199 research outputs found
GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker
OBJECTIVE: To analyze glucose transporter 1 expression patterns in malignant tumors of various cell types and evaluate their diagnostic value by immunohistochemistry. INTRODUCTION: Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans. Glucose transporter 1 is aberrantly expressed in several tumor types. Studies have implicated glucose transporter 1 expression as a prognostic and diagnostic marker in tumors, primarily in conjunction with positron emission tomography scan data. METHODS: Immunohistochemistry for glucose transporter 1 was performed in tissue microarray slides, comprising 1955 samples of malignant neoplasm from different cell types. RESULTS: Sarcomas, lymphomas, melanomas and hepatoblastomas did not express glucose transporter 1. Fortyseven per cent of prostate adenocarcinomas were positive, as were 29% of thyroid, 10% of gastric and 5% of breast adenocarcinomas. Thirty-six per cent of squamous cell carcinomas of the head and neck were positive, as were 42% of uterine cervix squamous cell carcinomas. Glioblastomas and retinoblastomas showed membranous glucose transporter 1 staining in 18.6% and 9.4% of all cases, respectively. Squamous cell carcinomas displayed membranous expression, whereas adenocarcinomas showed cytoplasmic glucose transporter 1 expression. CONCLUSION: Glucose transporter 1 showed variable expression in various tumor types. Its absence in sarcomas, melanomas, hepatoblastomas and lymphomas suggests that other glucose transporters mediate the glycolytic pathway in these tumors. The data suggest that glucose transporter 1 is a valuable immunohistochemical marker that can be used to identify patients for evaluation by positron emission tomography scan. The function of cytoplasmic glucose transporter 1 in adenocarcinomas must be further examined
The detached dust shells of AQ And, U Ant, and TT Cyg
Detached circumstellar dust shells are detected around three carbon variables
using Herschel-PACS. Two of them are already known on the basis of their
thermal CO emission and two are visible as extensions in IRAS imaging data. By
model fits to the new data sets, physical sizes, expansion timescales, dust
temperatures, and more are deduced. A comparison with existing molecular CO
material shows a high degree of correlation for TT Cyg and U Ant but a few
distinct differences with other observables are also found.Comment: Letter accepted for publication on the A&A Herschel Special Issu
Dissolution Control of Mg by Cellulose AcetateâPolyelectrolyte Membranes
Cellulose acetate (CA)-based membranes are used for Mg dissolution control: the permeability of the membrane is adjusted by additions of the polyelectrolyte, poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA). Spin-coated films were characterized with FT-IR, and once exposed to an aqueous solution the film distends and starts acting as a membrane which controls the flow of ions and H2 gas. Electrochemical measurements (linear sweep voltammograms, open-circuit potential, and polarization) show that by altering the CA:PDMAEMA ratio the dissolution rate of Mg can be controlled. Such a control over Mg dissolution is crucial if Mg is to be considered as a viable, temporary biomedical implant material. Furthermore, the accumulation of corrosion products between the membrane and the sample diminishes the undesirable effects of high local pH and H2 formation which takes place during the corrosion process.Peer reviewe
X Her and TX Psc: Two cases of ISM interaction with stellar winds observed by Herschel
The asymptotic giant branch (AGB) stars X Her and TX Psc have been imaged at
70 and 160 microns with the PACS instrument onboard the Herschel satellite, as
part of the large MESS (Mass loss of Evolved StarS) Guaranteed Time Key
Program. The images reveal an axisymmetric extended structure with its axis
oriented along the space motion of the stars. This extended structure is very
likely to be shaped by the interaction of the wind ejected by the AGB star with
the surrounding interstellar medium (ISM). As predicted by numerical
simulations, the detailed structure of the wind-ISM interface depends upon the
relative velocity between star+wind and the ISM, which is large for these two
stars (108 and 55 km/s for X Her and TX Psc, respectively). In both cases,
there is a compact blob upstream whose origin is not fully elucidated, but that
could be the signature of some instability in the wind-ISM shock. Deconvolved
images of X Her and TX Psc reveal several discrete structures along the
outermost filaments, which could be Kelvin-Helmholtz vortices. Finally, TX Psc
is surrounded by an almost circular ring (the signature of the termination
shock?) that contrasts with the outer, more structured filaments. A similar
inner circular structure seems to be present in X Her as well, albeit less
clearly.Comment: 11 pages, Astronomy & Astrophysics, in pres
Seeing eye to eye: social augmented reality and shared decision making in the marketplace
Firms increasingly seek to improve the online shopping experience by enabling customers to exchange product recommendations through social augmented reality (AR). We utilize socially situated cognition theory and conduct a series of five studies to explore how social AR supports shared decision making in recommenderâdecision maker dyads. We demonstrate that optimal configurations of social AR, that is, a static (vs. dynamic) point-of-view sharing format matched with an image-enhanced (vs. text-only) communicative act, increase recommendersâ comfort with providing advice and decision makersâ likelihood of using the advice in their choice. For both, these effects are due to a sense of social empowerment, which also stimulates recommendersâ desire for a product and positive behavioral intentions. However, recommendersâ communication motives impose boundary conditions. When recommenders have strong impression management concerns, this weakens the effect of social empowerment on recommendation comfort. Furthermore, the stronger a recommenderâs persuasion goal, the less likely the decision maker is to use the recommendation in their choice
Disposable sensors in diagnostics, food and environmental monitoring
Disposable sensors are lowâcost and easyâtoâuse sensing devices intended for shortâterm or rapid singleâpoint measurements. The growing demand for fast, accessible, and reliable information in a vastly connected world makes disposable sensors increasingly important. The areas of application for such devices are numerous, ranging from pharmaceutical, agricultural, environmental, forensic, and food sciences to wearables and clinical diagnostics, especially in resourceâlimited settings. The capabilities of disposable sensors can extend beyond measuring traditional physical quantities (for example, temperature or pressure); they can provide critical chemical and biological information (chemoâ and biosensors) that can be digitized and made available to users and centralized/decentralized facilities for data storage, remotely. These features could pave the way for new classes of lowâcost systems for health, food, and environmental monitoring that can democratize sensing across the globe. Here, a brief insight into the materials and basics of sensors (methods of transduction, molecular recognition, and amplification) is provided followed by a comprehensive and critical overview of the disposable sensors currently used for medical diagnostics, food, and environmental analysis. Finally, views on how the field of disposable sensing devices will continue its evolution are discussed, including the future trends, challenges, and opportunities
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