1,668 research outputs found

    The effects of Quadmill training on balance: An intervention study 2017

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    The purpose of this study was to observe and compare the effects of two separate training interventions using the QuadmillTM to a control group on balance in college-aged individuals. It was hypothesized that both experimental groups (I1 and I2) would experience improvements in balance over the intervention whereas the control group would remain at baseline. It was secondarily hypothesized that I2 would experience greater improvements than I1 in balance due to the nature of the exercise protocol. Data was collected using three systems; Balance Tracking Systems, Star Excursion Balance Test, and the Biodex Balance system. A two-way mixed methods ANOVA revealed no significant group by time interaction or group main effects for any dependent variable. Further analysis showed a significant main effect of time for nine dependent variables with a statistical significance for each of p\u3c .05. It was concluded that there was no difference between the two QuadmillTM training methods (I1, I2) on improving balance. It was also concluded that there was no difference between I1 and I2 and the control group C1

    Abemaciclib: A CDK4/6 inhibitor for the treatment of HR+/HEeR2- advanced breast cancer

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    Although early breast cancer (BC) is highly curable, advanced or metastatic disease poses numerous challenges in terms of medical management and treatment decisions and is associated with significantly worse prognosis. Among the new targeted agents, anticancer drugs exploiting the cell-cycle machinery have shown great potential in preclinical studies. CDK4/6 inhibitors target the cyclin D/CDK/retinoblastoma signaling pathway, inducing cell-cycle arrest, reduced cell viability and tumor shrinking. As the cyclin D/CDK complex is activated downstream of estrogen signaling, the combination of CDK4/6 inhibitors with standard endocrine therapies represents a rational approach to elicit synergic antitumor activity in hormone receptor-positive BC. The results of clinical trials have indeed confirmed the superiority of the combination of CDK4/6 inhibitors plus endocrine therapies over endocrine therapy alone. Currently approved are three compounds that exhibit similar structural characteristics as well as biological and clinical activities. Abemaciclib is the latest CDK4/6 inhibitor approved by the US Food and Drug Administration (FDA) in view of the results of the MONARCH 1 and 2 trials. Further trials are ongoing as other important questions await response. In this review, we focus on abemaciclib to examine preclinical and clinical results, describing current therapeutic indications, open questions and ongoing clinical trials

    Changes in Exercise Habits of University Students During the Covid-19 Lockdown

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    The purpose of this investigation was to investigate how the exercise habits of college students changed during the COVID-19 pandemic lockdown. Data were collected via an online survey distributed through the University of Southern Maine student email distribution list. All current university students were invited to participate in the survey starting in February 2021 through March 2021. The study included a questionnaire designed to capture the exercise habits of university students three months before the lockdown of COVID-19 (January – March 2020) and their exercise habits after a lockdown in (February - April 2021). The survey questions were based on the American College of Sports Medicine (ACSM) physical activity guidelines to analyze the participant's exercise habits. The participants showed a decrease in the exercise along with an increase in weekly sitting time. Before COVID-19, 21.8% of participants were sitting >35 hours per week. After the COVID-19 lockdown, 50.45% of participants were sitting >35 hours per week. The results of this study could be used for further research to promote an increase in exercise at home. With the uncertainty of the pandemic, motivating people to stand and walk more could be the first step in breaking the increase in sitting habits and help to increase exercise habits. The COVID-19 pandemic has indeed imposed many restrictions on our daily routines, but it could also guide us to new approaches for prescribing exercise programs in the future

    Utilizzo di Mineral Trioxide Aggregate nella riparazione di perforazioni della forcazione: due casi clinici

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    Aims: Mineral Trioxide Aggregate (MTA), a Portland Cement-like materi- al, developed in 1993 by M. Torabine- jad, has been suggested in the treat- ment of furcal perforation. The aim of this study is to describe two case reports of teeth with furcal perforation treated with mineral trioxide aggre- gate. Clinical cases: two molars with a furcal perforation, due to decay and iatro- genic mistake, respectively, were treated with Mineral Trioxide Aggregate during the conventional retreatment. Clinical and radiological controls show the healing of periodontal tissues. Conclusions: the MTA seems to be the best material in the treatment of furcal perforation. Its excellent action may be connected with highly reduced quantity of liquid and bacterial leak- age, and this clinical condition seems to allow the healing of periodontal tissues

    THE IMPACT OF THE COVID-19 PANDEMIC ON THE EMOTIONAL FUNCTIONING AND PSYCHOLOGICAL WELL-BEING OF ADOLESCENTS AND EMERGING ADULTS. Long-term consequences and the role of some mediators

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    openA distanza di più di tre anni dallo scoppio della pandemia di Covid-19, l’Italia ed il Mondo si trovano di fronte alle conseguenze, socio-economiche e psicologiche, di una crisi apparentemente senza precedenti. La crisi economica si inserisce su un impianto nazionale precario, le differenze sociali si acuiscono, i mesi di lockdown hanno ritardato lo sviluppo dei compiti evolutivi nelle fasce d’età più sensibili. Il disagio è in aumento, la domanda di un sostegno psicologico da parte delle più giovani generazioni è in crescita, ma tali aspetti sembrano essere invisibili alla maggioranza delle istituzioni. Questa tesi sperimentale si propone di indagare tale disagio e di analizzare le ripercussioni della pandemia di Covid-19 sulla salute mentale e sul benessere psicologico di adolescenti e adulti emergenti. La tesi, suddivisa in cinque capitoli, origina da una ricerca condotta, mediante un questionario self-report, su un campione di 513 adolescenti e adulti emergenti, con un’età compresa tra i 12 e i 26 anni. Il questionario si costituisce di una parte anagrafica iniziale seguita da sette diverse scale volte ad analizzare nello specifico: la capacità di regolazione emotiva (DERS, Difficulties in Emotion Regulation), il supporto sociale percepito (MSPSS, Multidimensional Scale of Perceived Social Support), l’autostima (RSES, Rosenberg Self Esteem Scale), la resilienza (ER89-R, Ego Resiliency Scale Revised), lo stress percepito in relazione al Covid-19 (CSSQ, Covid Student Stress Questionnaire), il possibile trauma associato al Covid-19 (IES-R, Impact of Event Scale – Revised) e lo stato generale di benessere psicologico (PGWBI, Psychological General Well-Being Index). L’ipotesi da cui la ricerca muove è quella di indagare la presenza di una correlazione tra lo stress esperito durante il periodo pandemico e l’impatto che questo ha avuto sul funzionamento psichico e il benessere di adolescenti e adulti emergenti nel lungo periodo. All’interno di tale analisi, la ricerca si propone di indagare il ruolo di alcuni fattori di mediazione: da un lato costrutti psicologici quali l’autostima, la resilienza, il supporto sociale percepito e la difficoltà di regolazione emotiva, dall'altro il ruolo del genere, dell’età e del sonno, dell’attività sportiva, e dell’uso dei social media
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