Effets et mécanismes d'action des immunoglobulines humaines à l'usage intraveineux (IgIV) lors des xénogreffes discordantes

*INRA, Centre de Versailles-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, 78850 Thiverval-Grignon (FRA) Diffusion du document : INRA, Centre de Versailles-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, 78850 Thiverval-Grignon (FRA) Diplôme : Dr. d'Universit

Effets et mécanismes d'action des immunoglobulines humaines à l'usage intraveineux (IgIV) lors des xénogreffes discordantes

*INRA, Centre de Versailles-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, 78850 Thiverval-Grignon (FRA) Diffusion du document : INRA, Centre de Versailles-Grignon, Laboratoire de Génétique Moléculaire et Cellulaire, 78850 Thiverval-Grignon (FRA) Diplôme : Dr. d'Universit

Normal human immunoglobulins for intravenous use (IVIg) delay hyperacute xenograft rejection through F(ab′)2-mediated anti-complement activity

Xenotransplantation between discordant species leads to a hyperacute rejection mediated by natural antibodies, both of the IgG and IgM isotypes, activation of complement and endothelial cell activation. The combination of these mechanisms leads to a transplant survival of minutes to a few hours. Polyclonal human immunoglobulins for intravenous use (IVIg) from normal donors have proved effective in a number of antibody-mediated disorders, as well as in inflammatory disorders. We demonstrate that administration of IVIg in a guinea pig to rat model of cardiac xenografting can effectively delay hyperacute rejection. This effect is mediated by the F(ab′)2 fragments of IVIg, and is correlated to an anti-complementary activity

Transition in health care from childhood to adulthood (TCA) for lysosomal diseases patients in France. Current state and priorities : The TENALYS study

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Enhanced ionic liquid mobility induced by confinement in 1D CNT membranes

International audienceWater confined within carbon nanotubes (CNT) exhibits tremendous enhanced transport properties. Here, we extend this result to ionic liquids (IL) confined in vertically aligned CNT membranes. Under confinement, the IL self-diffusion coefficient is increased by a factor 3 compared to its bulk reference. This could lead to high power battery separators

3D Dispersion of Spherical Silica Nanoparticles in Polymer Nanocomposites: A Quantitative Study by Electron Tomography

cited By 15International audienceA simple methodology is proposed to quantitatively discuss the quality of the 3D dispersion of grafted silica nanoparticles (NPs) mixed with free chains in nanocomposites. 3D observations of NPs are obtained by transmission electron tomography (TEMT). The NPs are individualized from the tomograms by segmentation and watershed processing. Equivalent dispersions of spherical objects are then generated. By computing 3D Voronoi tessellation from the spheres, the local environment is investigated for each NP through geometrical measurements. Two types of populations of NP can be extracted: either densely packed or isolated. As the length of the free chains decreases, when the length of the free chains are close to the ones of the grafted chains, this second population becomes predominant and the quality of the dispersion gradually increases. The width of the local volume fraction distribution surrounding each NP can be considered as a quantitative parameter indicative of the homogeneity of the microstructure. It becomes narrower as the quality of the dispersion increases. © 2014 American Chemical Society