequences of high levels of sitting (SWAL: 90.7%; SWAL plus desk: 88.2%) and motivated them to change their sitting time (SWAL: 77.5%; SWAL plus desk: 85.77%). A high percentage of participants (70%) reported finding the group catch up session helpful and worthwhile. However, focus groups highlighted mixed responses to the group catch-up sessions, sitting less challenges and self-monitoring intervention components. Participants in the SWAL plus desk group felt that having a height-adjustable desk was key in changing their behaviour, with intrinsic as well as time based factors reported as key influences on the height-adjustable desk usage. In both intervention groups, participants reported a range of benefits from the intervention including more energy, less fatigue, an increase in focus, alertness, productivity and concentration as well as less musculoskeletal problems (SWAL plus desk group only). Work-related, interpersonal, personal attributes, physical office environment and physical barriers were identified as barriers when trying to sit less and move more. Conclusions: Workplace champion and participant feedback on the intervention was largely positive but it is clear that different behaviour change strategies worked for different people indicating that a ‘one size fits all’ approach may not be appropriate for this type of intervention. The SWAL intervention could be tested in a broader range of organisations following a few minor adaptations based on the champion and participant feedback. Trial registration: ISCRCTN registry (ISRCTN11618007)

A multicomponent intervention to reduce daily sitting time in office workers: the SMART Work & Life three-arm cluster RCT

Background: Office workers spend 70–85% of their time at work sitting. High levels of sitting have been linked to poor physiological and psychological health. Evidence shows the need for fully powered randomised controlled trials, with long-term follow-up, to test the effectiveness of interventions to reduce sitting time. Objective: Our objective was to test the clinical effectiveness and cost-effectiveness of the SMART Work & Life intervention, delivered with and without a height-adjustable workstation, compared with usual practice at 12-month follow-up. Design: A three-arm cluster randomised controlled trial. Setting: Councils in England. Participants: Office workers. Intervention: SMART Work & Life is a multicomponent intervention that includes behaviour change strategies, delivered by workplace champions. Clusters were randomised to (1) the SMART Work & Life intervention, (2) the SMART Work & Life intervention with a height-adjustable workstation (i.e. SMART Work & Life plus desk) or (3) a control group (i.e. usual practice). Outcome measures were assessed at baseline and at 3 and 12 months. Main outcome measures: The primary outcome was device-assessed daily sitting time compared with usual practice at 12 months. Secondary outcomes included sitting, standing, stepping time, physical activity, adiposity, blood pressure, biochemical measures, musculoskeletal issues, psychosocial variables, work-related health, diet and sleep. Cost-effectiveness and process evaluation data were collected. Results: A total of 78 clusters (756 participants) were randomised [control, 26 clusters (n = 267); SMART Work & Life only, 27 clusters (n = 249); SMART Work & Life plus desk, 25 clusters (n = 240)]. At 12 months, significant differences between groups were found in daily sitting time, with participants in the SMART Work & Life-only and SMART Work & Life plus desk arms sitting 22.2 minutes per day (97.5% confidence interval –38.8 to –5.7 minutes/day; p = 0.003) and 63.7 minutes per day (97.5% confidence interval –80.0 to –47.4 minutes/day; p < 0.001), respectively, less than the control group. Participants in the SMART Work & Life plus desk arm sat 41.7 minutes per day (95% confidence interval –56.3 to –27.0 minutes/day; p < 0.001) less than participants in the SMART Work & Life-only arm. Sitting time was largely replaced by standing time, and changes in daily behaviour were driven by changes during work hours on workdays. Behaviour changes observed at 12 months were similar to 3 months. At 12 months, small improvements were seen for stress, well-being and vigour in both intervention groups, and for pain in the lower extremity and social norms in the SMART Work & Life plus desk group. Results from the process evaluation supported these findings, with participants reporting feeling more energised, alert, focused and productive. The process evaluation also showed that participants viewed the intervention positively; however, the extent of engagement varied across clusters. The average cost of SMART Work & Life only and SMART Work & Life plus desk was £80.59 and £228.31 per participant, respectively. Within trial, SMART Work & Life only had an incremental cost-effectiveness ratio of £12,091 per quality-adjusted life-year, with SMART Work & Life plus desk being dominated. Over a lifetime, SMART Work & Life only and SMART Work & Life plus desk had incremental cost-effectiveness ratios of £4985 and £13,378 per quality-adjusted life-year, respectively. Limitations: The study was carried out in one sector, limiting generalisability. Conclusions: The SMART Work & Life intervention, provided with and without a height-adjustable workstation, was successful in changing sitting time. Future work: There is a need for longer-term follow-up, as well as follow-up within different organisations. Trial registration: Current Controlled Trials ISRCTN11618007